Category Archives: Pennsylvania Stem Cells

In Lancaster County, Pennsylvania there are about 520,000 people. Since there are about 40 million people in the United States, this means that there is an incredible 63,000 people in Lancaster who are suffering from arthritis.

Arthritis, such as arthritis in the knee, hip, shoulder and lower back, is affecting an enormous amount of people in Lancaster County. Until this time the only solution for arthritis was surgery. It was believed that arthritis was an irreversible condition. Until recently the only solution for arthritis was to replace the arthritic joint with a prosthetic joint. Thankfully we now have other options.

Stem Cell Therapy has allowed tens of thousands of people to essentially rebuild the joints that are affected by arthritis. Incase you are unaware; stem cells are considered undifferentiated cells. This means that they can transform into other cells in which they come into contact.

When you inject stem cells into an arthritic joint the cells come in contact with the cartilage in your joint that has began to wear away, this is whats causing the arthritis pain. The cells transform into the cells that make up the cartilage in your joints and the joints begin to rebuild themselves.

Lets take a look at some of the conditions we treat with stem cell therapy.

Most likely youre experiencing pain in your knee because of typical wear and tear. Tires on your car slowly wear away because of everyday wear and tear. The same situation is taking place in your knees as we speak. Youve put stress on your knees your entire life, youve won away the cartilage in your knee joint and now you have pain.

We receive the stem cells from a mother during a scheduled C-section birth. The stem cells from this area keep the mother and her baby completely safe, while providing us with the best stem cells for orthopedic treatments. After we inject the stem cells into your knee joint, over time the stem cells will begin to rebuild the cartilage in your knee. Youll walk into the office and back out of the office in about an hour. Within a few weeks you may feel a decrease in pain in your knees.

Here are a few knee conditions we treat with stem cell therapy

If you have hip pain youll definitely know it. Unfortunately, hip surgery is on the rise with people of all ages. According to arthritis.org there were 310,000 hip replacements in 2010, which was a 92% increase since the year 2000. The reason why more and more people are opting for surgery is most likely because arthritis is becoming more common and people arent getting educated for regenerative treatments such as stem cell therapy. People are experiencing hip pain and immediately seeking an orthopedic surgeon. What is stem cell therapy for the hip?

In Lancaster, PA stem cell therapy is even offered for hip pain. Just like with knee pain we obtain stem cells from a Mother during a scheduled C-Section birth. After the cells are sent and approved at an FDA approved lab they are sent to us for orthopedic hip treatments. We will inject the stem cells into the hip joint thats causing you problems and over a period of time your hip joint may begin to repair itself. The worn cartilage in your hip may rebuild and youll be able to walk again, pain free.

Heres some painful hip conditions we treat with stem cell therapy

Did you know that in Lancaster County Pennsylvania between 60-80% of adults has lower back pain? To be conservative there are about 75,000 people walking around Lancaster County Pennsylvania with lower back pain. Thats so sad. The even more unfortunate problem is that majority of those people will believe that surgery is their only option. However, stem cell therapy has also be treating thousands of people with lower back pain.

The reason why you are experiencing lower back pain is because the cartilage in between your vertebrae has slowly worn away over the years. Since the cartilage isnt fully present you may now be experiencing painful arthritis-like symptoms. An injection of concentrated stem cells have shown promising signs of rebuilding the won out cartilage in peoples lower backs.

Heres some lower back pain conditions we commonly treat with Stem Cell Therapy

Shoulder pain doesnt just happen to baseball pitchers and bull riders. Shoulder pain is an extremely common symptom, which occurs in many people over the age of 50. Just like any other joint, the shoulder is not invincible. The shoulder endures a lifetime of stress, injury and over time cartilage degeneration. If you are experiencing shoulder pain and youre in your 50s youre not alone.

If you arent experiencing the later stages of arthritis, meaning you dont have a complete bone-on-bone condition then you should absolutely look into stem cell therapy. If you still have some cartilage in your shoulder we may be able to regrow your shoulder joint and keep you away from invasive shoulder surgery.

If you have any of these painful shoulder conditions we may be able to help you with stem cell therapy.

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Stem Cell Therapy in Lancaster Pennsylvania | Stem Cell ...

Lung Institute is a medical research institution that is working on integrating stem cells with regenerative medicine. Heres our review of everything you need to know about Lung Institute.

Lung Institute is a research institution that aims to use stem cells to help solve chronic disease problems like:

-Chronic obstructive pulmonary disease (COPD)-Pulmonary fibrosis-Chronic bronchitis-Emphysema-Interstitial lung disease

The institute currently offers a range of treatments to sufferers of the above diseases. There are blood (venous) treatments available as well as bone marrow treatments.

Stem cells are the building blocks of life and are essential to every organism. Theyre cells that self-renew and replicate and have the ability to form any type of tissue in the body.

