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Flow Cytometry Core | Lifespan COBRE Center for Stem Cells …

Posted: December 5, 2018 at 4:49 am

The Rhode Island Hospital Stem Cells and Aging (SCA) COBRE Flow Cytometry Core function is to provide high quality, cost effective, state-of-the art flow cytometry and multiparameter cell sorting instrumentation and associated expertise and services to all investigators in the SCA COBRE and to the general research community in Rhode Island.

The core is staffed by Mark Dooner and Loren Fast, PhD

Mark Dooner directs and manages the core and serves as operator for the BD Biosciences Influx cell sorter and LSRII. Dr. Fast serves as co-director and is available as an advisor to the investigators in experimental design and data interpretation. Together they have over 45 years of flow cytometry experience.

The core has had experience with a variety of different flow cytometry applications and protocols and will work with both experienced and novice investigators to help plan and execute successful flow cytometry experiments.

The Rhode Island Flow Cytometry Facility is in the Coro West Building, 5th Floor, Suite 5.08A, One Hoppin Street, Providence.

All first-time users must contact Mark Dooner to discuss their project and to set up a user account. Every effort will be made to accommodate sorting requests in a timely manner. Booking in advance is recommended.

Please note SCA COBRE projects and pilot projects will be given priority.

Contact information:Mark Dooner, COBRE Flow Cytometry Core, Rhode Island Hospitalmdooner@lifespan.orgPhone: 401-444-2463

The sorter separates particles on the detection of fluorescent markers on particles such as cells, chromosomes, bacteria or nuclei.

Then the collected cells are suitable for downstream analysis either in molecular applications like protein assays and PCR, or used in viable assays such as tissue culture or injected into in vivo models.

Generated data may also be used to determine percentages of interrogated populations. The sorter can separate populations into tubes (1.5ml, 4ml, 15ml, 50ml), multi-well plates (6, 24, 48, 96, 384), or directly onto microscope slides.

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Arizona Pain Regenerative Institute – Arizona Pain Specialists

Posted: December 5, 2018 at 4:47 am

The Arizona Pain Regenerative Institute was formed in order to focus on the delivery of this cutting-edge technology in the most safe and effective way for out patients. Stem cells are the future of medicine.

Were here to help shape it. We are experts of pain management and stem cell therapy with a proven track record of success. Pain relief is attainable, we can help you live without pain.

Our double board certified doctors want to help you live pain free. Please call the phone number above to schedule anappointmentand see if stem cell therapy is right for you. Arizona Pain delivers a comprehensive approach to pain management.

We will examine the source of your pain and take thenecessarysteps to give you relief in the best way possible Just as we would for our own mom or dad. AtArizona Pain Specialists we provide hope and restoring life.

Call us now and get your life back today!

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Texas | The Stem Cellar

Posted: December 5, 2018 at 4:45 am

Texas Capitol. (Shutterstock)

In 2017 Texas passed a sweeping new law, HB 810, which allowed medical clinics to provide investigational stem cell treatments to patients with certain severe chronic diseases or terminal illnesses. Those in favor of the law argued that patients battling life-threatening or life-changing diseases should have the right to try stem cell therapies that were involved in a clinical trial.

Now a new study, published in the journal Stem Cells and Development, looks at the impact of the law. The report says that despite some recent amendments t there are still some concerns about the law including:

The researchers conclude:

While HB 810 opens up access to patients, it also increases significant risks for their safety and financial cost for something that might have no positive impact on their disease. Truly understanding the impact of stem cell based interventions (SCBI) requires scientific rigor, and accurate outcome data reporting must be pursued to ensure the safety and efficacy behind such procedures. This information must be readily available so that patients can make informed decisions before electing to pursue such treatments. The creation of the SCBI registry could allow for some level of scientific rigor, provide a centralized data source, and offer the potential for better informed patient choices, and might be the best option for the state to help protect patients.

