PALM BEACH, Fla., April 14, 2022 /PRNewswire/ -- FinancialNewsMedia.com News Commentary - CAR-T therapy is a sort of treatment in which a patient's T cells which is a type of immune system cell, are genetically modified to attack cancer cells in the lab. T cells are extracted from the blood of a patient. The gene for a specific receptor that binds to a specific protein on the patient's cancer cells is then transferred to T cells in the lab. A chimeric antigen receptor is a unique type of receptor (CAR). CAR-T units are generated in large numbers in the lab and then infused into the patient. CAR-T therapy is used to treat specific types of blood malignancies, and it is also being researched for other cancers. CAR T therapy is also known as Chimeric antigen receptor T-cell therapy. T cells are used in CAR T therapy since they are generally responsible for destroying malignant cells and virus-infected cells. Cancer cells are known to hide from the immune system, but scientists have been able to improve T cells' ability to locate and kill cancer cells using CAR T therapy. A report from Polaris Market Research projected that the global CAR-T cell therapy market was valued at USD 1,965.8 million in 2021, expected to grow at a CAGR of 31.16 % during the forecast period (2029). The report said: "CAR T therapy market is expected to grow due to the growing prevalence of cancer cases across the globe. This treatment has captured the attention of researchers and the public because of the remarkable responses they have produced in patients. The Food and Drug Administration (FDA) approved two CAR T treatments in 2017, one for children with acute lymphoblastic leukaemia (ALL) and the other for adults with advanced lymphomas." Active biotech and pharma companies in the markets this week include Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Sierra Oncology, Inc (NASDAQ: SRRA), Antares Pharma, Inc. (NASDAQ: ATRS), Clovis Oncology, Inc. (NASDAQ: CLVS), Turning Point Therapeutics, Inc. (NASDAQ: TPTX).
"Continuous growth has been witnessed in biotechnology and life science sectors for the treatment of cancer using chimeric antigen receptors. Increased patient assistance programs (PAPs), increased government activities for cancer awareness, rising cancer prevalence worldwide, and strong R&D initiatives from key companies are all driving CAR-T cell therapy market expansion. With the growing need for cell-based therapy, producers have started investing in the manufacturing of this therapy. North America is expected to dominate the global CAR-T cell therapy market due to the increasing cancer cases and growing emergence of the biotechnological sector. North America is witnessing an increasing number of cancer cases which is increasing the market demand for cancer therapies in the region The presence of key players in the region are focusing on expanding their global presence, is fueling the CAR-T cell therapy market."
Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) BREAKING NEWS: Oncolytics Biotech Announces Publication of Preclinical Data Demonstrating the Synergistic Anti-Cancer Activity of Pelareorep Combined with CAR T Cell Therapy in Solid Tumors in Science Translational Medicine- Oncolytics Biotech today announced the publication of preclinical data demonstrating the synergistic anti-cancer activity of pelareorep combined with chimeric antigen receptor (CAR) T cell therapy in solid tumors. The paper, entitled "Oncolytic virus-mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice," was published in Science Translational Medicine in collaboration with researchers at several prestigious institutions, including the Mayo Clinic and Duke University. A link to the paper can be found by clicking here.
"Having these results published in such a high-impact journal provides important external validation of their significance," said Thomas Heineman, M.D., Ph.D., Chief Medical Officer of Oncolytics Biotech Inc. "While CAR T cells have generated long-term cures in hematologic malignancies1, the immunosuppressive tumor microenvironments (TMEs) of solid organ cancers have thus far limited their efficacy in these indications. Pelareorep has repeatedly been shown to reverse immunosuppressive TMEs, and in the present publication pelareorep is shown to enable the effectiveness of CAR T cells in multiple murine solid tumor models. This is a powerful finding that, if translated to the clinic, could significantly improve the prognosis of patients with a variety of highly prevalent cancers by providing a novel and potentially durable treatment option. By demonstrating the ability to improve T cell perseverance, reduce antigen escape, and overcome challenging solid tumor TMEs, the inclusion of pelareorep addresses the three most challenging roadblocks to effective CAR T therapy."
