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Large Buying Action and Inflow of Money Witnessed in iShares Nasdaq Biotechnology Index Fund – Highland Mirror

Posted: February 8, 2017 at 8:49 am

iShares Nasdaq Biotechnology Index Fund (IBB) dropped by -0.35 or -0.98 points during the last session to $282.56 per share. One of the highlights of the day was the net money flow figure, which stood at $2 million even as the stock accepted $4.91 million in upticks but rejected $2.91 million in downticks. The up/down ratio for the last observation was a 1.69. The 1-week percentage change for the stock price is registered at -0.17%.Block trades are executed by Investment Banking firms or Wealth Managers shifting positions or Day traders taking advantage of trading signals.

Stock price is down 6.42% since it reached the one year high price and is down $ -19.39 since then. The company shares are up 17.52% from one year low and is up $42.11 since then. The Stock has a 52 week low of $240.3 and one year high of $301.8.

iShares Nasdaq Biotechnology Index Fund (NASDAQ:IBB) stock ended Tuesday session in the red zone in a volatile trading. The stock closed down 1.13 points or 0.4% at $282.41 with 1,137,322 shares getting traded. Post opening the session at $284.2, the shares hit an intraday low of $280.87 and an intraday high of $284.48 and the price was in this range throughout the day. The company has a market cap of $8,275 million and the number of outstanding shares has been calculated to be 29,300,000 shares. The 52-week high of iShares Nasdaq Biotechnology Index Fund (NASDAQ:IBB) is $301.8 and the 52-week low is $240.3.

The ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND seeks investment results that correspond generally to the price and yield performance, before fees and expenses, of companies primarily engaged in the biotechnology industry, as represented by the NASDAQ Biotechnology Index.

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Large Buying Action and Inflow of Money Witnessed in iShares Nasdaq Biotechnology Index Fund - Highland Mirror

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Insider Selling: Puma Biotechnology Inc (PBYI) Insider Sells … – Sports Perspectives

Posted: February 8, 2017 at 8:49 am

Insider Selling: Puma Biotechnology Inc (PBYI) Insider Sells ...
Sports Perspectives
Puma Biotechnology Inc (NYSE:PBYI) insider Robert Charnas sold 3008 shares of the firm's stock in a transaction that occurred on Wednesday, February 1st.
Puma Biotechnology Inc Risk Points versus Health Care - CMLvizCML News
The Puma Biotechnology Inc (PBYI) Insider Sells $95744.64 in StockDailyQuint
Robert Charnas Sells 3008 Shares of Puma Biotechnology Inc (PBYI) StockCommunity Financial News
Fiscal Standard
all 8 news articles »

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Insider Selling: Puma Biotechnology Inc (PBYI) Insider Sells ... - Sports Perspectives

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Two Biotechnology Names Are Hot: Bioverativ (BIVV), Novavax (NVAX) – The Independent Republic

Posted: February 8, 2017 at 8:49 am

Bioverativ Inc. (BIVV) ended last trading session with a change of 3.76 percent. It trades at an average volume of 13.38M shares versus 3.28M shares recorded at the end of last trading session. The share price of $44.44 is at a distance of 4.81 percent from its 52-week low and down -4.22 percent versus its peak. The company has a market cap of $4.86B and currently has 109.41M shares outstanding. The share price is currently 0.85 percent versus its SMA20, 0.85 percent versus its SMA50, and 0.85 percent versus its SMA200. The stock has a weekly performance of 0 percent and is -1.2 percent year-to-date as of the recent close.

Bioverativ Inc. (BIVV) is a biotechnology company. The Company is focused on the discovery, research, development and commercialization of therapies for the treatment of hemophilia and other blood disorders. It markets approximately two products, including ELOCTATE [Antihemophilic Factor (Recombinant), Fc Fusion Protein], and ALPROLIX [Coagulation Factor IX (Recombinant), Fc Fusion Protein], extended half-life clotting-factor therapies for the treatment of hemophilia A and hemophilia B, respectively.

Novavax, Inc. (NVAX) recently recorded -1.5 percent change and currently at $1.31 is 12.93 percent away from its 52-week low and down -84.57 percent versus its peak. It has a past 5-day performance of 0 percent and trades at an average volume of 7.16M shares. The stock has a 1-month performance of -4.38 percent and is 3.97 percent year-to-date as of the recent close. There were about 271.06M shares outstanding which made its market cap $355.09M. The share price is currently -3.43 percent versus its SMA20, -2.25 percent versus its SMA50, and -68.14 percent versus its SMA200.