Adult stem cells from one organ can create tissue used by another organ. This is called plasticity.

The Lung Institute specifically uses stem cells to treat pulmonary conditions. To do that, the Lung Institute uses autologous stem cells, which are stem cells that come from the patients own body.

In order to undergo the Lung Institutes stem cell treatment, youll first need to undergo a blood (venous) treatment or bone marrow treatment, during which stem cells are extracted from your body.

Heres what the three step treatment process looks like:

Step 1) A small blood or bone marrow sample is taken from the patient to harvest stem cells

Step 2) The stem cells are separated from other cells in the sample

Step 3) The concentrated stem cells are returned into the patients blood stream, at which point they begin to promote healing

The stem cells naturally target the lungs because they fall into something called the pulmonary trap, which is where the stem cells are trapped naturally by the lungs where they begin to regenerate damaged lung tissue.

When your body receives medication, blood, or stem cells through an IV, it travels directly to the right side of your heart. Then, within one or two heartbeats, your heart has distributed it to your lungs.

When researchers observe stem cells traveling through the right passage of the heart, they notice that the stem cells become trapped in the lungs. Thats bad if youre using stem cells to treat other conditions, but its not a bad thing if youre treating pulmonary conditions.

The first step to beginning your stem cell treatment through the Lung Institute is to sign up for a free consultation online. By filling out the form at LungInstitute.com, you can see if you qualify for stem cell therapy.

You can also call the company at 800 729-3065 to schedule a free consultation through the patient coordinators.

Or, attend one of the companys upcoming events and seminars. The company launches numerous events throughout the year. Over the next few months, its hosting seminars in Tampa, Scottsdale, Dallas, and Nashville, where attendees can learn more about how Lung Institute stem cell therapy works.

Currently, Lung Institute stem cell therapy is only available in five states across America, where you can undergo treatment at one of the following five locations:

-Tampa, Florida-Nashville, Tennessee-Scottsdale, Arizona-Pittsburgh, Pennsylvania-Dallas, Texas

The medical treatment is available to anyone who qualifies, and the company appears to have many patients who fly into town specifically for the treatment.

Whether or not you qualify for treatment depends on a few things, including what condition youre currently in, how long youve been diagnosed with your condition, what treatments youve already undergone (if any), and your date of birth.

Lung Institute doesnt post scientific evidence regarding its effectiveness. However, the company does list dozens of customer testimonials from people who have gone through the procedure.

The company recently celebrated its 1000th stem cell treatment patient. You can view customer testimonials here.

Testimonials are separated into sections based on their condition: like asthma, bronchiectasis, COPD, interstitial lung disease, emphysema, and pulmonary fibrosis. Although the procedure does not work on all patients, a large number of people seem to have been able to treat their lung condition by using the procedures offered by Lung Institute.

Prior to undergoing a procedure through Lung Institute, youll receive contact information from previous patients who have undergone the therapy.

Reviews online seem to indicate a positive overall response to the Lung Institutes stem cell therapy.

The Lung Institute doesnt post the full costs of its treatment online. However, it does list that the treatment is not typically covered by medical insurance, because insurance only covers conventional treatments and does not cover alternative treatments like stem cell therapy.

The company also lists a number of fundraising ideas you can use to cover the costs of your treatment including crowd sourcing sites, charity concerts, garage sales, and social media donation pages.

To get a finite price, youll need to contact a Lung Institute representative. However, there are over 100 stem cell clinics across America today, most of which charge approximately $10,000 USD per treatment. Some reports claim that stem cell clinics have a very high profit margin, with procedures only costing about $1000 to $2000 to perform, which is why weve seen some clinics reduce prices to $7,000 or $8,000 per treatment.

You may need to undergo multiple stem cell therapies for the procedure to work. Read this local news article to find out how a coach raised $70,000 for his own stem cell therapy, for example. Meanwhile, Mexico-based clinics that offer Stemedica stem cell treatment advertise stem cell therapies at a total cost of $32,000 to $40,000 per treatment.

Ultimately, the Lung Institute is one of many stem cell clinics across America offering stem cell therapy. However, its one of the few that specializes in the treatment of pulmonary (lung) conditions.

The scientific verdict on stem cell therapies is still out. We dont know for sure whether or not they work, and the Lung Institute doesnt post much science regarding the effectiveness of its own treatments. However, if youre a believer in stem cell therapies and are currently suffering from a lung condition, then Lung Institutes stem cell therapies may be the right option for you.

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Lung Institute Review | Do Stem Cell Treatments Work?

Cells Weekly is a digest of the most interesting news and events in stem cell research, cell therapy and regenerative medicine. Cells Weekly is posted every Sunday night!

1. Gene therapy of eye disease succeeded in Phase 3 trialThis week, US-based gene therapy company Spark Therapeutics reported positive data from their Phase 3 trial in inherited retinal dystrophies.