Andrew de Guttadauro, President of Oncolytics Biotech U.S. and Global Head of Business Development, added, "Despite revolutionizing the treatment of certain cancers and surpassing a billion dollars in sales last year, CAR T therapies currently only serve a small subset of patients suffering from hematologic malignancies. With these latest results, we now have strong preclinical evidence that pelareorep can fully unlock the value of CAR T therapies by expanding their commercial potential to the significantly larger market of cancer patients who are battling solid tumors."
Preclinical studies published in the paper evaluated the persistence and efficacy of pelareorep-loaded CAR T cells ("CAR/Pela therapy") in multiple murine solid tumor models. The effects of combining CAR/Pela therapy with a subsequent intravenous dose of pelareorep ("pelareorep boost") were also investigated. Key data and conclusions from the paper include:
Dr. Matt Coffey, President and Chief Executive Officer of Oncolytics Biotech Inc. and co-author of the paper commented, "These exciting results are an excellent example of how we are leveraging collaborations with key opinion leaders and premier research institutions to broaden pelareorep's potential therapeutic impact. This allows us to remain primarily focused on our lead breast cancer program, which has shown how pelareorep's ability to promote tumor T cell infiltration leads to synergy with checkpoint inhibitors in the clinic. These newly published preclinical findings show pelareorep's synergistic benefits extend even beyond checkpoint inhibitors and highlight an opportunity to increase our addressable patient population. As we pursue this opportunity moving forward, we intend to utilize relationships with academic or industry partners so that we can continue to execute on our clinical and corporate objectives with efficiency." CONTINUED Read this full press release and more news for ONCY at: https://www.financialnewsmedia.com/news-oncy/
Other recent developments in the biotech industry of note include:
GlaxoSmithKline plc (NYSE: GSK) and Sierra Oncology, Inc (NASDAQ: SRRA)recently announced that the companies have entered into an agreement under which GSK will acquire Sierra Oncology, a California-based, late-stage biopharmaceutical company focused on targeted therapies for the treatment of rare forms of cancer, for $55 per share of common stock in cash representing an approximate total equity value of $1.9 billion (1.5 billion).
Myelofibrosis is a fatal cancer of the bone marrow impacting the normal production of blood cells. Anaemia represents a high unmet medical need in patients with myelofibrosis. At diagnosis, approximately 40% of patients are already anaemic, and it is estimated that nearly all patients will eventually develop anaemia.Patients treated with the most commonly used JAK inhibitor will often require transfusions, and more than 30% will discontinue treatment due to anaemia.Anaemia and transfusion dependence are strongly correlated with poor prognosis and decreased overall survival. Momelotinib has a differentiated mode of action with inhibitory activity along key signalling pathways.
Antares Pharma, Inc. (NASDAQ: ATRS) recently announced that the U.S. Food and Drug Administration granted final approval for TLANDO (testosterone undecanoate), an oral treatment for testosterone replacement therapy ("TRT") indicated for conditions associated with a deficiency or absence of endogenous testosterone, or hypogonadism in adult males.
Robert F. Apple, President and Chief Executive Officer of Antares Pharma, commented, "The FDA approval of TLANDO brings to market an oral formulation of testosterone that we believe will prove beneficial to physicians and their patients. We have recently expanded our commercial organization to 108 sales representatives and expect to leverage our relationships with urologists and endocrinologists to drive adoption of TLANDO. This approval also reinforces the opportunity for Antares to continue to drive share gains in the TRT market with both TLANDO and XYOSTED and support our future growth with an expanded commercial portfolio.
Clovis Oncology, Inc. (NASDAQ: CLVS), recently announced that two abstracts featuring non-clinical data from studies evaluating FAP-2286 and Rubraca and a Trial-in-Progress poster detailing the Phase 1 portion of the LuMIERE study will be presented at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2022, being held April 8-13, 2022, in New Orleans.
