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Category Archives: New Hampshire Stem Cells

Stem Cells Can Be Collected Without Destroying Embryos …

Posted: October 5, 2017 at 12:45 pm

But obtaining human embryonic stem cells has been controversial, because until now it required the destruction of living embryos.

In the current technology, embryonic stem cells are derived by extracting a mass of cells from an embryo.

Since an early embryo is made of only a few cellsabout eight to tentaking enough to create viable cultures kills the embryo.

"Many people, including [U.S.] President Bush, are concerned about destroying life in order to save life," Lanza said.

U.S. law currently prohibits the use of federal funds for research in which a human embryo is destroyed.

Colony of Stem Cells

Last year Lanza's team showed that it's possible to remove a single cell from a mouse embryo without destroying the embryo.

Through various manipulations, the team grew that cell into a colony of mouse embryonic stem cells.

The extraction procedure is similar to that used during in vitro fertilization to remove a single cell for preimplantation genetic diagnosis (PGD).

PGD is a very early form of diagnosis that tests a human embryo for genetic abnormalities before it is implanted in a woman's uterus.

"This is a relatively simple biopsy procedure that has been used to generate over 2,000 healthy babies," Lanza said.

(See 3-D illustrations of a fetus growing in the womb.)

Using spare human embryos from in vitro fertilization for their most recent study, the scientists used a tiny pipette to extract one cell from each embryo and then grew each cell in a hormone-laden culture.

Just like in the case of PGD tests, embryos with only one cell removed would have survived and gone on to grow into fetuses. To get the most from their samples, however, Lanza's team took several cells from each embryo, destroying the embryos in the process.

From a total of 91 cells taken from 16 embryos, Lanza said his team "obtained two stable human embryonic stem cell lines, which have been growing over eight months at this point."

He says the new stem cell lines behave exactly like conventional embryonic stem cells.

"The resulting cells could be used for genetic testing as well as to create stem cells without affecting the subsequent chances of [the embryos developing into children]," Lanza said.

Ethical Quandary Resolved?

Ronald M. Green, director of the Ethics Institute at Dartmouth College in Hanover, New Hampshire, says the research directly addresses the ethical concerns that many people have about stem cell research.

"It is very, very unusual for scientific research to resolve an ethical quandary, and this is one of those rare instances," Green said. "I do believe it solves the ethical problems."

(Explore the stem cell debate in National Geographic magazine: see photos, take a poll, and join the forum.)

Scientists hope the results will soon lead to the release of U.S. federal funding for embryonic stem cell research.

"This could conform to both the ethical and maybe even the legal thinking that has motivated the [U.S.] President to oppose this," Green said.

"I hope he sees this as an opportunity consistent with his values."

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Amanda Grappone Osmer breaks down car sales stereotypes with focus on kindness, integrity – The Keene Sentinel

Posted: August 18, 2017 at 10:41 am

In 2014, during a speech in Manchester, Amanda Grappone Osmer made a startling admission.

I know why you hate me, she began, when it came her time to speak at TEDx Amoskeag Millyard. You all have memories of someone like me that takes you back to a time and place that you wish you didnt have to think about.

Your palms start to sweat. Your stomach is in a knot. Like me, your heart races. You just have an overall feeling of dread.

Mentally, you start to make a tally when you see me coming of all the ways you might get ripped off.

She describes further this experience with her at its center.

When you see me, you load up for bear. Because you know you need to, just to get through our conversation, she says.

You hate me because I am a car salesman. A fourth-generation car salesman.

And with a deep breath, she adds, I understand.

Osmers speech spoke to a stereotypical experience someone might have purchasing a car, an experience that she likened to being under the ether and one that her companys philosophy seeks to counter. Her personal mission and that of Grappone Automotive Group in Bow, for which she is CEO, moves well past the showroom to all aspects of the business, employee relationships and the manner in which she leads an engaged community life.

The business mission: Dedication to building lifelong relationships with our team members, guests and community by serving with integrity, kindness and respect.

And ingrained among her personal objectives is being a little bit better than the day before.

Osmer, the keynote speaker for The Keene Sentinels Extraordinary Women Awards on Aug. 24, graduated from the University of New Hampshire with a degree in humanities. In her teens, she worked at her familys dealership, which was started by her great-grandparents in Concord in 1924 as a Gulf service station. It is now five dealerships. But, despite her early work at the dealership, Osmer didnt envision a future for herself in the cars.

