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Category Archives: Michigan Stem Cells

BREAKING: A woman gives birth to the Son of God (Part II) – INQUIRER.net

Posted: January 5, 2020 at 3:48 am

Really? Mary is the Mother of God,Theotokos, Mater Dei, Ina ng Diyos?

When YHWH God finally decided that the Second Person of the Blessed Trinity would assume the human nature (the Incarnation) to save humankind, He chose Mary, 16, a maiden from Nazareth, daughter of Joachim and Anne, as the best person for the most unique role of the Mother of God. As St. Paul captures in one line: When the fullness of time came, God sent His Son, born of a woman, born a subject of the Law (Galatians 4:4).

I begin to suspect, if I may, that the Law mentioned by St. Paul refers not only to the Jewish Law but also to the law of nature, particularly the natural law of human pregnancy and birth. It includes Marys uterus, the placenta shared by both mother and Child, and the umbilical cord of the prenatal Jesus. The Second Person of the Blessed Trinity who can scan the heights of the heavens and the width of the universe obeyed the biological process and stayed in Marys womb for nine solid months from March 25 to December 25.

Lets focus at the placenta for a moment, and discuss three motives that make it so remarkable.

First, YHWH God, the Creator of the universe, so designs that the placenta is the only organ in human biology that is made by two persons, together, in a remarkable cooperation at the stem-cellular level.

Second, as a vital feto-maternal organ, the placenta is partly of the mother and partly of the growing baby. The placenta, according to the Human Placenta Project (HPP) of the US-based National Institutes of Health, influences not just the health of a woman and her fetus during pregnancy, but also the lifelong health of both mother and child.

And third, somenaturally acquired pregnancy-associated progenitor cells(PAPCs) of the prenatal child migrate into the mother and integrate into her body and some cells from the mother migrate into the prenatal child, and suchtransplacental trafficking of stem cells happens infeto-maternal microchimerism.

When the advances in prenatal imaging and the field of immunology is applied to Marys pregnancy, Christians all over the world now pay attention to how Marys maternal organs through which she and her prenatal Child interfaced in the most astonishing sync of integration known asfeto-maternal microchimerism. It is most astonishing in five ways.

First, Dr. Kristin Marguerite Collier, Assistant Professor of Internal Medicine at the University of Michigan Medical School, said that Jesus Christ (True God) redeemed every stage and aspect of human pregnancy and birth, a natural process through which He has developed as a human person (True Man).

Second, and the Word became Flesh (John 1:14) happened in Marys uterus on a specific day in human, nine months before the birth of Christ some 2,000 years ago. And because Mary is a bona fide member of human species, the Word became Flesh makes every mothers uterus a sacred space.

Third, infeto-maternal microchimerism, we can infer that some of Jesus cells transferred across the placenta into the Blessed Mother.

Fourth, I should mention the deduction made by the Redemptorist Founder and Saint Alphonsus de Liguori, CSsR (16961787):Caro Jesu caro Mariae est.It means the flesh of Jesus is the flesh of Mary one hundred percent because Jesus was conceived by the Holy Spirit in the uterus of the Virgin who knew no man.

Finally, even after His Virgin Birth, when Jesus physically left His Mothers womb, part of Him remained in her and remains in her forever. It means that, after birth (a very Merry Christmas to all!), Mary kept a pregnancy souvenir, just like all mothers, consisting of stem cells that are not her own. Hence, like Jesus, YHWH God didnt allow Marys body to suffer corruption of the body but both her body and soul were assumed into heaven at the end of her earthly life.

Why do I love thee, Mary, the Mother of my Lord? Let me count the ways. On the first day of the New Year, I salute thee in the words of the Archangel Gabriel: Hail Mary, full of grace, the Lord is with you. Blessed are you among women and blessed is the fruit of your womb, Jesus. We declare our belief in her divine maternity as we say Holy Mary, Mother of God (Luke 1:26-38).

