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Whole tomato extract may prevent, treat stomach cancer – Medical News Today

Posted: May 15, 2017 at 2:42 pm

Numerous studies have suggested that tomatoes have anti-cancer properties. A new study provides further evidence of this, after finding that whole tomato extract has the potential to treat and even prevent stomach cancer.

Researchers from the United States and Italy found that whole extracts from two varieties of tomato - San Marzano and Corbarino - blocked the growth of stomach cancer cells and dampened their malignant characteristics.

Study co-author Prof. Antonio Giordano, director of the Sbarro Institute for Molecular Medicine at Temple University in Philadelphia, PA, and colleagues recently reported their findings in the Journal of Cellular Physiology.

According to the American Cancer Society, there will be around 28,000 cases of stomach cancer diagnosed in the U.S. this year.

Also referred to as gastric cancer, stomach cancer is most common among older adults; around 60 percent of adults diagnosed with the disease are aged 65 or older.

Previous studies have suggested that compounds found in tomatoes - such as lycopene, a carotenoid that gives tomatoes their red color - may help to fight cancer.

However, Prof. Giordano and colleagues note that few studies have investigated the anti-cancer effects of whole tomatoes - a research gap they set out to address with their new study.

To reach their findings, the researchers tested the effects of whole extracts from San Marzano and Corbarino tomatoes on stomach cancer cell lines.

They found that each extract not only halted the growth of gastric cancer cells, but they also interfered with cell migration - whereby cancer cells begin to move away from the primary tumor to invade surrounding tissues - and led to cancer cell death.

Furthermore, the researchers found that the anti-cancer effects of the tomato extracts were not down to one particular compound.

"Their anti-tumoral effect seem not related to specific components, such as lycopene, but rather suggest that tomatoes should be considered in their entirety," says study co-author Daniela Barone, of the Oncology Research Center of Mercogliano in Italy.

According to the researchers, their findings indicate that whole tomato extracts may be useful for the prevention and treatment of stomach cancer.

"Our results prompt further assessment of the potential use of specific nutrients not only in the cancer prevention setting but also as a supportive strategy along with conventional therapies."

Prof. Antonio Giordano

The team notes that certain varieties of tomatoes may have different effects on cancer cells, something which future studies should investigate.

Learn how the consumption of alcohol and processed meat may raise the risk of stomach cancer.

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Dr. Stephan Grupp to Lead Cellular Therapy & Transplant Section in CHOP Cancer Program – PR Newswire (press release)

Posted: May 15, 2017 at 2:41 pm

Grupp has been an attending physician and oncology researcher at CHOP since 1996, after earning his MD and a PhD in Immunology from the University of Cincinnati. He completed his clinical training in pediatrics and pediatric hematology/oncology at Boston Children's Hospital, Dana Farber Cancer Institute, and Harvard Medical School, performing postdoctoral research in immunology at Harvard. He joined the University of Pennsylvania medical faculty in 1996, and is now a Professor of Pediatrics in Penn's Perelman School of Medicine.

Since arriving at CHOP two decades ago, Grupp has led a basic science lab studying cell therapy, signal transduction and novel therapies in ALL and other pediatric cancers.Reflecting the translational focus of his work, he also developed and led clinical trials that established tandem stem cell transplantation (two separate transplant procedures) as a standard of care for children with high-risk neuroblastoma. He helped to develop and lead clinical trials that resulted in FDA approval of a new treatment for veno-occlusive disease, a deadly complication of stem cell transplantation. In addition, he led the pediatric hematology/oncology fellowship training program at CHOP for almost a decade. Eight current CHOP faculty trained in his lab.

His outstanding contribution to oncology is in the clinical development of chimeric antigen receptor (CAR) T cell therapy for relapsed and refractory ALL in children and young adults. Collaborating with Dr. Carl June's team at the University of Pennsylvania, Grupp's lab did many of the preclinical in vivo studies, and then developed the first pediatric trial and treated the first pediatric patient at CHOP with CAR T cell therapy in 2012.