We saw substantial restoration of vision in patients who were progressing toward complete blindness, said Albert M. Maguire, MD, principal investigator in the trial and professor of ophthalmology at the Perelman School of Medicine of the University of Pennsylvania. The majority of the subjects given SPK-RPE65 derived the maximum possible benefit that we could measure on the primary visual function test, and this impressive effect was confirmed by a parallel improvement in retinal sensitivity. If approved, SPK-RPE65 should have a positive, meaningful impact on the lives of patients with this debilitating condition.

Sparks results are remarkable, because this is a first success in Phase 3 gene therapy trials under FDA jurisdiction. It was a pivotal trial before application to FDA for approval their gene therapy drug on a market:

Based on these results, Spark intends to file a Biologics License Application with the U.S. Food and Drug Administration in 2016 as the first step in executing its global regulatory and commercialization strategy.

Hopefully, US will get the first approved gene therapy drug on a market next year.As a follow-up from this release, yesterday the company reported that positive effects persist for 3 years:

Since the final-stage trial only has tracked patients for a year, Spark also presented at the conference the longer-term data on patients who had been treated in an earlier study and were available for follow-up. Out of eight patients who would have qualified for the final-stage trial, all seven who were available for follow-up after three years sustained their improvement

2. CRISPR gene editing used to create humanized organs in pigsA group of researchers, led by Harvards Professor George Church, reported today in Science a technique of simultaneous gene edit of 62 porcine endogenous retrovirus genes in kidney cell line. Excerpt from Science Insider:

Church believes the new work could revive the idea of xenotransplantation, as the use of animal organs in people is called. Basically, this whole field has been in the doldrums for 15 years, he says. Theres been kind of a few true believers that had it on life support. But I think this changes the game completely.Church believes the new work could revive the idea of xenotransplantation, as the use of animal organs in people is called. Basically, this whole field has been in the doldrums for 15 years, he says. Theres been kind of a few true believers that had it on life support. But I think this changes the game completely.That cells even survived having their DNA hacked up in 62 places is remarkable, says molecular biologist Jennifer Doudna of the University of California, Berkeley, one of the original developers of CRISPR.

Wyss Institute press release called this technique an explosive leap forward in CRISPR capability. It is definitely an advance in CRISPR-based techniques, but its potential yet to be tested in vivo experiments.

3. Advances in growing kidneys and intestinesAustralian scientists reported a technique for growing the most complete version of human kidney in vitro from iPS cells. From Nature commentary:

It is vital to emphasize that the result of this process is not a kidney, but an organoid. The structures fine-scale tissue organization is realistic, but it does not adopt the macro-scale organization of a whole kidney. For example, it is not plumbed into a waste drain, and it lacks large-scale features that are crucial for kidney function, such as a urine-concentrating medulla region containing mature forms of structures called loops of Henle and radially arranged collecting ducts. There is a long way to go until clinically useful transplantable kidneys can be engineered, but Takasato and colleagues protocol is a valuable step in the right direction.

The most advanced model of whole human intestine was recently reported by David Hackams group. The most important feature of their model is addition of normal micro-flora bacteria into the bioengineered organ:

Intestinal progenitor cells from mice or humans were cultured with myofibroblasts, macrophages and/or bacteria, and evaluated in mice via omental implantation. Mucosal regeneration was evaluated in dogs after rectal mucosectomy followed by scaffold implantation.

4. Immunogenicity of iPS cell derivatives determined by immune microenvironmentSome studies showed that auto- or syngenic cells, derived from iPS cells are immunogenic. New short study, published online in Stem Cells, confirms previous findings and explains this phenomenon by lack or abundance of dentritic cells in local tissue site where iPS cell-derived cells implanted:

While some studies conclude that certain cells derived from iPSCs are immunogenic in syngenic recipients when transplanted subcutaneously, one study has shown that various cells differentiated from iPSCs are not immunogenic when transplanted under kidney capsule. To resolve this critical issue on the safety of iPSCbased therapy, we now demonstrate that kidney capsule lacks functional dendritic cells (DCs) and thus prevents Tdependent immune responses to minor antigens expressed by iPSC derivatives.

5. Animal serum in MSC translationDemocratizing Cell Technologies blog posted a great piece on use and regulation of animal serum in clinical production of mesenchymal stromal cells (MSC):

While small-scale clinical studies can be conducted with a single batch of FBS, both supply chain and performance challenges increase when attempting to scale up production for large-scale clinical trials and commercial cell manufacturing. The ability to reserve large lots of batch-tested FBS is needed as hMSC-based therapies become commercialized.

