Category Archives: Testosterone Replacement Therapy

Global Testosterone Replacement Therapy Market Research Report will give its customers Full Analytical Research, that gives all in-out detailes about Key Players like company profile, product portfolio, capacity, price, cost and revenue for forecast period of 2020 2027. This Report gives full evaluation of Testosterone Replacement Therapy Market that containes Future trend, Current Growth Factors, attentive opinions, facts, historical data, and statistically supported and industry validated market data.

This Testosterone Replacement Therapy Market Research makes clear explanation on How or Why this market will take growth hike on mentioned period. A specific data of perticular characteristic such as Type, Size, Application, and end-user have been scanned in this research report. There are the basic segments included in segmentation analysis which are outcomes of SWOT analysis and PESTEL analysis.

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AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals are some of the major organizations dominating the global market.

Key players in the Testosterone Replacement Therapy market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All measurement shares, splits, and breakdowns have been resolute using secondary sources and verified primary sources. The Testosterone Replacement Therapy Market report begins with a basic overview of the industry lifecycle, definitions, classifications, applications, and industry chain structure and all these together will help leading players understand scope of the Market, what characteristics it offers and how it will fulfill customers requirements.

The report also makes some important proposals for a new project of Testosterone Replacement Therapy Market before evaluating its feasibility. Overall, the report covers the sales volume, price, revenue, gross margin, historical growth and future perspectives in the Testosterone Replacement Therapy market. It offers facts related to the mergers, acquirement, partnerships, and joint venture activities widespread in the market.

This report includes the estimation of market size for value (million US$) and volume (K MT). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Testosterone Replacement Therapy market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.

What Testosterone Replacement Therapy Market report offers:

Regions Covered in This Report

The complete knowledge of Testosterone Replacement Therapy Market is based on the latest industry news, opportunities and trends. Testosterone Replacement Therapy Market research report offers a clear insight about the influential factors that are expected to transform the global market in the near future. Both top-down and bottom-up approaches have been used to estimate and validate the market size of Testosterone Replacement Therapy market, to estimate the size of various other dependent submarkets in the overall market.

Remarkable Attributes of Testosterone Replacement Therapy Market Report:

Customisation of the Report-In case of any queries or customisation requirements please connect with our Experts by Clicking Here who will ensure that your requirements are met.

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Testosterone Replacement Therapy Market Scope and Price Analysis of Top Manufacturers Profiles 2020-2027 - Primo Journal

The global Testosterone Replacement Therapy market is broadly and deeply studied in the report with key focus on the competitive landscape, regional growth, market segmentation, and market dynamics. We have used latest primary and secondary research techniques for compiling this comprehensive research study. The report offers Porters Five Forces analysis, PESTLE analysis, competitive analysis, manufacturing cost analysis, revenue and production analysis, and various other types of analysis to provide a complete view of the global Testosterone Replacement Therapy market. Each segment of the global Testosterone Replacement Therapy market is carefully analyzed on the basis of market share, CAGR, and other vital factors. The global Testosterone Replacement Therapy market is also statistically presented with the help of Y-o-Y growth, CAGR, revenue, production, and other important calculations.

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We can customize the report as per your requirements. Our analysts are experts in market research and analysis and have a healthy experience in report customization after having served tons of clients to date. The main objective behind preparing the research study is to inform you about future market challenges and opportunities. The report is one of the best resources you could use to secure a strong position in the global Testosterone Replacement Therapy market.

Market Segmentation:

Following are the segments covered by the report are:GelsInjectionsPatchesOtherBy Application:HospitalsClinicsOthersKey Players:The Key manufacturers that are operating in the global Testosterone Replacement Therapy market are:AbbVieEndo InternationalEli lillyPfizerActavis (Allergan)BayerNovartisTevaMylanUpsher-SmithFerring PharmaceuticalsKyowa KirinAcerus Pharmaceuticals

Regional GrowthThe report offers in-depth analysis of key regional and country-level Testosterone Replacement Therapy markets, taking into account their market size, CAGR, market potential, future developments, and other significant parameters. The Middle East and Africa (GCC Countries and Egypt) North America (the United States, Mexico, and Canada) South America (Brazil etc.) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Key Questions Answered What will be the size and CAGR of the global Testosterone Replacement Therapy market in 2025? Which product will gain the highest demand in the global Testosterone Replacement Therapy market? Which application could show the best growth in the global Testosterone Replacement Therapy market? What will be the nature of the competitive landscape in future? Which players will lead the global Testosterone Replacement Therapy market in the coming years? Which region will gain the largest share of the global Testosterone Replacement Therapy market?