O Maria, Ina ng Diyos(THEOTOKOS), ipanalangin mo kaming makasalananNgayon at kung kamiy mamamatay (pray for us sinners, now and at the hour of our death).Amen!

Jose Mario Bautista Maximiano (facebook.com/josemario.maximiano) is the author of MDXXI (1521): Ecclesia semper purificanda (Claretian, 2020) and 24 PLUS CONTEMPORARY PEOPLE: God Writing Straight with Twists and Turns (Claretian, 2019).

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BREAKING: A woman gives birth to the Son of God (Part II) - INQUIRER.net

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Collaborative Robots: Rai… – Robotics Online

Posted: December 19, 2019 at 2:47 am

by Tanya M. Anandan, Contributing Editor Robotic Industries Association Posted 12/16/2019

Collaborative robotics is more than one kind of robot. It often involves a human working alongside a robot, and the collaborative robot (or cobot) is usually fenceless, but not always. They can have one arm, two arms, or none at all. They can be mobile or portable, small or large. They can work alone or as a fleet. Even standard industrial robots are fair game, thanks to innovations like FreeMove.

Last month we set out to broaden your view of human-robot interaction and collaboration. Were back to do it again. Well show how robots tackle labor shortages, reduce costs and optimize floor space. How they elevate the jobs humans do while improving process efficiency.

From making floral bouquets to inspecting bumpers, and bagging this seasons hottest tech toys, cobots are transforming the human-robot paradigm and knocking down barriers on the shop floor, between entire industries, and on a global scale.

Bumper-to-Bumper CobotsTier 1 automotive supplier Flex-N-Gate Corporation puts collaborative robots to work on the assembly line inspecting bumpers and other fascia components. These camera-wielding cobots use machine vision to inspect assembled components for proper orientation and installation. The robots work alongside their human coworkers without safety cages or other hard guarding to separate man from machine.

The Urbana, Illinois-based company supplies bumpers, exterior trim, lighting, chassis assemblies, and other automotive products. At the suppliers Ionia, Michigan facility, they stamp and assemble steel bumpers for the Ford Ranger pickup truck, among other vehicle platforms. Here, cobots inspect parts in two different assembly areas.

We supply a full bumper assembly module delivered directly to assembly plants, explains Nick Wiegand, Director of Advanced Manufacturing Global Metals and Assembly Group at Flex-N-Gate. We fabricate the steel shells via a progressive stamping process. The steel shells are then either painted, or chrome plated, or in some cases powder coated. Then we have other components that have to be affixed to the bumper, including internal structural components, fasteners, air dams, fog lamps, bezels, front parking assist (FPA) sensors, rear parking assist (RPA) sensors, blind-spot warning (BSW) sensors, integrated wiring harnesses, active air dams/grille shutters, and myriad other plastic and composite finishing accessories.

The amount of electronics that go into a bumper assembly these days is mind-boggling, says Wiegand. Were utilizing camera-carrying cobots in our assembly processes to ensure we have the right color/style combinations, and that all the requisite components based on the part recipe are present and installed correctly.

In one area of the shop floor, workers load a steel bumper onto a fixture in front of a green cobot arm. The FANUC CR-7 collaborative robot outfitted with a Cognex camera and integrated lighting swoops across the part inspecting and error-proofing assembled components. While the robot does its job, the operator can be tending to other areas of the assembly module.

On the moving assembly line, inverted FANUC cobots mounted just above the line workers heads maneuver at different angles, examining parts as they advance down the line. Watch Flex-N-Gates camera-wielding cobots at work.

Our biggest challenge was programming the cobots for line tracking, says Wiegand. Flex-N-Gate was the first in the industry to attempt this feat. We worked with the robot supplier and system integrator to solve issues as they arose.

Cost SavingsAutomated inspection has evolved at Flex-N-Gate. Traditionally, error proofing was done with a bank of overhead cameras, but this approach had its limitations. Fixed cameras made it difficult to see parts at optimal angles for the vision systems to read accurately and repeatedly. Company engineers had a better idea.

