Study Offers Fertility Preservation Option to Young Boys with Cancer

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Newswise WINSTON-SALEM, N.C. Oct. 1, 2014 Wake Forest Baptist Medical Center is one of a few centers in the world and the only one in North Carolina offering young boys with cancer the opportunity to participate in a research study focused on fertility preservation and restoration.

The research, conducted by the Medical Centers Wake Forest Institute for Regenerative Medicine (WFIRM) under the direction of Anthony Atala, M.D., institute director, gives boys who have a high risk of becoming sterile the option to bank a small piece of testicular tissue prior to treatment.

The average survival rates for childhood cancer are around 80 percent, but a side effect of some treatments can be permanent sterility, said Thomas W. McLean, M.D., a pediatric cancer specialist, who co-leads the experimental biological bank with Hooman Sadri-Ardekani, M.D., Ph.D., a male infertility specialist at WFIRM. Preserving or restoring the ability of our patients to one day have children is an important aspect of their treatment.

From the stored tissue, researchers can extract spermatogonial stem cells (SSCs), which are responsible for the continuous production of sperm throughout adult life. Physicians and scientists hope that when the boys reach adulthood, the cells can be transplanted back into their testicles through a simple injection and they will be able to produce sperm.

SSC transplantation has not yet been attempted in humans, but has been performed successfully in several species of animals, including monkeys, said Sadri-Ardekani, who developed the first laboratory protocol to isolate and grow human SSCs from small testicular biopsies.

McLean said a treatment to preserve fertility in boys who are not sexually mature is especially needed because no options currently exist for them. Older boys and men, on the other hand, can bank sperm for future use and women and girls can bank eggs or ovarian tissue.

SSCs are particularly sensitive to radiation and chemotherapy. Examples of cancers that involve these treatments that have a high risk of infertility are certain leukemias, Hodgkins disease, brain tumors and bone cancer.

For the current research study, participants have a small piece of testicular tissue harvested under general anesthesia while they are undergoing another procedure associated with their care, such as putting a catheter in the chest to deliver chemotherapy drugs.

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Study Offers Fertility Preservation Option to Young Boys with Cancer