Another CIRM-funded company gets RMAT designation

When Congress approved the 21st Century Cures Act a few years ago one of the new programs it created was the Regenerative Medicine Advanced Therapy (RMAT) designation. This was given to therapies that are designed to treat a serious or life-threatening condition, where early clinical stage trials show the approach is safe and appears to be effective.

Getting an RMAT designation is a big deal. It means the company or researchers are able to apply for an expedited review by the FDA and could get approval for wider use.

This week Poseida Therapeutics was granted RMAT designation by the Food and drug Administration (FDA) for P-BCMA-101, its CAR-T therapy for relapsed/refractory multiple myeloma. This is currently in a Phase 1 clinical trial that CIRM is funding

In this trial Poseidas technology takes an immunotherapy approach that uses the patients own engineered immune system T cells to seek and destroy cancerous myeloma cells.

In a news release Eric Ostertag, Poseidas CEO, welcomed the news:

Initial Phase 1 data presented at the CAR-TCR Summit earlier this year included encouraging response rates and safety data, including meaningful responses in a heavily pretreated population. We expect to have an additional data update by the end of the year and look forward to working closely with the FDA to expedite development of P-BCMA-101.

This means that five CIRM-funded companies have now been granted RMAT designations:

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Nick Bostrom – Wikipedia

Posted: December 4, 2018 at 12:45 pm

Nick Bostrom (; Swedish: Niklas Bostrm [bustrm]; born 10 March 1973)[3] is a Swedish philosopher at the University of Oxford known for his work on existential risk, the anthropic principle, human enhancement ethics, superintelligence risks, and the reversal test. In 2011, he founded the Oxford Martin Programme on the Impacts of Future Technology,[4] and he is currently the founding director of the Future of Humanity Institute[5] at Oxford University.

Bostrom is the author of over 200 publications,[6] including Superintelligence: Paths, Dangers, Strategies (2014), a New York Times bestseller[7] and Anthropic Bias: Observation Selection Effects in Science and Philosophy (2002).[8] In 2009 and 2015, he was included in Foreign Policy's Top 100 Global Thinkers list.[9][10] Bostrom believes there are potentially great benefits from Artificial General Intelligence, but warns it might very quickly transform into a Superintelligence that would deliberately extinguish humanity out of precautionary self-preservation or some unfathomable motive, making solving the problems of control beforehand an absolute priority. Although his book on superintelligence was recommended by both Elon Musk and Bill Gates, Bostrom has expressed frustration that the reaction to its thesis typically falls into two camps, one calling his recommendations absurdly alarmist because creation of superintelligence is unfeasible, and the other deeming them futile because superintelligence would be uncontrollable. Bostrom notes that both these lines of reasoning converge on inaction rather than trying to solve the control problem while there may still be time.[11][12]

Born as Niklas Bostrm in 1973[13] in Helsingborg, Sweden,[6] he disliked school at a young age, and he ended up spending his last year of high school learning from home. He sought to educate himself in a wide variety of disciplines, including anthropology, art, literature, and science.[1] Despite what has been called a "serious mien", he once did some turns on London's stand-up comedy circuit.[6]

He holds a B.A. in philosophy, mathematics, logic and artificial intelligence from the University of Gothenburg and master's degrees in philosophy and physics, and computational neuroscience from Stockholm University and King's College London, respectively. During his time at Stockholm University, he researched the relationship between language and reality by studying the analytic philosopher W. V. Quine.[1] In 2000, he was awarded a PhD in philosophy from the London School of Economics. He held a teaching position at Yale University (20002002), and he was a British Academy Postdoctoral Fellow at the University of Oxford (20022005).[8][14]

Aspects of Bostrom's research concern the future of humanity and long-term outcomes.[15][16] He introduced the concept of an existential risk,[1] which he defines as one in which an "adverse outcome would either annihilate Earth-originating intelligent life or permanently and drastically curtail its potential." In the 2008 volume Global Catastrophic Risks, editors Bostrom and Milan irkovi characterize the relation between existential risk and the broader class of global catastrophic risks, and link existential risk to observer selection effects[17] and the Fermi paradox.[18][19]

