Mouse Mesenchymal Stem Cell Marker Antibody Panel

Background: Mesenchymal Stem Cells

Researchers use different techniques to isolate, culture, and differentiate mesenchymal stem/stromal cells (MSCs). Variations in experimental approaches as well as differences in the MSC starting population may account for experimental variability and some of the contradictory data that have been published in this field. SeeDetails

One way to minimize experimental variation is to clearly define the starting cell population by using a functional or phenotypic assay. R&D Systems offers the Mouse Multipotent Mesenchymal Stromal Cell Marker Antibody Panel, which uses expression of multiple established markers to assess MSC identity.

The Mouse Multipotent Mesenchymal Stromal Cell Marker Antibody Panel:

The term mesenchymal stromal cells is commonly used to describe a heterogeneous population of cultured cells that are adherent to plastic, have a distinct morphology, and express a specific set of marker proteins. Within this heterogeneous population are cells referred to as mesenchymal stem cells. SeeDetails

Mesenchymal stem cells are multipotent, self-renewing cells that have the ability to differentiate into adipocytes, chondrocytes, and osteoblasts when cultured in vitro.

Although mesenchymal stromal cells were once referred to as mesenchymal stem cells, a change to mesenchymal stromal cells was proposed by the International Society for Cellular Therapy in 2006.1

The change in nomenclature originates from two important factors:

Data supporting MSC self-renewal and multipotency have been obtained using in vitro conditions, which does not adequately reflect the in vivo environment. The lack of in vivo data has led some researchers to question the validity of the term mesenchymal stem cell providing further support for the use of mesenchymal stromal cells to describe MSCs.2 While mesenchymal stromal cells may be the more scientifically accurate term for MSCs, the two terms are often used interchangeably in the literature. R&D Systems recognizes the use of both mesenchymal stem cells and mesenchymal stromal cells and uses MSC to indicate mesenchymal stem/stromal cells to account for both designations.

The Mouse Multipotent Mesenchymal Stromal Cell Marker Antibody Panel includes 8 primary antibodies for the positive and negative identification of Mouse MSCs by flow cytometry. SeeDetails

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Mouse Mesenchymal Stem Cell Marker Antibody Panel