In a new non-clinical data analysis, FAP-2286 demonstrated potent affinity for human fibroblast activation protein (FAP) by biochemical and cell-based assays. Additionally, lutetium-177 (177Lu)-FAP-2286 showed longer tumor retention, resulting in greater tumor inhibition as compared to lutetium-177 (177Lu)-FAPI-46, a FAP-targeted radiotracer developed for therapeutic applications at the University of Heidelberg, Germany.
Turning Point Therapeutics, Inc. (NASDAQ: TPTX), a clinical-stage precision oncology company developing next-generation therapies that target genetic drivers of cancer, recently announced positive topline results from the registrational TRIDENT-1 study across all fourROS1-positive advanced non-small cell lung cancer (NSCLC) cohorts, as reported by Blinded Independent Central Review (BICR).
"We are very encouraged by the topline results from the pooled Phase 1 and Phase 2 portions of TRIDENT-1 by BICR shared today and continue to believe repotrectinib is a potentially best-in-class drug candidate for patients withROS1-positive advanced NSCLC," said Athena Countouriotis, M.D., President and Chief Executive Officer. "The confirmed ORR data and 95% confidence intervals across all four cohorts remain strong, and the initial estimated Kaplan-Meier landmark analyses based on limited median follow-up of approximately 10 months for both duration of response and progression free survival in the TKI-nave population are trending in the direction we had hoped for given this is the highest area of unmet medical need. We believe a differentiated profile is built upon a strong ORR and durability of response that could improve upon the current standard of care."
DISCLAIMER: FN Media Group LLC (FNM), which owns and operates FinancialNewsMedia.com and MarketNewsUpdates.com, is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with any company mentioned herein. FNM and its affiliated companies are a news dissemination solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security. FNM's market updates, news alerts and corporate profiles are NOT a solicitation or recommendation to buy, sell or hold securities. The material in this release is intended to be strictly informational and is NEVER to be construed or interpreted as research material. All readers are strongly urged to perform research and due diligence on their own and consult a licensed financial professional before considering any level of investing in stocks. All material included herein is republished content and details which were previously disseminated by the companies mentioned in this release. FNM is not liable for any investment decisions by its readers or subscribers. Investors are cautioned that they may lose all or a portion of their investment when investing in stocks. For current services performed FNM expects to be compensated forty nine hundred dollars for news coverage of the current press releases issued by Oncolytics Biotech Inc. by a non-affiliated third party. FNM HOLDS NO SHARES OF ANY COMPANY NAMED IN THIS RELEASE.
This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.
Contact Information:Media Contact email:[emailprotected]+1(561)325-8757
SOURCE FinancialNewsMedia.com
Read more here:
Advancements of CAR-T Cell Therapies Importance Grows While Cancer Cases Increasing - PR Newswire
- Global Testosterone Replacement Therapy Market Size To Worth USD 2.93 Billion By 2033 | CAGR Of 4.0% - Yahoo Finance - April 21st, 2024
- Testosterone replacement therapy: Yes or no - MD Anderson Cancer Center - January 6th, 2024
- 5 Best Testosterone Replacement Therapy Services 2023 - Men's Health - January 6th, 2024
- How Much Is Testosterone? The Cost of Replacement Therapy - Hone Health - January 6th, 2024
- Testosterone Replacement Therapy - Department of Urology - January 6th, 2024
- Testosterone Replacement Therapy for Low T - Ageless Men's Health - January 6th, 2024