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Table of Contents

Report Overview: It includes six chapters, viz. research scope, major manufacturers covered, market segments by type, Testosterone Replacement Therapy market segments by application, study objectives, and years considered.

Global Growth Trends: There are three chapters included in this section, i.e. industry trends, the growth rate of key producers, and production analysis.

Testosterone Replacement Therapy Market Share by Manufacturer: Here, production, revenue, and price analysis by the manufacturer are included along with other chapters such as expansion plans and merger and acquisition, products offered by key manufacturers, and areas served and headquarters distribution.

Market Size by Type: It includes analysis of price, production value market share, and production market share by type.

Market Size by Application: This section includes Testosterone Replacement Therapy market consumption analysis by application.

Profiles of Manufacturers: Here, leading players of the global market are studied based on sales area, key products, gross margin, revenue, price, and production.

Testosterone Replacement Therapy Market Value Chain and Sales Channel Analysis: It includes customer, distributor, Testosterone Replacement Therapy market value chain, and sales channel analysis.

Market Forecast Production Side: In this part of the report, the authors have focused on production and production value forecast, key producers forecast, and production and production value forecast by type.

About Us:QYResearch always pursuits high product quality with the belief that quality is the soul of business. Through years of effort and supports from huge number of customer supports, QYResearch consulting group has accumulated creative design methods on many high-quality markets investigation and research team with rich experience. Today, QYResearch has become the brand of quality assurance in consulting industry.

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Testosterone Replacement Therapy Market Projections From 2020-2026 With Research Data on Consumption Analysis, Investment Cost, Profits Data and...

A Republican lawmaker in Tennessee has introduced a bill which would prevent trans athletes in schools from playing on teams that match their gender identity.

Tennessee Representative Bruce Griffey has introduced the bill. If passed, trans students who participate in team sport would have to play as the wrong gender in the state.

He has claimed that he wants to ensure fairness in team sports at school level and insisted that there is no ill will intended by House Bill 1572, Nashville Channel 5 reports.

What its simply trying to do is, I think science and experience and just society, the Republican said. We all know that traditionally males generally have bigger hearts, bigger upper body strength, and that can give them a genetic advantage when competing against women in a number of sports.

Under the bizarre law, schools could be fined $10,000 if they were to allow a trans student participate in a team sport in line with their gender identity.

If the bill is passed, state officials who knowingly violate the ban would be forced to give up their position and would be ineligible to hold any public office for a five year period.

Some members of the General Assembly have not made an effort to understand that trans youth are a part of our school population and we need to serve and protect them like all students.

The new bill has been slammed by LGBT+ activists in the state. Chris Sanders of the Tennessee Equality Project told Nashville Channel 5: Some members of the General Assembly have not made an effort to understand that trans youth are a part of our school population and we need to serve and protect them like all students.

He said the bill is part of the 2020 slate of hate bills, a series of bills designed to attack the LGBT+ community in Tennessee this year. He called the new bill insulting to trans youth.

The myth that trans women have an advantage over cisgender women in sport is pervasive, despite the fact that numerous LGBT+ sporting organisations have repeatedly debunked the claims.

Last year, lesbian tennis player Martina Navratilova sparked controversy when she wrote a column for The Sunday Times arguing that trans athletes should not be allowed to compete in competitive sport. LGBT+ sporting organisation Athlete Ally subsequently cut ties with her and released a statement debunking her claims.

Athlete Ally pointed out that there is no evidence at all that the average trans woman is any bigger, stronger, or faster than the average cisgender woman, but there is evidence that often when athletes lower testosterone through hormone replacement therapy, performance goes down.

Read more:
Republican politician introduces law to ban trans athletes from playing on teams that match their gender identity - PinkNews

Global Testosterone Replacement Therapy Market Research Report provides a comprehensive analysis of this industry to help the clients in making strategic business decisions. The demand and supply-side analysis will provide revenue, volume, portfolio analysis, business strategies, innovations and latest developments in Testosterone Replacement Therapy Industry. The demand side analysis of Testosterone Replacement Therapy Market focuses on end-user analysis, consumer demands, expectations, and user behavior. The SWOT analysis of top Testosterone Replacement Therapy Market players will list the strength, weakness, opportunities, and threats of the industry. The company profiles of top Testosterone Replacement Therapy Market players will provide financial analysis listing the company revenue, and market share. The past and present revenue of top players will offer forecast revenue estimates and growth rates.