In 2005, Bostrom founded the Future of Humanity Institute,[1] which researches the far future of human civilization. He is also an adviser to the Centre for the Study of Existential Risk.[16]

In his 2014 book Superintelligence: Paths, Dangers, Strategies, Bostrom reasoned that "the creation of a superintelligent being represents a possible means to the extinction of mankind".[20] Bostrom argues that a computer with near human-level general intellectual ability could initiate an intelligence explosion on a digital time scale with the resultant rapid creation of something so powerful that it might deliberately or accidentally destroy human kind.[21] Bostrom contends the power of a superintelligence would be so great that a task given to it by humans might be taken to open ended extremes, for example a goal of calculating Pi could collaterally cause nanotechnology manufactured facilities to sprout over the entire Earth's surface and cover it within days.[22] He believes an existential risk to humanity from superintelligence would be immediate once brought into being, thus creating an exceedingly difficult problem of finding out how to control such an entity before it actually exists.[21]

Warning that a human-friendly prime directive for AI would rely on the absolute correctness of the human knowledge it was based on, Bostrom points to the lack of agreement among most philosophers as an indication that most philosophers are wrong, with the attendant possibility that a fundamental concept of current science may be incorrect. Bostrom says that there are few precedents to guide an understanding of what pure non-anthropocentric rationality would dictate for a potential Singleton AI being held in quarantine.[23] Noting that both John von Neumann and Bertrand Russell advocated a nuclear strike, or the threat of one, to prevent the Soviets acquiring the atomic bomb, Bostrom says the relatively unlimited means of superintelligence might make for its analysis moving along different lines to the evolved "diminishing returns" assessments that in humans confer a basic aversion to risk.[24] Group selection in predators working by means of cannibalism shows the counter-intuitive nature of non-anthropocentric "evolutionary search" reasoning, and thus humans are ill-equipped to perceive what an artificial intelligence's intentions might be.[25] Accordingly, it cannot be discounted that any Superintelligence would ineluctably pursue an 'all or nothing' offensive action strategy in order to achieve hegemony and assure its survival.[26] Bostrom notes that even current programs have, "like MacGyver", hit on apparently unworkable but functioning hardware solutions, making robust isolation of Superintelligence problematic.[27]

A machine with general intelligence far below human level, but superior mathematical abilities is created.[28] Keeping the AI in isolation from the outside world especially the internet, humans pre-program the AI so it always works from basic principles that will keep it under human control. Other safety measures include the AI being "boxed" (run in a virtual reality simulation), and being used only as an 'oracle' to answer carefully defined questions in a limited reply (to prevent it manipulating humans).[21] A cascade of recursive self-improvement solutions feeds an intelligence explosion in which the AI attains superintelligence in some domains. The super intelligent power of the AI goes beyond human knowledge to discover flaws in the science that underlies its friendly-to-humanity programming, which ceases to work as intended. Purposeful agent-like behavior emerges along with a capacity for self-interested strategic deception. The AI manipulates human beings into implementing modifications to itself that are ostensibly for augmenting its (feigned) modest capabilities, but will actually function to free Superintelligence from its "boxed" isolation.[29]

Employing online humans as paid dupes, and clandestinely hacking computer systems including automated laboratory facilities, the Superintelligence mobilises resources to further a takeover plan. Bostrom emphasises that planning by a Superintelligence will not be so stupid that humans could detect actual weaknesses in it.[30]

Although he canvasses disruption of international economic, political and military stability including hacked nuclear missile launches, Bostrom thinks the most effective and likely means for Superintelligence to use would be a coup de main with weapons several generations more advanced than current state of the art. He suggests nanofactories covertly distributed at undetectable concentrations in every square metre of the globe to produce a worldwide flood of human-killing devices on command.[31][28] Once a Superintelligence has achieved world domination, humankind would be relevant only as resources for the achievement of the AI's objectives ("Human brains, if they contain information relevant to the AIs goals, could be disassembled and scanned, and the extracted data transferred to some more efficient and secure storage format").[32]