In 2001, after school and marriage, she moved to the West Coast, to the North Bay region of San Francisco. Her marriage ended after a short time, leaving her uncertain what to do next. She applied for all sorts of jobs with no luck, she says. Needing something and knowing something about cars, she found herself selling for Lexus of Marin.

I had never sold anything in my life, she says from her second-floor office at Grappones Toyota franchise, not far from the end of Interstate 89. Her notion of sales, she says, was all wrong, and she learned, You have to be nice to people and honest, and you will earn their business.

Three years later, she was back at her family dealership, in charge of fixed operations service, paint and collision. She described this as the hardest job of my life.

It was difficult to find technicians who met company standards, and there were myriad other workforce challenges, not the least of which is that few women run collision and service centers.

I knew nothing about that world, she recalls. It was constant stress.

But it was in this role that she discovered new ways of doing things that would change her and the company she would come to run. She found a mentor in Jeffrey Liker, the author of The Toyota Way, a best-seller at more than 650,000 copies and translated into 27 languages.

Liker, with whom Osmer corresponds, is professor of industrial and operations engineering at the University of Michigan and has written extensively about how Toyotas manufacturing processes employed principles to reduce waste, boost efficiency and create collaborative workforces to solve problems. He has also profiled other companies using these strategies and measurements, first pioneered by W. Edwards Deming in post-World War II Japan.

I fell in love with lean manufacturing, says Osmer, referring to the umbrella term under which these principles exist.

She opens Likers book frequently; her copy is dog-eared, heavily highlighted and fingerprinted and never far from reach. There are, in the lean world, seven categories of waste transport, inventory, motion, waiting, overproduction, over-processing and defects.

Osmer considers it one of her lifes highlights being invited to speak at the headquarters of Dupont in Delaware at a gathering of collision center specialists a conference at which Liker was speaking, too.

Shes asked if Grappone is an efficient operation.

Its a goal, she says candidly, referring to a never-ending focus on continuous improvement.

From the service operation, Osmer was promoted to COO and director of sales. The sales process was going through a similar evolution, she says.

We had peeled away from the current (traditional) way of doing things, she says, referring to the industry standard of commission-based selling. We had to figure out what is our way I really started to notice that we didnt have anyone recognizing the human experience.

The company hired a director of corporate potential a key decision and embarked on strategic planning that led to an unusual, if not dramatically different approach to business. Its primary commitment, she says, is to Grappones 340 employees. They come first in the mission statement by design. Second, the company seeks lifelong relationships with customers and believes this is best achievable if the sales and service experience is not one of negotiation. This, she says, creates integrity and expectations of consistent treatment. Theres a set price for everything, including financing terms. Everyone pays the same, removing the ether to which she referred in her TEDx speech.

Her sales team does not operate on commissions.

It didnt make sense to race to the bottom on pricing, she says.

Having Toyota as a flagship franchise was helpful; expectations of franchises are reasonable, she says, allowing room for Grappones way.

Always trying to be less wasteful as a company, Osmer said an eighth measure of waste also became a Grappone focus the waste of human creativity. Maybe more than any of the other principles, Osmer emphasizes a workplace that allows innovation to occur. As she describes ways this has been manifested, Ron Malachi, the companys inventory pricing specialist, walks by her office.

He ducks in when asked and rattles off several recent problems a team of folks has solved, including storing extra car inventory at a nearby indoor sports facility.

They get some income, and we get a place (to keep the cars), he says.

Osmer is one of five children born to Robert and Beverly Grappone. Her younger brother, Greg, was her only sibling to be part of the business, eventually becoming the groups chief information officer.

Greg, who had health challenges early in his life, developed cutaneous T-cell lymphoma in his 30s. He found he needed a blood stem cell transplant when the disease turned aggressive.

Osmer was a match for the transplant. Treatment involved eradicating Gregs immune system and injecting new stem cells through a transfusion of Osmers blood. The cancer was killed, but a gruesome side effect graft versus host disease took hold. Osmer described the horrific condition that transpired as one that literally hardened his tissues.

Greg died in 2015, leaving behind a wife and a two-year-old daughter.

