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Category Archives: New Hampshire Stem Cells
Posted: July 21, 2021 at 2:05 am
BELIZE CITY, BelizeA discarded bicycle lay on a dimly lit side street near a pool of blood, surrounded by around a dozen bullet shells in Belizes biggest city.
Local cops surveyed the scene, moving the body of 17-year-old Gerald Tillett Jr. into the back of a pickup truck as onlookers gawked at the most recent victim of a long-simmering Bloods and Crips gang war that started in the U.S.
In Belize City, Tillett Jr. was gangster royalty. Both his father and uncle, also murdered in 2016 and 2012 respectively, were leaders of an infamous Blood clique known as the George Street Gang, named for the street that traverses the rough-and-tumble Southside neighborhood where the gang is based.
Only a few blocks from where he grew up, Tillett Jr. was riding his bike on May 7 in hostile territory reportedly run by a rival Blood set known as the Taylor's Alley Gang when he was ambushed and shot to death.
Such gang violence has become all too common in Belize City, explained Police Senior Superintendent Gualberto Garcia, since the gangs started way back in the 1980s, when we started having the influx of deportees [from the U.S.], and they started the Crips and the Bloods.
As years progressed, these two gangs splintered, said Garcia. So, we have a very big number now, maybe 20 to 25 different gangs, scattered throughout the city, small factions with their own little affiliation to the Crips and the Bloods.
Now, Bloods fight Bloods and Crips fight Crips, with loyalty mostly boiling down to the block you were raised on, and longstanding beefs being handed down from generation to generation.
The murder of George Street Gang member Tillett Jr. was especially worrisome.
We are already expecting retaliation from his side, Garcia told VICE World News as he rode through the Southside in a police van.
It didn't take long.
Roughly 48 hours after Tillett Jr.'s murder, radio chatter alerted Garcia to shots fired on the corner of Church and George streetsonly a few blocks from where the teenager was murdered. Police arrived to a gruesome scene.
Blood-covered domino pieces lay strewn throughout a one-room hovel; one man dead, two others wounded, one of whom would die later at the hospital. Gunmen riding a motorbike had arrived at the small dwelling, well known locally as a place for dominoes betting games, and opened fire indiscriminately. As police quarantined the scene, family members of one of the men came to identify the body. They couldn't believe that 51-year-old Raymond Garcia, a successful bank manager and loving father, could be a victim of a gang war.
Garcia, no relation to the superintendent, had been the valedictorian of his class. He didn't have any gang affiliation. Days later his mother, Natividad Rita Garcia, told VICE World News that he had one vice: Dominoes.
He said, I love my dominos and that is a part of my life, said the elder Garcia, claiming she'd tried to get him to stop visiting the Southside domino spot off George Street. He has been playing in that area for quite some time, for many years before the guns ever started.
But after his death, she also heard the rumors of how his love of dominoes led to his death.
Those men had been playing dominoes with him for a very long time, but according to what I heard, one of the men, his children, are in the gangs, she said.
The rumor was that a man who frequented the domino games had several sons connected to a rival clique of the George Street Gang, but after the death of Tillett Jr., he hadn't come around, knowing that he and his sons could be targets. When they couldn't find the sons, they shot up the domino den even though the father wasn't there.
As Garcias yellow casket was lowered into a plot in a cemetery on the outskirts of Belize City a few days later, a family member placed a cross decorated with dominoes on top.
I couldn't believe that this would ever have happened to my family. I couldn't believe that this would happen to my son, she said. Not in the wildest of my dreams.
Belize is perhaps best known as a small picturesque tourism destination roughly the size of the U.S. state of New Hampshire, famed for its beautiful islands and coral reefs along the Caribbean coast, and its dense jungles and Mayan ruins inland. That contrast has also come to represent its racial diaspora, with more of an Afro-descendant Black population along the coast and an indigenous Mayan and Mestizo culture inland.
It stands out from other nations in mainland Central America as the only where English is the first language. Its large Black population is a lasting legacy of British colonization and the remnant of the slave trade that saw kidnapped Africans forced to work for the European settlers in the logwood industry. Belize only became fully independent from the United Kingdom in 1981 and had long been named British Honduras before changing its name in the 70s.
In 1961, a hurricane decimated the country leading to a large exodus of its inhabitants migrating to the United States, and by the end of the millennium, around 30 percent of Belizeans lived in the U.S. A large swath of them settled in California, and like many migrants who came from impoverished regions, a vulnerable subsection of that population became involved in crime.
While immigrants from other Spanish-speaking countries in the region became involved in Hispanic street gangs like the Latin Kings or the Mexican Mafia, the English-speaking Afro-descendant Belizeans who chose to enter the gang life mostly joined predominately Black gangs that sprung up in the late 1960s and 70s, like the Bloods and the Crips.
Soon after, the Bloods and Crips started appearing in Belize.
Behind the walls of the countrys central prison, Leslie Pipersburgh recalled the early days of the gangs in Belize.
Known on the streets as Pipe, the former Crip admitted he was an infamous person and had witnessed the rise of the gangs firsthand before going down for a double murder connected to a botched robbery in 2002.
The deportees, from that it started, and it never stopped. Just keep at retaliation, retaliation, retaliation. One after the other, said Pipe. So then other guys get deported, and that just strengthens it more and men adapted like cells, more and more. Then they start to learn about extortion, robberies, selling drugs. It just got out of hand from there.
Researchers have traced a small presence of Bloods and Crips in Belize to the deportation of members in the early 80s. But Pipe and numerous people interviewed by VICE World News recalled a boom in gang growth after the release of the 1988 film Colorsa cop drama directed by Dennis Hopper that follows two white police officers as they investigate the Bloods and Crips, along with a fictional multiracial gang, in South Central Los Angeles.
At the time, Colors made waves in the U.S., being released before gangster rap albums like N.W.A's Straight Outta Compton and preceding other L.A. street films like Boyz n the Hood and Menace II Society. The film also gained notoriety for using real gang members as extras in the film, and became especially controversial after a Crip murdered a Blood waiting in line to see the movie in Stockton, California.
In the soundtracks eponymous theme song, a bass-heavy Bloods and Crips anthem, Ice-T ominously raps:
Red or Blue, Cuz or Blood, it just don't matter.
Sucker die for your life when my shotgun scatters.
The gangs of L.A. will never die,
In Belize, that turn of phrase was prescient.
Although there may have been a few Bloods and Crips before, Pipe called the film the branch that spread like wildfire.
Growing up as kids, none of them claimed red nor blue. But when the movie came out, now everyone started to claim a color.
Around that time, the U.S. deported a Blood named Heathcliff Reyes and a Crip named Fredrick Lynch, aka Diggy Dap, who didn't get along.
These two guys were the leaders, said Pipe. They were cool to their own kind, but to their enemy, they got no love for their enemy.
Reyes founded a Blood clique near George Street, while Diggy Dap headed a Crips set on the other side of town near Pinks Alley, and that's how the war started.
That is where all the O.G's (Original Gangsters) came from that really know about gangs, said Pipe. Then another block started to copy them and claim the color red, and some claim the color blue, and it branched out. Then the war really started.
Belize City, and especially its ramshackle Southside neighborhood, is home to much of the country's impoverished parts of the Afro-descendant population. Its also where the majority of its gangs fight over turf. Although Belize only has a population of roughly 400,000 and Belize City is home to some 60,000 of those, its murder rate per capita often ranks as one of the highest in the world with the majority of killings happening in the Southside.
Pipe believed the rising murder rate was tied to a criminal code that has faded as more and more of the older generation were murdered, disappeared, or ended up in prison. Heathcliff Reyes would eventually be gunned down by the police in the 2000s, and Diggy Dap is rumored to have fled the country over a decade ago after witnessing the murder of one of his close associates, another Crip leader named George Junie Balls McKenzie, in 2007.
Back then in the 90s these guys didn't hurt innocent people. They only hurt who they had a problem with, said Pipe. Nowadays, the guys hurt anybody. They hurt brothers, sisters, mothers, and fathers. Anyone who they could catch, they hurt. Like this crew that is there right now, has no sense, no discipline. Theyre ruthless.
Pipe spoke with VICE World News just days after the May 7 murder of Gerald Tillett Jr. and the prison walls were buzzing with the recent arrival of 18-year-old Kalief Caceres, who police alleged had been the trigger man in the slaying. It was well known that the two teenagers had beef. They'd both been held together in the youth ward of the prison in March 2020 and grew up blocks from each other.