Responding to a life-threatening complication of T cell therapy, called cytokine release syndrome, he and his team pioneered a successful treatment for this complication, and thereby revolutionized T cell immunotherapy. Grupp and his colleagues at CHOP have since treated over 150 children with CAR T cell therapy, and he recently led the first multicenter global study of an engineered CAR T cell product that is expected to lead to FDA approval later this year.

About Children's Hospital of Philadelphia: Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide.Its pediatric research program is among the largest in the country. In addition, its unique family-centered care and public service programs have brought the 546-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu

Contact: Amy Burkholder The Cancer Center, Children's Hospital of Philadelphia Phone: (267) 426-6083 BurkholdAS@email.chop.edu

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/dr-stephan-grupp-to-lead-cellular-therapy--transplant-section-in-chop-cancer-program-300457482.html

SOURCE Children's Hospital of Philadelphia

http://www.chop.edu

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Can outdoor temperatures influence gestational diabetes? – Medical News Today

Posted: May 15, 2017 at 2:40 pm

Gestational diabetes is a birth complication affecting millions of women worldwide. New research examines the link between air temperature and the risk of developing this condition.

Gestational diabetes (GD) is a temporary form of diabetes that affects some women during pregnancy. These future mothers often have no history of diabetes prior to getting pregnant, but their blood sugar increases by the time they are halfway through their pregnancy.

In 2014, the Centers for Disease Control and Prevention (CDC) reported that in the United States, as many as 9.2 percent of pregnant women may be affected by GD. Worldwide, around 1 in 7 births are affected by this complication.

GD occurs when the hormones in the placenta trigger insulin resistance, meaning that healthy blood sugar levels cannot be maintained.

Sensitivity to insulin is known to be improved by exposure to cold temperatures, during which the body produces more heat to keep itself warm. However, could it be that outside air temperatures have a larger impact on the risk of developing GD?

Researchers from St. Michael's Hospital, the Institute for Clinical Evaluative Sciences (ICES), Mount Sinai Hospital, and the University of Toronto - all in Ontario, in Canada - set out to explore the connection between outdoor air temperature and the risk of GD.

The findings were published in CMAJ.

The study examined 555,911 births from 396,828 women over a period of 12 years, from 2002 to 2014.

The women were 31 years old on average, and lived in the Greater Toronto Area. Approximately half of the mothers were not born in Canada.

Extremely cold outdoor temperatures were defined as an average of 10C or less, and hot temperatures as 24C on average.

The women were exposed to these different temperatures for 30 days before being screened for GD.

GD occurred in 4.6 percent of the women that had been exposed to extremely cold temperatures, but this number jumped to 7.7 percent for the women who had been exposed to hot temperatures.

Furthermore, each 10C increase in temperature correlated with a 1.06 times higher risk of GD. A similar trend was found when the temperature increased between two pregnancies in the same mother.

"By further limiting our analysis to pregnancies within the same woman, we controlled for a whole number of factors," says co-lead author Dr. Joel Ray, a researcher at St. Michael's and ICES. "Doing so allowed us to eliminate factors like ethnicity, income, activity, and eating habits that would differ between two different women."

Lead author Dr. Gillian Booth, a researcher at St. Michael's and ICES, reports on the findings:

"We observed a direct relation between outdoor temperature and the risk of gestational diabetes among nearly 400,000 women residing in a single urban area in Canada.

After adjusting for influential risk factors, each 10C increase in [...] temperature was associated with a 6-9 percent relative increase in the risk of gestational diabetes mellitus."

Although the study was observational and cannot provide causality, Dr. Booth offers a potential explanation for the seemingly counterintuitive results:

"Many would think that in warmer temperatures, women are outside and more active, which would help limit the weight gain in pregnancy that predisposes a woman to gestational diabetes. However, it fits a pattern we expected from new studies showing that cold exposure can improve your sensitivity to insulin, by turning on a protective type of fat called brown adipose tissue."

"Although we studied a single geographical region, our findings are likely to be generalizable to other regions in North America and worldwide," say the authors.

They also warn that, if their findings are correct, this could potentially mean that the worldwide number of GD cases might continue to increase as a consequence of global warming.

"Although changes in temperature of this size may lead to a small relative increase in the risk of gestational diabetes mellitus, the absolute number of women affected in Canada and elsewhere may be substantial," the authors conclude.

Learn how the link between depression and GD can work two ways.