On Jan. 19, 2017 Novavax, Inc. (NVAX) announced the initiation of a Phase 2 clinical trial of its respiratory syncytial virus F-protein nanoparticle vaccine candidate (RSV F Vaccine) in older adults (60 years of age and older).

The objective of the trial is to assess safety and immunogenicity to one and two dose regimens of the RSV F Vaccine, with and without aluminum phosphate or Novavax` proprietary Matrix-M(TM) adjuvant, in older adults. The trial is a randomized, observer-blinded, placebo-controlled trial designed to enroll up to 300 older adults in the Southern Hemisphere. Participants are being enrolled and vaccinated outside of the RSV season to best assess immunogenicity. Top-line results are expected in the third quarter of 2017.

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Two Biotechnology Names Are Hot: Bioverativ (BIVV), Novavax (NVAX) - The Independent Republic

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Integrative Biology Conference | Biology Conferences …

Posted: February 8, 2017 at 8:49 am

Sessions/Tracks

Conference Series Ltd invites participants from all over the world to 5thInternational Conference onIntegrative Biology(Integrative Biology 2017) is scheduled to be held during June 19-21, 2017in London, UK,which aims to gather the most elegant societies and industries along with the renowned and honorable persons form top universities across the globe.

Integrative Biology 2017 offers a premier forum to inspire collaboration among biologists and to share trans-disciplinary integrative thinking to unravel the underlying principal mechanisms and process in biology and medicine. Integrative Biology 2017 mainly emphasis on understanding cellular and molecular mechanisms related to health and disease. Integrative Biology become a label of choice for research, to address and generates new information and new ideas by bringing diverse expertise to problems, so that individual and institutional expertise becomes broader and more exploratory as a consequence.

As name Integrative Biology reflects belief that the study of biological systems is best approached by incorporating many perspectives like Cell Biology,Molecular biology, Genetic Engineering and rDNA Technology, Computational Biology & Bioinformatics, Systems Biology, Developmental Biology,Structural biology,Bio-Engineering, Genomics, Cancer Biology, Biophysics. We bring together a diversity of disciplines that complement one another to unravel the complexity of biology. The concept includesanatomy, physiology,cell biology,biochemistryandbiophysics, and covers animals, human and microorganisms. Our broad range of expertise includes: cell biologist, geneticists, physiologists, molecular biologist, computational biologist, systems biologists, structural biologist, expert in bioinformatics, biophysicists and biotechnologists.

Our Conference will provide a perfect platform addressing:

Londons life sciences sector is a shining jewel and a cornerstone of the citys economy. With a rich history of achievements and medical firsts, the sector employs more than 21,000 in private sector industry, hospitals and research facilities including more than 2,000 researchers. The sector impact is in the manner: $720 Million Indirect benefits/ Economic Spinoffs; 780 number of principal researchers and 19 research institutes.

About London:

Londonis thecapitaland most populous city ofEnglandand theUnited Kingdom.Standing on theRiver Thamesin the south east of the island ofGreat Britain, London has been a major settlement for two millennia. It was founded by theRomans, who named itLondinium.London's ancient core, theCity of London, largely retains its 1.12-square-mile medievalboundaries. Since at least the 19th century, "London" has also referred to the metropolis around this core, historically split betweenMiddlesex,Essex,Surrey,Kent, andHertfordshire,which today largely makes upGreater Londongoverned by theMayor of Londonand theLondon Assembly.

London is a leadingglobal city,in the arts, commerce, education, entertainment, fashion, finance, healthcare, media, professional services, research and development, tourism, and transport.It is one of the world's leadingfinancial centresand has thefifth- or sixth-largest metropolitan area GDP in the world.London is a world cultural capital.

Integrative Biology 2017invites all interested participants to join us for this esteemed event at the exquisite destination London. For more:conferenceseries.com

Track: Integrative Biology

An Integrative Biology approach addresses the biological question(s) by integrating holistic (genome wide; omics-) approaches with in depth functional analysis and computation biology (modeling), thereby integrating wet and dry lab approaches. Integrative Biology 2017 offers a premier forum to share trans-disciplinary integrative thinking to unravel the underlying principal mechanisms and process in biology and medicine.