Clinton Harris, 33, a former Blood in prison for a 2012 murder, knew Tillett Jr. and Caceres well; he'd worked as a youth mentor in the prison's under 18 facility when the two were behind bars the year prior.
All they did was fight and quarrel, said Harris.
In the 2000s, the Tillett family became prominent players in the George Street Gang, led by Sheldon Pinky Tillett, and his brother, Gerald Shiny Tillett Sr. The George Street Gang had become bitter enemies with a rival Blood clique a few blocks away called the Taylors Alley Gang. That feud hit overdrive in 2012 when the leader of the Taylors Alley Gang, Arthur Young, allegedly gunned down Pinky Tillett at a gas station in a murder that went viral in Belize and is still visible on Youtube. Pinky Tilletts death led to a series of retaliatory killings and a week later Arthur Young died at the hands of police. Tilletts murder still loomed large over the Southside.
Harris explained that while Caceres wasnt a member of Arthur Youngs family, the elder Blood had been close with Caceres and brought him into the gang from an early age, so in a way, while not connected by blood, they were Bloods.
It was a shadow over those guys, recalled Harris about Tillett Jr. and Caceres. They believed that they had to continue that conflict.
After the death of Pinky Tillett, his brother, Gerald Shiny Tillett Sr. led the gang for several years before being gunned down himself in 2016. Tillett Jr. was only 12 years old at the time of his fathers murder, but by then, he thought that the George Street Gang was his duty in life, explained Harris.
Tillett Jr. had no intention of trying to leave the gang because he believed that was his place because of his dad.
In the days and weeks after Tillett Jrs murder, several alleged gang affiliates were murdered around the Southside, along with numerous other non-fatal shootings. But the still-unsolved murders of Raymond Garcia and Wayne Peteau in the domino den shocked the city as citizens became more concerned that the tentacles of gang violence could reach anyone in the wrong place at the wrong time.
Belize saw a change of the guard in November 2020 when Johnny Briceo became Prime Minister and his People's United Party (PUP) won a majority government, unseating the United Democratic Party (UDP) which, had held power for the previous 12 years.
Briceo entered office facing a long laundry list of challenges, the most immediate being an economy that relies heavily on tourism for roughly 40 percent of its GDP and was decimated by the coronavirus pandemic. His government quickly instituted pay cuts across the government, authorities, and civil society, leading to large protests especially by the teachers union.
Gang violence had fallen into the background of the national discussion as a strict pandemic curfew led to a decrease in violence, but the recent uptick in violent incidents immediately vaulted the country's gang problem back into the forefront half a year after the PUP took office. May would end with 21 murders in Belize, tying with April 2021 and March 2018 as the highest monthly death tolls since 2009.
The issue of gang violence is not something that just happened. It is something that has been coming up over the years. And it's unfortunate that the previous government did not have a well thought out plan on how to deal with it, Prime Minister Johnny Briceo told VICE World News less than a week after the spate of killings. And we're seeing the results, the crime is getting more outrageous, more brazen, more in your face.
He said the killing of innocent people as retaliation in gang violence was something that has rarely happened in Belize. And we are all outraged about it.
During the 12 year reign of the UDP, the former prime minister Dean Barrow instituted a two fold policy to stem gang violence. The UDP infamously negotiated several truces between the gangs, even going so far as to create a work program that paid stipends to those who agreed to stop warring in 2011. While it did lead to a drop in homicides, the program eventually ran out of money the following year and gang violence spiked again.
Barrow also took a firm hand policy against the gangs, most notoriously with the creation of a special police force in 2010 known as the Gang Suppression Unit (GSU). Over the years, a handful of prominent gangsters died at the hands of the cops, although firm accusations of extrajudicial murders by the GSU were never proven.
Several incidents gave the unit a murky reputation.
Arthur Young, the Taylor's Alley Gang boss who died in police custody in 2012, gave numerous interviews over the years claiming that the police wanted to kill him and he even threatened GSU family members on the local news a month before his death. The following year, the corpses of four high-ranking members of the George Street Gang were discovered with their throats slit in an apartment in the Southside. Many have long suspected the GSU committed the killings.
Barrow met with family members of the slain George Street Gang members in the weeks following but claimed there were no truce negotiations. However, by 2014, the police had publicly negotiated another ceasefire. It quickly failed a few months later when old disputes led to seven murders in a 10 day period.
Briceo called the negotiations the biggest mistake of the UDP's time in power because it gave the gangs legitimacy.
Since taking office, Briceo maintains that he wont negotiate with the gangs and promptly followed through on a campaign process to disband the GSU. Although the division did disappear, a new unit quickly took its place called the GI3, which stands for the Gang Intelligence, Investigation and Interdiction Unit. The PUP government claims the new unit will focus more on intelligence gathering rather than hard-handed tactics, but many critics believe its more of the same, old strategy.
Briceo said that his government is trying to change the mindset of the police and to get the respect and support from the community, and you don't get that by beating people.
Over two evenings of ride alongs with the Belize City Quick Response Team, a tactical unit that patrols the city, the police repeatedly pulled over cars and stopped young men on bikes, patting them down looking for drugs and guns, and even broke up a child's birthday party as the family screamed profanities at the officers. The prime minister believed that the strong presence in the Southside was necessary as a way to deter retaliation after Tillett Jr.'s death triggered four murders in five days.
After the flare-up in violence the now opposition UDP quickly put out a statement urging the PUP government to institute a state of emergency in the Southside, which would allow for massive sweeps of known gang members that will take them off the streets for several months without charges. Last year, during his final year in power Dean Barrow instituted two different states of emergencies in the Southside in an attempt to curb the rise in gang violence. Known gang members were arbitrarily detained and held at the Belize Central Prison for several months which, along with coronavirus curfews, led to a significant drop in homicides once again. But the results were not long-lasting. If anything, it led to the recent spate of killings.
Two people picked up in one of those sweeps were Gerald Tillett Jr., and Kalief Caceres, who were housed together in the youth ward for a month where their disagreements intensified.
The PUP remains hesitant about taking such drastic measures, which they see as ineffective and an overreach of power.
We have to be very careful on how we infringe on the rights of our citizens, and its not something that we just do flippantly, we have to think very carefully before we go down that road, said Briceo. We just have to continue to monitor those areas, those hotspots, and it can be done by a police presence. And I think wed rather do that before we start calling a state of emergency in certain areas of the city.
Instead, Briceos government hoped to institute a number of programs to address gang violence, like creating a cadet corps for youths to instill exercise and discipline, provide free education, apprenticeships and job training. These new initiatives have been delayed by financial constraints related to coronavirus.
We believe that these young kids would now have something to do as opposed to being out in the streets and have nothing to do, and the older guys prey on them, and tell them Hey you want to make a quick buck? Go on and commit a crime, said Briceo. But the only way we can deter that is by getting the economy going again, growing the economy, creating jobs.
Another avenue that the government is seriously considering is legalizing marijuana, which is a primary source of income for many of the gangs.
It's something whose time has come. But we just have to be very careful as to how were going to do it," he said. Ensuring that we have the necessary laws in place as to where we are able to grow, how are you going to cultivate it, and of course, to ensure that the government gets its fair share of taxes, and then how it's going to be sold.
On a dusty side street in a corner of the Southside, a Crip set hangs around, drinking beer, smoking weed, and keeping an eye out for intruders.
This is a dead end, this is we hole, this is we block, nobody who ain't from around here come through here, explained one member who heads the marijuana distribution for the clique.
We supply all this, waving his hands around to show that he sells to the whole neighborhood. The dealer talked about how much of the violence is related to the weed, the beef, and the colors.
But he didn't think legalization would calm things, once it went legal, boy, there'll be more war, be a lot of war.
He suggested that everyone would have weed, but also people would move into other crimes. His arguments didn't make much sense, besides explaining that the weed is a part of everything because without the weed I think, we can't eat.
That's how I live, I don't gotta job. This is what I do for a living. I got my people and I try to take care of them, said the dealer. Me, I'm the breadwinner for my peoples.
These gangsters aren't rich, they don't move kilos of cocaine or run large-scale extortion rackets. It's mostly nickel and dime street-level marijuana dealing that puts food on their plates. At one point, they even start asking for money for booze.
The dealer recalled the job program that Dean Barrow instituted in 2013 as one of the few times when the violence really dipped because they had opportunities, but when that ended, the killings continued.
Another member of the Crip set who works as an enforcer felt he had no other option than to join the gang because of where he was from.
I was born around blue. If I was born around red, I'd be red, said the clique's enforcer.
Killing became a part of life early; he had to murder someone to join the Crips and to prove you're strong enough. Now, he spends most days on his block, helping move weed, and protecting his circle.