In his name, Osmer works on a project that would develop a six-mile abandoned rail line into a new bike and walking path that connects to the Northern Rail trail and would link Concord to Lebanon. It is but one page in her deep portfolio of community work.

She says this involvement in social causes is informed by her familys work.

We were always taught its not about us, she says. Dad just didnt get hung up on material things. I dont get upset when I dont have more things. Its better to express me through how much I help people.

She sees herself as dedicated to serving a lot of people, and it starts with the employees, as the mission suggests.

People need to feel safe; psychological safety, physical safety and having flexibility, she says, describing how the company culture is modeled.

In such an environment, creativity is unleashed, efficiencies are found and people are retained. That environment includes an immaculate, welcoming Toyota dealership building that features a grand piano on its second floor a gift to Osmer from her grandfather.

So, its not a surprise that her team of six directors has more than 140 years of collective service to Grappone.

Away from the dealership, Osmers list of community-service positions is extensive and includes: board member, New Hampshire Public Broadcasting System; corporator, Canterbury Shaker Village; board member, The Endowment for Health; member, Partners for Community Wellness; member, New Hampshire Lemon Law Board; advisory member, Spark New Hampshire; advisory member, Stay Work Play New Hampshire; and advisory member, New Hampshire Charitable Foundations New Hampshire Tomorrow Initiative.

Recently, she became involved in President Donald Birx move to reorganize Plymouth State University into seven educational clusters, beginning this fall. They are: arts and technology; education, democracy and social change; exploration and discovery; health and human enrichment; innovation and entrepreneurship; justice and security; and tourism, environment and sustainable development.

I try to go where I can be most useful, she says, adding she prefers, in many cases, serving one term on a board rather than more to allow broader service.

Osmer lives with her husband, Tom, and three children (two girls and a boy) in a log home in Canterbury. The community, known for its Shaker history, suits her in many ways, from the caring she can expect from the Canterbury Library staff if she drops her son off some afternoon, to the wooded setting that allows her to indulge in trail running, to the neighborly warmth of the Canterbury Fair, recently held.

And, its just the right setting to play her banjo, her instrument of choice.

Osmers is a life being well lived and one seemingly grounded in the words she used to finish her TEDx speech.

So, this is not just about car sales. Its not just about a fourth-generation family business in Bow Junction, New Hampshire, she says. Ask yourselves. Do integrity, kindness and respect form the foundation of all of your relationships, with the people you love the most, with the people you work with, with the people you meet every day? Do they?

If they dont, dont worry about it, she says. Just know that you are under the ether with all of the rest of us. And its time to wake up.

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A Chip That Reprograms Cells Helps Healing, At Least In Mice – New Hampshire Public Radio

Posted: August 12, 2017 at 6:42 am

Scientists have created an electronic wafer that reprogrammed damaged skin cells on a mouse's leg to grow new blood vessels and help a wound heal.

One day, creator Chandan Sen hopes, it could be used to be used to treat wounds on humans. But that day is a long way off as are many other regeneration technologies in the works. Like Sen, some scientists have begun trying to directly reprogram one cell type into another for healing, while others are attempting to build organs or tissues from stem cells and organ-shaped scaffolding.

But other scientists have greeted Sen's mouse experiment, published in Nature Nanotechnology on Monday, with extreme skepticism. "My impression is that there's a lot of hyperbole here," says Sean Morrison, a stem cell researcher at the University of Texas Southwestern Medical Center. "The idea you can [reprogram] a limited number of cells in the skin and improve blood flow to an entire limb I think it's a pretty fantastic claim. I find it hard to believe."

When the device is placed on live skin and activated, it sends a small electrical pulse onto the skin cells' membrane, which opens a tiny window on the cell surface. "It's about 2 percent of the cell membrane," says Sen, who is a researcher in regenerative medicine at Ohio State University. Then, using a microscopic chute, the chip shoots new genetic code through that window and into the cell where it can begin reprogramming the cell for a new fate.

Sen says the whole process takes less than 0.1 seconds and can reprogram the cells resting underneath the device, which is about the size of a big toenail. The best part is that it's able to successfully deliver its genetic payload almost 100 percent of the time, he says. "No other gene delivery technique can deliver over 98 percent efficiency. That is our triumph."