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The competitive profiles of top Testosterone Replacement Therapy Industry players will provide a comparative study based on product offerings, applications, regional presence, employee size, market share, revenue, and production capacity. The entire Testosterone Replacement Therapy Market is analyzed based on market value, volume, the average sales price of the product. Both the positive and negative impacts of various factors like market drivers, restraints, and opportunities on each segment of Testosterone Replacement Therapy Industry is stated in this study. Also, a complete analysis of Testosterone Replacement Therapy value-chain, pricing structure, macroeconomic factors, and PESTEL analysis is provided. The primary and secondary data sources comprise of the paid primary interview with key opinion leaders of the industry, annual reports, press releases, and trustable data sources.

The market is segmented based on the following factors:

Market analysis by top players:

TevaKyowa KirinAbbVieFerring PharmaceuticalsUpsher-SmithNovartisActavis (Allergan)BayerEli lillyAcerus PharmaceuticalsMylanEndo InternationalPfizer

Market analysis by key product types:

GelsInjectablesPatches

Market analysis by top applications:

HospitalsClinicsOthers

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Summary:

The report begins with market definition, segmentation, macroeconomic factors and executive summary of Testosterone Replacement Therapy Industry. In the next segment, PESTEL analysis, Value chain analysis, SWOT analysis, and pricing analysis is conducted. The market estimation and forecast analysis by product type, application, players and regions are conducted. Testosterone Replacement Therapy Regional analysis by Market size estimation and forecast view covers North America, Europe, EMEA, Latin America, Asia-Pacific, and others. The forecast numbers and year-on-year growth rate is analyzed from 2019 through 2025. The top-down and bottom-up research methodology is applied to derive the market numbers and provide precise analysis. The product innovations, partnerships, and acquisitions in Testosterone Replacement Therapy industry, emerging market segments are studied comprehensively.

The quantitative and qualitative analysis of Testosterone Replacement Therapy Industry with the 360-degree market view will help users in understanding the competitive environment, potential segments, and growth opportunity. We excel in providing premium progressive statistical surveying of market research reports to help the global clients in overcoming business challenges and achieving sustainable growth.

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Global Testosterone Replacement Therapy Market Expected To Feasible Growth , Recent Trends Over 2025 - Testifyandrecap

TRT Vitor Belfort was the scariest fighter Ive seen and that is including former UFC heavyweight champ, Andrei Arlovski in his first title run. It looks like that version of Belfort is back.

He shared a video of himself and his coach boxing and he looks jacked. it also looks like he skipped leg day. Never skip leg day Vitor

The former UFC light heavyweight champion is now signed to the Singapore based ONE organization. This means he is not subject to rigorous USADA testing and TRT could very well be pumping through his veins making the 42 year old move like a man in his early 30s. We are not confirming that he is back on testosterone replacement therapy but he does look better than he did at the end of his last UFC run.

What do you think?

Original post:
Watch: It looks like TRT Vitor is back and he skipped leg day. - Pro MMA Now

(Photo : pixabay)

Female-to-male surgery or FTM surgery is a type of sex reassignment surgery, which is also called gender-affirming surgery or gender affirmation surgery. This can take different forms, including a mastectomy, the removal of breasts and the altering of the genital region, also known as bottom surgery.

Examples of bottom surgery include the removal of the uterus known as hysterectomy, removal of the vagina known as vaginectomy, construction of a penis through phalloplasty or metoidioplasty.

Surgery

Before having FTM gender-affirming surgery, a person will receive testosterone replacement therapy. They may then undergo one or more of the following types of procedure.

Chest restructuring

Someone undergoing surgery to transition from female to male usually has a subcutaneous mastectomy to remove breast tissue. The surgeon will also make alterations to the appearance and position of the nipples. Meanwhile, testosterone therapy will stimulate the growth of chest hair.