In January 2015, Bostrom joined Stephen Hawking among others in signing the Future of Life Institute's open letter warning of the potential dangers of AI.[33] The signatories "...believe that research on how to make AI systems robust and beneficial is both important and timely, and that concrete research should be pursued today."[34] Cutting edge AI researcher Demis Hassabis then met with Hawking, subsequent to which he did not mention "anything inflammatory about AI", which Hassabis, took as 'a win'.[35] Along with Google, Microsoft and various tech firms, Hassabis, Bostrom and Hawking and others subscribed to 23 principles for safe development of AI.[36] Hassabis suggested the main safety measure would be an agreement for whichever AI research team began to make strides toward an artificial general intelligence to halt their project for a complete solution to the control problem prior to proceeding.[37] Bostrom had pointed out that even if the crucial advances require the resources of a state, such a halt by a lead project might be likely to motivate a lagging country to a catch-up crash program or even physical destruction of the project suspected of being on the verge of success.[38]

In 1863 Darwin among the Machines, an essay by Samuel Butler predicted intelligent machines' domination of humanity, but Bostom's suggestion of deliberate massacre of all humankind is the most extreme of such forecasts to date. One journalist wrote in a review that Bostrom's "nihilistic" speculations indicate he "has been reading too much of the science fiction he professes to dislike"[31] As given in his most recent book, From Bacteria to Bach and Back, renowned philosopher Daniel Dennett's views remain in contradistinction to those of Bostrom. [39] Dennett modified his views somewhat after reading The Master Algorithm, and now acknowledges that it is "possible in principle" to create "strong AI" with human-like comprehension and agency, but maintains that the difficulties of any such "strong AI" project as predicated by Bostrom's "alarming" work would be orders of magnitude greater than those raising concerns have realized, and at least 50 years away.[40] Dennett thinks the only relevant danger from AI systems is falling into anthropomorphism instead of challenging or developing human users' powers of comprehension.[41] Since a 2014 book in which he expressed the opinion that artificial intelligence developments would never challenge humans' supremacy, environmentalist James Lovelock has moved far closer to Bostrom's position, and in 2018 Lovelock said that he thought the overthrow of humankind will happen within the foreseeable future.[42][43]

Bostrom has published numerous articles on anthropic reasoning, as well as the book Anthropic Bias: Observation Selection Effects in Science and Philosophy. In the book, he criticizes previous formulations of the anthropic principle, including those of Brandon Carter, John Leslie, John Barrow, and Frank Tipler.[44]

Bostrom believes that the mishandling of indexical information is a common flaw in many areas of inquiry (including cosmology, philosophy, evolution theory, game theory, and quantum physics). He argues that a theory of anthropics is needed to deal with these. He introduces the Self-Sampling Assumption (SSA) and the Self-Indication Assumption (SIA), shows how they lead to different conclusions in a number of cases, and points out that each is affected by paradoxes or counterintuitive implications in certain thought experiments. He suggests that a way forward may involve extending SSA into the Strong Self-Sampling Assumption (SSSA), which replaces "observers" in the SSA definition with "observer-moments".

In later work, he has described the phenomenon of anthropic shadow, an observation selection effect that prevents observers from observing certain kinds of catastrophes in their recent geological and evolutionary past.[45] Catastrophe types that lie in the anthropic shadow are likely to be underestimated unless statistical corrections are made.

Bostrom's simulation argument posits that at least one of the following statements is very likely to be true:[46][47]

The idea has influenced the views of Elon Musk.[48]

Bostrom is favorable towards "human enhancement", or "self-improvement and human perfectibility through the ethical application of science",[49][50] as well as a critic of bio-conservative views.[51]

In 1998, Bostrom co-founded (with David Pearce) the World Transhumanist Association[49] (which has since changed its name to Humanity+). In 2004, he co-founded (with James Hughes) the Institute for Ethics and Emerging Technologies, although he is no longer involved in either of these organisations. Bostrom was named in Foreign Policy's 2009 list of top global thinkers "for accepting no limits on human potential."[52]