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Track: Cell Biology

Cell biologyis a branch of biology that studies cells their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. This is done both on a microscopic and molecular level. The advancing live cell imaging encompasses its applications to Biochips for cell biology, Single-cell ros imaging and Experimental models and clinical transplantation in cell biology and indeed many more.

Session includes following Topics:

Cell Organelles: Function and Dysfunction, Cell Biology of Host-Pathogen Interactions,Cancer Cell Biology, Cell Biology of Metabolic Diseases,Cell Biology of Ageing, Cell Signaling and Intracellular Trafficking,Cell Death, Cell Stress, Cell Division and Cell Cycle.

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Track: Developmental Biology

Developmental Biology session mainlyfocuses on mechanisms ofdevelopment, differentiation, andgrowthinanimals molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning,cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals. Research Areas Include:- Molecular geneticsof development, Control ofgene expression, Cell interactions and cell-matrix interactions, Mechanisms of differentiation, Growth factors and oncogenes,Regulation of stem cell populations, Evolution of developmental control, and Gametogenesis and fertilization.

AgainNational Science Foundationhas bought its focus on Developmental Biology Branch too for funding and encouraging research. TheWelcome Trusttoo supports the Four Year PhD Programme with its funding to encourage the growing research interest in the field.

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Track: Molecular Biology

Molecular biologyconcerns the molecular basis of biological activity between the various systems of a cell, including the interactions between the different types of DNA, RNA and proteins and theirbiosynthesis, and studies how these interactions are regulated. It has many applications like in gene finding, molecular mechanisms of diseases and its therapeutic approaches by cloning, expression and regulation of gene. Research area includes gene expression, epigenetics and chromatin structure and function,RNA processing, functions of non-coding RNAs, transcription. Nowadays, Most advanced researches are going on these topics: Molecular biology, DNA replication, repair and recombination,Transcription, RNA processing, Post-translational modification, proteomics, Mutation, Site-directed mutagenesis,Epigenetics,chromatin structure and function, Molecular mechanisms of diseases.

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Trcak: Structural Biology

Structural biologyseeks to provide a complete and coherent picture of biological phenomena at the molecular and atomic level. The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life. Most recent topics related to structural biology are: Structural Biochemistry,Structure and Function Determination, Hybrid Approaches for Structure Prediction,Structural Biology In Cancer Research,Computational Approaches in Structural Biology,Strucutural Biology Databases.

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Track: Cancer Biology

Cancer biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. More explicitly, because cancer spans multiple biological, spatial and temporal scales, communication and feedback mechanisms across the scales create a highly complex dynamic system.

Cancer biologytherefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks,epigenetics, cellular behavior, histology, (pre)clinical manifestations and epidemiology. Basic researchers and clinicians have progressively recognized the complexity of cancer and of its interaction with the micro- and macro-environment, since putting together the components to provide a cohesive view of the disease has been challenging and hampered progress. Most recent research are going onCancer Genetics,Carcinogenesis,DNA damage and repair, Apoptosis,angiogenesis, and metastasis, Tumor microenvironment, Molecular mechanisms of Cancer Pathogenesis ,Cancer stem cells, Discovery of tumor suppressor genes, Aberrant signaling pathways in tumor cells, Roles of ubiquitination pathways in cancer,Molecular cancer epidemiology, Cancer detection and therapy.

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Track: Genetic Engineering and rDNA Technology

Genetic engineeringis a broad term referring to manipulation of an organisms nucleic acid. Organisms whose genes have been artificially altered for a desired affect is often called genetically modified organism (GMO).Recombinant DNA technology(rDNA) is technology that is used to cut a knownDNA sequencefrom one organism and introduce it into another organism thereby altering the genotype (hence the phenotype) of the recipient. The process of introducing the foreign gene into another organism (or vector) is also called cloning. Sometimes these two terms are used synonymously.

Basically, these techniques are used to achieve the following:

Study the arrangement, expression andregulation of genes, Modification of genes to obtain a changed protein product, Modification ofgene expressioneither to enhance or suppress a particular product, Making multiple copies of anucleic acid segmentartificially, Introduction of genes from organism to another, thus creating a transgenic organism, Creation of organism with desirable or altered characteristics.

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Track: Genomics

Genomics researchoften requires the development of new techniques utilizing Genomics and bioinformatics tools for target assessment, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. In this respect, the field is entering a new and exciting era; rapidly improving next-generationDNA sequencingtechnologies, Cloud computing, hadoop in genomics, now allow for the routine sequencing of entire genomes and Transcriptomes, or of virtually any targeted set of DNA or RNA molecules.

