Research Progress Evaluating the Function and Mechanism of Anti-Tumor | CMAR – Dove Medical Press

Xinxing Pan, Juan Xu, Xuemei Jia

Department of Gynecology, Womens Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, Peoples Republic of China

Correspondence: Xuemei JiaDepartment of Gynecology, Womens Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfeixiang, Mochou Road, Nanjing 210004, Jiangsu Province, Peoples Republic of ChinaTel/Fax +86-25-84460507Email xmjia@njmu.edu.cn

Abstract: Malignant tumors cause a high mortality rate worldwide, and they severely threaten human health and negatively affect the economy. Despite the advancements in tumor-related molecular genetics and effective new processes in anti-tumor drug development, the anti-tumor drugs currently used in clinical practice are inadequate due to their poor efficacy or severe side effects. Therefore, developing new safe and efficient drugs is a top priority for curing cancer. The peptide has become a suitable agent due to its exact molecular weight between whole protein and small molecule, and it has high targeting ability, high penetrability, low immunogenicity, and is convenient to synthesize and easy to modify. Because of these advantages, peptides have excellent prospect for application as anti-tumor agents. This article reviews the recent research progress evaluating anti-tumor peptides and their anti-tumor mechanisms, and may act as a reference for the future development and clinical application of anti-tumor peptides.

Keywords: anti-cancer, small biomolecule, medicine, drug development

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Research Progress Evaluating the Function and Mechanism of Anti-Tumor | CMAR - Dove Medical Press