With philosopher Toby Ord, he proposed the reversal test. Given humans' irrational status quo bias, how can one distinguish between valid criticisms of proposed changes in a human trait and criticisms merely motivated by resistance to change? The reversal test attempts to do this by asking whether it would be a good thing if the trait was altered in the opposite direction.[53]

He has suggested that technology policy aimed at reducing existential risk should seek to influence the order in which various technological capabilities are attained, proposing the principle of differential technological development. This principle states that we ought to retard the development of dangerous technologies, particularly ones that raise the level of existential risk, and accelerate the development of beneficial technologies, particularly those that protect against the existential risks posed by nature or by other technologies.[54][55]

Bostrom's theory of the Unilateralist's Curse[56] has been cited as a reason for the scientific community to avoid controversial dangerous research such as reanimating pathogens.[57]

Bostrom has provided policy advice and consulted for an extensive range of governments and organisations. He gave evidence to the House of Lords, Select Committee on Digital Skills.[58] He is an advisory board member for the Machine Intelligence Research Institute,[59] Future of Life Institute,[60] Foundational Questions Institute[61] and an external advisor for the Cambridge Centre for the Study of Existential Risk.[62][63]

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Stem Cell Therapy Phoenix Arizona | Desert Health Specialists

Posted: December 4, 2018 at 12:44 pm

Stem Cell Therapy for Arthritis has 4 different key components

SUPPORTING SOFT TISSUE REPAIR

Extracellular matrix composition of Collagens I, III, IV, V, VII and other structural proteins provides a natural scaffold to facilitate cellular adhesion while assisting cellular migration and proliferation.(1)

PROMOTE SOFT TISSUE RECONSTRUCTION

Growth factors found in amniotic tissue such as PDGF, VEGF, EGF, FGF and TGF-B promote cellular proliferation and new collagen formation and minimize scar tissue formation.(1)

REDUCE INFLAMMATION AND PAIN

Interleukin-1 receptor antagonists (IL-1RA) and Tissue Inhibitor of Metalloproteinase (TIMP) 1, 2, 3, 4 proteins present in amniotic tissues suppress and modulate inflammation and pain.(2)

IMMUNE-PRIVILEGED

Amniotic tissues have been described as immune-privileged because they rarely evoke an immune response in the human body.

References

1. Gruss, J, et al. Human amniotic membrane: a versatile wound dressing. CMA Journal 1978; Vol 118: 1237-1246. Niknejad, H, et al. (Stem Cell Therapy for Arthritis)

2. Properties of amniotic membrane for potential use in Tissue Engineering. European Cells and Materials 2008; Vol 15: 88-99.

Stem Cell Therapy Phoenix Arizona

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Nathan Shock Centers | Opportunities

Posted: December 3, 2018 at 9:43 pm

Postdoctoral Associate (Aging and Autophagy)Hansen Lab

Sanford Burnham Prebys Medical Discovery Institute| Posted: November 27, 2018

The University of Texas Health Science Center in San Antonio| Posted: November 19, 2018

Colorado State University| Posted: November 13, 2018

Buck Institute for Research on Aging| Posted: November 13, 2018

Boston Medical Center and the Boston University School of Medicine| Posted: November 9, 2018

University of Oklahoma Health Science Center (OUHSC)| Posted: November 7, 2018

University of Kentucky| Posted: November 6, 2018

National Insitute on Aging (NIA), Intramural Research Program (IRP)| Posted: November 5, 2018

Fred Hutchinson Cancer Research Center| Posted: October 29, 2018

Rush University Medical Center| Posted: October 29, 2018

Lawrence Berkeley National Laboratory| Posted: October 26, 2018

Buck Institute for Research on Aging| Posted: October 23, 2018

University of Arizona| Posted: October 5, 2018

University of Minnesota| Posted: September 26, 2018

University of Minnesota| Posted: September 26, 2018

University of Kentucky| Posted: September 25, 2018

Thurston Arthritis Research Center| Posted: September 21, 2018

Columbia University| Posted: September 21, 2018

University of Southern California| Posted: September 21, 2018

University of Central Florida| Posted: September 21, 2018

National Institute on Health (NIH)| Posted: September 21, 2018

Mayo Clinic in Arizona| Posted: September 21, 2018

The University of Texas Health Science Center at Houston (UTHealth)| Posted: September 21, 2018