Genomic labs have the fastest growing market with nearly 250 universities concentrating on its research majorly to be named Whitetail Genetic Research Institute, Stanford University, National Human Genome Research Institute. Major companies concentrating on the research are Affymetrix, Applied Biosystems, Foster City, Genentech etc.The scope and research areas of genomics includes genomics and bioinformatic tools for target assessment, structural,functional and comparitive genomics,genomics in marine monitoring,applications of genomics and bioinformatics, infectious disease modelling and analysis,oncogenomics,clinical genomics analysis,microbial genomics, plant genomics,medical genomics,epigenomics and DNA and RNA structure/functionstudies but are not limited to this only. The promise of genomics is huge. It could someday help us maximize personal health and discover the best medical care for any condition. It could help in the development of new therapies that alter the human genome and prevent (or even reverse) complications from the diseases we inherit.

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Track: Computational Biology & Bioinformatics

Computational Biologyis both an umbrella term for the body of biological studies that use computer programming as part of their methodology, as well as a reference to specific analysis by Bioinformatic tools for protein analysis that are repeatedly used, particularly in the fields of Structural andfunctional genomics,comparative genomicsand bioinformatics insystems biology. Common uses of bioinformatics include the identification of candidategenes and nucleotides(SNPs). Often, such identification is made with the aim of better understanding the Translational bioinformatics forgenomic medicine, Genomics in marine monitoring, andapplications of genomicsand bioinformatics.

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Track: Systems Biology

Systems biologyis the study ofTheoretical aspects of systems biologyof biological components, which may be molecules, cells, organisms or entire species. Living systems are dynamic and complex and their behavior may be hard to predict from the properties of individual parts.

It involves the computational (involvingInsilico modeling in systems biology,Biomarker identification in systems biology) and mathematical modeling of complex biological systems. An emerging engineering approach applied to biomedical and biological scientific research, systems biology is a biology-based inter-disciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological and biomedical research involving the use of In vitro regulatory models in systems biologyusingOMICS tools. Particularly from year 2000 onwards, the concept has been used widely in the biosciences in a variety of contexts.

ManyFunding Opportunitiesin this research has been bought up bySupport ISB,National Science Foundation,NIHand many CollaborativeFunding Opportunities.

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Track: Bio-Engineering

Biological engineering (Cellular and Molecular Bio-Engineering) or bioengineering (including biological systems engineering) is the application of concepts and methods of biology (and secondarily of physics, chemistry, mathematics, and computer science (In vitro testing in bioengineering) to solve real-world problems related to the life sciences or the application thereof, using engineering's own analytical and synthetic methodologies (defined asSynthetic bioengineering) and also its traditional sensitivity to the cost and practicality of the solution(s) arrived at. In this context, while traditional engineering applies physical and mathematical sciences to analyze, design and manufacture inanimate tools, structures and processes, biological engineering uses primarily the rapidly developing body of knowledge known as molecular biology to study and advance applications of living organisms and to create biotechnology likeCancer Bioengineeringused forOrgan bioengineering and regeneration.

Bio-engineering study remains the main interest of research with more than 340 schools focusing on it majorly beingJohns Hopkins University in Baltimore,Georgia Institute of Technology,University of California - San Diego,University of Washington,and Stanford University.

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Track: Biophysics

Biophysicsis that branch that applies the principles of physics and chemistry and the methods of mathematical analysis and computer modeling to understand how biological systems work. It seeks to explain biological function in terms of the molecular structures and properties of specific molecules. An important area of biophysical study is the detailed analysis of the structure of molecules in living systems. The recent research areas are biophysical approaches tocell biology, cellular movement andcell motility, computational and theoretical biophysics, molecular structure and behavior of lipids, proteins and nucleic acids, molecular structure & behavior ofmembrane proteins, role of biophysical techniques in analysis and prediction, biophysical mechanisms to explain specific biological processes and Nano biophysics. Most recent researchers are going on: Biophysical approaches to cell biology,Cellular Movement and Cell Motility,Computational and theoretical biophysics,Molecular Structure and Behavior of Lipids,Proteins and Nucleic Acids,Molecular Structure & Behavior of Membrane Proteins,Role of Biophysical Techniques in analysis and prediction,Biophysical Mechanisms to explain specific biological processes.