Removal of the uterus, ovaries, and fallopian tubes

A person may wish to undergo this type of surgery if they are uncomfortable having ovaries, a uterus, or fallopian tubes, or if hormone therapy does not stop menstruation. In a partial hysterectomy, a surgeon will remove only the uterus. In a total hysterectomy, they will also remove the cervix. A bilateral salpingo-oophorectomy or BSO involves the removal of the right and left fallopian tubes and ovaries.

Metoidioplasty

A metoidioplasty is a method of constructing a new penis, also known as neopenis. It involves changing the clitoris into a penis. A person will receive hormone therapy before the surgery in order to enlarge the clitoris for this purpose. During the procedure, the surgeon will also remove the vagina, called a vaginectomy.

Also, they lengthen the urethra and position it through the neopenis. To get the exact length, the surgeon uses tissues from the labia minora, the cheek or other parts of the vagina. The aim of this is to allow the person to urinate while standing.

Another option is a Centurion procedure, which involves repositioning round ligaments under the clitoris in order to increase the girth of the penis.

A metoidioplasty usually takes 2 to 5 hours. After the initial surgery, additional procedures may be needed. A Centurion procedure takes around 2.5 hours and removing the female reproductive organs will add to this time. An advantage of a metoidioplasty is that the neopenis may become erect, because of the erectile abilities of clitoral tissue. However, neopenis resulting from metoidioplasty is usually to small for penetrative sex.

Phalloplasty

A phalloplasty uses grafted skin that is usually from the thigh, arm, abdomen or back, in order to form a neopenis. Doctors consider taking skin from the forearm to be the best option in penile construction. Compared with metoidioplasty, a phalloplasty results in a larger penis. However, this neopenis can't become erect on its own.

After a period of recovery, a person can have a penile implant. This can allow them to get and to maintain erections and have penetrative sex. During a phalloplasty, the surgeon performs a vaginectomy and lengthens the urethra to allow urination through the penis.

The disadvantages of a phalloplasty include the number of surgical visits and revisions that may be needed, as well as the cost, which is usually higher than that of a metoidioplasty.

Scrotoplasty

A person may decide to have a scrotoplasty, which is the creation of a scrotum, alongside a metoidioplasty or phalloplasty. In a scrotoplasty, a surgeon hollows out and repositions the labia majora to form a scrotum and inserts silicone testicular implants.

ALSO READ: In Oregon, Teenagers Can Now Undergo Sex Change

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What You Need To Know About Female-to-Male Surgery - Science Times

Latest release from SMI with title Testosterone Replacement Therapy Sales Market Research Report 2019-2026 (by Product Type, End-User / Application and Regions / Countries) provides an in-depth assessment of the Testosterone Replacement Therapy Sales including key market trends, upcoming technologies, industry drivers, challenges, regulatory policies, key players company profiles and strategies. Global Testosterone Replacement Therapy Sales Market study with 100+ market data Tables, Pie Chat, Graphs & Figures is now released BY SMI. The report presents a complete assessment of the Market covering future trends, current growth factors, attentive opinions, facts, and industry-validated market data forecast until 2026.

Global Testosterone Replacement Therapy Sales Market Segmentations

The segmentation chapter allows readers to understand aspects of the Global Testosterone Replacement Therapy Sales Market such as products/services, available technologies, and applications. These chapters are written in a way that describes years of development and the process that will take place in the next few years. The research report also provides insightful information on new trends that are likely to define the progress of these segments over the next few years.

Download Free Sample Report with Latest Industry Trends 2019 @ https://www.stratagemmarketinsights.com/sample/8711(**Note: Free Sample with TOC, Graph, Charts)

Global Testosterone Replacement Therapy Sales Market and Competitive Analysis

Know your current market situation! Not only an important element for new products but also for current products given the ever-changing market dynamics. The study allows marketers to stay in touch with current consumer trends and segments where they can face a rapid market share drop. Discover who you really compete against in the marketplace, with Market Share Analysis know market position, % market Share and Segmented Revenue of Testosterone Replacement Therapy Sales Market

Segmentation and Targeting

Essential demographic, geographic, psychographic and behavioral information about business segments in the Testosterone Replacement Therapy Sales market is targeted to aid in determining the features company should encompass in order to fit into the business requirements. For the Consumer-based market the study is also classified with Market Maker information in order to better understand who the clients are, their buying behavior and patterns.