To test the device's healing capabilities, Sen and his colleagues took a few mice with damaged leg arteries and placed the chip on the skin near the damaged artery. That reprogrammed a centimeter or two of skin to turn into blood vessel cells. Sen says the cells that received the reprogramming genes actually started replicating the reprogramming code that the researchers originally inserted in the chip, repackaging it and sending it out to other nearby cells. And that initiated the growth of a new network of blood vessels in the leg that replaced the function of the original, damaged artery, the researchers say. "Not only did we make new cells, but those cells reorganized to make functional blood vessels that plumb with the existing vasculature and carry blood," Sen says. That was enough for the leg to fully recover. Injured mice that didn't get the chip never healed.

When the researchers used the chip on healthy legs, no new blood vessels formed. Sen says because injured mouse legs were was able to incorporate the chip's reprogramming code into the ongoing attempt to heal.

That idea hasn't quite been accepted by other researchers, however. "It's just a hand waving argument," Morrison says. "It could be true, but there's no evidence that reprogramming works differently in an injured tissue versus a non-injured tissue."

What's more, the role of exosomes, the vesicles that supposedly transmit the reprogramming command to other cells, has been contentious in medical science. "There are all manners of claims of these vesicles. It's not clear what these things are, and if it's a real biological process or if it's debris," Morrison says. "In my lab, we would want to do a lot more characterization of these exosomes before we make any claims like this."

Sen says that the theory that introduced reprogramming code from the chip or any other gene delivery method does need more work, but he isn't deterred by the criticism. "This clearly is a new conceptual development, and skepticism is understandable," he says. But he is steadfast in his confidence about the role of reprogrammed exosomes. When the researchers extracted the vesicles and injected them into skin cells in the lab, Sen says those cells converted into blood vessel cells in the petri dish. "I believe this is definitive evidence supporting that [these exosomes] may induce cell conversion."

Even if the device works as well as Sen and his colleagues hope it does, they only tested it on mice. Repairing deeper injuries, like vital organ damage, would also require inserting the chip into the body to reach the wound site. It has a long way to go before it can ever be considered for use on humans. Right now, scientists can only directly reprogram adult cells into a limited selection of other cell types like muscle, neurons and blood vessel cells. It'll be many years before scientists understand how to reprogram one cell type to become part of any of our other, many tissues.

Still, Morrison says the chip is an interesting bit of technology. "It's a cool idea, being able to release [genetic code] through nano channels," he says. "There may be applications where that's advantageous in some way in the future."

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Tech firms all-in for biofabrication with launch of Kamen’s Manchester ARMI project – NewHampshire.com

Posted: August 4, 2017 at 1:50 am

By MARK HAYWARDNew Hampshire Sunday NewsJuly 30. 2017 1:30AM Project Manager Stephanie Robichaud (holding the clipboard) leads a tour group at the ARMI BioFabUSA launch event in the Millyard in Manchester on Friday.(DAVID LANE/UNION LEADER)MANCHESTER - Collaboration was the buzzword Friday when scientists, tech company owners and government officials flocked to the Manchester Millyard for what Gov. Chris Sununu called "the birth of an entire new industry."

If Manchester inventor Dean Kamen and New Hampshire political leaders have their way, that collaboration will bring the the country's biofabrication industry to the banks of the Merrimack River.

"These are the kinds of investments we need to be making for the future of this city," Sen. Jeanne Shaheen, D-N.H., told a crowd of nearly 400. The crowd gathered for the official launch of Kamen's latest endeavor - the Advanced Regenerative Manufacturing Institute, or ARMI, and its BioFabUSA subsidiary.

ARMI is a military-backed endeavor that hopes to make the manufacture of human body parts as streamlined as the production of iPhones.

But it remained unclear last week how far the $294 million in government and private investment will translate into jobs and economic growth in Manchester.

Several people who attended the event had high praise for the collaboration that will flow from BioFab-USA. But physical proximity is not as important in this age of connectivity and instant communication, they said.

"Being physically co-located is not really necessary," said Rohan Shirwaiker, an associate professor and director of 3D tissue manufacturing research at North Carolina State University.

During tours, Shirwaiker demonstrated his research, which measures the electrical charges generated by cells to safely indicate cell health. The equipment could be used to measure the performance of stem cells used to generate human tissue.

