A research team led by Francesca Luca, Ph.D., associate professor of Wayne State Universitys Center for Molecular Medicine and Genetics, has published a study that annotated environmental components that can increase or decrease disease risk through changes in gene expression in 43 genes that could exacerbate or buffer the genetic risk for cardiovascular disease. Their results highlight the importance of evaluating genetic risk in the context of gene-environment interactions to improve precision medicine.
Interpreting Coronary Artery Disease Risk Through GeneEnvironment Interactions in Gene Regulation was published in Genetics, the journal of the Genetics Society of America.
The study, said Dr. Luca, also of the WSU Department of Obstetrics and Gynecology, illustrates that combining genome-wide molecular data with large-scale population-based studies is a powerful approach to investigate how genes and the environment interact to influence risk of cardiovascular disease.
By identifying regions of DNA important for endothelial cell response to different common environmental exposures, the researchers discovered that caffeine can influence the risk of cardiovascular disease. The study demonstrates the potentially beneficial and/or detrimental effects of certain environmental exposures on the cardiovascular disease risk differ depending on individual DNA sequence.
The study focused on cardiovascular disease, Dr. Luca said, because it is the leading cause of death, both in the United States and worldwide. Also, the disease is highly multifactorial, with large contributions from both environmental and genetic risk factors. By treating endothelial cells under a controlled environment, we can discover how these genetic and environmental risk factors influence each other at the molecular level, she said. Our lab has developed expertise in cardiovascular research, with additional projects using endothelial cells to develop new assays to test the regulatory activity of genetic variants. The approach outlined in this paper can be applied to many different diseases; for example, our lab has also focused on how bacteria in the human gut affect gene expression in the colon, and also on the effect of psychosocial stress on asthma.
While the work identified regions of the genome important for how endothelial cells respond to the environment and can influence the risk of cardiovascular disease, the researchers do not yet know exactly which genetic variants are directly responsible. A former graduate student, Cynthia Kalita, developed an assay to test thousands of genetic variants for gene regulatory activity. The researchers can test the variants discovered in their study using that assay to validate and explore the mechanisms by which they exert their effects, Dr. Luca said. They also are developing computational/statistical methods that can yield better personalized risk scores.
We have extended our approach to study cardiomyocytes, which are the muscle cells of the heart. Healthy heart tissue is difficult to obtain, so we have collaborated with researchers at the University of Chicago to derive cardiomyocytes from stem cells, Dr. Luca said. This will allow us to shift our focus from the vasculature to the heart itself, where we can study diseases like cardiomyopathies and arrhythmias.
As the cost of DNA sequencing continues to decrease, Dr. Luca expects that genetic testing will play a greater role in preventive health care. To fully realize the potential of precision medicine, we need to consider both genetic and environmental risk factors of disease, and how they interact. While there are already direct-to-consumer tests that prescribe an individualized diet based on DNA, these products currently offer no demonstrated clinical value. However, with very large numbers of individuals for whom we have both DNA sequencing and information on diet and lifestyle, we may one day be able to offer better recommendations.
Others involved in the study included Anthony Findley, an M.D./Ph.D. student; Allison Richards, Ph.D., a research scientist; Cristiano Petrini, of the Center for Molecular Medicine and Genetics; Adnan Alazizi, lab manager; Elizabeth Doman, of the Center for Molecular Medicine and Genetics; Alexander Shanku, Ph.D., research scientist; Gordon Davis, of the Center for Molecular Medicine and Genetics; Nancy Hauff, Department of Obstetrics and Gynecology; Yoram Sorokin, M.D., professor of Obstetrics and Gynecology; Xiaoquan Wen, of the Department of Biostatistics at the University of Michigan; and Roger Pique-Regi, Ph.D., associate professor of the Center for Molecular Medicine and Genetics, and of the Department of Obstetrics and Gynecology.