I sell weed, you know. We just drink, smoke, enjoy ourselves, you know and anyone wanna fuck with us, we got the tools, we got the heat, we gonna do what we gotta do, said the enforcer. So if you violate me, I bout to kill you like point-blank right. I could meet you at the shop, home, in your yard, anywhere.
As he speaks, a car comes peeling into the alley. A third man who claims that he's one of the bosses of the clique gets out in a huff, speaking in nearly inaudible profanities in a mix of Belizean Creole and English, shouting baow.
The guys said baow, that's what we into, huh? said the enforcer. If you fuck with us you just gonna hear baow, it's easy.
The enforcer careened his head to overhear the conversation breaking out among the other Crips in the yard.
Sounds like somebody wants to bust on us right now. That's what he's saying, said the enforcer. He gets up, ends the interview, finds a gun stashed nearby, and disappears.
The boss explained that he'd been in his car when a rival crew spotted him and unleashed a hail of bullets. He'd been able to escape unharmed, this time.
He'd been shot three times before: My leg, my back and then my arm. But still he didn't think about imminent death often because too much thinking is bad for the brain.
In Belize City, the violence always comes and goes, said the boss, like fruits right, got the mango season. Sometimes its the killing season. It's like a disease, like AIDS, theres no cure.
Ben Solomon, Maeva Bambuck, Zach Caldwell, and Jose A. Sanchez contributed to this report.
See the rest here:
How the US Exported a Bloods and Crips Gang War to Belize - VICE
Posted: June 23, 2020 at 5:50 pm
An online game that lets students learn about stem cells and tissue engineering also offered them information about high school and college internship programs to further spur their interest in regenerative medicine.
Through the game, aimed mainly at seventh graders through high school seniors, students competed in daily challenges to win swag and the chance to meet inventor Dean Kamen (virtually in this pandemic age).
The vision is to help inform young people about all the really cool things that are happening in this space, said Alexander Titus, the freshly minted chief strategy officer at the Advanced Regenerative Manufacturing Institute in Manchesters Millyard.
The game helps to inspire students as they choose their classes, their elective classes in high school and particularly majors in college, Titus said last week.
Nearly 100 students took part in the game, which ended Friday. The content about regenerative medicine will remain online through June.
ARMI, which is working to manufacture human tissue commercially, is working on recruiting tomorrows workforce one cool video at a time.
I think the timing of this couldnt be any better, said Julie Demers, executive director of the New Hampshire Tech Alliance. The pandemic has limited in-person, work-based learning opportunities and interactions with industry professionals. Interactive opportunities to get students interested in and thinking about career opportunities are critical.
Titus said a chief goal is to build a pipeline of future workers.
Its all tied together in attracting students while theyre young to understand the process of what to study along the way to get to college and a job when theyre done, said Titus, who earned a Ph.D. in quantitative biomedical sciences at Dartmouth.
Titus said he expects the game to help ARMI officials learn what draws the interest of students so they can develop other programming they know will garner student interest, he said.
The ARMI challenge, called TEMPtation, featured profiles of businesses from more than a dozen states as well as universities and colleges interested in regenerative medicine.
Arizona State University holds summer camps for middle and high school students that are interested in learning more about science and mathematics, read one profile.
From Georgia Tech in Atlanta: Georgia Tech has a Center for Career Discovery & Development, which offers internships, co-ops, and career services that give students the resources they need to support their search for employment following their graduation.
Formerly employed at the U.S. Department of Defense, Titus returned to New Hampshire to join ARMI.
The mission, he said, is marrying science and manufacturing.
Bring the science to the stage where we can automate it and market the new technologies we couldnt make before, said Titus, previously assistant director for biotechnology within the Office of the Under Secretary of Defense for Research & Engineering.
ARMI features more than 150 partners and more than $300 million in government and private investment committed.
If we want to be able to produce a replacement heart for people who have heart disease, what are the components that go into that? Titus said.
He hopes ARMI can attract startups in the Manchester area, allowing for ARMI to mentor them until they are viable companies.
The idea is for companies to move into New Hampshire and move into our ecosystem if you will, Titus said.
I think especially given now, where were seeing so many people in the cities during COVID have a hard time social distancing, I expect well see some shifting of people out of the cities, said Titus, who speculated some could settle in New Hampshire.
Whats Working, a series exploring solutions for New Hampshires workforce needs, is sponsored by the New Hampshire Solutions Journalism Lab at the Nackey S. Loeb School of Communications and is funded by Eversource, the New Hampshire Charitable Foundation, Dartmouth-Hitchcock Medical Center, the New Hampshire College & University Council, Northeast Delta Dental and the New Hampshire Coalition for Business and Education. Contact reporter Michael Cousineau at firstname.lastname@example.org. To read stories in the series, visit unionleader.com/whatsworking.
Posted: June 13, 2020 at 4:45 pm
Fortunately there are dozens of fun things to do in Hampshire which are within an hours drive of Portsmouth.
Although we are still in lockdown because of the coronavirus pandemic, some attractions which had been closed are working on plans to reopen.
We have put together a list of activities, museums and heritage sites in our area you can enjoy with the family once lockdown is over.
Many of these places will be closed until government restrictions are lifted please check with the individual places website to see if they are open.
These include free things to do, as well as ones you can do if it is raining outside.
It displays ongoing constructions of Iron Age buildings based on real sites, crops from prehistory and rare breeds of animals.
There is loads of space for the kids to run around and the farms special events are worth checking out.
Little Woodham, near Gosport
Step back in time to the 17th century. Immerse yourself in the everyday life of people who lived in a small village in the 1600s.
Walk through real homes, watch weavers spinning wool or find the potter at his wheel.
There are hundreds of animals to admire at Marwell, including giraffes, tigers, meerkats, and penguins.
There are also three adventure playgrounds and a train, in case the animals arent enough to keep the little ones occupied.
A place to learn about the history of the industry. The building was saved because of its unique history when it closed in 1974 the men working there still worked in the same way as their Victorian and Edwardian forefathers.
Head over to Hinton Ampner, a country manor with a tranquil garden and breathtaking views across the South Downs. You can explore the garden, wander the estate, and discover the house, which was rebuilt following a fire in 1960.
The house is currently closed but the gardens and parkland are open.
Winchester Science Centre
Use a fully-functioning pinball machine to learn how we harness the potential of stem cells to repair our bodies, visit the Ancient Wisdom zone, or go on a journey of discovery through an enormous colon.
Yes, you read that right.
Hensting Alpacas, Eastleigh
If everyone needs a little fresh air, heres a fun way to trick the wee ones into walking. Hensting Alpacas like to take their animals out for a roam when the weather is good so the general public can come and meet them.
Uppark House and Gardens, Petersfield
Home to peaceful gardens, woodland for exploring and one of the best examples of a 17th century dolls house, Uppark illustrates the difference between comfortable life upstairs and the difficult life of servants downstairs.
The house is not currently open but the garden is open to visitors.
Portchester Castle was originally built late in the 3rd century and is the best-preserved of the Roman 'Saxon Shore' forts. You can visit the exhibition on the history of the castle and Portchester, and you can enjoy a family picnic surrounded by history.
This trail uses the Hayling Billy coastal path which runs along the west coast of Hayling Island. The five-mile round path is regularly used by walkers, cyclists and horse riders. The route starts at the car park at North Halt on Havant Road and is clearly signposted.
Alpine Snowsports, Southampton
The centre is a great place for new and experienced snowsports fans to have a go on the slopes. There are qualified instructors to take you through the basics of skiing and snowboarding, and they offer lessons for adults and juniors as well as childrens parties.
Fort Nelson is one of five defensive forts built on Portsdown Hill in the 1860s overlooking Portsmouth. Visit the museum to find out more about the collection of artillery and how it changed the nature of battles over hundreds of years. Admission is free.
This small, volunteer-led attraction is the UKs only museum dedicated to diving. There is a wide range of diving equipment including diving bells, chambers and atmospheric diving suits, as well as the prototype helmet used in the worlds first commercial dive.
Solent Sky Museum, Southampton
There are more than 20 aircraft to explore at the Solent Sky Museum, from the golden age of aviation. Among others you can learn the fascinating history of the Supermarine Spitfire F24, which has Southampton as its birthplace.
Spend the day with goats, pigs, rabbits and more at Manor Farm. On a rainy day you can also enjoy walking round the traditional barns and workshops, farmhouse and cottage.
Watercress Line, New Alresford
Take a ride on the popular heritage railway which runs between Alresford and Alton. In February and March 2020 there is a chance to see the world-famous Flying Scotsman locomotive on its tracks.