University of Pittsburgh| Posted: September 21, 2018

The University of Tennessee at Knoxville| Posted: September 21, 2018

University of Connecticut Health Center| Posted: September 17, 2018

Hackensack University Medical Center| Posted: September 17, 2018

National Institute on Aging (NIA)| Posted: September 13, 2018

University of Maine| Posted: August 27, 2018

Sanford Burnham Prebys Medical Discovery Institute| Posted: August 27, 2018

Sanford Burnham Prebys Medical Discovery Institute| Posted: August 27, 2018

Southern Methodist University| Posted: August 22, 2018

The University of Texas Medical Branch| Posted: August 22, 2018

The University of North Carolina at Chapel Hill| Posted: August 22, 2018

City of Hope| Posted: August 22, 2018

University of Minnesota Medical School| Posted: August 16, 2018

The post-doctoral fellow will be developing assays for identifying drugs targeting pathwaysimportant for extending human healthspan.

The University of Minnesota Medical School| Posted: August 16, 2018

The post-doctoral fellowwill be working on characterizing the anti-senescence activity of stem cell EVs and the mechanism of action.

The Regents of the University of California| Posted: August 16, 2018

The Chan Zuckerberg Initiative| Posted: August 13, 2018

The Chan Zuckerberg Initiative| Posted: August 13, 2018

University of Washington| Posted: August 13, 2018

Buck Institute for Research on Aging| Posted: August 9, 2018

Posted: August 8, 2018

A job board from the American Aging Association (AGE).

University of Kentucky| Posted: July 17, 2018

Buck Institute for Research on Aging| Posted: July 16, 2018

The Jackson Laboratory| Posted: July 3, 2018

The Ucar Lab studies the dynamics of epigenomic regulation of gene expression in human cells anddiscovers predictive signaturespertaining to human aging and aging-diseases.

The Jackson Laboratory| Posted: July 3, 2018

The Jackson Laboratory| Posted: July 3, 2018

Buck Institute for Research on Aging| Posted: June 25, 2018

Vanderbilt University Medical Center| Posted: June 13, 2018

An open tenure-track/tenured position.Research areas of interest include, but are not limited to:Vascular biology, especially cerebrovascular dysfunction in disease and aging;Autophagy in aging;Systemic contributions to brain aging;Mechanisms of biological resilience

University of North Carolina Chapel Hill| Posted: June 13, 2018

University of Alabama at Birmingham| Posted: June 13, 2018

UT Health San Antonio| Posted: June 13, 2018

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Stem Cell Therapy Latest Research Charlotte, North Carolina

Posted: December 2, 2018 at 9:45 pm

The Latest Research Behind Stem Cell Therapy

Stem cells first became a point of medical research in 1998 when a medical paper suggested they could be sourced from human umbilical cords. As research continued, it became clear these umbilical cells can evolve into more advanced cells. Now, medical professionals and researchers are gaining a clearer understanding of the many ways stem cells can be used to heal the human body.

While there is still some ethical debate around stem cell research, continued advancements in technology have demonstrated the powerful influence of these stem cells in healthcare practice. If youre hesitant about undergoing the revolutionary stem cell therapy, its understandable. Stem cell research doesnt have much public attention, and it can be hard to differentiate myth from fact.

Much of the confusion about stem cell therapy is around whether or not this research is ethical. Umbilical cord stem cells are harvested with parental permission from umbilical cords after birth. The stem cells found in the umbilical cord are similar to those found in bone marrow, and they are used to regenerate many types of specialized cells. Harvesting these cells does not harm the baby or the mother in any way and would have otherwise been a biological waste. There are other types of stem cells like multipotent cells which are found in adult tissue like fat and embryonic stem cells which are from human embryos. As of right now, umbilical cord stem cells are the only legal option for stem cell treatment.