*** For the global version, a list of below countries by region can be added as part of customization at minimum cost.North America (United States, Canada & Mexico)Asia-Pacific (Japan, China, India, Australia, etc)Europe (Germany, UK, France, etc)Central & South America (Brazil, Argentina, etc)Middle East & Africa (United Arab Emirates, Saudi Arabia, South Africa, etc)

Testosterone Replacement Therapy Sales Product/Service Development

Knowing how the product/services fit the needs of clients and what changes would require to make the product more attractive is the need of an hour. Useful approaches to focus group by utilizing User Testing and User Experience Research. Demand-side analysis always helps to correlate consumer preferences with innovation.

Marketing Communication and Sales Channel

Understanding marketing effectiveness on a continual basis help determine the potential of advertising and marketing communications and allow us to use best practices to utilize an untapped audience. In order to make marketers make effective strategies and identify why the target market is not giving attention, we ensure the Study is Segmented with appropriate marketing & sales channels to identify potential market size by Revenue and Volume* (if Applicable).

Pricing and Forecast

Pricing/subscription always plays an important role in buying decisions; so we have analyzed pricing to determine how customers or businesses evaluate it not just in relation to other product offerings by competitors but also with immediate substitute products. In addition to future sales Separate Chapters on Cost Analysis, Labor*, production* and Capacity are Covered.

How geography and sales fit together

This study is helpful to all operators who want to identify the exact size of their target audience at a specific geographic location. Testosterone Replacement Therapy Sales Market allows entrepreneurs to determine local markets for business expansion. This study answers the questions below:

1. Where do the requirements come from?2. Where do non-potential customers reside?3. What is the buying behavior of customers in a specific region?4. What is the spending power of the customers in a particular region?

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Having our reviews and subscribing our report will help you solve the subsequent issues:

*Uncertainty about the future: Our research and insights help our customers predict the upcoming revenue pockets and growth areas. This will guide customers to invest their resources.

*Understanding market sentiments: It is very important to have a fair understanding of market sentiment for your strategy. Our insights will help you see every single eye on market sentiment. We maintain this analysis by working with key opinion leaders on the value chain of each industry we track.

*Understanding the most reliable investment center: Our research evaluates investment centers in the market, taking into account future demand, profits, and returns. Clients can focus on the most prestigious investment centers through market research.

*Evaluating potential business partners: Our research and insights help our clients in identifying compatible business partners.

Furthermore, the years considered for the study are as follows:

Historical year 2013-2018Base year 2018Forecast period** 2019 to 2026 [** unless otherwise stated]

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Testosterone Replacement Therapy Sales Market In-Depth Analysis on Forthcoming Development And Forecast By 2026 - Market Reports Observer

Global Testosterone Replacement Therapy Market Size, Status and Forecast 2019-2027 offers a primary overview of the Testosterone Replacement Therapy industry coveringDefinition, Classification, Industry Value, Price, Cost, and Gross Profit, Share via Region, New Challenge Feasibility Evaluation, Analysis and Guidelines on New mission Investment. Testosterone Replacement Therapy Market report presents the in-intensity insight ofCompany Profile, Capacity, Product Specifications, Production Value, Sales, Revenue, Price, Gross Margin, Market Size and Market Sharesfor topmost prime key vendors. In the end, there are 4 key segments covered in this Testosterone Replacement Therapy market report: competitor segment, product type segment, end use/application segment, and geography segment.

Target Audience of Testosterone Replacement Therapy Market:Suppliers, Channel Partners,Production Companies, Market Consultants,Marketing Authorities, Research Institutions, Subject Matter Experts, Financial Institutions, Government Authorities.

To Get the Concise Free Sample PDF of the Testosterone Replacement Therapy Market Report, Along With the TOC, Statistics, and Tables Please Visit

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Testosterone Replacement Therapy Market Summary:This report includes the estimation of market size for value (million US$) and volume (K sqm). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Testosterone Replacement Therapy market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares split, and breakdowns have been determined using secondary sources and verified primary sources.

Based on Classification,each type is studied as Sales, Testosterone Replacement Therapy Market Share (%), Revenue (Million USD), Price, Gross Margin and more similar information.each type, including:

Market Taxonomy:-

Global Testosterone Replacement Therapy market is segmented on the basis of product type, cereals, distribution channel, and region

By Players By Product Type By Applications By Distribution Channel By Segments

Testosterone Replacement Therapy Market: Regional Analysis Includes:

1. Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)2. Europe(Turkey, Germany, Russia UK, Italy, France, etc.)3. North America(the United States, Mexico, and Canada.)4. South America(Brazil etc.)5. The Middle East and Africa(GCC Countries and Egypt.)