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Mick Mulvaney gets schooled about diabetes after saying it’s caused by poor lifestyle choices – Salon

Posted: May 15, 2017 at 2:40 pm

The American Diabetes Association is teaching Mick Mulvaney, who serves as head of the Office of Management and Budget under President Donald Trump, a valuable lesson about human biology.

On Thursday, Mulvaney told an audience at the Light Forum at Stanford University that people who get diabetes may not deserve affordable health insurance.

That doesnt mean we should take care of the person who sits at home, eats poorly and gets diabetes. Is that the same thing as Jimmy Kimmels kid? I dont think that it is, Mulvaney told the audience, according to a report by the Washington Examiner.

Butas the American Diabetes Association pointed out in a public statement on Friday, the notion that the condition is solely caused by poor lifestyle choices is both offensive and inaccurate.

All of the scientific evidence indicates that diabetes develops from a diverse set of risk factors, genetics being a primary cause, the statement said. People with diabetes need access to affordable health care in order to effectively manage their disease and prevent dangerous and costly complications. Nobody should be denied coverage or charged more based on their health status.

This isnt the first time that Mulvaney has made comments which critics perceived as calloused and factually challenged. In March, Mulvaney caught flak for arguing that cutting funds to Meals on Wheels was probably one of the most compassionate things we can do because it allowed the government to guarantee to you that that money is actually being used in a proper function.

Not only was this remark derided for its insensitivity, but it ignored the fact that Meals on Wheels has been demonstrably very effective.

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Have diabetes? Trump’s budget director says you brought it on yourself, so no health care for you – Daily Kos

Posted: May 15, 2017 at 2:40 pm

Mick Mulvaney, now in charge of deciding who deserves health care.

The debate over Trumpcare has exposed Republican attitudes toward the people they represent more than any debate in recent memory. We've always known that they value some lives more than others, but they don't say it out loud very ofteninstead, it's dog-whistled most of the time. Now, though, when we're talking actual life and death formillions of people, they're unleashed.

First it was Rep. Mo Brooksof Alabamawith his comparison of"those people who lead good lives, they're healthy" and have pre-existing health conditions "through no fault of their own," versus the people who brought it on themselves and therefore don't deserve affordable insurance. Now it's popular vote loser Donald Trump's budget director, Mick Mulvaney, who is doling out health care on the basis of virtue.

"We have plenty of money to deal with that. We have plenty of money to provide that safety net so that if you get cancer you don't end up broke," Mulvaney said at the Leaders in Global Healthcare and Technology forum.

But then he drew a distinction between people like [Jimmy] Kimmel's son, born with a congenital heart disease, and people who end up with conditions like diabetes. "That doesn't mean we should take care of the person who sits at home, eats poorly and gets diabetes," Mulvaney said, according to a Washington Examiner account consistent with real-time social media reports. "Is that the same thing as Jimmy Kimmel's kid? I don't think that it is."

The American Diabetes Association would like Mulvaney to understand that lifeand diabetesdon't work that way.

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#DBlogWeek Day 1 Diabetes and the Unexpected – A Sweet Life

Posted: May 15, 2017 at 2:40 pm

Ill be responding to the prompts provided over the course of the week. I recommend checking out the topics and posts hereto keep up with all the bloggers participating this week.

Okay, time to respond to prompt #1! Here it is:

The prompt: Diabetes can sometimes seem to play by a rulebook that makes no sense, tossing out unexpected challenges at random. What are your best tips for being prepared when the unexpected happens? Or, take this topic another way and tell us about some good things diabetes has brought into your, or your loved ones, life that you never could have expected?

Expect the unexpected is one of the many taglines of the reality television show, Big Brother (of which I am, unashamedly, a fan). Its a warning to contestants that curveballs could, and will, be lobbed at them when they least anticipate it, and it certainly translates well into the life of a person with diabetes. Over the years, Ive experienced a number of mini emergenciesrunning out of test strips, forgetting my meter at home, dealing with failed insulin pods, coping with burnoutthese are just a few examples of episodes that always seem to happen when its the least convenient timing.