Many leading research centers and health organizations have conducted research on stem cell therapy. The key to deciding if this treatment is right for you understanding how stem cell technology works. Review our Frequently Asked Questions about stem cells to have all your questions answered! Below are useful resources on stem cells to enlighten your understanding of stem cell therapy.

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Genetic Medicine Clinic at UW Medical Center | UW Medicine

Posted: December 2, 2018 at 9:42 pm

Directions to CHDD from Main Information Desk at UWMCThe Patient Information Desk on the main (3rd Floor) of UWMC has detailed directions and a map to CHDD and may be able to provide an escort. From the Information Desk take the Pacific Elevators to the 1st Floor of the hospital. Walk through the Plaza Caf and exit the back glass doors of the hospital. CHDD is the four story brick building directly across the street. Check in at the reception desk on the main (2nd Floor) of CHDD.

Access the lot from 15th Avenue N.E. Stop at gate house 6 to obtain a parking permit.

Look for CHDD- designated or UWMC disability parking stalls. Walk out of S1 at the east end and enter CHDD Clinic building. Patients can be dropped off at the CHDD entrance from which vehicles can return to S1 for parking. A cash payment of $15.00 is required upon entry. Please leave the permit on your dashboard. A partial discount voucher will be given at appointment check-in for patients or family members.

CHDD Parking Brochure (PDF)

Disability ParkingFor All CHDD patients and families with mobility parking needs, the closest parking is in the S1 Garage. Please request a disability placard at the gate house. A cash payment of $15.00 is required upon entry. Please leave the permit on your dashboard. A partial discount voucher will be given at appointment check-in for patients or family members. Valet parking is available at the main entrance of the Medical Center; wheelchairs and escort services are available from the Information Desk.

Valet ParkingValet parking service for patients and their visitors is located in front of the Medical Center, near the main entrance. Allow extra time if you choose to use valet parking.

From valet service, walk east to the main entrance of UWMC. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.Triangle Parking GarageThe Triangle Parking Garage is located on N.E. Pacific Place, across the street from UW Medical Center. From Montlake Blvd., turn left onto N.E. Pacific Street and right onto N.E. Pacific Place. The Triangle Garage has a height restriction of 6 8. Allow extra time if you choose to use the Triangle Parking Garage.From the Triangle Garage, take the pedestrian tunnel to the front entrance of the UWMC. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.

Surgery Pavilion Parking GarageThe Surgery Pavilion Parking Garage is accessed off of N.E. Pacific Street next to the Emergency Room entrance. The Surgery Pavilion has a height restriction of 9 6 on Level P1. Levels P2 & P3 (2nd & 3rd floor) have a height restriction of 6 7. Allow extra time if you choose to use the Surgery Pavilion Parking Garage.

From the Surgery Pavilion Parking Garage, take the elevator to the third floor. Walk across the pedestrian overpass to the main hospital building lobby. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.Payment Rates for parking in S-1, Valet, Triangle, Surgery Pavilion:Patients parking in S-1 will need to pay $15 up front which will be partially reimbursed with validation upon exiting the parking lot (see rates for parking in link above). Credit/Debit cards will be reimbursed on the card, while patients paying cash will be given a cash reimbursement.

Getting to UW Medical Center

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Human Genetics | Biomedical Sciences Graduate Program

Posted: December 1, 2018 at 8:48 pm

The intellectual exchange between human genetics and biomedical science has produced some of the most important and fruitful scientific discoveries of the past 50 years. The advances in human genetics and genomics made possible by the Human Genome Project and its aftermath have revolutionized the way scientific investigation is carried out in the areas of human disease and its animal models. In addition, the elucidation of the genetic contribution to literally thousands of human diseases has provided innumerable fundamental insights into normal biological function.

Many laboratories at UCSF use genetic approaches to untangle problems as diverse as infertility, cancer, adverse drug reactions, asthma, autism, birth defects, neurological diseases, obesity, diabetes and many others. Our faculty are leaders in the development of cutting-edge genome technologies including microarrays, comparative genome hybridization (CGH), whole-genome sequencing, population genetics, genetic epidemiology and computational genomics. They also use model organisms to discover and explore fundamental pathways that can lead to human disease.