Do You Have Any Query Or Specific Requirement? Ask Our Industry Expert

Industrial Chain, Sourcing Strategy and Downstream Buyers (2019 2027) Industrial Chain Analysis of Testosterone Replacement Therapy market Upstream Raw Materials Sourcing Raw Materials Sources of Testosterone Replacement Therapy Market by Major Manufacturers Downstream Buyers

Testosterone Replacement Therapy Market Capacity, Production, Revenue, Consumption, Export, and Import (2019 2027) Testosterone Replacement Therapy Market Capacity, Production, and Growth Production, Consumption, Export, and Import Revenue and Growth of Market

Testosterone Replacement Therapy Market Forecast (2019 2027) Testosterone Replacement Therapy Market by Capacity, Production, Revenue Forecast Production Forecast by Type and Price Forecast Consumption Forecast by Application Production, Import, Export and Consumption Forecast Testosterone Replacement Therapy Market Production, Consumption, Import and Export Forecast by Regions (Provinces)

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Testosterone Replacement Therapy Market is Poised to be Worth US$ XX Mn in 2027 - Market Research Sheets

the global Testosterone Replacement Therapy market. It also includes discussion on historical trends, current market status, competitive landscape, growth opportunities and challenges which are backed by factful feedbacks. The report extensively provides quantitative analysis of the industry from 2014-2026,by Region, Type, Application. Consumption assessment by application, production by type in different regions. Furthermore, the report quantifies the market share held by the major players of the industry and provides an in-depth view of the competitive landscape. The market size in terms of revenue (USD) and production is calculated for the study period along with the details of the factors affecting the market growth (drivers and restraints). The worldwide market for Testosterone Replacement Therapymarket will reach xxx Million USD in 2020 and is expected to grow at a CAGR of xx% 2021-2026.

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Geographically, global Testosterone Replacement Therapy market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer; the top players includingAbbVieEndo InternationalEli lillyPfizerActavis (Allergan)BayerNovartisTevaMylanUpsher-SmithFerring PharmaceuticalsKyowa KirinAcerus Pharmaceuticals

On the basis of product, we research the production, revenue, price, market share and growth rate, primarily split intoGelsInjectionsPatchesOther

For the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Testosterone Replacement Therapy for each application, includingHospitalsClinicsOthers

Production, consumption, revenue, market share and growth rate are the key targets for Testosterone Replacement Therapy from 2014 to 2026 (forecast) in these regionsChinaUSAEuropeJapanKoreaIndiaSoutheast AsiaSouth America

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Global Testosterone Replacement Therapy Market Research Report 2020 By Manufacturers, Regions, Types And Applications - Bulletin Line

This article highlights the 10 most popular news stories published by European Pharmaceutical Review in 2019.

European Pharmaceutical Review has covered a wide range of news stories this year, from recalls to approvals, to clinical trials and patent cases.

As this year comes to an end, we reflect on our biggest and most popular stories from 2019. To read the full pieces, click on the title of each news story.

Kicking off our tenth most popular story was the news that Stelara (ustekinumab), a monoclonal antibody (mAb), had been submitted to the European Medicines Agency (EMA) for approval.

The drug is intended to treat patients with moderate-to-severe ulcerative colitis and is the first mAb to target the interleukin (IL)-12 and IL-23 cytokines, believed to be key in the development of inflammation.

The treatment had previously been submitted in a supplemental Biologics License Application (sBLA) to the US Food and Drug Administration (FDA).

Since January, the drug has been approved for the treatment of the condition for patients who have had an inadequate response with, lost response to or were intolerant to conventional therapy.1

Our next most popular story highlighted the effect of the US government shutdown in January on the FDA. The regulatory body clarified which operations it could carry out during the lack of funding.

According to the FDA, it was able to continue its usual activities that were crucial to ensure public safety in the US.

The statement also emphasised that the agency would guarantee the monitoring and response to emergency situations.

The shutdown ended on 25 January 2019, once President Donald Trump was able to reach a provisional deal with congressional leaders.2

August saw an outbreak of African swine flu in China threaten the supply of a pharmaceutical ingredient to the US.