How have I prepared myself for the unexpected? Its become about anticipating all the possible scenarios: Maybe my pod will fail, so Ill need a backup, extra wipes, and insulin. Maybe I will have more than one low blood sugar on the go today, so Ill pack extra snacks. Maybe my PDM will run out of battery, so Ill carry replacements in my purse. Its a matter of being armed at all times with more supplies than its probably necessary to have, but Id rather be safe than sorry. In fact, my T1D mom and I always say to each other that wed rather have something and not need it, than not have it and need it. Its much easier to deal with the unexpected when you do everything you can to prepare for challengesI stress much less and dont panic to the same degree when I have everything I might need on my person.

To address the second part of the prompt, I think that one good thing that diabetes has brought into my life is a little more control over my eating habits than I might have without it. Since I was diagnosed with diabetes at the age of four years old, I grew up understanding the importance of portion control because it was detrimental to my carb counting and accurate dosing. As an adult, I can also see how this has been a positive influence on my weight management and knowing when I may be going overboard with portion sizes.

I have moments when Im angry/frustrated/burnt-out from my diabetes, but every so often I like to remind myself that its not the worst thing in the world. Its made me stronger in ways I never expected, and for that, Im grateful.

Molly Johannes was diagnosed with type 1 diabetes in 1997 at the age of four. She controls her diabetes with an OmniPod insulin pump, Dexcom continuous glucose monitor, and daily exercise. Molly graduated cum laude from the University of Massachusetts Amherst in December 2014 with a degree in English. Currently, she works fulltime as an associate editor for a financial company. In her spare time, Molly enjoys spending time with her loved ones, reading books, watching movies, and playing games. Shes an avid fan of Disney, dark chocolate, wine, Harry Potter, and fun times. While Molly does not know a life without diabetes, she is determined to defy the daily obstacles the disease presents.

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Agricultural biotechnology crucial for feeding world population – Clearwater Times

Posted: May 14, 2017 at 6:47 pm

By Murray McLaughlin

SARNIA, Ont. /Troy Media/ - It took until 1800 for the world population to reach one billion people. The second billion was reached in only 130 years (1930), the third billion in less than 30 years (1959), the fourth billion in 15 years (1974) and the fifth billion in only 13 years (1987).

During the 20th century alone, the global population grew from 1.6 billion to over six billion people.

In 1970, there were roughly half as many people in the world as there are today.

In The Population Bomb (1968), Paul Ehrlich writes: "The world, especially the developing world, is rapidly running out of food ... in fact the battle to feed humanity is already lost in the sense that we will not be able to prevent large-scale famine in the next decade or so."

How was this global starvation catastrophe averted?

One element high on the list is innovation. Crop production science and innovation led to new technologies that produce more per acre and more per crop inputs.

Dr. Norman Borlaug was an American agronomist known as "the father of the Green Revolution." Borlaug developed new varieties of wheat that were planted around the world and had tremendous yield responses. His approach was adopted by other scientists to improve other crops. He was awarded the Nobel Peace Prize in 1970 for his contributions to world peace through increasing food supply. Borlaug is often credited with saving over a billion people from starvation.

With new technologies based on Borlaug's research, the successes continue. Biotechnology is a new set of tools that enhance crop breeding for new plant traits. Products from biotechnology have shown tremendous improvement since first provided to farmers in 1995. Biotech-bred crops allow farmers to reduce pesticide use, and improve quality and yields with reduced input costs. Biotech-enhanced crops are now grown by 18 million farmers, most of them in developing countries.

In Canada, corn, soybeans and canola are grown using biotechnology (often referred to as genetically-modified organisms or GMOs). All are designed to reduce pesticide use while improving yields. In 1940, corn varieties yielded 25 to 40 bushels per acre. Now, with hybrids and biotechnology, yields are typically 150 to 200 bushels per acre.

GMOs have helped Canadian farmers manage production costs, increase yields and provide safe, nutritious food to the world's consumers. There is tremendous experience and knowledge about the safety and benefits of GMO crops, based on years of development, testing and production.

The predictions of major hazards, by critics of GMO, have not materialized. GMO crops have played a vital role in improving world agricultural food production per capita. And this will be an ongoing need as the world's population heads to 10 billion people later this century.