Why dont we put a camera at the end of a robot arm and take the camera to the inspection instead? says Wiegand. That was phase one in our evolution.

They mounted a camera on a conventional robot arm. Now they were able to position the camera in ideal locations for inspection and view aspects of parts they couldnt see before. Now they only had one camera to maintain instead of up to a dozen fixed cameras.

Wiegand says some of these cameras can range from $10,000 to $15,000 a piece, so the savings were significant. The next phase in their evolution deploying cobots would further reduce costs.

Space SavingsFlex-N-Gate was performing vision inspection with conventional high-speed, low-payload robots for about a year. Meanwhile, collaborative power and force limiting robots were garnering more attention as their applications grew, setting the stage for the suppliers transition to inspection with collaborative robots.

We were doing this with traditional robots, which required them to be caged and guarded per the RIA safety standards, just like you would any other industrial robot, says Wiegand. Were now able to do the exact same thing with collaborative robots and eliminate all of the guarding and a majority of the safety-related hardware costs. Now an operator can actually work beside the robot in that same station, enabling human work and robotic vision inspection simultaneously.

This collaborative robot cell not only saves costs associated with guarding and required safety devices and interlocks, but it also saves the floor space often required for fenced robot cells.

Inverted collaborative robots inspect automotive components alongside assembly line workers without requiring hard safety fencing. (Courtesy FANUC America Corporation)

Safety FirstThere are different ways to achieve a collaborative robotics application, as explained in Testing Thresholds for Collaborative Robot Safety and evidenced on the bumper assembly line. Besides the inherently collaborative nature of power and force limiting robots, Flex-N-Gate uses an area laser scanner in conjunction with their cobots to further support safety while optimizing production efficiency.

In order for it to be a collaborative application, were limited to a maximum collaborative speed for safety reasons, says Wiegand. In some cases that can be problematic, because were unable to get all the work completed in time with the slower robot travel speeds. In some cases, weve used a safety scanner so that when an operator is not in the area, the robot can run at full speed. When humans come near the robot, it slows down to a safe collaborative speed. The operator can simply touch the robot and it stops.

You can physically just push them out of the way, too. When you restart the robots, they go right back to where they were and carry on with their jobs, he adds.

Wiegand says safety is number one at Flex-N-Gate.

We dot our Is and cross our Ts to ensure that we are in fact integrating these units per the RIA standards and that we are 100 percent safe, he says. We also go a step further and require third-party safety certification.

Proper training for personnel working with and around the new collaborative robots was also a priority.

Traditional robotic safety and avoidance of human-robot interaction is so engrained in our workforce, says Wiegand. Our technicians were sent for collaborative robot-specific training (provided by the robot supplier) and we did safety demonstrations with the plant personnel and operators. It was a bit of a paradigm shift, but it didnt take long for team members to become comfortable working around the collaborative robots.

Ive spent my entire career in automation and robotics, he says. Robots and people occupying the same space has always been a huge no-no. Its cool to see how getting over that hump was surprisingly easy. A lot of it boils down to physically demonstrating that it is, in fact, safe. Showing people something, versus telling them, has a different impact.

Flex-N-Gate has deployed 33 collaborative robots at different facilities throughout the U.S. and Mexico. Worldwide they have approximately 2,000 traditional robots across 62 facilities.

In the last year, weve really gone hard and heavy in the collaborative space, says Wiegand, noting that right now, they primarily use the cobots for vision inspection. As more opportunities present themselves, well continue to look at collaborative robots as a potential solution.

On the West Coast, a different manufacturer was looking to cobots as a potential solution for labor shortages. A robot integrator came to the rescue with two sets of collaborative arms.

Cobot Twins Curb Labor WoesPromotional products supplier iClick had a problem. Their popular PopSockets grips for mobile phones were flying off the shelves, but the Seattle-based company couldnt hire enough workers to keep up with demand. Kitting and bagging product was a tedious job.