6. Pricing of gene therapy drugsThe Signals blog has very interesting post on the first prescription of Glybera and on pricing of gene therapy drugs:

September 2015 has been an historic month for regenerative medicine. For the first time ever in the Western world, a prescription has been issued for a gene therapy, Glybera. At the ESGCT and FSGT Collaborative Congress, Helsinki, this news was welcomed and spurred discussion on broader challenges in the gene therapy field.When discussing gene therapies, the question Is it worth it? is often muttered. At such a high cost, can these products really be justified? Is it worth investing in what has proven historically to be a risky area? If there is a clear patient need addressed with appropriate business models, effective management, and exceptional science demonstrating clear, material results, this question will go away.

As gene therapy drugs are getting close to marketing approvals, a lot of discussions are happening on pricing. Id encourage you to discuss it on blogs or twitter!

7. Chinese company criticized for plans to market gene-modified petsLast week, Nature reported about plans of Chinese genomic sequencing giant BGI to market gene-edited micropigs as pets. The criticism of BGI plans in western world is getting bigger and bigger. From the Guardian:

But the idea has horrified animal welfare groups, and some scientists. The idea is completely unacceptable, Dr Penny Hawkins, head of the RSPCAs research animals department, told the Observer. In the past, pets have been bred by selecting animals, generation by generation, to produce a desired trait. Inducing a massive change in one go risks creating animals that suffer all sorts of horrific impairments.The RSPCA is concerned that the technique risks creating animals that may have long-term health and welfare problems that are difficult to predict. It is also worried that pet owners will not be able to properly care for or monitor the animals.

from LA Times:

Kenneth Bondioli, a professor of animal sciences at Louisiana State University, said BGIs gene-edited micro pigs would need to be evaluated to see if they develop healthily and to determine whether they would could harm the environment or other livestock if they were released or escaped. It is unclear whether BGI intends to offer its pigs for sale outside China, but if Americans wanted them, U.S. regulators would have to determine whether they could be imported.

If these and other questions are addressed, the fact that they are gene-edited is irrelevant, Bondioli said.

8. New methods and protocols:CUBIC protocols for whole-brain and whole-body clearing (Nature Protocols)Reprogramming via bacterial injection of defined transcription factors (Sci Reports)Human iPS cell-derived insulin producing cells form vascularized organoids (PLoS ONE)Generation of kidney organoids from human pluripotent stem cells (Protocol Exchange)Rapid assay of stem cell functionality and potency using electric cell-substrate impedance sensing (Stem Cell Res Ther)Reprogramming of mouse fibroblasts into iPSCs (Protocol Exchange)3D hydrogel scaffolds for articular chondrocyte culture (JoVE)Rapid generation of hepatocyte-like cells from adipose-derived stem cells (Stem Cell Res Ther)Isolation of mouse bone marrow-derived monocytes (Protocol Exchange)

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Cells Weekly October 11, 2015 - stemcellassays.com

One of the next big leaps in biomedical science and engineering is likely to come when more secrets are revealed about the workings of stem cells. Currently, stem cells investigation is growing fast and the outcomes have been very promising. Most cities in the United States including Pittsburgh are still in clinical trial phase, close to legally approved therapies.

Pittsburgh is the second largest city in Pennsylvania. Since the collapse of many industries, Pittsburgh has adapted its economy. The region has shifted to high technology, robotics, health care, nuclear engineering, tourism, biomedical technology, finance, education and services. Stem cells research is definitely part of the citys target points.

As some examples of how Pittsburgh is involved in the stem cells world, the University of Pittsburg has The Adipose Stem Cells Research Laboratory, which consists of 1200 square feet of space in the Biomedical Science Tower; directed by Kacey G. Marra, PhD. This laboratory conducts scientific investigation in multiple interdisciplinary areas. Novel biomaterials are being designed for soft tissue, skin and nerve regeneration. This laboratory isolates adult stem cells from human adipose tissue, and is exploring applications of these cells in soft tissue reconstruction.

On the other hand, the Center for Cellular and Molecular Engineering at the Pittsburgh University is employing adult mesenchymal stem cells from a variety of sources including bone marrow, trabecular bone, adipose tissue, umbilical cord and dental pulp to engineer a variety of tissues. The number and utility of the cells varies with the source. Adult mesenchymal stem cells are easily obtainable, have a broad capacity for stable differentiation, and contribute to wound healing and graft acceptance through their tropic and immunomodulatory effects.

Advancements in autologous stem cell treatment are giving patients from Norwin, Gladwyne, Fox Chapel, Sewickley Heights and Edgeworth the ability to fight back against diseases once thought untreatable. Stem Cells Transplant Institute in Costa Rica takes the most advanced and effective elements of Stem Cell Therapy and Regenerative Medicine, and combines them with the best environment to recover.Apply now.