Biotechnology in agriculture production should be embraced the same way we have embraced innovation in medicine, transportation, communication and any number of other sectors. Biotechnology will continue to help reduce global poverty.

We need more people like Borlaug. Through research, science and innovation, he helped ensure we have the necessary tools for a healthy future. Biotechnology will be an important part of that future.

Dr. Murray McLaughlin is an adviser to and former executive director of Bioindustrial Innovation Canada, based in Sarnia, Ont., and a former Saskatchewan deputy minister of agriculture.

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Mixing Music and Medicine: Meet Grammy-Nominated Producer … – NBCNews.com

Posted: May 14, 2017 at 6:46 pm

Grammy award winning recording artist Bilal with his son Ramzee, who suffers from Sickle Cell, at Sickle Cell Thalassemia Patients Network (SCTPN) in Brooklyn, NY. Karole Collier

Before getting into music professionally, you were actually on the path to a very different career in the medical field. What brought about the change in your career path?

Nana Kwabena: I don't come from a musical family. I was actually raised to become a doctor and I was pre-med in college. That was the path that my parents wanted me to take. As much as my parents pushed me down this path, my mom knew that I was going to be a musician. They were all just in denial about it because being a musician was taboo as a first-gen Ghanaian-American.

I went through school with two different lives. On one hand I'm studying to become a doctor with the idea of using that expertise to treat sickle cell disease by day, but then by night I was living a whole different life. I would be in Philly and have about 30 different Philly rappers in the room, their own Wu-Tang if you will, and I'm producing beats and then I have to say alright guys it's six in the morning and I'm going to get an hour of sleep and then go take organic chemistry.

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I remember graduating from UPenn [University of Pennsylvania] and thinking that these two things are getting too big and something's got to give. I never quite knew how to make them work in concert with each other, so what do you do? You buy time.

I deferred my acceptance to George Washington University, to the Milken School of Public Health with the hopes of making it in music. I moved to New York and gave myself a year with the idea that if that didn't work out, I was going to go back and continue pursuing the medical field. In my first year in New York I wrote a song with John Legend and thought maybe I should continue.

In 2011, when you were just starting off in the music industry, you lost your younger brother Kwame to sickle cell disease. How did that experience mobilize you to bring your background in the medical field and music together in order to raise awareness about the disease?

All of a sudden these two halves of my life (music and medicine) that always felt in conflict with each other, once my brother passed they became one. They became the yin and yang to each other. Music and the medicine. Music was the medicine. So out of that I created a non- profit called AllOneBlood with the idea to change the conversation around sickle cell disease.

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My brother Kwame had conviction and he had passion and that was always his default and it didn't matter who you were. He was just always unapologetic about his own light and what he believed in. So when he passed I think that I inherited that idea of really just being able to be audacious, regardless of what people think you're supposed to be or the limitations you may have.

Death really, really clarifies things. It puts life in perspective. It gave me the ability to realize that sickle cell did not have to be a forgotten disease and we could educate people and rally around the cause for a cure.

As someone who suffers from sickle cell disease, what would you say are some of the major misconceptions that people have about it? How is your organization AllOneBlood working to help change that?

I think sickle cell is a disease that within the context of America feels like a black disease, or it only affects black people and because of that it kind of becomes a disease that gets less attention. There are diseases that affect far less people in number and have ten times the budget for their national organizations.

I think there are a lot of misconceptions around the disease or thoughts around the disease that make people feel like if they don't suffer from it, then they can't support it. There are many faces to sickle cell disease and a lot of people don't know that. What AllOneBlood tries to do is kind of just change the conversation around the disease and kind of open up the spectrum to show that on a global level when you remove this national lens you see that it affects people of all races.

There's also this stigma with chronic disease where we feel like when you have these things you have to hide it. I studied abroad in Ghana while in college and I did a research study looking at elementary aged children that had sickle cell disease and whether or not they disclosed or concealed having the disease.

There were many kids that had sickle cell disease and they would endure sickle cell pain crisis, which are like terrible, awful pain attacks. It's the kind of pain that I have had as an adult and have been screaming to the top of my lungs, so imagine a kid dealing with this. These children would be at home having that level of pain and would go into a closet in their bedroom and close the door where they would stay and sob, not telling their parents. Why? It was because they didn't want to go to the hospital and miss school the next day and have people say oh that person missing might be a 'sickler'.