Titchfield Abbey was first built in the 13th century and was originally the home of a community of Premonstratensian canons. Later the buildings were transformed into a great Tudor house, featuring a grand turreted gatehouse.
See the article here:
19 fun things to do in Hampshire with the family - Portsmouth News
Posted: April 22, 2020 at 4:42 am
With a motto of Live Free or Die it is no wonder that New Hampshire has happily taken to the idea of stem cell therapy and does not really have any legislation that would hinder researchers in their state from making breakthroughs in the fledgling medical field. The state currently has 9 stem cell clinics, which is surprisingly a lot considering the small population of the state. While stem cell therapy in New Hampshire is fairly new when compared with other states, it is growing and will probably continue to do so in the near future.
If you are thinking about getting stem cell therapy in New Hampshire, then you have two choices for the type of stem cell therapy that you can get. Currently, in the state, autologous bone marrow and autologous adipose-derived stem cells are the only stem cells that are being offered, but this does not mean that you wont be able to get the treatment that you need. A majority of the treatments that are offered throughout the country are based on these stem cells, so there is a fairly good chance that you will be able to get the treatment that you desire in New Hampshire.
Some of the stem cell therapies that are available in New Hampshire are:
Pain managementAchilles TendinitisAchilles TearsAnkle SprainsArthritisBack PainCarpal Tunnel SyndromeCartilage DefectsDegenerative Disc DiseaseElbow TendonitisFailed Back Surgery SyndromeFractures Golfers ElbowPhantom Limb PainPlantar FasciitisPost-herpetic NeuralgiaPost-laminectomy SyndromeRheumatoid ArthritisRotator Cuff TendonitisTension HeadachesTrigeminal Neuralgia
After looking at the list of treatments above if you do not see the particular treatment that you are looking for, dont fret, as it might just not be listed. Putting forth a list of every single stem cell treatment offered in the state would be untenable and so our list represents only a cross-section of what is offered in the state. Be sure to reach out to us so that we can offer you more complete information and if need be refer you to a clinic near you.
The only law that is currently enforceable in New Hampshire in regard to stem cell research or therapy is that researchers are not allowed to maintain an unfrozen fertilized embryo for more than 14 days. This means that for the most part researchers who are interested in studying embryonic stem cells are able to do so as long as they operate within the confines of that piece of legislation.
Even though there are a number of new and exciting stem cell therapies available in New Hampshire it is always important to remember that most of these treatments are not FDA approved. As of now the only stem cell therapies that are FDA approved are a few related to certain types of bone and blood cancers. Outside of this, all therapies are considered to be experimental and as such your insurance company will more than likely not cover the costs of the treatment.
If you are looking to better educate yourself on the benefits of stem cell therapy in New Hampshire, then call Stem Cell Authority toll-free today. Since there is so much information and misinformation out there in regard to stem cells it is important to get all of the facts before you make a decision to undergo treatment. At Stem Cell Authority we can help you do just that, so give us a call today.
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How Propanc Biopharma Is Joining the Fight with Cancer Patients Who Are Increasingly Vulnerable to the COVID-19 Global Pandemic – Business Wire
Posted: at 4:42 am
MELBOURNE, Australia--(BUSINESS WIRE)--Propanc Biopharma, Inc. (OTC: PPCB) (Propanc or the Company), a biopharmaceutical company developing new cancer treatments for patients suffering from recurring and metastatic cancer, announced today that its Chief Executive Officer, Mr James Nathanielsz, predicts a significant and unmet need for need for new cancer treatments that are not only more effective and less toxic, but critically, also enhance the immune response of patients. As a direct result of the COVID-19 pandemic, the risk of infection for cancer sufferers undergoing chemotherapy or radiation is life threatening. Propanc Biopharmas lead product candidate, PRP, not only stops the cancer from returning and spreading, but also enhances the bodys own immune system, which is considered a key to overcoming cancer.
According to the World Health Organization over 18.1 million cancer cases were diagnosed and 9.6 million cancer related deaths were recorded in 2018, globally. The threat of the global pandemic penetrating this vulnerable and significantly large patient group, globally, whilst undergoing treatment is extremely high. Recently, there were a number of instances where COVID-19 infections have been discovered among staff and patients in oncology wards in hospitals, such as the Alfred Hospital in Melbourne, Australia.
I am gravely concerned for cancer sufferers worldwide during this global crisis and it especially came to my attention when three COVID-19 positive patients from the Alfred hematology and oncology ward, died as a result of exposure. My heart goes out to those families, said James Nathanielsz, Propancs Chief Executive Officer. There is no doubt this group of patients are particularly vulnerable, and we need to put all our resources into every avenue of healthcare to ensure a better quality of life for human kind. Now that we have the backing of our institutional investor, financially, we are expending every effort to fast track PRP into the clinic so we can determine its effectiveness as a less toxic, targeted therapy for the treatment and prevention of metastatic cancer from solid tumors, where patients can enjoy a better quality of life.
Professor Klaus Kutz, Chief Medical Officer for Propanc Biopharma, recognizes the need for more effective and less toxic treatments, but also recognizes that supporting immune function will become an imperative for his medical colleagues, who are not only battling cancer, but the risk of secondary infection from treatment, often resulting in patients admitted to critical care and many dying from infection.
When I first joined the Propanc Scientific Advisory Board, my first task was to assess a small number of terminal cancer patients treated on the grounds of compassionate use, and what I observed was not only an overall improvement in life expectancy, but also no severe, or even serious side effects from treatment, no hair loss, no nausea and no immune suppression, said Professor Kutz, Propancs Chief Medical Officer. After more than ten years of research, I am keen to see the positive effects from treatment in a First-In-Human study for advanced cancer patients, a vulnerable, at risk patient group who need better treatments for a sustained, better quality of life.
Dr Julian Kenyon, who serves as Chief Scientific Officer at Propanc Biopharma, whilst also Medical Director of his clinic in Hampshire, UK, has focused his expertise on looking after patients who are at risk from COVID-19 infection due to underlying health conditions, by helping improve their innate and acquired immunities. He believes this gives his patients the best possible chance of overcoming this global pandemic.
My clinical expertise over the years in treating chronic diseases, including cancer, often focuses on how I can improve the immune function of my patients, as we know that adequate immune function means that any patient with COVID-19 has increased chances of surviving, and also those without COVID-19 are less likely to develop a positive infection, said Dr Kenyon. Our lead product candidate, PRP, has the potential to not only treat cancer patients, but improve their immune response towards fighting against the cancer, as well as secondary infection. This is something we have long understood as a medical need, but COVID-19 has brought this to the forefront as a pressing issue for these vulnerable patients. I believe a product which can achieve this objective in clinical trials will likely see significant and rapid uptake among healthcare practitioners.
About Propanc Biopharma, Inc.
Propanc Biopharma, Inc. (the Company) is developing a novel approach to prevent recurrence and metastasis of solid tumors by using pancreatic proenzymes that target and eradicate cancer stem cells in patients suffering from pancreatic, ovarian and colorectal cancers. For more information, please visit http://www.propanc.com.
The Companys novel proenzyme therapy is based on the science that enzymes stimulate biological reactions in the body, especially enzymes secreted by the pancreas. These pancreatic enzymes could represent the bodys primary defense against cancer.
To view the Companys Mechanism of Action video on its anti-cancer lead product candidate, PRP, please click on the following link: http://www.propanc.com/news-media/video
All statements other than statements of historical facts contained in this press release are forward-looking statements, which may often, but not always, be identified by the use of such words as may, might, will, will likely result, would, should, estimate, plan, project, forecast, intend, expect, anticipate, believe, seek, continue, target or the negative of such terms or other similar expressions. These statements involve known and unknown risks, uncertainties and other factors, which may cause actual results, performance or achievements to differ materially from those expressed or implied by such statements. These factors include uncertainties as to the Companys ability to continue as a going concern absent new debt or equity financings; the Companys current reliance on substantial debt financing that it is unable to repay in cash; the Companys ability to successfully remediate material weaknesses in its internal controls; the Companys ability to reach research and development milestones as planned and within proposed budgets; the Companys ability to control costs; the Companys ability to obtain adequate new financing on reasonable terms; the Companys ability to successfully initiate and complete clinical trials and its ability to successful develop PRP, its lead product candidate; the Companys ability to obtain and maintain patent protection; the Companys ability to recruit employees and directors with accounting and finance expertise; the Companys dependence on third parties for services; the Companys dependence on key executives; the impact of government regulations, including FDA regulations; the impact of any future litigation; the availability of capital; changes in economic conditions, competition; and other risks, including, but not limited to, those described in the Companys Registration Statement on Form S-1, Amendment No. 1, filed with the U.S. Securities and Exchange Commission (the SEC) on January 24, 2020, and in the Companys other filings and submissions with the SEC. These forward-looking statements speak only as of the date hereof and the Company disclaims any obligations to update these statements except as may be required by law.