The Stem Cells Transplant Institute of Costa Rica specializes in the legal treatment of Rheumatoid Arthritis, Diabetes, COPD, Knee Injury, Multiple Sclerosis, Lupus, Alzheimer, Cardiovascular Disease, Parkinson, Osteoarthritis, Erectile Dysfunction, Myocardial infarction, Neuropathy and Critical limb isquemia.Contact us.

Your journey to wellness begins here at Stem Cells Transplant Institute in Costa Rica, with a wide knowledge and understanding of adult stem cell therapy. At Stem Cell Transplant Institute in Costa Rica, we provide care for people suffering from diseases that may be alleviated by access to adult stem cell based regenerative treatment. Dont miss what you enjoy the most! Watch your favorite games of Pittsburgh Pirates, Pittsburgh Steelers and Pittsburgh Penguins with no pain!!!! Get more information about legally approved stem cell therapies now.

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Pittsburgh, Pennsylvania - Stem Cells Transplant Institute

Degenerative joint conditions and injuries causing constant pain is typically alleviated through invasive surgery. Wouldnt it be more convenient if there was a way to cure your ailments without the inconvenience of a major procedure? Advancements have helped us find a way to achieve this through specialized therapy, using stem cells and blood platelets from your own body.

Our breakthrough technique does not require going through surgery, and treatment is completed in a single day. Existing cells are harvested and then replaced back into the body to immediately begin treated your condition. Patients are left with a greater sense of comfort once their injuries have the opportunity to heal properly.

Nagging shoulder pain is typically caused by previous injuries that failed to heal properly. Doctors offer surgery, but it has a considerably low success rate of completely repairing the internal issues after enduring a lengthy recovery. Traditional surgery for the shoulder can be difficult because of the complexity of the joint, and it often requires a painful, lengthy rehabilitation process to restore the full range of motion.

Stem cell therapy for shoulders may be an ideal nonsurgical alternative for those who suffer from shoulder pain because of a rotator cuff injury or pain related to osteoarthritis, or muscle sprains and strains. Non-surgical stem cell treatment targets the damage and promotes regeneration without any inconvenient side effects.

Rotator Cuff Tears

AC Joint Separation

Arthritis of the shoulder joint

Labral tears / degeneration

Rotator Cuff Tendonitis

Recurrent Shoulder Dislocations

Mild to moderate osteoarthritis

Thoracic outlet syndrome

If you spent earlier years engaging in sports, its very likely that youll develop some degree of pain from the stress on your knees. Its easy to tear cartilage, injure a ligament, or feel the ache of arthritis even if you dont realize youve overworked yourself. Blood platelet treatments stimulate natural regeneration to help patients avoid invasive ligament repairs or joint replacements.

While cortisone and other drugs only provide temporary pain relief, stem cells actually restore degenerated tissue while providing pain relief. The growth factors in amniotic stem cells may replace damaged cells in your body. Additionally, stem cell injections contain hyaluronic acid, which lubricates joints and tendons, easing the pain and helping restore mobility.

Arthritis / Osteoarthritis

MCL, ACL, PCL, or LCL sprain or tear

Knee instability

Hamstrings Tendinopathy

Cartilage Damage

Patellar Tendonitis

Meniscus Tear

Pes Anserine Bursitis

There is no way to avoid the symptoms of hip pain once you have suffered from an injury to the joint or surrounding tendons. Hip pain can be very difficult to deal with on a day-to-day basis and traditionally requires long-term pain management if the problem is not corrected.

As a hip surgery alternative, stem cell therapy may help you to return to daily activities that were difficult before the treatment using a simple in-office injection procedure. Our approach works without surgery by amplifying the concentration of a persons own stem cells in the problem area, boosting the bodys ability to heal itself naturally. Our patients are typically encouraged to walk the same day, and most experience little to no down time from the procedure.

Avascular Necrosis

Osteonecrosis

Bursitis

Arthritis

Tendinopathy

Labral / labrum tear

Wrist and hand surgeries can be complicated and painful. Besides the risks and cost of the surgeries, a long rehabilitation is usually required. Many a times the functionality never completely returns after these surgeries. The main reason individuals experience torn ligaments and other injuries in their wrist area is the lack of cushion in such a compact spot. Everyday activities, such as typing, constantly add unnecessary strain that will eventually require treatment to alleviate. We recommend stem cell therapy to help your body naturally heal in a simple procedure.

Instability

Arthritis

Carpal Tunnel

Its never the wrong time to finally put a stop to your physical suffering with the help of our talented surgeons. Simply fill out the contact form so that we can determine if you are eligible for the non-surgical treatment we offer.

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Stem Cell Therapy in York County, Pennsylvania

Sometimes kids trip and fall, and their teeth take the hit. Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth, it can hinder blood supply and root development, resulting in what is essentially a dead tooth.

Until now, the standard of care has entailed a procedure called apexification that encourages further root development, but it does not replace the lost tissue from the injury and, even in a best-case scenario, causes root development to proceed abnormally.