See original here:
Researchers identify environmental components that affect gene expression in cardiovascular disease - The South End
- New drug candidate uses novel absorption method to target cancer cells in mice - Michigan Medicine - August 22nd, 2022
- Jianping Fu Mechanical Engineering - University of Michigan - July 11th, 2022
- Cell Culture Market Key Drives Zeroing In On The Main Merchants | Danaher Corporation, Thermo Fisher Scientific Designer Women - Designer Women - July 11th, 2022
- Erasing The Stigma Of Sickle Cell Disease Through Advocacy - Essence - June 22nd, 2022
- This One Group Of People Holds The Key To Staying Young, Study Says Eat This Not That - Eat This, Not That - May 2nd, 2022
- Primary Cells Market 2022 is set to experience a significant growth rate | PromoCell GmbH, HemaCare Corporation, Thermo Fisher Scientific ... - May 2nd, 2022
- 3D Cell Culture Market to 2030 | Industry Statistics, Emerging Demands, Forecast to 2030 | 3D Biotek, LLC Advanced Biomatrix, Inc. Becton, Dickinson... - May 2nd, 2022
- Oral Cavity | histology - University of Michigan - April 19th, 2022
- Unraveling Stem Cells' Secrets: Immortality of Germline Cells and the Function of Junk DNA - SciTechDaily - April 19th, 2022
- Scientists De-Aged a Woman's Skin Cells by 30 Years - The Daily Beast - April 19th, 2022
- Longboat residents recall the greatest gifts - YourObserver.com - December 24th, 2021
- Nebraska Athletics News: Recruiting Season, Living Robots and Stuck in IKEA - Corn Nation - December 10th, 2021
- Duke Faculty Promoted or Appointed to the Rank of Full Professor - Duke Today - November 8th, 2021
- Lab-Growing Everything Might Be The Only Way To Attain A Sustainable World - Intelligent Living - November 8th, 2021
- Male Infertility Could Be Treated With Monkey Cells; New Study Shows How These Animals Could Help Address the Condition - Science Times - October 28th, 2021
- Insights & Outcomes: Place cells, planarians, and 'prewet' proteins - Yale News - October 28th, 2021
- Using a mini heart model to develop new therapies - MSUToday - October 5th, 2021
- Rowan University hosts National Science Foundation research program for undergrads - Rowan Today - August 31st, 2021
- Loss of a top autism gene may alter neuron structure - Spectrum - January 17th, 2021
- Rogel team receives $11.2M to leverage the microbiome against GVHD - Newswise - October 28th, 2020
- Latest Update 2020: What Are the Key Players Evolving In the Growth of the 3D Cell Culture Market? - re:Jerusalem - October 28th, 2020
- Listings - CON, THE on ABC | TheFutonCritic.com - The Futon Critic - October 15th, 2020
- ABC News Debuts New Primetime Series THE CON Narrated by Whoopi Goldberg - Broadway World - October 8th, 2020
- HOME GROWN: Pumpkins best left on the vine for as long as possible - The Oakland Press - October 8th, 2020
- Official Missteps in Michigan's Worst Covid Prison Outbreak - The Intercept - September 29th, 2020
- Regenerative medicine and war: The next breakthrough in treating injured veterans? - Genetic Literacy Project - September 29th, 2020
- Hematopoietic Stem Cells (HSCs) Market Primary Research, Secondary Research, Product Research, Trends And Forecast By 2026- Kite Pharma Inc., Thermo... - September 29th, 2020
- New research connects the hormones we're born with to lifetime risk for immunological diseases - MSUToday - September 20th, 2020
- School of Science grows by 10 - MIT News - September 10th, 2020
- COVID-19 Drug Discovery and Development Why Diverse Strategies Are Critical - Technology Networks - September 10th, 2020
- Hesperos Human-on-a-Chip used to model Alzheimer's and MCI - SelectScience - June 2nd, 2020
- Are immune-compromised kids at greater risk from Covid-19? - Health24 - May 3rd, 2020
- Erika Hersch-Green Wins CAREER Award for Biodiversity Research - Michigan Tech News - May 2nd, 2020