Posted: March 11, 2020 at 6:46 am
A hospital patient from London who was the second person in the world to be cleared of HIV has revealed his identity.
Adam Castillejo, 40, achieved sustained remission from HIV after being treated at Hammersmith Hospital, Imperial College Healthcare NHS Trust announced last year over a decade after the first known case in Berlin in 2007.
By publicly revealing my identity and my story I hope to help improve peoples understanding of the science and HIV generally, Mr Castillejo, who works in the hospitality industry, said in a statement.
I want to thank all those who have supported me on this journey particularly my medical team at Hammersmith Hospital whom without I would not be here today.
Mr Castillejo was diagnosed with HIV infection in 2003 and developed an Aids-defining cancer, advanced Hodgkins lymphoma, in 2012.
In 2016, he received a transplant of haematopoietic stem cells from a donor carrying a genetic mutation in the HIV receptor CCR5, which hinders the HIV virus from entering human cells.
After antiretroviral drugs were discontinued, researchers said Mr Castillejo has been in remission for 30 months with no viable virus in bloods, brain fluid, intestinal or lymph tissue.
Mr Castillejo, who revealed his identity in an interview with the New York Times, is of mixed Spanish-Dutch heritage and said he is very proud to consider himself a Londoner.
He was head chef in a corporate dining room when he was diagnosed with cancer in 2011 while working a second job on weekends to save money for travel.
After a couple of years the chemo became too intense and I could no longer continue to work, his statement said.
My life fell apart at that stage I lost my job and I couldnt afford my flat so lost that too.
I am now starting again, rebuilding my life as I steadily get stronger. The journey has given me the chance to gain more knowledge and understanding about cancer research and the world beyond me.
Now, I am looking forward to building a new path as an Ambassador of Hope for millions of people around the world living with HIV.
Whilst my treatment is not possible for all, I hope it will offer scientists insights that can help us on the journey to better treatment and a cure.
Mr Castillejo said he plans to share his experiences through a podcast and his Twitter and Instagram accounts, @londonpatient and LondonPatientofficial, and said he recently began to rekindle his passion for cooking as a trained chef.
On March 10, a follow-up report on Mr Castillejos case will be presented by Professor Ravindra Gupta at this years Conference on Retroviruses and Opportunistic Infections (CROI) in Boston, USA where the Londoner will share his story.
Asymmetrex Partners in Manufacturing USA Institute January 23, 2020The Advanced Regenerative Manufacturing Institute – PR Web
Posted: January 25, 2020 at 6:48 am
BOSTON (PRWEB) January 23, 2020
Asymmetrex LLC is part of a new public-private Manufacturing USA initiative, the Advanced Regenerative Manufacturing Institute (ARMI). Headquartered in Manchester, New Hampshire, ARMI is the 12th Manufacturing USA Institute. ARMI brings together a consortium of over 100 partner organizations from industry, government, academia and the non-profit sector to develop next-generation manufacturing processes and technologies for cells, tissues and organs.
Approximately $80 million from the federal government will be combined with more than $200 million in cost share to support the development of tissue and organ manufacturing capabilities. As part of continuing efforts to help revitalize American manufacturing and incentivize companies to invest in new technology development in the United States, ARMI will lead the Advanced Tissue Biofabrication (ATB) Manufacturing USA Institute on behalf of the Department of Defense.
Under the umbrella of Manufacturing USA, a public-private network that invests in the development of world-leading manufacturing technologies, ARMI will work to integrate and organize the fragmented collection of industry practices and domestic capabilities in tissue Biofabrication technology to better position the US relative to global competition. ARMI will also focus on accelerating regenerative tissue research and creating state-of-the-art manufacturing innovations in biomaterial and cell processing for critical Department of Defense and civilian needs.
We need to develop 21st century tools for engineered tissue manufacturing that will allow these innovations to be widely available similar to how a 15th century tool (the printing press) allowed knowledge to spread widely during the Renaissance, said inventor Dean Kamen, ARMIs chairman.
ARMIs efforts are supported by forty-seven industrial partners, twenty-six academic and academically affiliated partners, and fourteen government and nonprofit partners. The ARMI partnership continues to grow.
About AsymmetrexAsymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. The companys patent portfolio contains biotechnologies that solve the two main technical problems production and quantification that have stood in the way of successful commercialization of human adult tissue stem cells for regenerative medicine and drug development. Asymmetrex markets the first technology for determination of the dose and quality of tissue stem cell preparations (the AlphaSTEM Test) for use in stem cell transplantation therapies and pre-clinical drug evaluations. For more information, please visit http://www.asymmetrex.com.
About ARMIThe Advanced Regenerative Manufacturing Institute (ARMI), headquartered in Manchester, NH, is the 12th Manufacturing USA Institute. It brings together a consortium of over 150 partners from across industry, government, academia and the non-profit sector to develop next-generation manufacturing processes and technologies for cells, tissues and organs. ARMI will work to organize the current fragmented domestic capabilities in tissue Biofabrication technology to better position the U.S. relative to global competition. For more information on ARMI, please visit http://www.ARMIUSA.org.
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From cow loos to dog fitbits: 20 ways technology will transform the countryside in 2020 – Countryliving (UK)
Posted: December 28, 2019 at 8:43 pm
Rural communities often take solace in the continuity associated with country life. Cities are the place for change, while our countryside is to be treasured for its slower pace. This can make the prospect of new ways of working a daunting one. But not all change is negative some technology increases productivity in farming, some benefits the environment.
Some things do need to change. The National Farmers Union (NFU) has pledged that the industry will reduce greenhouse emissions to zero by 2040, which means farmers are having to come up with eco-friendly ways to meet growing demand.
People often think of agriculture as conservative and slow to adapt, but it has always been about experimentation and trying new things, says Dr Helen Ferrier, chief science and regulatory affairs adviser at the NFU. Technology has a history of making life easier, replacing some jobs and creating new ones, adds Farmers Guardian editor Ben Briggs.
If new technologies help to make agriculture more profitable, they should be welcomed. So, let us introduce 20 innovations that could be coming to a field near you
We all want animals to live stress-free, but how do you ask a pig how its feeling? Scientists at Bristol Robotics Laboratory are using 3D scanners to find out. The machines use artificial intelligence to identify emotions on the animals faces. Farmers could eventually use similar technology to check that their pigs arent in pain or distress, thereby improving animal welfare.
Ammonia and nitrogen pollution harms more than 60% of UK land by acidifying soil and fresh water, and destroying plants. Unfortunately, cows and their bodily functions are partly to blame. But Dutch designer Henk Hanskamp might have the answer: a cow loo. Cows will pay a visit voluntarily (their daily feed given nearby as encouragement), toxins will then be removed from the waste, with the remainder used as fertiliser. The machine could be on sale in the Netherlands in 2020, before it is exported abroad.
Soon, everything and everyone in National Parks could be connected to the internet. Rubbish bins will send alerts to rangers when theyre full, so that they only have to be checked when they need emptying, reducing emissions, while sensors in footpaths will call out rangers to deal with fallen trees and flooding. Signposts at the end of a route will also be sending messages to your oven to have supper ready for when you arrive home well, we can dream, cant we?
Suffolk Punch horses, Britains oldest native breed, once happily ploughed our fields, but now they are dying out, with only about 70 breeding females left. What to do? Equine reproduction specialists Stallion AI Services has found a way to determine the gender of semen so that it can impregnate a filly with a female foal. More breeding females mean more horses in years to come
The ethics of egg-farming can make for uncomfortable reading: farmers require female chickens, as they lay the eggs, leaving the difficult question about what to do with the males. All chicks in Britain are incubated to full term, but German company Seleggt has found a way to determine the sex of a chick before it is born by testing a fluid sample from the egg. Males can then be used in animal feed before they hatch. Seleggt eggs are already sold in Germany and the company hopes to expand across Europe soon.
Meet Tom, Dick and Harry, three autonomous planters that are currently being tested in Hampshire by Waitrose & Partners; Harry plants, Tom places soil on top and Dick zaps weeds with lasers. Being smaller and lighter than tractors, these four-wheeled machines reduce compaction of the soil, improving yields. Theyre also pretty good workers. Small Robot Company CEO Ben Scott-Robinson says, People get tired, but robots dont nor do they get distracted. Robots would support rather than replace farmers, he says, adding that the technology needs further trials.