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The UK is one of the best places in the world for life sciences, on a par with premier life science destinations such as Boston, San Francisco, San Diego and Singapore. We have 4 of the top 10 universities in the world, 19 of the top 100 universities, one of the worlds 3 major financial centers, a stable of quality service providers, world class charitable supporters of the industry and a rich heritage of globally recognized medical research. There are nearly 5,633 life sciences companies in the UK employing an estimated 222,000 people and generates a combined estimated turnover of 60.7 billion. The industry sells into a global industry with current total market values of US$956bn for pharmaceutical and biologics, US$349bn for medical technology and US$50bn for the rapidly growing industrial biotechnology market. There are significant levels of health life sciences employment. This breaks down into: 107,000 employed in the biopharmaceutical sector and service and supply chain in 1,948 companies, generating 39.7 billion turnover; 115,000 employed in the medical technology sector and service and supply chain in 3,685 companies, generating 21 billion turnover. Two thirds of employment is outside of London and the South-East with significant concentrations in the East of England (15%, almost 34,000 people) and North-West (12%, almost 26,000 people). It shows that the UK is second only to the US in terms of life science Foreign Direct Investment projects along with the UKs relative strength in the academic base and clinical research landscape. Combined with the strength of the health life sciences supply chain, these factors are driving investment, growth and employment across the country.

Adjusting for these methodology changes overall jobs growth in the sector is estimated to be 2.9% and overall revenue growth is estimated to be 0.8%. The life science industry is global and 42% of employment is at UK owned companies and 49% of employment is at overseas-owned companies and 10% where the ownership location is unknown.

UK life science companies continue to tackle long-term health challenges such as cancer and antimicrobial resistance, and in addition to this many companies are using bioscience to address a range of issues including environmental challenges and chemical production. This predominantly healthcare manifesto also recognizes the growing importance of these new applications.

Why London??

Londons life sciences sector is a shining jewel and a cornerstone of the citys economy. With a rich history of achievements and medical firsts, the sector employs more than 21,000 in private sector industry, hospitals and research facilities including more than 2,000 researchers. The sector impact is in the manner: $720 Million Indirect benefits/ Economic Spinoffs; 780 number of principal researchers and 19 research institutes. The Major Biotech Companies in London are: Albert Browne Ltd, Parexel Informatics, Alcon Laboratories (UK) Ltd, Baxter Healthcare Ltd, Galderma Laboratories, Agilent Technologies, Abbott Laboratories, and Bayer Healthcare.

London's biotech universities and their spin out companies are Gene Expression Technologies, Photobiotic, Biogenic, Spirogen, Genexsyn, Nervation, Inpharmatica, Immune Regulation Ltd, Cerestem, and MedPharm, Immexis, and Antisoma plc.

London is the capital and most populous city of England, United Kingdom and the European Union. With an estimated 2015 population of 8.63 million within a land area of 1,572 km, London is a leading global city, with strengths in the research and development, arts, commerce, education, entertainment, fashion, finance, healthcare, media, professional services, tourism, and transport all contributing to its prominence. It is one of the world's leading financial centers and has the fifth-or sixth-largest metropolitan area GDP in the world depending on measurement.

London is a world cultural capital. It is the world's most-visited city as measured by international arrivals and has the world's largest city airport system measured by passenger traffic. London's 43 universities form the largest concentration of higher education institutes in Europe.

List of major societies in UK:

Royal Society of Biology Royal Society of Chemistry BBSRC (Biotechnology and Biological Sciences Research Council) The Oxford University Society British Society for Cell Biology Royal Society of Edinburgh Royal Society of Medicine Biochemical Society Astrobiology Society of Britain British Medical Association British Society for the History of Medicine Genetics Society The Mammal Society Royal Institute of Public Health Society for Experimental Biology Zoological Society of London

List of universities and institutes in London:

The Francis Crick Institute, London University College London Imperial College London University of East London Kingston University London University of Westminster Birkbeck, University of London Goldsmiths, University of London King's College London Queen Mary University of London St George's, University of London

The major universities and institutes in UK are:

University of Leeds, University of Leicester, Leeds Trinity University, University of Glasgow, University of Exeter, University of Essex, University of Edinburgh, University of Dundee, Durham University, Cardiff University, University of Chester, University of Bristol, University of Birmingham, University of Bath, University of Cambridge, Anglia Ruskin University, Aston University, University of Bradford, University of East Anglia, University of Liverpool, Loughborough University, University of Nottingham, University of Reading, Queen's University Belfast, University of Sheffield, University of Southampton, University of Sussex, University of Warwick and University of York.

