Stem Cell Therapy for Arthritis has 4 different key components
SUPPORTING SOFT TISSUE REPAIR
Extracellular matrix composition of Collagens I, III, IV, V, VII and other structural proteins provides a natural scaffold to facilitate cellular adhesion while assisting cellular migration and proliferation.(1)
PROMOTE SOFT TISSUE RECONSTRUCTION
Growth factors found in amniotic tissue such as PDGF, VEGF, EGF, FGF and TGF-B promote cellular proliferation and new collagen formation and minimize scar tissue formation.(1)
REDUCE INFLAMMATION AND PAIN
Interleukin-1 receptor antagonists (IL-1RA) and Tissue Inhibitor of Metalloproteinase (TIMP) 1, 2, 3, 4 proteins present in amniotic tissues suppress and modulate inflammation and pain.(2)
IMMUNE-PRIVILEGED
Amniotic tissues have been described as immune-privileged because they rarely evoke an immune response in the human body.
References
1. Gruss, J, et al. Human amniotic membrane: a versatile wound dressing. CMA Journal 1978; Vol 118: 1237-1246. Niknejad, H, et al. (Stem Cell Therapy for Arthritis)
2. Properties of amniotic membrane for potential use in Tissue Engineering. European Cells and Materials 2008; Vol 15: 88-99.
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