Workers were manually attaching the grips to promotional cards and then feeding them one at a time to an automated bagging machine, a labor-intensive process. Even with a crew of four, the workers couldnt keep up with the bagging machine to maximize capacity. Labor continued to be difficult to find and retain.

In an effort to move workers to higher-value jobs, iClick sought out robot integrator House of Design to offer a collaborative robot solution. The FlexBagger system was born.

The robotic kitting and bagging system consists of two ABB YuMi dual-arm collaborative robots. In a carefully choreographed dance of their seven-axis arms, each robot attaches PopSockets to promotional cards and then drops them into the automated bagging machine.

Watch the cobot twins take turns bagging branded PopSockets.

Since each robot must occupy the same space as they deposit assembled items in the bagging area, the timing of the arms needs to be coordinated to avoid collisions. House of Design used ABB RobotStudio to program the robot workstation and ensure smooth movements of its kinematically redundant arms.

Flexible Kitting and BaggingChad Svedin, Project Manager for House of Design in Nampa, Idaho, says the manual bagging process was painstaking. Human workers werent able to put the product in the bags fast enough. With two dual-arm robots working in concert, they can perform the work of four people and keep the automated bagger fully stocked.

Launched in February 2018, this was iClicks first foray into robotics. It was so successful that less than a year later, they ordered another FlexBagger system.

House of Design markets the FlexBagger for other kitting and bagging applications. The YuMi cobot is equipped to grab various small items such as screws, nuts or washers and assemble them in bags. Check out this demo with different sizes and colors of interlocking toy bricks.

Like other power and force limiting cobots, YuMi has special characteristics to help it work collaboratively in close proximity or directly with its human coworkers. It was important to iClick to have a collaborative robot so its workforce could easily enter the robots operating space to remove defective items or replenish products when necessary. The dark gray areas on YuMis arms are padded for safety in the event of contact.

If someone juts their hand into the working system, it bumps into them and freezes in its spot, notes Svedin. A minor bump will stop it from moving.

House of Design trained iClick personnel on safety, and how to run and program the robots.

They loved that the robots looked very humanlike and that they could approach it, says Svedin. It wasnt this thing in a box away from them. They saw it as a part of their crew.

Cobots are part of the crew in unexpected places. Manufacturing isnt the only sector with labor woes. The floral industry is on the verge of a labor crisis and looking to automation for solutions.

Roses and RobotsVisitors to the Automate Show last April may have caught a glimpse of a cobot arranging small bouquets of roses, or you may have even taken home a souvenir bouquet. Some of us skipped the buds for the backstory.

FloraBot is the brainchild of Founder and CEO Alex Frost, a second-generation florist who grew up in his parents retail flower business. For the past dozen years, his Fort Lauderdale, Florida-based software company, QuickFlora, has been providing cloud-based ERP systems for floral retailers.

We work with a lot of retailers in the U.S. and Canada helping them manage their software technology frontend and backend systems. We have a front-row seat to some of their challenges. Over the last 5 to 10 years, there have been fewer and fewer people going into the flower business, so its hard to find qualified floral designers to work in flower shops.

He says you compound that with increasing minimum wage rates in many places such as California, and you have a real labor shortage in the floral industry. Its an environment he thinks is ripe for collaborative robots.

We see them flipping hamburgers, making pancakes and serving coffee. We decided last year, lets bring one of these machines in here and see what it can actually do, says Frost. Can we program it to make flower arrangements? Can we create a turnkey cell for end users?

If you think of Kroger, they have 4,000 stores across the country (marketed under different supermarket brands). Each store needs about 10 to 30 arrangements every day, he says. Those are all made by hand right now. Usually, you have 50 to100 people in a cooler set at 34 degrees. The process is very labor-intensive and you cant scale it. When Valentines Day or Mothers Day comes around and volume increases 5 or 10 times, you cant just hire 5 or 10 times the people that fast when you dont have space. Theres a labor shortage issue, a labor cost issue, and a scalability issue.