I wanted the conversation around the disease to go beyond the notion that this is something that is debilitating or that this is something that cripples us and it be looked at as a feature. I decided that I would let everyone and anyone know that I have sickle cell. When you can be in tune with the things that make you different it actually makes you stronger. It makes you powerful.

In your opinion, what role can music play in creating change and what responsibility do music and musicians have to use their art to effect change?

Music is one of the biggest and easiest and most effective ways to connect people that would otherwise not be connected to each other.

I've always appreciated artists' who made art that wasn't just art for art's sake. It was art that actually had real tangible impact on people's lives. I grew up listening to Bob Marley, Michael Jackson, Fela Kuti and Tupac. These were people for me that if you only made the rubric about creatives then they were the best. But, if you also open up the rubric and judge them in terms of the real impact they had on the world, these are people whose music shifted the entire world.

That's what I want to use music for. I don't want to just use music to be someone that's like, yeah we'll just make dope beats and have fun and it will be an escape to the harsh realities of the world.

I want it to be a tool that deals with the harsh realities of the world. That to me is the motto that I live by and I've always loved the ability music has to have that kind of influence.

It's actually bigger than music, but the music is a very strong vehicle to help effect real change in people's lives. And, I've had the pleasure of working with not only creative people and really talented people in that way, but some of the best and greatest spirits of our generation as well.

What are some things you do that you help manage sickle cell disease and what keeps you motivated?

Your general health and general well-being has a large effect on how you deal with sickle cell and whether or not you have attacks. Your nutrition is the biggest thing. If you can have a healthy diet and stay away from too much processed food as well as properly hydrate yourself and also exercise, it is so important. These are some of the things that I do. Being in a positive mental space is also extremely important.

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Although there are some limitations due to sickle cell disease I encourage those who also have the disease to push themselves to live a wholesome life and not allow it to be something that stops your from living your dreams or simply living.

What keeps me motivated is being around people and finding inspiration that keeps that torch inside of me fueled. To not feel anything at all is a dangerous thing and I spend most of my life trying to guard my own fire, protect my fire and then add to that fire.

John Legend visiting the Sickle Cell Pediatrics unit at the Children's Hospital Los Angeles with AllOneBlood. He spent time and spoke with the kids who were getting treatment, surprising them with a performance in between rounds of treatment and therapy. Corwin Levi

What is the progress you have seen in terms of awareness and education about sickle cell since you started AllOneBlood in 2012?

I think that there have been tremendous strides made recently where there are treatments that could cure the disease, but not a lot of people know about them. However, the beauty of this is that the disease is actually curable in within our lifetime.

AllOneBlood partnered Universityof Illinois Medical School, where doctors recently cured sickle cell disease in 16 of 19 patients without using traditional chemotherapy in 2016. This year, we're working to raise funds so that more families who qualify for the treatment can be covered in addition to helping families across the country with other care related expenses.

My goal is to make it (a cure) a reality and that's what my life is dedicated to. My life is literally using music as the vehicle to cure sickle cell disease off the planet. I really have two goals that's one of them. The second is building the bridges throughout the African diaspora.

I'm Ghanaian-American and I really have this belief that Africa has this desire for all of its children to be able to recognize Africa no matter the time goes by. Africa has been erased and has been consistently been erased from history of its contributions to the entire world. My life is about making sure that it gets the recognition that it deserves.

Nana Kwabena Oz Shaw

What's next for AllOneBlood and what can we expect from you as far as new music projects this year?

We are working on our inaugural fundraiser gala where we will bring all our partners together to share information and enjoy performances that will contribute to making a difference. Right now we are in the planning phases of that and we really look forward to that. That's what's next for AllOneBlood in particular.

Outside of that, creatively, more music is on the way. I'm working on a couple of projects. Janelle's getting ready to drop what I actually believe is going to be her best album, which I've had the pleasure of being involved with. Jidenna and I are working on album two, there's also a short film. There's a lot going on, but I'm just trying to live the most fully expressed life and be on the highest vibration as long as I possibly can.