- Science Becomes A Dividing Issue In Year Of Election And Pandemic - Michigan Radio - May 2nd, 2020
- In a CRISPR first, Editas therapy used to fix genes in the body - BioPharma Dive - March 11th, 2020
- Stopping Smoking Allows Healthy Lung Cells to Proliferate - Medscape - February 8th, 2020
- After a bone injury, shape-shifting cells rush to the rescue - University of Michigan News - January 29th, 2020
- Engineer the future of human health with a PhD in biomedical engineering - Study International News - January 29th, 2020
- The Unexpected Diversity of Pain - Scientific American - January 24th, 2020
- BREAKING: A woman gives birth to the Son of God (Part II) - INQUIRER.net - January 5th, 2020
- Collaborative Robots: Rai... - Robotics Online - December 19th, 2019
- VetStem Biopharma Shares the Success Story of Jesse Who was Treated with VetStem Cell Therapy - PR Web - December 8th, 2019
- Stem Cell Therapy Michigan | Regenerative Medicine 248-216 ... - February 27th, 2019
- Stem Cell Treatments Bloomfield Hills, MI | 248-216-1008 - January 9th, 2019
- Michigan Integrative Health Dr. Roy Picard, D.C. - December 27th, 2018
- Breast Cancer Stem Cells Stopping Them In Their Tracks ... - November 23rd, 2018
- Stem Cell Treatments MI | Michigan Center for Renerative ... - November 2nd, 2018
- Michigan Stem Cell Therapy - Foot HealthCare Associates - November 2nd, 2018
- Cancer Stem Cell Research | University of Michigan Rogel ... - November 2nd, 2018
- University of Michigan Stem Cell Research | Treatment and ... - November 2nd, 2018
- Detroit Michigan Stem Cell Therapy - americanregen.com - September 28th, 2018
- Combination of traditional chemotherapy, new drug kills ... - September 4th, 2018
- Stem Cells FAQ Michigan Stem Cell Institute - August 29th, 2018
- Anti-Aging, Regeneration and Stem Cell Supplements - August 7th, 2018
- Families raise money for research into rare diseases - KARE - September 8th, 2017
- Cells that stand in the way of HIV cure: Discovery expands understanding of marrow's role - Medical Xpress - August 5th, 2017
- Turmeric and black pepper fight cancer stem cells - November 26th, 2016
- Michigan company mines stem cells in search of Fountain of ... - November 18th, 2016
- stem cell research | Michigan Radio - October 6th, 2016
- Stem Cell Therapy Treatment at Allure Medical Spa in Michigan - October 6th, 2016
- University of Michigan Stem Cell Research | Experts List - September 20th, 2016
- Five years after Michigan vote on human embryonic stem ... - August 26th, 2016
- Scientists coax stem cells to form 3-D mini lungs ... - August 11th, 2016
- Cancer stem cells - University of Michigan Comprehensive ... - July 25th, 2016
- Michigan Catholic Conference: Home - October 19th, 2015
- Michigan Stem Cell Amendment, Proposal 2 (2008 ... - July 2nd, 2015
- University of Michigan Stem Cell Research | Embryo Donation - May 12th, 2015
- University of Michigan Stem Cell Research | Stem Cell ... - April 22nd, 2015
- How to grow a human lung - March 25th, 2015
- Novogen (NVGN) Promising Data in Brain Cancer; eFuture Information Technology (EFUT) and ... - March 5th, 2015
- Stem Cell Research - Right to Life of Michigan - February 24th, 2015
- Breast Cancer Stem Cell Research - University of Michigan ... - January 17th, 2015
- What makes pancreatic cancer so aggressive? New study sheds light - January 16th, 2015
- Leukemia Stem Cell Research | University of Michigan ... - January 4th, 2015
- Seeing Is Believing - December 12th, 2014
- Swiston receives Commitment to Education Award - November 29th, 2014
- Bone marrow registration drive to be held at Saint Mary's College - November 18th, 2014
- Researchers devise a means for growing near 2-D chemical gardens (w/ Video) - November 11th, 2014
- Stem cells help doctors restore womans smile, regenerating bone to hold dental implants - November 5th, 2014
- Reason to Bree-Lieve: Greenville girl continues to beat the odds - November 5th, 2014