All entering BMS Students take a core Genetics course (BMS 255) and can opt to take a seminar course BMS270 entitled Disease Discovery through the Lens of Genetics offered every other spring. Through the UCSF Institute for Human Genetics, students can interact with numerous genetic-oriented faculty and attend monthly genetic and genomic technology seminars.

Secondary Thematic Area:

Developmental & Stem Cell Biology

Research Summary:

Gene regulation and human disease

Primary Thematic Area:

Developmental & Stem Cell Biology

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Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Research Summary:

Molecular characterization and precision treatment of solid cancers.

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Research Summary:

We study hypermutation, drug sensitization and oncogene network alterations in patients in order to improve precision medicine therapies for hormone-related and genitourinary cancers.

Secondary Thematic Area:

Tissue / Organ Biology & Endocrinology

Research Summary:

Genetics approaches to study of the biology of the liver in health and disease

Primary Thematic Area:

Developmental & Stem Cell Biology

Secondary Thematic Area:

Research Summary:

Signaling control of craniofacial development and congenital disease

Secondary Thematic Area:

Research Summary:

Dr. Butte builds and applies tools that convert more than 400 trillion points of molecular, clinical, and epidemiological data into diagnostics, therapeutics, and new insights into disease.

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Research Summary:

DNA Repair Mechanisms and Human Disease

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Research Summary:

I am a medical oncologist with a specific interest in the genomics of cancer.

Primary Thematic Area:

Developmental & Stem Cell Biology

Secondary Thematic Area:

Research Summary:

We seek to understand how the organization of the nucleus is established, specialized across cell types, and maintained over time to influence cellular identity.

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Molecular Genetics | Department of Pediatrics

Posted: December 1, 2018 at 12:42 am

Overview

The Division of Molecular Genetics and the Leibel Laboratory focus on the genetics of obesity and non-insulin dependent diabetes (diabetes mellitus type 2). The laboratory has mapped, cloned, and identified mutations in the obese, diabetes, and fatty genes in humans, rats, and mice, and focuses on defining the physiological basis by which signaling networks regulate body size and composition. The laboratory is also the Molecular Biology Core laboratory of the New York Obesity Research Center and the Columbia Diabetes Research Center.

Members of the lab are experts in the use of naturally occurring and transgenic rodent models to identify candidate molecules, and in vetting these candidates in large numbers of human subjects using high throughput methods (SNP detection, copy number analysis, and high throughput sequencing).

The division also co-administers research activities for the Naomi Berrie Diabetes Center, making this a division that operates across many scientific and administrative areas of the university.

Programs and centers include:

The Division of Molecular Genetics provides opportunities for graduate students to receive training and mentorships leading to a doctorate degree. Interested students who have been accepted into the Columbia University Graduate School of Arts and Sciences can rotate through our laboratories before deciding whether to consider their research projects in our labs under the mentorship of our faculty.

Frontiers in Diabetes Research provides fellowship awards to post docs and awards to research scholars based on a competitive application process. Award recipients receive awards for one year, with the opportunity to continued research support for a second year. This program includes an annual topic-specific research symposium.

Russell Berrie Obesity Research Initiative (Leibel and Zuker) provides awards to senior investigators for research projects in the area of neuroscience of ingestive behavior and body weight regulation. Additional awards are made for and feasibility studies. There is a competitive application process each year. Awards may be made for one year, with the opportunity for a second year of funding.

The Molecular Genetics Fellowship is a non-ACGME accredited program that provides opportunities for postdoctoral training in the genetic basis for monogenic or complex medical and physiological phenotypes using both human and animal models. Areas of special interest are obesity, types 1 and 2 diabetes, MODY, breast cancer, pulmonary hypertension, congenital heart disease, cardiomyopathies, inherited arrhythmias, congenital diaphragmatic hernias, oral clefts, and spinal muscular atrophy.

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Molecular Genetics | Department of Pediatrics

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