Genetics, Epigenetics, and Cancer: What Data Are We Missing? – AJMC.com Managed Markets Network

During the discussion of disparities in cancer care, one panelist explained that the National Institutes of Health definition of precision medicine is broader than most people realize.

A flashpoint in the discussion of disparities in cancer care concerns data:If most of the data collected on genetic mutations come from White Europeans, what insights might we have missed? Will approved therapies offer the same level of efficacy in patients of color?

More importantly, what data beyond a persons genetics are not accounted for in todays clinical trials that could affect cancer outcomes? And how can artificial intelligence (AI) enable these factors to be part of the care equation?

During the discussion on cancer care disparities at Patient-Centered Oncology Care, Karen Winkfield, MD, PhD, executive director of the Meharry-Vanderbilt Alliance, asked John Carpten, PhD, of the Keck Schoolof Medicine at the University of Southern California Norris Comprehensive Cancer Center the following question: If we are talking about getting the right treatment to the right patient at the right time, what are some of thedata points that were currently missing?

The answer, Carpten replied, starts with the basic concept of precision medicine itself. And this is broader than most people realize if one looks at the definition given by the National Institutes of Health (NIH), he said.

"Im going to say this sensitivelyits consistently dumbed down to performing a genetic assay and trying to understand how to manage disease based on the individuals genetics," Carpten pointed out. "But if youlook at the NIH definition, it broadens it: it talks about lifestyle [and] environmental factors that can also [have] a significant impact on individual exposures."

These can include stresses, the built environment, and other factors that affect a persons living condition, Carpten said, in addition to their genetic ancestry. This area, epigenetics, involves individual behaviors and external factors that can alter how genes work. Epigenetics plays a huge role in cancer because if these other factors are not taken into account, targeting a patients mutation wont bring about the expected result.

"There are so many aspects of managing disease that go beyond just, 'Theres an alteration, its linked to this drug, so that drug should be effective in that setting. And we know that thats not always the case because there are so many other things that can impact that individuals response,' " Carpten said.

The future, he continued, should involve building cancer care models that would take both genetic and epigenetic factors into account. Winkfield used the example of smoking and how a mothers smoking during pregnancy can affect multiple generations of a family.

The more data we generate, the more we learn, and the more we can contribute to the model," Carpten said. "My hope is that it wont be about one measurement, it will be about a model. And in order to develop those models, we have to perform the studies that generate the data."

An opportunity exists for trauma, poverty, and institutional racism, for example, to finally be factored into such a model. "Im starting to be more vocal about the fact that racism is trauma, right? Its generational trauma," said Winkfield.

According to Carpten, models are beginning to take structural racism into account, including how exposure to environmental and social stressors affected the rate of reactive oxygen species development. This, in turn, led to effects such as chronic inflammation that are known to increase cancer risk. For all his excitement over the possibilities of AI, Carpten offered a warning: disparities could be exacerbated if not everyone has access. We have to take it one step at a time," he said. "[but] I think weve made a lotof progress."

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Genetics, Epigenetics, and Cancer: What Data Are We Missing? - AJMC.com Managed Markets Network