New results of a clinical trial, jointly led by Songtao Shi of the University of Pennsylvania and Yan Jin, Kun Xuan, and Bei Li of the Fourth Military Medicine University in Xian, China, suggest that there is a more promising path for children with these types of injuries: using stem cells extracted from the patients baby teeth. The work was published in the journal Science Translational Medicine.

This treatment gives patients sensation back in their teeth. If you give them a warm or cold stimulation, they can feel it; they have living teeth again, says Shi, professor and chair in the Department of Anatomy and Cell Biology in Penns School of Dental Medicine. So far we have follow-up data for two, two and a half, even three years, and have shown its a safe and effective therapy.

Shi has been working for a decade to test the possibilities of dental stem cells after discovering them in his daughters baby tooth. He and colleagues have learned more about how these dental stem cells, officially called human deciduous pulp stem cells (hDPSC), work, and how they could be safely employed to regrow dental tissue, known as pulp.

The Phase 1trial was conducted in China, which has a research track for clinical trials.The 40 children enrolled had each injured one of their permanent incisors, and still had baby teeth. Thirty were assigned to hDPSC treatment and 10 to the control treatment, apexification.

Those whoreceived hDPSC treatment had tissue extracted from a healthy baby tooth. The stem cells from this pulp were allowed to reproduce in a laboratory culture, and the resulting cells were implanted into the injured tooth.

Upon follow-up, the researchers found that patients who received hDPSCs had more signs than the control group of healthy root development and thicker dentin, the hard part of a tooth beneath the enamel, as well as increased blood flow.

At the time the patients were initially seen, all had little sensation in the tissue of their injured teeth. A year following the procedure, only those who received hDPSCs had regained some sensation. Examining a variety of immune-system components, the team found no evidence of safety concerns.

As further support of the treatments efficacy, the researchers had the opportunity to directly examine the tissue of a treated tooth when the patient re-injured it, and had to have it extracted. They found that the implanted stem cells regenerated different components of dental pulp, including the cells that produce dentin, connective tissue, and blood vessels.

For me, the results are very exciting, Shi says. To see something we discovered take a step forward to potentially become a routine therapy in the clinic is gratifying.

It is, however, just a first step. While using a patients own stem cells reduces the chances of immune rejection, its not possible in adult patients who have lost all of their baby teeth. Shi and colleagues are beginning to test the use of allogenic stem cells, or cells donated from another person, to regenerate dental tissue in adults. They are also hoping to secure FDA approval to conduct clinical trials using hDPSCs in the United States.

Eventually, they see even broader applications of hDPSCs for treating systemic disease, such as lupus, which Shi has worked on before.

Were really eager to see what we can do in the dental field, Shi says, and then building on that to open up channels for systemic disease therapy.

The research was supported by the National Key Research and Development Program of China, the NaturalScience Foundation of China and a pilot grant from Penn Dental Medicine.

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Regrowing dental tissue with stem cells from baby teeth ...

The Institute for Regenerative Medicine at the University of Pennsylvania differs from many stem cell centers by bringing together talent and discoveries from medicine, bioengineering, veterinary sciences, and more. Together, we are working to understand the basis by which we can generate new cells and tissues for therapeutics, diagnostics, and research.

Ken Zaret, Ph.D.Director, Institute for Regenerative Medicine

The goal of the Institute for Regenerative Medicine (IRM) at UPenn is to create new cells and tissues for research, diagnostics, and organ repair and replacement therapies. To this end, the IRM enables diverse experts to come together for basic research in stem cell biology and tissue regeneration and translates our discoveries into new clinical therapies to alleviate suffering and disease.

The IRM at UPenn is distinct from other stem cell and regenerative medicine institutes around the world by engaging scientists, clinicians, and ethicists from medicine, engineering, veterinary sciences, dental medicine, a childrens hospital, and the arts and sciences. Together, IRM investigators use cutting-edge methods to understand how cells and tissues are formed in the natural processes of embryonic development and during the bodys ability to repair itself. We use the principles learned from the natural processes to generate new cells and tissue fragments in the laboratory and to control tissue regeneration in the body. Our work is aimed to model and study human diseases, to develop new diagnostics and medicines, and, ultimately, to replace damaged, aged, or diseased body parts.

The IRM sponsors annual Symposia with speakers from around the world, Distinguished Lecturers from leaders in the field, Stem Cell Club for trainees and faculty, Faculty Lunch meetings, specialty Program meetings, IRM Training Fellowships, and IRM Collaborative Research grants, all of which foster collaborative interactions among our outstanding faculty and trainees, along with diverse resources including a stem cell and tissue differentiation core facility. Our latest collaborative initiatives include support for high-throughput screenings to alter cell fate, single cell analyses of cell function, and optimizing conditions to control the differentiation of cells from stem cells.