Automating Floral DesignFrost sees an emerging market, not only in North America but worldwide. In fact, most of his inquiries come from Western Europe, because labor costs are higher and the European market tends to be more receptive to adopting automation technologies. He notes the evolving niche for precision agriculture, which we examined in Cultivating Robotics and AI for Sustainable Agriculture, where startups and established companies are adapting collaborative robotics for farming.

We sort of fit into that category because were dealing with product that is very sensitive, not heavy, that requires specialized grippers, force control, and vision systems to actually make it work, says Frost. There are a lot of similarities between our technology and that technology in terms of trying to handle delicate flower stems of all shapes and sizes, and then pick and place them into specific xyz coordinates with reasonable cycle time and low defect rate.

He was skeptical himself at first. But as their research and product testing progressed over the last year, he became a believer. They decided to start with a Universal Robots collaborative robot because of their relative ease of use and ease of programming. They have a built-in ecosystem of compatible hardware makers and apps. Theyre also easily portable.

The current FloraBot system uses a UR5 cobot with a Robotiq Hand-E gripper. Previous testing was conducted with grippers from Ubiros and Soft Robotics. Frost says the gripper system has been a big part of the learning process.

What we realized is that nothing worked off the shelf. Absolutely nothing. We had to come up with our own proprietary fingers. Now were working on our own proprietary servo-electric gripper. It will give our end users more flexibility.

Check out this early iteration of the FloraBot system in action on the trade show floor.

Turnkey and Travel-ReadyWhile patents are still pending, FloraBot wont release shots of the near production-ready system. They are currently pilot testing at one company in Miami. They plan to start shipping units in January 2020 right after their official launch at the Consumer Electronics Show (CES).

Frost says the system can assemble AIFD-quality floral arrangements at 100-200 units per hour, 24/7, and with an ROI in less than a year. Right now they plan to sell the system, but eventually, he expects to move to a RaaS model. That way flower companies and growers will be able to try it without making a CapEx investment.

FloraBot supposedly excels at small arrangements about 12 cubic inches. But when you get into larger arrangements like a dozen long-stem roses in a vase, it requires a different kind of gripper. Thats where FloraBot will have to turn to proprietary grippers of their own.

Frost is envisioning a turnkey system they can ship on a 48 in. x 48 in. pallet, basically one robot cell that can do specific tasks within an assembly line. For example, to create an arrangement you may need six cells on the line. One robot that cuts the foam for the container, one that hydrates the foam, one that picks/places the foliage, then one that picks/places the flowers, one that sleeves the arrangement, and another that puts it in the box.

Right now, we see that the machines are capable of doing 75 percent of what humans do in the floral business, whether its a typical flower shop or the mass market, says Frost. Thats really the sweet spot for this technology, the mass market because they crank out high volumes (2000-3000 bouquets) of the same type of arrangements on a daily basis. There will always be a market for people that want something custom. But the reality is most retail florists make the same arrangements week in and week out.

FloraBot has been approached by companies that put flower arrangements in boxes and ship them around the world. There are a lot of new, innovative players in the flower business. Frost says most of the new upstarts are the most receptive to automation.

Weve had requests to do Hawaiian flower leis, which is a very labor-intensive process. Others want us to make different animals covered with roses, which is popular in many countries. Thats also very labor-intensive because you have to cut out a foam model of a little French poodle and then put 600 roses on it. That usually takes 4 to 8 hours. There are definitely cases where machines will take over in terms of production capability.

You might not know that it was created by a robot and you might not care, says Frost. If the customer gets a beautiful flower arrangement that has 12 to 24 stems, the color palette is wonderful and its at their price point, theyre going to be happy. At the end of the day, its about delivering the most value for the customer.

In June, FloraBot exhibited at the International Floriculture Expo (IFE) in Miami, touted as the largest B2B floral event in North America. Frost was astounded by the interest.