North Carolina State University was one of 50 organizations on hand for the launch. They represent only a fraction of the regenerative medicine industry, which numbers about 700 companies, according to research cited in a 2017 National Academy of Medicine article.

The same article said the industry is expected to grow to $67.6 billion by 2020.

"We know that some (of the 50) are already making plans to move here or open operations to the state," said Gray Chynoweth, chief membership officer for ARMI.

For example, Kamen announced Friday that ARMI has hired the head of the biologics group at the Food and Drug Administration. Dr. Richard MacFarland now lives in a Millyard loft, Kamen said.

"It will only accelerate our ability to learn quickly. We can grow faster here," said Dr. James Hoying, a researcher and division chief at Advanced Solutions. He said six or seven people will be part of the move.

His company has applied for patents for a six-axis BioAssemblyBot, or BAB for short, a human tissue 3D printer.

All sorts of details have to be worked out for tissue regenerations, such as the creation of hair-thin blood vessels to supply the organs, Hoying said. That hasn't happened yet, and that's why the collaboration at ARMI will be important, he said.

Others see ARMI as a way to take their research from the laboratory to the factory floor.

"We can manufacture only up to a certain level. DEKA (Kamen's Millyard company) has the ability to scale up that; frankly, we don't have," said Melanie Rodrigues, an instructor of surgery at Stanford University. Stanford is affiliated with TauTona Group, a venture capital/incubator organization in the biotech industry.

TauTona has had success in the laboratory with stem cell bandages, which would be applied to large wounds, burns and other injuries suffered in combat. It would also be helpful for diabetics, the elderly and people with blood-borne genetic disorders.

The stem cells are derived from fat cells obtained through liposuction, Rodrigues said.

She said ARMI has several advantages: the ability to automate a Defense Department connection, and Kamen.

"Dean Kamen is a genius," Rodrigues said.

She said it's too early to say where production of the product would take place, but she didn't rule out southern New Hampshire.

Other firms said ARMI amounts to a networking opportunity.

South Florida-based Akron Biotech joined ARMI to understand where the industry is going in terms of tissue engineering and regenerative medicine, said Ezequiel Zylberberg, a company representative who passed out literature at the event.

Akron Biotech, a small company that manufactures biotech raw materials such as growth factors and purified proteins, hopes to supply those to companies working on ARMI-supported projects, he said. He said Akron is satisfied with South Florida at this point, and interconnectivity makes it easy to supply material to customers far away.

"For us it's just being at the table," Zylberberg said. "We don't have to be physically present."

mhayward@unionleader.com

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Bone Marrow or Stem Cell Transplant – New Hampshire

Posted: October 23, 2016 at 11:41 pm

What is a bone marrow or stem cell transplant?

A bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) is a treatment for some types of cancer and bone marrow problems. Bone marrow is spongy tissue in the center of many bones. It makes red blood cells, white blood cells, and platelets. Red blood cells carry oxygen from the lungs and bring the oxygen to the rest of the body. White blood cells fight infections. Platelets are necessary for blood to clot.

Stem cells are young blood cells in the bone marrow that can become red blood cells, white blood cells, or platelets. Most bone marrow stem cells are in the marrow, but some are in the bloodstream. Blood in the human newborn umbilical cord also contains stem cells. Stem cells can be obtained from any of these sources for use in transplants.

A bone marrow or stem cell transplant may be done to:

A common reason for the use of stem cell transplants in cancer treatment is to make it possible for you to have very high doses of chemotherapy or total-body radiation therapy. These treatments destroy cancer cells throughout the body, but they also destroy normal bone marrow and stem cells. A stem cell transplant right after high-dose chemotherapy and radiation helps your body have healthy bone marrow again. The transplanted cells go to the bone marrow and become the new stem cells, replacing the stem cells that were destroyed by treatment. Your body can then make the blood cells you need.

Stem cell transplants are most often used in the treatment of 3 types of cancer: leukemia, myeloma, and lymphoma. Stem cell transplants are also used to treat other cancers, such as testicular cancer. Researchers are studying stem cell transplants to see if they will help with other diseases.

Follow all of the instructions provided by your healthcare provider. If you need to take a medicine before donating stem cells, take the medicine exactly as prescribed. If you are to have general anesthesia for the collection of bone marrow cells, eat a light meal, such as soup or salad, the night before the procedure. Do not eat or drink anything after midnight and the morning before the procedure. Do not even drink coffee, tea, or water.