Almost half the dogs in the UK are overweight, according to vet charity PDSA. The solution? A canine activity tracker attached to your pets collar, monitoring his or her movements and how many calories they are burning. PitPat can tell you whether your dog has been playing, running or walking (39, pitpat.com), while FitBark (65, fitbark.com/store-uk) can also track your dogs sleep restless nights could indicate health problems.
A third of our wild bees and hoverflies are in decline, according to a 2019 study by the Centre for Ecology and Hydrology, but help is on the way in the form of tiny bee-like drones that fly between plants and cross-pollinate them. Created by Harvard University, the solar-powered RoboBee X-Wing can flap its two sets of wings at a rate of 170 beats per second. Growers could use similar drones in greenhouses within five to 10 years.
Farms floating in harbours could make food more sustainable by reducing how far produce travels to consumers while also increasing the land available for agriculture. In Rotterdam, 32 Meuse-Rhine-Issel cows are helping to test this very notion, living on a 30m x 30m, three-storey pontoon, in a project by Dutch property company Beladon. The team is looking to expand into China and one day it could happen here
Almost a third of Britons believe well all be happily chomping away at insects by 2029, according to the Agricultural Biotechnology Council. Insects are great sources of protein, while farming them requires little space and water, and releases fewer greenhouse gases than conventional animal farms. Want a taster? Sainsburys already sells snack-sized packs of grasshoppers, crickets, buffalo worms and mealworms, produced by Eat Grub in the Netherlands (from 4.29 for 20g, also from eatgrub.co.uk), while Selfridges stocks chocolate-chip cricket cookies (5.99, in store only), produced by Bug Farm Foods in St Davids, Wales.
In New Zealand, drones are increasingly taking on sheepdog duties and farmers are now trying them over here. Mark Rutter, of Harper Adams University in Shropshire, thinks its more ethical: sheep happily follow drones, as they already lead them to food, whereas they only obey dogs because they see them as predators. Drones can also cover a fair bit of ground (about four miles), dont mind hilly terrain and wont leave muddy paw prints on the carpet. A basic model such as the DJI Mavic Pro 2 can handle winds of up to 24mph and costs roughly 1,300. Drones that work in the rain cost nearer 6,000. Farmers dont need a licence, but they should be aware of the risks, especially to birds. They also dont like to be scratched behind the ears
Sometimes it just isnt possible to cross the country to see wildlife, but now it can come to you. Webcams run by The Wildlife Trusts follow grey seals in Cumbria and puffins in Alderney, allowing you to watch them from your phone or computer (wildlifetrusts.org/webcams). Most activity takes place from the spring, but theres plenty of grass-munching year-round at The Donkey Sanctuary in Sidmouth, Devon (thedonkeysanctuary.org.uk/webcams).
Wondering where your food really comes from? Started by two farmers, new app Happerley allows you to find out where food is produced by scanning the QR code on the packaging. About 250 food and drink producers have signed up, including Simon Weaver Organic in the Cotswolds, Hayes Fruit Farm in Gloucestershire and Grass Fed Meats, which operates across the UK. Happerley is free and available on the App Store and Google Play.
New energy sources are vital as we move away from fossil fuels and grass could be a solution. In Lincolnshire, the local council, the Environment Agency and The Wildlife Trusts have been turning roadside cuttings into electricity. A tractor-like machine sucks up the grass and takes it to an anaerobic digestor, which converts it into energy. It is estimated that Lincolnshires 5,500 miles of rural roads could generate a years worth of electricity for 4,500 homes.
In the US, you can already buy burgers and meatballs made of meat grown in labs from animal stem cells, while in Europe, Netherlands-based Mosa Meat predicts its product could be in supermarkets within four years. Still hesitant? Conventional farming will continue to have a place. The NFUs Dr Helen Ferrier says lab-grown meat will simply start a useful conversation about what people want to eat.
Most of the prawns we eat in the UK come from farms in the Far East and Central America, but the future could be different. Great British Prawns, the worlds first sustainable, clean-water, land-based prawn farm, in Balfron, Stirlingshire, began harvesting a million prawns last summer, selling them to nearby chefs. The company is now planning more farms to supply restaurants across the UK.
Sompong Sriphet / EyeEmGetty Images
Good news for professional gardeners and groundsmen RootWave has patented a wand-like device that zaps weeds with an electric pulse, killing them without chemicals and allowing them to decompose in the soil. The zapper is already available to commercial growers, and CEO Andrew Diprose hopes a version will eventually be available for hobby gardeners.
In 2019, there was a shortfall of 6,000 soft-fruit pickers in the UK. More robots to the rescue. Hall Hunger Farm, near Chichester, West Sussex, is trying out machines on wheels with 3D cameras and four sets of grippers. Designed by the University of Plymouths Fieldworks Robotics lab, the machines (below) are expected to go into production within a year.
Fruit and vegetables could be grown in some of the UKs 150,000 abandoned coal mine shafts, predicts Professor Saffa Riffat, president of the World Society of Sustainable Energy Technology. This would reduce the environmental costs of transporting food from far away, as well as cutting the need for pesticides. Salads grown in tunnels in south-west London are already sold through Ocado (Growing Underground, 2.59 for 70g, ocado.com).
Want to cut down on garden plastic? Bristol-based start-up Candide Labels has devised an app that identifies plants and creates virtual labels you store on your phone. Simply hold your camera-phone up to a plant and tap the screen, enabling it to identify the plant and tag it. Candide is free and available on the App Store and Google Play.
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Posted: November 28, 2019 at 5:52 am
Vapotherm (NYSE:VAPO) and Invivo Therapeutics (NASDAQ:NVIV) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their valuation, dividends, profitability, earnings, institutional ownership, risk and analyst recommendations.
This table compares Vapotherm and Invivo Therapeutics net margins, return on equity and return on assets.
Institutional & Insider Ownership
60.0% of Vapotherm shares are owned by institutional investors. Comparatively, 7.0% of Invivo Therapeutics shares are owned by institutional investors. 34.4% of Vapotherm shares are owned by insiders. Comparatively, 0.3% of Invivo Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.
This is a summary of current ratings and target prices for Vapotherm and Invivo Therapeutics, as provided by MarketBeat.
Vapotherm presently has a consensus price target of $26.50, indicating a potential upside of 143.57%. Given Vapotherms higher probable upside, research analysts plainly believe Vapotherm is more favorable than Invivo Therapeutics.
Earnings & Valuation
This table compares Vapotherm and Invivo Therapeutics top-line revenue, earnings per share and valuation.
Invivo Therapeutics has lower revenue, but higher earnings than Vapotherm. Vapotherm is trading at a lower price-to-earnings ratio than Invivo Therapeutics, indicating that it is currently the more affordable of the two stocks.
Vapotherm beats Invivo Therapeutics on 6 of the 11 factors compared between the two stocks.
Vapotherm, Inc., a medical technology company, focuses on the development and commercialization of proprietary Hi-VNI technology products used to treat patients of various ages suffering from respiratory distress worldwide. The company offers precision flow systems, such as Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox that use Hi-VNI technology to deliver heated, humidified, and oxygenated air at a high velocity to patients through a small-bore nasal interface. It also provides companion products, including Vapotherm Transfer Unit and Q50 compressor; and disposable products comprising single-use disposables and nasal interfaces. The company sells its products to hospitals. Vapotherm, Inc. was founded in 1993 and is headquartered in Exeter, New Hampshire.
About Invivo Therapeutics
InVivo Therapeutics Holdings Corp., a research and clinical-stage biomaterials and biotechnology company, engages in developing and commercializing biopolymer scaffolding devices for the treatment of spinal cord injuries. It is developing Neuro-Spinal Scaffold implant, an investigational bioresorbable polymer scaffold for implantation at the site of injury within a spinal cord. InVivo Therapeutics Holdings Corp. has research collaboration with the Q Therapeutics, Inc. for the evaluation of the combination of PLGA-PLL based Neuro-Spinal Scaffold with adult neural progenitor cells, including those from induced pluripotent stem cells. The company was founded in 2005 and is headquartered in Cambridge, Massachusetts.