Everyone at the flower show, big growers and bouquet makers, came over to the booth and asked how they could use the robot to cut their payroll. No one asked or cared about the technology, or whether it worked or not. It just came down to cost and ROI. CFOs came over. I never had so many C-suite-level people engage in serious discussions at a show. That really tells us were on the right path.

FloraBot recently beat a path all the way to Boston, where they opened a new office at MassRobotics, one of the major robotics clusters. It will be interesting to see what comes next.

Five years from now there will be no humans making flower arrangements, says Frost, because when you see labor savings in the range of 50 to 75 percent, it just doesnt make economic sense anymore.

From rosebuds to electrical connectors, cobots are popping up in industries far and wide.

Mobile Production AssistantCollaborative robots also come in mobile varieties, including this mobile manipulator that integrates an autonomous mobile platform with a six-axis articulating arm. Stubli Electrical Connectors relies on the HelMo mobile robot system from Stubli Robotics to help supplement production during peak demand or during human workforce shortages due to illness or other unforeseen absences.

Once trained, HelMo can handle almost any manual job on the various assembly lines at the connector manufacturers facility in Allschwil, Switzerland. The production assistant navigates to its own workstation, decelerates or stops when human coworkers come too close, and then automatically resumes its operation when the protected workspace is clear.

As soon as HelMo arrives at its workstation, the cobot precisely positions itself within a tenth of a millimeter by referencing three permanent orientation points at the workstation. HelMo then connects itself via a multi-coupling to the fixed supply sockets for electricity and compressed air, then starts its shift.

The mobile cobot is also equipped with an automatic tool change system. One day it could be working with connector housings and contact pins. The next day might be some other stage in the assembly process, wherever its needed.

Integrated atop the mobile platform is a standard Stubli TX2-90L robot with a 15 kg payload and 1,200 mm reach. Watch the HelMo mobile robot system autonomously load rotary tables for manufacturing pneumatic couplings, and later in the footage safely navigate around human coworkers and other equipment in the production space.

The flexible production assistant monitors its environment with three integrated laser scanners. HelMo can perform its tasks automatically or in collaboration with humans.

Material Transport CobotsIn Japan, a fleet of mobile robots collaborates with humans. OMRONs FA sensor manufacturing facility in Ayabe wanted to upgrade its material transport system with a fully automated solution for transporting work-in-progress (WIP) components throughout the factory.

Ayabe is both a production facility and a development facility. In addition to producing OMRON technologies for customers, it also serves as an environment for testing and optimizing new products, including the OMRON LD mobile robot. Moving away from cumbersome conveyor belts that are difficult to rearrange, the engineering team opted for this flexible mobile solution where robots autonomously navigate their way through dynamic environments.

Each LD mobile robot gets its configuration data from the Enterprise Manager, which helps optimize traffic flow by sharing each robots position and trajectory with other robots in its vicinity. This allows each mobile robot to make path adjustments on the fly to avoid people, obstacles and other robots in its path.

The Enterprise Manager allows operators to manage map and configuration updates from a central communication point. These updates are then pushed to each mobile robot in the fleet. The Enterprise Manager also provides a queuing manager to receive job requests from call buttons and automation equipment, and then dispatch jobs to the mobile robots.

In the Ayabe factory, the mobile robots carry product containers between the assembly, final inspection and shipment stations. Since the mobile robot system is connected with the manufacturing engineering system (MES), transportation orders through the MES are conducted according to the work in progress. Watch Ayabes mobile robot fleet in action.

To make transportation more efficient, each LD mobile robot has two lifts, one on the front and one on the back, which makes it possible to carry materials to two destinations in a single trip.

We were able to automate 75 percent of all material transport tasks using these mobile robots, says OMRONs Assistant Manager Makoto Kasuya. People used to move containers in batches, but now robots can move them more frequently. As a result, the lead time needed to transport material has decreased by 80 percent on average.

The overall solution also reduces the expense and effort required for future investments, as LD mobile robots can be easily implemented in other factories without incurring new design costs.