The major Biotech Companies in UK are:

GSK (Stevenage), Martindale Pharmaceuticals Ltd (Brentford), Nova Bio-pharma Holdings Limited, Oxoid Ltd, Omega Pharma Ltd, Quintiles Ltd (Guys Research Centre), Sauflon Pharmaceuticals Limited, Immuno Diagnostic Systems Ltd, Merck Serono Ltd, Quest Diagnostics Ltd, and Fujifilm Diosynth Biotech UK Ltd.

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Integrative Biology Conference | Biology Conferences ...

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British Synbio’s Llama Antibodies recruited for Cancer T-Cell Therapy – Labiotech.eu (blog)

Posted: February 8, 2017 at 8:48 am

Isogenica has licensed its synthetic llama antibody library to Maverick Therapeutics, which develops cancer T-cell therapies designed to reduce side effects.

Isogenica is a synthetic biology company near Cambridge that develops libraries of therapeutic antibodies. The biotech has granted US-based Maverick Therapeutics licenses to its llamdA VHHantibody library for the discovery, development and commercialization of therapeutic products. In exchange, it will receive upfront, annual and milestone payments as the antibodies are developed by the client.

Isogenicas llamdA VHH library comprisessingle domain llama antibodies created and screened in vitro,which consumes half the time and creates greater diversity than immunizing llamas. According to the company, its llamdA system routinely interrogates the equivalent to the whole antibody repertoire of one million llamas.

Maverick Therapeutics is a very young biotech, spun out from Harpoon Therapeuticsjust last year. The company is backed by MPM Capital, a USVC managed by biotech veteran Patrick Bauerle from Munich.

The company is developing a unique approach to T-cell cancer therapy. Its antibodies are designed to be inactive when administered and only activate in the tumor microenvironment. This way, theT-cells do not attack healthy tissues, avoiding side effects. Japanese big pharma Takeda recently offered the young company 117M ($125M) to develop this technology.

Mavericks approach looks promising since severe side effects are common in T-cell therapies such asCAR-T, with some companies reporting thedeathof several patients. Other companieslike the French Cellectis and Stimunity are also developing their own strategies to increase the safety of CAR-T.

If successful, the development of Isogenicas antibodies by Maverick could bring the British biotech revenues to accelerate the launch of its new library of fully synthetic human antibodies.

Images from Sergey Didenko /Shutterstock

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British Synbio's Llama Antibodies recruited for Cancer T-Cell Therapy - Labiotech.eu (blog)

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Sitting not linked to incident diabetes, new research suggests … – Science Daily

Posted: February 8, 2017 at 8:46 am


9Coach (blog)
Sitting not linked to incident diabetes, new research suggests ...
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Sitting may not be as deadly as previously thought, with new research ruling out sitting as a direct cause of diabetes.
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Sickle cell trait skews common diabetes test – Reuters

Posted: February 8, 2017 at 8:46 am

(Reuters Health) - A genetic trait that affects red blood cells and is fairly common among African Americans and Hispanic Americans can cause an important blood sugar test to miss signs of diabetes, researchers say.

The test known as hemoglobin A1c (HbA1c) estimates long-term blood sugar levels by measuring the amount of glucose sticking to red blood cells, but blood cells from people with sickle cell trait don't live as long, so they have less time to collect glucose.

When lead author Mary Elizabeth Lacy from Brown University School of Public Health in Providence, Rhode Island, and her colleagues used standard HbA1c cutoffs to screen for diabetes, we identified 40 percent fewer cases of prediabetes and 48 percent fewer cases of diabetes in individuals with sickle cell trait than in those without sickle cell trait, she told Reuters Health by email.

Sickle cell disease is a serious condition that occurs when a person has two copies of a defective gene responsible for making part of the hemoglobin molecule in red blood cells. Hemoglobin allows the cells to carry oxygen to the tissues that need it, but in people with two copies of the faulty gene, blood cells can turn sickle-shaped, causing painful crises and even death.

People with only one copy of the defective gene are said to have sickle cell trait, and most have no symptoms of sickle cell disease. The gene is most common among people with ancestry in sub-Saharan Africa, Central America and South America, Saudi Arabia, India, Turkey, Greece and Italy.

The U.S. Centers for Disease Control and Prevention estimates that 1 in 13 African American babies are born with sickle cell trait.