Plan for your care and recovery after the procedure, especially if you are to have general anesthesia. Arrange to have someone take you home and stay with you for a while after the procedure. Allow for time to rest. Try to find people to help you with your daily duties for 24 hours after the procedure

First the bone marrow or stem cells must be collected, which is called harvesting. You may be able to donate your own bone marrow or stem cells; in this case, you are your own donor. Or someone else may donate cells that you will then receive as a transplant.

If you are going to use your own marrow as a transplant, the marrow is harvested before you have chemotherapy or radiation treatment. The marrow is usually collected from the hipbones with a needle. This is done under regional or general anesthesia at the hospital. A regional anesthetic numbs part of your body, preventing you from feeling pain while you remain awake. A general anesthetic puts you to sleep and prevents you from feeling pain while some of the marrow is removed. The procedure for harvesting the marrow takes about an hour.

Stem cells may be harvested from the blood rather than the hipbone. This is called a peripheral blood stem cell transplant. The stem cells can be collected from a donor or from your own blood before you have chemotherapy or radiation therapy. Before the stem cells are collected from your blood, you may be given medicine for a few days to stimulate the production and release of stem cells from the marrow into the bloodstream. This increases the number of stem cells that can be harvested from the blood. The blood is obtained through a large vein in your arm or through a tube placed in a vein in your neck, chest, or groin. The blood goes through a machine that removes the stem cells. The blood is then returned to the donor and the stem cells that were removed from the blood are stored. The collection of the stem cells from the blood takes about 4 to 6 hours. It can be done at an outpatient clinic. Stem cells can be frozen until they are needed.

When it is time for the transplant, the bone marrow or stem cells are given through a vein (IV), like a blood transfusion. The transplant takes 1 to 5 hours.

After you donate bone marrow, the area where the marrow was taken out may feel stiff or sore for a few days, and you may feel tired. Within a few weeks, your body will replace the donated marrow. Some people are back to their usual routine within 2 or 3 days, but others may need 3 to 4 weeks to fully recover their strength.

If you donated stem cells from your blood, you may have some side effects from the medicine used to stimulate the release of stem cells from the marrow into the bloodstream. Possible side effects include fever, bone and muscle aches, headaches, fatigue, nausea, vomiting, and trouble sleeping. These side effects generally go away in 2 to 3 days after the last dose of the medicine.

When you are given a transplant, the stem cells will travel to the bone marrow inside your bones. The cells will begin to make new, healthy blood cells in 2 to 4 weeks. Until the stem cells start to produce new blood cells, you will have a higher risk for infection and bleeding. You may also have a reaction to the transplanted cells if they are not your own. During this time, precautions are taken to prevent infections until your bone marrow can produce enough white blood cells. You may be given platelets to prevent or control any bleeding and antibiotics to prevent or treat infection. You may also be given transfusions of red blood cells to treat severe anemia.

After the transplant, you will have frequent blood tests to see how well your bone marrow is making new blood cells. You may also have a test called bone marrow aspiration, which is the removal of a small sample of bone marrow through a needle for examination under a microscope. This helps your provider see how well your bone marrow is producing new cells and platelets.

Although your body will start making new blood cells in 2 to 4 weeks, it will take much longer for your immune system to completely recover. It could take up to several months if your own stem cells are used and 1 to 2 years if the stem cells were donated by someone else.

When used as a part of the treatment for cancer or other diseases, a stem cell transplant makes it possible for you to receive very high doses of chemotherapy or radiation therapy. The transplant can restore your ability to make new, healthy blood cells and to fight disease.

When you donate bone marrow, there are usually no serious risks other than the risks of the general or regional anesthesia used during the procedure. You should discuss the risks of anesthesia with your healthcare provider. There is no risk from anesthesia when stem cells are harvested from the blood because anesthesia is not needed.

When you receive a stem cell transplant:

You should ask your healthcare provider how these risks apply to you.

Call your provider right away if:

For more information about bone marrow transplants, contact:

Disclaimer: This content is reviewed periodically and is subject to change as new health information becomes available. The information provided is intended to be informative and educational and is not a replacement for professional medical evaluation, advice, diagnosis or treatment by a healthcare professional.