For more information on the non-profit All One Blood, please visit

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Stem Cell Tourism Is the Controversial Subject of a New Cannes Documentary – Vogue.com

Posted: May 14, 2017 at 6:46 pm

A fascinating documentary that is making the rounds at film festivals like Tribeca and Cannes gives a rare view of a controversial treatment that more and more Americans are paying up to $50,000 to receive. Stem cell therapy is widely considered to be the next big hope in medicine, with researchers everywhere from Stanford to Johns Hopkins investigating the technologys potential to treat seemingly every ailment known to mankindAlzheimers, cancer, joint injuries, even basic signs of aging. The only hitch: With one tiny exception, it isnt legal in the United States.

We all know the stem cell revolution is occurring outside the U.S., says Brian Mehling, M.D., a Manhattan-based orthopedic surgeon who is certainly doing his part to foment the insurgency. A coproducer of the film, as well as its charismatic recurring subject, Mehling is bringing stem cell tourism into the spotlight and determined to lift the curtain on a medical field that remains mysterious to most. His Blue Horizon medical clinics, with locations in China and Slovakiaand three more set to open in Mexico, Israel, and Jamaicacater to American tourists looking to cutting-edge therapy for help when traditional medicine fails.

Stem cells are the undifferentiated cells that abound in newborns and have the ability to transform into blood, nerve, or muscle cells and aid the body in self-repair. Proselytizers like Mehling say they constitute the latest in holistic medicine, allowing the body to healwithout drugs, surgery, or side effects. At clinics such as Mehlings, doctors either inject the cells, which are generally obtained from umbilical cords during C-sections, into a patients spinal cord (much like an epidural), or administer them via IV drip. The process is alarmingly quick, and patients can typically check out of the facility by the end of the day. One of the few stem-cell therapies approved for use in the United States is one used to treat the blood disease known as beta thalassemia; in that instance, the treatment replaces damaged blood in the immune system and saves tens of thousands of lives each year. Few other stem cell applications, however, have been proven effective in the rigorous clinical trials the Food and Drug Administration requires before signing off on any treatment.

In fact, stem cell clinics remain completely unregulated, and there have been incidents of related troubles. In one recent report , Jim Gass, a resident of San Diego who traveled to stem cell clinics in Mexico, China, and Argentina to help recover from a stroke, later discovered a sizable tumor on his spinal columnand the cancerous cells belonged to somebody else. Troubling cases also emerged at a loosely regulated clinic in Sunrise, Florida where, earlier this spring, three women suffering macular degeneration reported further loss of vision after having stem cells, extracted from their belly fat via liposuction, injected into their eyes. Though, on the whole, reports of treatments at clinics gone awry remain relatively few.

In his film, Stem Cells: The Next Frontier , which is set to appear at Cannes Film Festival this month, Mehling offers a persuasive side of the story, with rapturous testimonials from patients, some of whom who have regained the ability to walk after their stem cell vacations. Added bonus: They come home with better skin, bigger sex drive, and (in the case of at least one balding patient) more hair.

However compelling, there is scant evidence that the injections actually make a difference, and most American doctors caution against buying into the hype. Stem cell researcher Jaime Imitola, M.D. and Ph.D, director of the progressive multiple sclerosis clinic research program at Ohio State University, says he is impressed by the evidence that stem cells can help with neurological disorders in animals. But the question is how can you translate it into clinical trials? We still dont know what were doing when we put stem cells in people.

David Scadden, a professor of medicine and stem cell and regenerative biology at Harvard, and the director of Harvards Stem Cell Institute, says that stem cell tourism is a waste of money for the time being. A world-renowned expert in stem cell science, he remains optimistic about its future applications. Researchers are currently looking into reprogramming, for instance, which effectively converts a mature cell into a stem cell. You rewind its history so it forgets its a blood cell or a skin cell and it rewinds back in time and it can become any cell type, he says. Youd be able to test drugs on these cells, and it could be used to reverse Type 1 diabetes.

For now, though, he does not recommend experimenting with stem cells before we understand them well enough to properlyand safelyharness their benefits. People call me about it all the timethey say, I have this knee thats bugging me, Im going to one of these clinics, he says. His response? For the most part they dont do harm. But nobody Ive spoken with has come back to me and said, You Harvard docs have to get on this . . . . Not yet.