In their study of 4,620 African Americans, including 367 with sickle cell trait, Lacys team found that HbA1c levels were 0.3 percent lower in those with the trait than in those without it, even though they had similar blood sugar levels.

While 0.3 percent may seem small, Lacy said, a difference of 0.3 percentage points in HbA1c could be the difference between being identified as high-risk (and being targeted for more frequent monitoring as well as additional diabetes prevention efforts) or not, or receiving a diagnosis of diabetes or not.

Among individuals with no history of diabetes and not taking diabetes medications, testing blood sugar directly detected pre-diabetic elevated blood sugar levels or full-fledged diabetes in equal numbers of people, regardless of whether they had sickle cell trait, the researchers report in JAMA.

But if HbA1c was used instead of blood sugar testing, pre-diabetic elevated blood sugar would be diagnosed in about 29 percent of those with sickle cell trait compared to 49 percent of those without the trait. Similarly, the HbA1c test would identify diabetes in about 4 percent of those with sickle cell trait and about 7 percent of those without the trait.

The results of HbA1c testing need to be interpreted with caution in patients with sickle cell trait, Lacy concludes. These findings were based on one method of HbA1c measurement. While it is approved for use in those with sickle cell trait, we are unable to say whether our findings are due to assay interference or a biological phenomenon in those with sickle cell trait.

Doctors should consider using a glucose tolerance test if they suspect diabetes in people with SCT whose HbA1c is close to the cutoff level, said Dr. Anthony J. Bleyer from Wake Forest School of Medicine in Winston-Salem, North Carolina, who coauthored a related editorial.

I think there needs to be more research in this area. The HbA1c is a really important test that we use all the time. We need to make sure it is accurate for individuals of all races and ethnicities, Bleyer said by email.

Approximately 10 percent of African American patients have sickle cell trait. It is prudent to test African American patients for hemoglobinopathy (sickle cell trait) before relying on HbA1c for diagnosis diabetes/prediabetes and before using HbA1c to monitor blood sugar control, Dr. Kristina Behan from the University of West Florida in Pensacola, who was not involved in the study, said by email.

SOURCE: bit.ly/2ln3Rap and bit.ly/2kovj9m JAMA, online February 7, 2017.

GENEVA The United Nations appealed on Wednesday for $2.1 billion to provide food and other life-saving assistance to 12 million people in Yemen who face the threat of famine after two years of war.

NEW DELHI A group backed by the Bill & Melinda Gates Foundation that works on India's immunization program will now be funded by the health ministry, a government official said, a move in part prompted by fears foreign donors could influence policy making.

The U.S. Food and Drug Administration has approved Amgen Inc's treatment for secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing dialysis, the U.S. biotech company said on Tuesday.

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Glycemic Response Independent of Initial Diabetic Medication Choice Among HIV-Infected Patients With Diabetes – Endocrinology Advisor

Posted: February 8, 2017 at 8:46 am

Glycemic Response Independent of Initial Diabetic Medication Choice Among HIV-Infected Patients With Diabetes
Endocrinology Advisor
Data from a longitudinal cohort study of patients with type 2 diabetes infected with HIV aims to elucidate whether initial choice of oral diabetic medication had effects on glycemic control. Glycemic response was not affected by specific diabetic oral ...

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Glycemic Response Independent of Initial Diabetic Medication Choice Among HIV-Infected Patients With Diabetes - Endocrinology Advisor

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Buckeye boy donates bone marrow to sick brother – ABC15 Arizona

Posted: February 7, 2017 at 11:48 am

BUCKEYE, AZ - As the saying goes: "blood is thicker than water." But when it comes to bone marrow, it is truer than ever especially because family is usually the only people to turn to for a match.

But, one Buckeye family is finding that the phrase could not be more perfectfor them because a brother has been serving as the lifeline for his sibling over the last few years.

Gloria Mesquias calls her 11-year-old son, Shaun, "the warrior."

"He takes every jab he gets and just rolls through," said Mesquias.

Shaun's 13-year-old brother Malik is called "the hero."

"They are actually like night and day, "Mesquias said. "They're brothers."

The three of them, and other supportive family members, have spent months at Phoenix Children's Hospital. Shaun has a condition where his body isn't producing new blood cells.

"He was diagnosed with severe aplastic anemia," Mesquias said.

That happened when he was just about 1 year old. Ever since then, he's been in and out of the hospital.

But, Malikhas served as a bone marrow and stem cell donor to his b brother not once, not twice but, three different times.