The IRM also promotes extensive outreach to the community, teaching at all levels about the science behind stem cells and regenerative medicine and the promise of the field to the future of humankind.

We invite you to see what the IRM at UPenn has to offer, participate in our diverse activities, and support our work with your donations.

Welcome to the IRM!

Ken Zaret, Ph.D.Director, Institute for Regenerative Medicine

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About Penn's IRM - Institute for Regenerative Medicine

Stem Cell Treatment in Philadelphia, PA

To treat joint and musculoskeletal system injuries, or if you suffer from chronic conditions affecting the joints or bones, there are options other than surgery to treat the issues. At World Wellness Health Institute, Dr. Daniel Lebowitz uses stem cell therapy on people living in and around Bala Cynwyd and Philadelphia, PA, who have chronic conditions and are in need of advanced treatment to heal injuries and relieve pain associated with injuries, arthritis, and other conditions.

What is Stem Cell Therapy?

Stem cell therapy is a cutting-edge treatment used in orthopedic injuries and other chronic conditions that affect the musculoskeletal system, such as arthritis and neck, back and joint pain. It is now a consideration for treatment instead of surgery. With stem cell therapy, many patients regain full function of the treated area without a lengthy recovery period, unlike with surgery. This type of stem cell therapy is FDA approved and takes stem cells from the patients own adipose tissue. This tissue (fat tissue) is rich in stem cells, primarily mesenchymalstem cells.

Benefits of Stem Cell Treatment

Stem cell injections are used primarily to relieve pain in the joints as they provide the following benefits:

How Does Stem Cell Therapy Work?

With stem cell therapy, fat is harvested in a process called lipoaspiration. The targeted area is numbed with a local anesthetic, then a small needle just a tad larger than a hypodermic needle is injected into the skin to remove about 10 to 20ccs of adipose tissue (fat). Once the fat is removed, it is run through another process called sterile gravity method and combined with high-density PRP (platelet-rich plasma) and injected into the site where the pain occurs. Stem cells stimulate the healing process providing several functions. They can differentiate or even change into the type of cells needed, whether its a ligament, tendon, bone or cartilage, at the injection site to start healing. We prescribe oral anti-anxiety medicine and pain medicines that you can take prior to the procedure. If necessary, Dr. Lebowitz may use local anesthetic to numb the injection sites. You typically need only one treatment but, if necessary, a follow-up treatment may be performed several weeks later.

Stem Cell Therapy Preparation

Much of the preparation for stem cell therapy involves determining if the patient is a good candidate for this type of treatment. It is necessary to stop taking any medications and/or supplements that may thin the blood at least one week prior to the treatment, as well as avoid smoking.

Stem Cell Therapy Recovery

Stem cell therapy treatment is not a painful procedure, as oral pain relievers and local anesthetics are used to numb the treatment areas. It is okay to return to work immediately after the procedure, as well as participate in any activities. Most patients notice improvement after two weeks and continue to experience improvement over the next few months following the treatment.

How Much Does Stem Cell Therapy Cost?

Stem cell therapy is a relatively new procedure and varies in cost depending on the area to be treated, how many treatments may be required and if it is done at the same time another treatment is performed. We can discuss the cost with you during your consultation, in addition to going over our payment options. We do offer financing through CareCredit.

Is Stem Cell Therapy Right for Me?

If you suffer from osteoarthritis or an injury to the knee, back, neck or other joint, stem cell therapy may be right for you. Stem cell therapy is an alternative to invasive surgery when the injured area is not fully collapsed.

Stem Cell Therapy Consultation

During your consultation to determine if you are a candidate for stem cell therapy, it is necessary for Dr. Lebowitz to examine and evaluate the area of your pain, as well as determine the root cause of the pain. Additionally, he will go over your current health, medical history, and lifestyle in terms of diet, exercise, and more. If you have any questions, he answers them in detail so that you fully understand the treatment plan.

If you are experiencing pain in any joint or other part of the musculoskeletal system as a result of an injury or chronic health condition, stem cell therapy offered at World Wellness Health Institute may be the solution. Dr. Daniel Lebowitz offers several treatments for musculoskeletal therapy to residents in Bala Cynwyd, Philadelphia and the surrounding areas of Pennsylvania. Contact ustoday!

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Stem Cell Treatment - Philadelphia Bala Cynwyd, PA: World ...

The painful joint conditions controlling the lives of individuals only become worse as time goes by without professional treatment. Patients may choose to live with the discomfort in order to avoid the time wasted rehabilitating after surgery. It would be more suitable to have an option that provides results without sacrificing months of life that could be spent productively. Luckily, our doctors now offer stem cell therapy solutions to patients that want a cure without the risk of failure.

Treatment includes a non-surgical liposuction of the stem cells so that they can be immediately taken into the lab for activation. Harvested cells are then injected into the damaged area to conclude the process in only one day.