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Novocure Announces 43 Presentations on Tumor Treating Fields at 24th Annual Meeting of the Society for Neuro-Oncology – Arizona Daily Star
Posted: November 21, 2019 at 7:59 am
Presentations on Tumor Treating Fields cover a broad and growing range of topics, with nearly 80 percent of presentations prepared by external authors
ST. HELIER, Jersey--(BUSINESS WIRE)--#btsm--Novocure (NASDAQ: NVCR) today announced 43 presentations on Tumor Treating Fields, including three oral presentations, will be featured at the 24th Annual Meeting of the Society for Neuro-Oncology (SNO) on Nov. 20 through Nov. 24 in Phoenix. Presentations on Tumor Treating Fields cover a broad and growing range of topics. External authors prepared 34 of the 43 presentations.
The oral presentations on Tumor Treating Fields include an EF-14 post hoc subgroup analysis on tumor growth rates, and the pilot study results of Tumor Treating Fields combined with radiotherapy and temozolomide for the treatment of newly diagnosed glioblastoma.
Highlights among poster presentations include the combinations of Tumor Treating Fields with other therapies such as radiation and immunotherapies, simulations, health economics and outcomes research, patient advocacy, and research on the mechanism of action.
Year after year, it is amazing to see the continued focus on Tumor Treating Fields at the SNO Annual Meeting, said Novocure CEO Asaf Danziger. From our first presentation at SNO in 2008 to today, more than 250 abstracts on Tumor Treating Fields have been included at one of the most important conferences in neuro-oncology worldwide. I am proud of our team for their relentless focus on innovative research and for their consistent drive in raising awareness of our therapy among the scientific community. We look forward to another productive year at SNO.
(Abstract #: ACTR-46) Tumor Treating Fields combined with radiotherapy and temozolomide for the treatment of newly diagnosed glioblastoma: Final results from a pilot study. R. Grossman. 2:45 to 2:50 p.m. MST Nov. 22.
(Abstract #: RTHP-28) TTFields treatment affects tumor growth rates: A post-hoc analysis of the pivotal phase 3 EF-14 trial. Z. Bomzon. 4:05 to 4:10 p.m. MST Nov. 22.
(Abstract #: QOLP-24) Patients/parents experiences of receiving Optune delivered tumor treatment fields: A Pediatric Brain Tumor Consortium Study: PBTC-048. J. Lai. 7:50 to 7:54 p.m. MST Nov. 22.
(Abstract #: RDNA-10) TTFields treatment planning for targeting multiple lesions spread throughout the brain. Z. Bomzon. 7:30 to 9:30 p.m. MST Nov. 22. (Radiation Biology and DNA Repair/Basic Science)
(Abstract #: NIMG-20) Evaluation of head segmentation quality for treatment planning of tumor treating fields in brain tumors. Z. Bomzon. 7:30 to 9:30 p.m. MST Nov. 22. (Neuro-Imaging/Clinical Research)
(Abstract #: HOUT-24) Challenges and successes in the global reimbursement of a breakthrough medical technology for treatment of glioblastoma multiforme. C. Proescholdt. 7:30 to 9:30 p.m. MST Nov. 22. (Health Outcome Measures/Clinical Research)
(Abstract #: EXTH-02) The blood brain barrier (BBB) permeability is altered by Tumor Treating Fields (TTFields) in vivo. E. Schulz. 7:30 to 9:30 p.m. MST Nov. 22. (Experimental Therapeutics/Basic Science)
(Abstract #: IMMU-06) TTFields induces immunogenic cell death and STING pathway activation through cytoplasmic double-stranded DNA in glioblastoma cells. D. Chen. 7:30 to 9:30 p.m. MST Nov. 22. (Immunology/Basic Science)
(Abstract #: DRES-06) Prostaglandin E Receptor 3 mediates resistance to Tumor Treating Fields in glioblastoma cells. D. Chen. 7:30 to 9:30 p.m. MST Nov. 22. (Drug Resistance/Basic Science)
(Abstract #: EXTH-34) In vitro tumor treating fields (TTFields) applied prior to radiation enhances the response to radiation in patient-derived glioblastoma cell lines. S. Mittal. 7:30 to 9:30 p.m. MST Nov. 22. (Experimental Therapeutics/Basic Science)
(Abstract #: CSIG-20) Effect of tumor-treating felds (TTFields) on EGFR phosphorylation in GBM cell lines. M. Reinert. 7:30 to 9:30 p.m. MST Nov. 22. (Cell Signaling and Signaling Pathways/Basic Science)
(Abstract #: CBMT-14) The dielectric properties of brain tumor tissue. M. Proescholdt. 7:30 to 9:30 p.m. MST Nov. 22. (Cell Biology and Metabolism/Basic Science)
(Abstract #: CSIG-26) Is intrinsic apoptosis the signaling pathway activated by tumor-treating fields for glioblastoma. K. Carlson. 7:30 to 9:30 p.m. MST Nov. 22. (Cell Signaling and Signaling Pathways/Basic Science)
(Abstract #: ATIM-08) Trial in Progress: CA209-9Y8 phase 2 trial of tumor treating fields (TTFs), nivolumab plus/minus ipilimumab for bevacizumab-nave, recurrent glioblastoma. Y. Odia. 7:30 to 9:30 p.m. MST Nov. 22. (Adult Clinical Trials Immunologic/Clinical Research)
(Abstract #: ACTR-60) A phase 2, historically controlled study testing the efficacy of TTFields with adjuvant temozolomide in high-risk WHO grade II and III astrocytomas (FORWARD). A. Allen. 7:30 to 9:30 p.m. MST Nov. 22. (Adult Clinical Trials - Non-Immunologic/Clinical Research)
(Abstract #: TMIC-54) Comparison of cellular features at autopsy in glioblastoma patients with standard treatment of care and tumor treatment fields. A. Lowman. 7:30 to 9:30 p.m. MST Nov. 22. (Tumor Microenvironment/Basic Science)
(Abstract #: ACTR-26) Safety and efficacy of bevacizumab plus Tumor Treating Fields (TTFields) in patients with recurrent glioblastoma (GBM): data from a phase II clinical trial. J. Fallah. 7:30 to 9:30 p.m. MST Nov. 22. (Adult Clinical Trials Non-immunologic/Clinical Research)
(Abstract #: RBTT-02) Radiosurgery followed by Tumor Treating Fields for brain metastases (1-10) from NSCLC in the phase 3 METIS trial. V. Gondi. 7:30 to 9:30 p.m. MST Nov. 22. (Randomized Brain Tumor Trials in Development/Clinical Research)
(Abstract #: INNV-16) Complete response of thalamic IDH wildtype glioblastoma after proton therapy followed by chemotherapy together with Tumor Treating Fields. M. Stein. 7:30 to 9:30 p.m. MST Nov. 22. (Innovations in Patient Care/Clinical Research)
(Abstract #: INNV-20) A systematic review of tumor treating fields therapy for primary for recurrent and glioblastoma. P. Shah. 7:30 to 9:30 p.m. MST Nov. 22. (Innovations in Patient Care/Clinical Research)
(Abstract #: STEM-16) Dual Inhibition of Protein Arginine Methyltransferase 5 and Protein Phosphatase 2a Enhances the Anti-tumor Efficacy in Primary Glioblastoma Neurospheres. H. Sur. 7:30 to 9:30 p.m. MST Nov. 22. (Stem Cells/Basic Science)
(Abstract #: CBMT-13) 3DEP system to test the electrical properties of different cell lines as predictive markers of optimal tumor treating fields (TTFields) frequency and sensitivity. M. Giladi. 5 to 7 p.m. MST Nov. 23. (Cell Biology and Metabolism/Basic Science)
(Abstract #: EXTH-37) A novel transducer array layout for delivering Tumor Treating Fields to the spine. Z. Bomzon. 5 to 7 p.m. MST Nov. 23. (Experimental Therapeutics/Basic Science)
(Abstract #: NIMG-41) Rapid and accurate creation of patient-specific computational models for GBM patients receiving Optune therapy with conventional imaging (T1w/PD). Z. Bomzon. 5 to 7 p.m. MST Nov. 23. (Neuro-Imaging/Clinical Research)
(Abstract #: HOUT-17) Utilities of rare cancers like malignant pleural mesothelioma and glioblastoma multiforme - do they compare? C. Proescholdt. 5 to 7 p.m. MST Nov. 23. (Health Outcome Measures/Clinical Research)
(Abstract #: INNV-17) Innovative educational approaches to enhance patient and caregiver understanding of Optune for glioblastoma. M. Shackelford. 5 to 7 p.m. MST Nov. 23. (Innovations in Patient Care/Clinical Research)
(Abstract #: EXTH-05) Therapeutic implications of TTFields induced DNA damage and replication stress in novel combinations for cancer treatment. N. Karanam. 5 to 7 p.m. MST Nov. 23. (Experimental Therapeutics/Basic Science)
(Abstract #: EXTH-31) Combination of tumor treating fields (TTFields) and paclitaxel produces additive reductions in proliferation and clonogenicity in patient-derived metastatic non-small cell lung cancer (NSCLC) cells. S. Michelhaugh. 5 to 7 p.m. MST Nov. 23 (Experimental Therapeutics/Basic Science)
(Abstract #: EXTH-53) Tumor Treating Fields leads to changes in membrane permeability and increased penetration by anti-glioma drugs. E. Chang. 5 to 7 p.m. MST Nov. 23. (Experimental Therapeutics/Basic Science)
