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    Newswise  LOS ANGELES (Sept. 4, 2014)  An    interdisciplinary research team in the Cedars-Sinai    Biomedical Imaging Research Institute,    Department of Biomedical Sciences, Regenerative Medicine Institute and    Department of Surgery received a grant from    the National Institutes of Health (NIH) to develop the first    imaging technique used to identify biomarkers that could    indicate patients have a painful, degenerative back condition.  
    Biomarkers are certain body substances, such as proteins or    body fluids that can indicate specific health conditions. When    noninvasive imaging procedures can identify exactly where the    biomarkers are, researchers may alleviate the need for painful    and invasive diagnostic procedures and, in the future, provide    targeted, stem cell-based therapies to patients with the    condition.  
    More than 85 percent of the United States population suffers    from low back pain, much of which is caused by intervertebral    disc degeneration. Disc degeneration is a progressive    condition, resulting in chronic pain in the back and neck. For    some patients, degeneration can occur for years before pain    sets in, presenting symptoms, while others are affected almost    immediately.  
    As described in an article in the journal Magnetic Resonance    in Medicine, identifying the exact disc that is the source    of pain by employing the latest imaging techniques may save    patients from painful and invasive diagnostic procedures, such    as procedures in which physicians inject a contrast agent or    non-toxic dye into patients spinal discs.  
    The goal of our institute is to develop and apply novel    imaging techniques that translate to clinical significance,    said Debiao Li, PhD, director of the Biomedical    Imaging Research Institute, corresponding author of the article    and a co-principal investigator on the NIH grant. This imaging    technology may allow us to do just this. By mapping a patients    lower spinal region, we can identify the discs causing    discomfort, which allows physicians to then treat accordingly.  
    In the study, investigators developed various imaging    techniques using magnetic resonance imaging, or MRI, which can    identify specific biomarkers to potentially provide a    noninvasive diagnostic approach to intervertebral disc    degeneration. The approach, which has been tested on patients    and in the laboratory, enabled investigators to precisely    pinpoint the origin of pain and monitor the progression of each    patients condition.  
    With this imaging technique, investigators in the Regenerative    Medicine Institute aim to generate a stem cell-based    therapeutic for patients suffering from the degenerative    condition.  
    Our research team is interested in the role of stem cells in    this disease and how we can utilize these cells to regenerate    the disc and turn it back into a functional tissue, said    Dan Gazit, PhD, co-principal investigator    on the grant and director of the Skeletal Regeneration and Stem Cell Therapy    Laboratory in the Department of Surgery, the Skeletal Program in the Regenerative    Medicine Institute and the Molecular and Micro Imaging Core    Facility. Using this novel imaging technique, we will be able    to evaluate the effect of our future stem cell therapies on    back pain.  
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Researchers Developing Noninvasive Method for Diagnosing Common, Painful Back Condition