- Understanding Hypogonadism, Testosterone Replacement Therapy, and Prostate Cancer Risk - Medriva - January 6th, 2024
- TRAVERSE Trial: Insights into Testosterone Replacement Therapy Safety - BNN Breaking - January 6th, 2024
- Testosterone replacement therapy may not increase risk of prostate cancer among men with hypogonadism - Medical Dialogues - January 6th, 2024
- Testosterone Replacement Therapy (TRT): Is It Right For You? - December 2nd, 2023
- Low Testosterone (Low T): Causes, Symptoms & Treatment - Cleveland Clinic - March 28th, 2023
- LowTCenter: Men's Health Clinic for Testosterone Replacement - March 28th, 2023
- Testosterone Replacement Therapy for Men | SynergenX - March 28th, 2023
- Male hypogonadism - Diagnosis and treatment - Mayo Clinic - February 6th, 2023
- Testosterone Replacement Therapy (TRT) Experts | Optimale - December 2nd, 2022
- Testosterone Replacement Therapy Clinic - EHormones MD - November 24th, 2022
- Options to Increase Your Testosterone - Healthline - November 16th, 2022
- Masculinizing hormone therapy - Wikipedia - October 29th, 2022
- Testosterone: What It Is and How It Affects Your Health - October 13th, 2022
- Testosterone What It Does And Doesn't Do - Harvard Health - October 13th, 2022
- Cork woman felt like she lost part of herself after going into menopause aged 27 - RSVP Live - October 13th, 2022
- The Global Testosterone Replacement Therapy Market is - October 4th, 2022
- Hypogonadism in Men | Endocrine Society - October 4th, 2022
- The One Thing This Doctor Says Is A Game Changer When It Comes To Hormones And Aging - TravelAwaits - October 4th, 2022
- Shirley Ballas on her difficult experience with menopause - Good Housekeeping - October 4th, 2022
- Foods That Boost Testosterone: 7 Options and How They Work - Healthgrades - October 4th, 2022
- Dr. Roach: Testosterone injections most likely led to severe stroke - Detroit News - October 4th, 2022
- What To Know About Perimenopause, And How To Manage Symptoms Once They Kick In - The Zoe Report - October 4th, 2022
- CORRECTION -- Marius Pharmaceuticals Receives FDA Approval of KYZATREX, an Oral Testosterone Replacement Therapy - GlobeNewswire - September 25th, 2022
- Testosterone replacement therapy - PubMed - September 16th, 2022
- Risks of testosterone replacement therapy in men - PMC - September 16th, 2022
- The Global Testosterone Replacement Therapy Market is expected to grow by $ 402.87 mn during 2022-2026, accelerating at a CAGR of 3.1% during the... - September 16th, 2022
- Testosterone injections most likely led to a very severe stroke - The Independent - September 16th, 2022
- Best DHEA Supplement (2022 Updated) - The Island Now - September 16th, 2022
- Testosterone Replacement Therapy in the Aged Male: Monitoring Patients | IJGM - Dove Medical Press - September 8th, 2022
- ROACH: Testosterone injections most likely led to a very severe stroke - New Castle News - September 8th, 2022
- Perform Your Best With Comprehensive Bloodwork - duPont REGISTRY News - September 8th, 2022
- What I Learned When I Stopped Testosterone Replacement Therapy |... - Cushing's Disease News - August 30th, 2022
- From White Plains Hospital: Feeling the Effects of Man-o-pause? - theLoop - August 30th, 2022
- SARMs Before And After Results Real SARM Results And Users Review In 2022 - Outlook India - August 30th, 2022
- Larry Wheels Stops Using Steroids: "I Am Going To Be On Testosterone Replacement Therapy" Fitness Volt - Fitness Volt - August 22nd, 2022
- Hormone Replacement Therapy for Men: What to Know - Healthline - August 14th, 2022
- Testosterone Replacement Therapy Market Trends, Analysis, Demand and Global Industry Research Report, Region, and Segment Forecasts 2028 - Digital... - August 14th, 2022
- Cycling and HRT: How will it affect me? - Cyclist - August 14th, 2022
- 6 LGBTQ2S+ musicians celebrate the artists who came before them - CBC.ca - August 14th, 2022