(Abstract #: RDNA-01) Tubulin and microtubules as molecular targets for TTField therapy. J. Tuszynski. 5 to 7 p.m. MST Nov. 23. (Radiation Biology and DNA Repair/Basic Science)
(Abstract #: SURG-01) OptimalTTF-1: Final results of a phase 1 study: First glioblastoma recurrence examining targeted skull remodeling surgery to enhance Tumor Treating Fields strength. A. Korshoej. 5 to 7 p.m. MST Nov. 23. (Surgical Therapy/Clinical Research)
(Abstract #: ATIM-39) Phase 2 open-labeled study of adjuvant temozolomide plus Tumor Treating Fields plus Pembrolizumab in patients with newly diagnosed glioblastoma (2-THE-TOP). D. Tran. 5 to 7 p.m. MST Nov. 23. (Adult Clinical Trials Immunologic/Clinical Research)
(Abstract #: ACTR-49) Initial experience with scalp preservation and radiation plus concurrent alternating electric tumor-treating fields (SPARE) for glioblastoma patients. A. Song. 5 to 7 p.m. MST Nov. 23. (Adult Clinical Trials - Non-Immunologic/Clinical Research)
(Abstract #: RTHP-25) TTFields dose distribution alters tumor growth patterns: An imaging-based analysis of the randomized phase 3 EF-14 trial. M. Ballo. 5 to 7 p.m. MST Nov. 23. (Radiation Therapy/Clinical Research)
(Abstract #: ACTR-19) Report on the combination of Axitinib and Tumor Treating Fields (TTFields) in three patients with recurrent glioblastoma. E. Schulz. 5 to 7 p.m. MST Nov. 23. (Adult Clinical Trials - Non-Immunologic/Clinical Research)
(Abstract #: PATH-47) TTF may apply selective pressure to glioblastoma clones with aneuploidy: a case report. M. Ruff. 5 to 7 p.m. MST Nov. 23. (Molecular Pathology and Classification Adult and Pediatric/Clinical Research)
(Abstract #: RARE-39) Combination of Tumor Treating Fields (TTFields) with lomustine (CCNU) and temozolomide (TMZ) in newly diagnosed glioblastoma (GBM) patients - a bi-centric analysis. L. Lazaridis. 5 to 7 p.m. MST Nov. 23. (Rare Tumors/Clinical Research)
(Abstract #: ACTR-31) The use of TTFields for newly diagnosed GBM patients in Germany in routine clinical care (TIGER: TTFields in Germany in routine clinical care). O. Bahr. 5 to 7 p.m. MST Nov. 23. (Adult Clinical Trials Non-Immunologic/Clinical Research)
(Abstract #: INNV-09) Clinical efficacy of tumor treating fields for newly diagnosed glioblastoma. Y. Liu. 5 to 7 p.m. MST Nov. 23. (Innovations in Patient Care/Clinical Research)
(Abstract #: EXTH-61) Celecoxib Improves Outcome of Patients Treated with Tumor Treating Fields. K. Swanson. 5 to 7 p.m. MST Nov. 23. (Experimental Therapeutics/Basic Science)
(Abstract #: INNV-23) Glioblastoma and Facebook: An Analysis Of Perceived Etiologies and Treatments. N. Reddy. 5 to 7 p.m. MST Nov. 23. (Innovations in Patient Care/Clinical Research)
(Abstract #: INNV-12) Outcomes in a Real-world Practice For Patients With Primary Glioblastoma: Impact of a Specialized Neuro-oncology Cancer Care Program. N. Banerji. 5 to 7 p.m. MST Nov. 23. (Innovations in Patient Care/Clinical Research)
(Abstract #: RBTT-11): NRG Oncology NRG-BN006: A Phase II/III Randomized, Open-label Study of Toca 511 and Toca FC With Standard of Care Compared to Standard of Care in Patients With Newly Diagnosed Glioblastoma. M. Ahluwalia. 5 to 7 p.m. MST Nov. 23. (Randomized Brain Tumor Trials Development/Clinical Research)
Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Tumor Treating Fields is a cancer therapy that uses electric fields tuned to specific frequencies to disrupt solid tumor cancer cell division. Novocures commercialized products are approved for the treatment of adult patients with glioblastoma and malignant pleural mesothelioma. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and liver cancer.
Headquartered in Jersey, Novocure has U.S. operations in Portsmouth, New Hampshire, Malvern, Pennsylvania and New York City. Additionally, the company has offices in Germany, Switzerland, Japan and Israel. For additional information about the company, please visit http://www.novocure.com or follow us at http://www.twitter.com/novocure.
Optune is intended as a treatment for adult patients (22 years of age or older) with histologically-confirmed glioblastoma multiforme (GBM).
Optune with temozolomide is indicated for the treatment of adult patients with newly diagnosed, supratentorial glioblastoma following maximal debulking surgery, and completion of radiation therapy together with concomitant standard of care chemotherapy.
For the treatment of recurrent GBM, Optune is indicated following histologically- or radiologically-confirmed recurrence in the supratentorial region of the brain after receiving chemotherapy. The device is intended to be used as a monotherapy, and is intended as an alternative to standard medical therapy for GBM after surgical and radiation options have been exhausted.
The NovoTTF-100L System is indicated for the treatment of adult patients with unresectable, locally advanced or metastatic, malignant mesothelioma (MPM) to be used concurrently with pemetrexed and platinum-based chemotherapy.
Important Safety Information
Do not use Optune in patients with GBM with an implanted medical device, a skull defect (such as, missing bone with no replacement), or bullet fragments. Use of Optune together with skull defects or bullet fragments has not been tested and may possibly lead to tissue damage or render Optune ineffective. Do not use the NovoTTF-100L System in patients with MPM with implantable electronic medical devices such as pacemakers or implantable automatic defibrillators, etc.
Use of Optune for GBM or the NovoTTF-100L System for MPM together with implanted electronic devices has not been tested and may lead to malfunctioning of the implanted device.
Do not use Optune for GBM or the NovoTTF-100L System for MPM in patients known to be sensitive to conductive hydrogels. Skin contact with the gel used with Optune and the NovoTTF-100L System may commonly cause increased redness and itching, and may rarely lead to severe allergic reactions such as shock and respiratory failure.
Optune and the NovoTTF-100L System can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure.
The most common (10%) adverse events involving Optune in combination with chemotherapy in patients with GBM were thrombocytopenia, nausea, constipation, vomiting, fatigue, convulsions, and depression.
The most common (10%) adverse events related to Optune treatment alone in patients with GBM were medical device site reaction and headache. Other less common adverse reactions were malaise, muscle twitching, and falls related to carrying the device.
The most common (10%) adverse events involving the NovoTTF-100L System in combination with chemotherapy in patients with MPM were anemia, constipation, nausea, asthenia, chest pain, fatigue, device skin reaction, pruritus, and cough.
Other potential adverse effects associated with the use of the NovoTTF-100L System include: treatment related skin toxicity, allergic reaction to the plaster or to the gel, electrode overheating leading to pain and/or local skin burns, infections at sites of electrode contact with the skin, local warmth and tingling sensation beneath the electrodes, muscle twitching, medical site reaction and skin breakdown/skin ulcer.
If the patient has an underlying serious skin condition on the treated area, evaluate whether this may prevent or temporarily interfere with Optune and the NovoTTF-100L System treatment.
Do not prescribe Optune or the NovoTTF-100L System for patients that are pregnant, you think might be pregnant or are trying to get pregnant, as the safety and effectiveness of Optune and the NovoTTF-100L System in these populations have not been established.
In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocures current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical trial progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as anticipate, estimate, expect, project, intend, plan, believe or other words and terms of similar meaning. Novocures performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, regulatory and political conditions as well as more specific risks and uncertainties facing Novocure such as those set forth in its Quarterly Report on Form 10-Q filed on July 25, 2019, with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.
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