Enjoying a normal life isnt easy if you experience pain anytime you move your shoulder joint. The results of corrective shoulder surgery require months of recovery, and there is a good chance that it will prove to be unsuccessful in curing the pain. Our solution to avoiding unnecessary downtime after an unreliable surgery is to let us perform non-surgical stem cell treatment instead.

Rotator Cuff Tears

AC Joint Separation

Arthritis of the shoulder joint

Labral tears / degeneration

Rotator Cuff Tendonitis

Recurrent Shoulder Dislocations

Mild to moderate osteoarthritis

Thoracic outlet syndrome

Its not uncommon for a person to cause wear or an injury to their knee when engaging in physical activity. One wrong movement can cause a dislocation or damage that may not result in serious side effects until many years have passed. Fortunately, blood platelet treatments are regenerative option provided by our doctors for individuals suffering from the side effects of damage or the onset of a joint condition.

Arthritis / Osteoarthritis

MCL, ACL, PCL, or LCL sprain or tear

Knee instability

Hamstrings Tendinopathy

Cartilage Damage

Patellar Tendonitis

Meniscus Tear

Pes Anserine Bursitis

Once a painful condition has started to cause discomfort in one or both of the hips, the damage is going to require treatment. A full hip replacement is an aggressive surgery that entails a fairly difficult recovery with months of downtime. If youve been dealing with the constant discomfort because you do not want to deal with the invasive options, stem cell treatment may be the cure youre looking for.

Avascular Necrosis

Osteonecrosis

Bursitis

Arthritis

Tendinopathy

Labral / labrum tear

The tiny, fragile bones compressed in the wrist are highly susceptible to injury from the slightest impact. Corrective wrist surgery to properly heal damage or remedy the pain of degenerative conditions is not only risky, it requires a significant amount of downtime and rehabilitation to regain strength. A better solution to cure any wrist-related ailments is gentle stem cell therapy.

Instability

Arthritis

Carpal Tunnel

We hope that you decide its time to put an end to your suffering so that you can get back to enjoying a normal life with your family. If you would like to schedule an evaluation, provide your information through our contact form so that we can get in touch.

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Stem Cell Therapy in Conewago Township, Pennsylvania

Stem Cell Biology

September 25 - 29, 2017

Abstract Deadline: July 28, 2017

Organizers:

The meeting will focus on the basic biology of stem cells and the dynamic interactions between stem cells and their microenvironment or niche. Topics will include the mechanisms controlling stem cell proliferation, differentiation, pluripotency and reprogramming. Emerging concepts about the regulation of multipotent cells during early embryo development, tissue regeneration and tumor progression will be emphasized.

Topics:

Keynote Speaker:

Irving Weissman, Stanford University

Confirmed Discussion Leaders:

Salvador Aznar Benitah, Institute for Research in Biomedicine, SpainKristin Baldwin, The Scripps Research InstitutePhilip Beachy, Stanford UniversityHongkui Deng, Peking University, ChinaGiacomo Donati, University of Turin, ItalyValentina Greco, Yale University School of MedicineKonrad Hochedlinger, Harvard Medical SchoolBrigid Hogan, Duke University Medical CenterMeritxell Huch, University of Cambridge, UKAllon Klein, Harvard Medical SchoolChris Lengner, University of PennsylvaniaSally Lowell, MRC Centre for Regenerative Medicine, UKEmmanuelle Passegue, Columbia University Medical CenterKathrin Plath, University of California, Los AngelesJayaraj Rajagopal, Massachusetts General HospitalKristy Red-Horse, Stanford UniversityHongjun Song, Johns Hopkins UniversityBen Stanger, University of Pennsylvania, Perelman School of MedicineKiku Tachibana-Konwalski, IMBA/Institute of Molecular Biotechnology, AustriaMagdalena Zernicka-Goetz, University of Cambridge, UKYi Zhang, Harvard Medical School

Please bring this notice to the attention of any of your colleagues who may be interested in participating in the meeting.

All abstracts must be submitted by the abstract deadline. Late registrations may be accepted after the abstract deadline if the meeting is not oversubscribed. In the event of over-subscription, every effort will be made to ensure that all groups who wish to participate will be represented. The status (talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Please apply in writing via email to Maureen Morrow and state your financial needs; preference will be given to those who submit abstracts.

Social MediaThe designated hashtag for this meeting is #cshlstemcell. Note that you must obtain permission from an individual presenter before live-tweeting or discussing his/her talk, poster, or research results on social media. Click the Policies tab above to see our full Confidentiality & Reporting Policy.

We look forward to seeing you at Cold Spring Harbor in September.

Pricing:Academic Package $1,455Graduate/PhD Student Package $1,210Corporate Package $1,865Academic/Student No-Housing Package $985Corporate No-Housing Package $1,250

Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.

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