HIA File hemo3503.htm Release 13/2010

2010 RelayHealth and/or its All rights reserved.

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Blood, Marrow Transplants: New Hampshire (NH) Vermont (VT …

Posted: August 7, 2016 at 6:46 am

Blood and marrow transplantsthe infusion of bone marrow or blood stem cellsoffer patients the chance for a cure or for extended remission of blood cancers.

High doses of chemotherapy normally destroy the ability to regenerate blood cells, but a blood stem cell transplant allows the body to produce new blood cells.

The Blood and Marrow Transplant Program at Norris Cotton Cancer Center in Lebanon, NH provides all types of bone marrow and blood stem cell transplants for the treatment of lymphoma, leukemia, multiple myeloma and other tumors, on an in-patient or out-patient basis. The program is the only National Marrow Donor Program (NMDP) transplant center in northern New England and is recognized as a specialized center for unrelated donor transplants.

We strive to provide a relaxed and caring environment, understanding that your emotional and mental well-being is as important to the healing process as the treatment itself.

This booklet (PDF) can help you to learn more about our Blood and Marrow Transplant program. In this guide, we will explain:

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New Hampshire Colorectal Cancer Screening Program …

Posted: October 19, 2015 at 5:49 pm

The New Hampshire Colorectal Cancer Screening Program (NHCRCSP) is a statewide effort to increase colorectal cancer screening for New Hampshire residents.

Contact Us Lebanon, NHCRCSP Team (DHMC) Phone: (603) 653-3702 Fax: (603) 727-7798

In March 2011, the New Hampshire Division of Public Health Services in collaboration with the New Hampshire Colorectal Cancer Screening Program created "Healthy Insights: Prevention news for the medical community of New Hampshire." Healthy Insights uses a similar technology as the New Hampshire Health Alert Network to notify providers of critical New Hampshire specific prevention messages throughout the year. Healthy Insights is sent via email to New Hampshire providers approximately six times per year, with the inaugural issue containing information on "Colorectal Cancer: One Of The Few Malignancies That Can Be Prevented As Well As Detected Early." An easy to use resource from the NHCRCSP, Screening and Surveillance Recommendations, was attached. Evaluation of this strategy to communicate important prevention messages to providers is ongoing.

New Hampshire Colorectal Cancer Screening Program (NHCRCSP) Information & Preparation Instructions for Your Colonoscopy

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Regenocyte is leading the medical industry in adult stem …

Posted: December 12, 2014 at 1:06 pm

2014 Stem Cell Pioneer Awards Stem Cell Awards Ceremony recognizing those pioneers in the field of Regenerative Therapy. Highlights of a few of the patients treated from 2006 to present. Treatments for heart, lung, neurologic and other diseases. Watch and see how some of the treated patients are doing -Awards Ceremony-Click here to watch the highlights

If you or a loved one suffer from severe heart, lung, or circulatory problems, it is possible that the latest therapies using adult stem cells can restore your quality of life to an unexpected level.

Because adult stem cell therapies are safe, simple, and minimally-invasive, they particularly help those who have exhausted the possibilities of other treatments.

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January 16, 2014: Brownsville "Doctor" Sentenced in Stem …

Posted: November 19, 2014 at 6:55 pm

HOUSTON Francisco Morales, 54, of Brownsville, has been sentenced for his role in a conspiracy to introduce misbranded and unapproved new drugs into interstate commerce, announced United States Attorney Kenneth Magidson. Morales and co-defendant Lawrence Stowe, 60, both falsely represented they were licensed to practice medicine in the United States. Morales operated a medical clinic in Brownsville, but was reportedly only licensed to practice in Mexico and carried out stem cell treatments for U.S. citizens in Mexico.

Today, U.S. District Judge Gray Miller handed Morales a sentence of 60 months in federal prison to be immediately followed by three years of supervised release. In handing down the sentence, Judge Miller noted his sentence was limited to 60 months by statute. Restitution was also ordered in the amount $479,862. Stowe is set for sentencing March 7, 2014.

On Sept. 5, 2012, Morales entered a guilty plea, admitting he sold an unapproved drug product to Stowe called SF 1019 knowing Stowe would sell this product to patients. Morales falsely represented to the public that he had extensive training and experience regarding stem cells and stem cell therapy, when his exposure was actually limited to attending seminars and reading materials published by researchers.