- 'I kept thinking I was having a heart attack but it was the perimenopause' - iNews - July 27th, 2022
- Obese women with high intake of vitamin C and B6 associated with lower breast cancer risk cohort study - NutraIngredients-Asia - July 27th, 2022
- Testosterone Replacement Therapy Market | Incredible Possibilities, Growth, Trend, Opportunities Detailed Analysis and Forecast to 2030 Travel... - July 19th, 2022
- Low on the Male Hormone? 5 Effective Ways to Boost It - Times Square Chronicles - July 19th, 2022
- Ostarine MK-2866 | Review, Alternatives,Side Effects and Results-Health News - Firstpost - July 19th, 2022
- Trans teens: We need to be heard, counted. In Michigan, the backlash is harsh - Bridge Michigan - July 19th, 2022
- Testosterone Therapy Improves Erectile Function and Libido in ... - July 11th, 2022
- Low Testosterone and What You Can Do About It - The Epoch Times - July 11th, 2022
- How Long Does It Take to Feel the Benefits of Testosterone Replacement ... - July 3rd, 2022
- TRT Testosterone Replacement Therapy Clinic - Peter Uncaged MD - July 3rd, 2022
- Men have it too - The Hans India - July 3rd, 2022
- New guidelines for menopause care say women should be offered personalised treatment including diet and HRT - iNews - July 3rd, 2022
- Head-To-Head Contrast: Biogen (NASDAQ:BIIB) and Clarus Therapeutics (NASDAQ:CRXT) - Defense World - July 3rd, 2022
- Im a GP heres the truth behind Davina McCalls claims about HRT and dementia... - The Sun - July 3rd, 2022
- How To Spot The Best Clinic For Your Hormone Replacement Therapy - My MMA News.com - June 22nd, 2022
- Testosterone May Aid Memory in Men With Uncontrolled Diabetes - Everyday Health - June 22nd, 2022
- Boyfriend has been secretly taking testosterone tablets and I worry he may go sterile... - The Sun - June 22nd, 2022
- Sex and aging: Overview, stats, and maintaining satisfaction - Medical News Today - June 22nd, 2022
- Once a Taboo Topic, Menopause Is (Finally) Having Its Wellness Moment - Vogue - June 4th, 2022
- Caitlyn Jenner can still hit golf ball nearly 300 yards after transitioning to female - Washington Times - June 4th, 2022
- Clarus Therapeutics Holdings, Inc. (NASDAQ:CRXT) Receives $6.88 Consensus PT from Analysts - Defense World - June 4th, 2022
- Juvenile Macular Degeneration Treatment Market Set to Grow According to Forecasts 2020 2030 Industrial IT - Industrial IT - June 4th, 2022
- Testosterone Replacement Therapy Market 2022 to 2028 Global Industry Analysis, Growth, Trends and Forecast Queen Anne and Mangolia News - Queen Anne... - May 15th, 2022
- Being trans and starting HRT - The Advocate - May 15th, 2022
- DHEA Levels and Their Role in Fertility for Functional Medicine Patients - Digital Journal - May 15th, 2022
- LPCN: First Quarter 2022 Financial and Operational Results - Benzinga - May 15th, 2022
- LIPOCINE INC. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-Q) - Marketscreener.com - May 15th, 2022
- No, red light therapy isnt a medically approved treatment for increasing testosterone - ABC10.com KXTV - May 2nd, 2022
- Tucker Carlsons answer to masculinitys supposed crisis? Testicle tanning - The Guardian - April 19th, 2022
- Gilbert Gottfrieds myotonic dystrophy: 5 things to know about the rare genetic disorder - cleveland.com - April 19th, 2022
- Lia Thomas started a conversation about transgender rights. It's time we dive into it. - The Emory Wheel - April 19th, 2022
- Who are the teens at the center of the legal fight over Alabamas law banning transgender treatment? - AL.com - April 19th, 2022
- In Venice, a Young Boatman Steers a Course of His Own - The New York Times - April 19th, 2022
- Female athletes are as capable as male athletes | Opinion | kansan.com - The University Daily Kansan - April 19th, 2022
- FDA Approves Oral Testosterone Replacement Therapy for Hypogonadism - Pharmacy Times - April 6th, 2022