And the fight for this little warrior, is not over yet. If his treatment goes well over the next few days, he will have a fourth surgery on Wednesday; another stem cell transplant.

Mesquias doing this all as a single mother. She also has a 5-year-old daughter, who has not seen Shaun since before Christmas.

"She understand;she gets it," Mesquias explained. "She knows brother is sick and she knows mom is here with Shaun."

But, while she tries to keep it together, all of the stress and days away from home are weighing on Mesquias. But, it's something she will never let her family see.

"At night time, I can go in the restroom and cry my eyes out or ball my face out in the pillow," Mesquias said. "But, I just don't do it in front of him."

So, the boys' Buckeye teacher, Carrie Brown, has also taken action to try and do something special for the family.

"She would never ask for help," Brown said. "She's not that kind of person. So, I just thought that this was one thing that I could do to relieve some of the worry that she has and to give her a little bit of comfort."

Brown started a GoFundMe page to try and help the family who has given so much to each other.

And Mesquias said she is making sure all of them get out of that hospital together.

"He has his moments too where he says he wants to go home," Mesquias explained. "And... I'm like, 'I'm not going home until you're going home. So, we're good."

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Bart Starr prepares to watch Super Bowl from home as health keeps improving – USA TODAY

Posted: February 7, 2017 at 11:46 am

Hall of Fame Packers QBs Bart Starr, left, and Brett Favre at a Thanksgiving game in Green Bay in 2015.(Photo: Mike Roemer, AP)

HOUSTON The MVP of the first Super Bowl has special plans for Super Bowl LI.

Hes going to watch Sunday'sgame at home with family and friends in Alabama, happy to be recovering his health again after all that hes suffered since 2014.

Its a long list for Bart Starr, 83. In 2014 and 2015, he suffered two strokes, a heart attack, a bronchial infection and a broken hip. Last year, he underwent bladder surgery and later developed a staph infection.

Im not even sure that he will go much further than hes gone because its just a miracle that hes even alive to begin with, Starrs wife, Cherry, told USA TODAY Sports.

Every day now is a victoryit seems much bigger than when the Hall of Fame quarterback led the Green Bay Packers to a 35-10 win against the Kansas City Chiefs in that historic game 50 years ago.

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Starr's latest setback was a staph infection linked to his previous bladder condition an ailment that required strong medication before he overcame it about six weeks ago, Cherry Starr said.Since then, she said her husband has made significant strides, showing improvement with his appetite, cognition, reading and physical exercise. Recently, she said he even enjoyed catching replays on television of Super Bowls I and II. Starr was named MVP of each game.

He actually recognized himself as being on the field playing football, she said. That was good. That was great.

Starr's reputation and his name also will be recognized again Saturday, when New England Patriots special teams captain Matthew Slater is scheduled to receive the Bart Starr Award, given annually to the NFL player who best exemplifies outstanding character and leadership in the home, on the field and in the community.

Bart Starr Jr., son of Bart and Cherry, will be on hand to present it before returning home to watch the game with his parents in Alabama.Cherry Starr notified Slater last month that he won the award, surprising him with a call that was put on speaker phone in a Patriots team meeting. Slater became emotional during the conversation. His father, Hall of Fame tackle Jackie Slater, won the same award in 1996.

Thank you so much, Slater said to Cherry Starr. Wow. I dont even know what to say. Im so humbled. I really ... Your husband. I know so much about him and what he stood for. Im blown away.

Starr still has that effect on peopleall these years later. In 2015, he made an improbable return to Green Bay for a Thanksgiving appearance on the field with Brett Favre, another legendary Packers quarterback. The crowd roared. But Cherry Starr said they probably wont be able to return to Green Bay because travel is too difficult for them now.

She also said her husband isnt likely to receive additional, experimental stem-cell treatments, which she credits for helping his condition improve in recent years. The Starrs made multiple trips to Tijuana, Mexico, for the treatments, which are not approved for use in the U.S. and have not been proven to be effective under U.S. standards. The cells are manufactured by Stemedica, a company in San Diego that ships them to a clinic in Tijuana for a clinical trial there.

Starr instead hopes to keep improving through rest and exercise. Cherry Starr said the recent staph infection was quite a setback and devastating.

Yet Bart Starr is still as tough as ever and beat it back.

I just see better things happening in the next few months, she said. His quality of life is going to be much better.

Follow reporter Brent Schrotenboer @Schrotenboer. E-mail: bschrotenb@usatoday.com

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