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Stem Cell Tourism Is the Controversial Subject of a New Cannes Documentary - Vogue.com

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5 Ways Diabetes Made Me A Better Mother – A Sweet Life (blog)

Posted: May 14, 2017 at 6:45 pm

Im not a huge fan of Mothers Day. Mind you: my kids are wonderful about it, and so is my husband. I just kind of want to live a life in which we all almost always appreciate one another, and remind one another of it. That said, I have someone or rather something special to thank this Mothers Day:

Say what?

Yes, you heard me right. Because while I did not know it when diabetes barreled into my daughters life nearly 20 years ago, it was the best worst thing that ever happened to me as a mother.

Diabetes has brought much grief, but I can say without hesitation that it has made me better in many ways. Its forced me to be strong and diligent, and given me skills and insights I didnt necessarily want, but that made me grow for the better. Part of who I am as a mother is thanks to diabetes.

And so, for Mothers Day this year, Im going to thank diabetes for a few things, like:

It takes guts to be a good mom. The easy way out for all parents, I think, is to let fear rule you. Diabetes pushed me to let go of fear, like the summer my daughter was six not yet even reading, and I dropped her off for two weeks at diabetes camp. I joke that I hid behind a tree for hours, popping out and yelling are you low??!! every few minutes that first day (not really but I did hang around for hours). Leaving her in the care of others, with barely any contact at all, took guts. And it taught me: she can be fine without me. I carried that courage over to the rest of my parenting life, not just with her, but with my daughter without diabetes

Nothing is more valuable than understanding what is a big deal and what isnt.

Things I used to sweat suddenly balanced out as not as big a deal. My kid didnt get the role she wanted in the middle school play? Hey, were all healthy and she can be perfectly happy in the chorus. Miss a birthday party because of a sickness? Life picks up and goes on the next day. Because diabetes is a never-ending practice of making the best of things (high? Well just fix it. Low? Weve got glucose tabs for that!), I learned as a mom to adopt that perspective in all my parenting moments (Okay most of them. I am a mere human). Over the years, things like getting (perhaps unfairly) cut from the soccer team became, instead of a world crisis, a paused, readjustment and chance to move forward.

Diabetes also taught me to reposition my own perspective. Its easy as a diabetes mom to feel sorry for yourself, to want to sink into the grief, anxiety and sometimes overwhelming duties attached to it all. But I learned early from teens and adults with diabetes themselves to change that view. Diabetes is not mine it is my childs. I dont live with it 24/7, she does. And until theres a cure, she always will. I had to learn that while my child is my heart, she is her own person and I am mine. I was not going to feel sorry for myself and not going to teach my daughter to feel sorry for herself.

Living with a chronic disease in your family opens your mind and heart to others who do as well. It also opens you to the realization that everyone even folks who dont have something like diabetes on boardsometimes are sad, hurt, scared, or overwhelmed by life. Sometimes, all someone needs is for you to let them know you know that.

Diabetes helped me see that. In the early years, someone who simply cared and let me know they felt empathy was like a balm to my wound. As I grew stronger, I realized as a mom knowing when to offer that balm to my own kids and my friends was a wonderful skill to have.

Diabetes helped me find my voice. Ive told my story make that my daughters story (perspective!) to senators, congressmen, even presidents. Ive stood on stages before thousands of people and movitated them to give money to JDRF and to do raise funds themselves. Ive ridden a bike 100 miles in one day through a desert, through three states, through a wind tunnel of marshes in northern Florida things I never thought Id have the power to do. Diabetes has pushed me to push my limits, to become more confident, to work harder, and to never give up. Thats a gift that serves me as a mother and as a human being. Diabetes helped me know I am stronger than I thought I was.

Diabetes has shown me how both my children the one with diabetes and the one without it can thrive in life despite it. It has introduced me to incredible friends. It has connected me to a world of true heroes. It has taken me places and taught me things I could never have learned without it.

So this Mothers Day, I thank diabetes for making me the mother I am today. Ill keep on working to banish diabetes from this earth, but until then, Ill continue to learn from it and soak up the very good from the very bad.

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