Stocks of heparin, an ingredient used in anticoagulant drugs and usually derived from pigs, were under pressure as 150 million of Chinas 440 million swine reportedly died as a result of the disease.

Six members of the US Congress wrote a letter to the FDA, outlining their concern for the pharmaceutical supply chain. According to the letter, 60 percent of the crude heparin used to manufacture the finished version of the ingredient in the US is sourced from China.

However, as of October, the FDA reported that the supply of heparin was not affected due to the swine fever.3

In one of many recalls seen this year, the UK Medicines and Healthcare products Regulatory Agency (MHRA) announced an alert in October in regard to Perrigo Companys ranitidine medicines.

The warning came after the discovery of levels of N-nitrosodimethylamine (NDMA), a probable human carcinogen, were found in ranitidine products.

In this case, all unexpired stock of the 150mg/10ml oral solution was recalled and healthcare professionals and retailers were told to cease supply of the medicines.

Since the recall, the EMA has announced that the risk of cancer in humans from the drugs is very low, but that marketing authorisation holders should take precautionary measures to mitigate the risk of nitrosamine formation in medicines.4

In February, the news broke that biologic drugs used to treat severe psoriasis could be used to prevent heart disease in patients with the skin condition. According to a study, after one year of treatment, biologic therapy improved coronary artery plaque, similar to the effect of a low-dose statin.

Systematic inflammation assessed by blood markers also reduced in the group taking biologic therapy, found the researchers.

According to the story, previous research has shown that in heart attack patients, anti-inflammatory biologic therapy reduces the risk of another cardiovascular event.

The study was published in Cardiovascular Research.

In another announcement, the MHRA announced that three batches of Losartan tablets would be recalled in a precautionary measure due to a possible contamination with the nitrosamine N-nitroso-N-methylamino butyric acid (NMBA).

The recall was part of a wider range of sartan medicines affected by potential contamination, a class of drugs to treat blood pressure and heart attacks.

The recent investigation into sartan medicines began in 2018, after NDMA was discovered in valsartan manufactured at a facility based in China.

In August, the FDA released a statement that emphasised the actual risk to patients from sartan medicines is very low and that there are ongoing investigations into the safety of this class of drugs.5

In our fourth most-read story, researchers in Poland and South Korea were reported to have developed a computer model that could be used to synthetically produce essential drugs, bypassing patent-protection.

To overcome the patents in place, the researchers froze the challenging portions from each target molecule, forcing the computer to substitute unconventional but chemically plausible molecules.

The team suggested that their software could help pharmaceutical companies to protect their intellectual properties and increase research into organic chemistry.

The study was published in Cell.

In April, an experimental male oral contraceptive pill called 11-beta-methyl-19-nortestosterone dodecylcarbonate (11-beta-MNTDC) passed human safety tests.

The tablet is formulated with a modified testosterone that has the combined actions of a male hormone (androgen) and a progesterone.

In 40 healthy men, taking the pill was associated with lower testosterone levels, but no side effects were reported, allowing it to pass the test.

According to the researchers, the study indicates that the contraceptive pill decreases sperm production while preserving libido.

The findings were published in The Journal of Clinical Endocrinology and Metabolism.

August saw the story break that the shortage of hormone replacement therapy (HRT) in the UK is likely to continue into 2020. The news led medical experts to call for a resolution to the disruption in supply.

Reportedly, around half of the most commonly prescribed HRT products are out of stock in many pharmacies.

The shortage was due to supply chain issues in China, causing manufacturers to stop production of the therapies. Other brands were consequently in high demand, reducing the availability of most products.

As of November, there were still issues with the HRT supply chain. However, pharmaceutical companies are reportedly addressing these problems and working with manufacturers to solve the issue.6

Our top story this year was in September, when the news broke that the FDA and EMA were investigating some ranitidine medicines after NDMA was detected in some drugs.

Both agencies announced that they would be examining the levels of NDMA found and would take the appropriate measures to protect those taking the medication.

Since then, the FDA has released a statement, after finding that the drugs tested contained no more NDMA than in grilled or smoked meats. However, they also emphasised that manufacturers are encouraged to continue conducting their own testing to ensure the safety of their medicines for patients.7

Original post:
EPR's news round-up 2019: the stories that defined the year - European Pharmaceutical Review