In June 2006, he received $8,300 from a couple to perform an unapproved stem cell procedure involving stem cells on their minor son who had experienced neurological problems after a near drowning incident. Prior to performing the procedure, Morales falsely represented that the stem cell procedure would be beneficial to combat the childs medical condition. He also falsely represented to two other patients that he obtained stem cells from private Universities and had treated more than 1000 patients using stem cells with only positive results.

Stowe admitted that beginning in January 2006, he utilized several businesses, Stowe BioTherapy Inc. and The Stowe Foundation to advertise and promote a medical treatment protocol for the treatment of amyotrophic lateral sclerosis (ALS) also known as Lou Gehrigs disease, multiple sclerosis (MS), Parkinsons and other neurological diseases. This treatment protocol, which was named Applied Biologics, consisted of supplements, vaccines, patient specific transfer factors and ultimately stem cell therapy. Stowe falsely represented to patients that this treatment protocol had been reviewed by all levels of the FDA and was effective in the treatment of ALS, MS and Parkinsons. There is currently no cure for these diseases.

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The Onrec Online Recruitment Exhibition – 21st October 2014, London – Free to attend

Posted: October 15, 2014 at 5:54 am

This is a invite to attend the Onrec ExhibitionFREE OF CHARGE - email stuart@onrec.com to book your place! Each delegate will receive a copy of the 2014 Onrec Yearbook

Our exhibition hall will offer a platform for suppliers to the industry to showcase their products and services to HR professionals, job boards, recruitment advertising executives, and all those involved in the online recruitment industry.

We are delighted to have the Anthony Nolan Trust as our conference charity. Their impressive ability to match donors to people needing transplants has great synergy with online recruitment industry, matching candidates to jobs.

Recruiting technology has always been about innovation the promise of sourcing and hiring great talent before the next guy. If, like us, you believe that hiring the best talent is of the utmost importance, then you should expect technology with a laser focus on helping you find today's greatest candidates.Delivering on the promise of innovation moves Jobvite forward every day.What started in 2003 as a unique way to supercharge employee referrals and spread job opportunities across social networks is now a recruiting platformused by the most-demanding customers, those who expect ceaseless recruiting innovation and social connection.Jobvite serves companies with the highest expectations of recruiting technology and candidate quality. Companies that value an easy-to-use applicant tracking system, social grown employee referrals, and positive candidate experiences choose Jobvite.

iCIMS, Inc. is an American software company founded in 1999. It is a leading provider of software-as-a-service (SaaS) talent acquisition software solutions for growing businesses. iCIMS' flagship product, the Talent Platform, supports clients from a wide range of industries. iCIMS is headquartered in central New Jersey, with offices in London, Beijing, New York, San Diego, Denver, Tampa, Portland (ME) Portland (OR), Dallas, and Vancouver.

Elevate Direct combines innovative technology with experienced recruitment professionals in order to help our clients source, hire and manage the right workers at the right time for their businesses. By taking this approach organisations both large and small can save time and money when sourcing their contractors.

Pulse is a UK based Umbrella Company and Accountancy for contractors, freelancers and small businesses. We offer award winning customer service, innovative and cutting edge technology, backed up by a super friendly team of experts and helpers. All of our services ensure maximum take home pay whilst providing complete peace of mind regarding tax and compliance. All for one low monthly fee with no hidden extras. At Pulse, we've been making people happy since 2009 so we've learned a thing or two along the way.

Every day, we match incredible individuals willing to donate their blood stem cells or bone marrow to people with blood cancer and blood disorders who desperately need lifesaving transplants. It all began in 1974. With her three-year-old son Anthony in urgent need of a bone marrow transplant, Shirley Nolan set up the world's first register to match donors with people in desperate need. Now, we help three people each day find that lifesaving match.

We have over fourteen years experience in the field of communication planning, consulting services and software development. Since 2006, we have been gamifying dozens of HR and marketing processes. Our solutions motivated, educated, and entertained close to 450.000 users. Our dreams and ideas generate continuous innovations for a more colorful and interesting show.

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The Onrec Online Recruitment Exhibition - 21st October 2014, London - Free to attend

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