Using its workforce for higher-value tasks instead of moving around products and materials will help Japans manufacturing sector address a growing labor shortage crisis as the countrys population continues its rapid decline. Workers at OMRONs Kusatsu factory used to manually transport up to 300 containers per day. Now the LD mobile fleet does what robots do best, enabling the people to focus on more creative work.

Creativity is still the human element. We need inspiration, ingenuity and vision, the kind that dreams up unique floral designs, innovative tech toys, and adds new functionality and value to age-old automotive components. Robots push us to be better.

RIA Members featured in this article:ABB RoboticsFANUC America CorporationOMRON AutomationStubli North America

Originally published by RIA via http://www.robotics.org on 12/16/2019

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Collaborative Robots: Rai... - Robotics Online

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VetStem Biopharma Shares the Success Story of Jesse Who was Treated with VetStem Cell Therapy – PR Web

Posted: December 8, 2019 at 3:44 pm

Jesse and Diane

POWAY, Calif. (PRWEB) December 03, 2019

Bold Brahim aka Jesse, a Spanish Arabian, was 11 years old when he suddenly went non-weightbearing lame on his right front leg. After several weeks of medical management, his condition worsened so his owner, Diane, sought a bone scan and MRI with Dr. Mark Martinelli of California Equine Orthopedics. Results revealed Jesse had a severe injury to his deep digital flexor tendon in his right front hoof capsule. Due to the severity of the injury, Dr. Martinelli recommended treatment with VetStem Cell Therapy and also referred Jesse to Dr. Sylvia Ouellette who specializes in equine lameness diagnosis and treatment.

Diane started an extensive rehabilitation plan laid out by Dr. Ouellette. The initial projection was that Jesses tendon would require a minimum of 15-18 months of diligent rehabilitation if it stood any chance of healing. At the same time, both veterinarians continued to recommend Jesse receive VetStem Cell Therapy to improve his chances of success. After researching the treatment and having a setback in the rehab, Diane agreed to move forward with stem cell therapy.

Dr. Ouellette collected fat from Jesses tailhead in a minimally invasive surgical procedure. The fat was packaged and shipped overnight to the VetStem laboratory in Poway, California. Once received, VetStem laboratory technicians processed the fat to extract Jesses stem and regenerative cells and created an injectable stem cell dose. Jesses stem cell injection was prepared for Dr. Martinelli who received and injected the cells within 48 hours of the initial collection. Jesse received one injection into his injured tendon.

Jesse and Dianes journey was not over yet, however. Jesse continued a rigorous rehabilitation schedule and experienced a few setbacks after which his improving lameness regressed. It was two years after his initial injury when Diane finally received the good news that Jesse was sound.

In a recent update from Diane, she reported that Jesse is now 24 years old and his tendon has remained sound. She stated, Though he has other age-related health issues, the deep flexor tendon has stayed strong and has served him well all of these years.

Stem cells are regenerative cells that can differentiate into many tissue types, reduce pain and inflammation, help to restore range of motion, and stimulate regeneration of tendon, ligament and joint tissues. In a clinical case series using VetStem Regenerative Cell Therapy in horses with tendon and ligament and joint injuries, it was found that VetStem Regenerative Cell Therapy helped these horses to return to full work or to the activity level that the owner desired.

About Mark Martinelli, DVM, PhD, DACVS, DACVSMRDr. Martinelli received his DVM from Michigan State University. He completed a surgical residency at the University of Illinois and then moved to Scotland where he lectured in equine surgery while completing a PhD in joint disease. He received his Diplomate status with the American College of Veterinary Surgeons in 1998. Dr. Martinelli owns California Equine Orthopedics where he specializes in the diagnosis and medical or surgical treatment of sports medicine issues of the equine athlete.

About Sylvia Ouellette, DVM, DABVPDr. Ouellette received her DVM from the University of California at Davis in 1995. She currently practices in Oregon at Oakhurst Equine Veterinary Services. In 2005 Dr. Ouellette became board certified as an equine specialist with the American Board of Veterinary Practitioners. She specializes in lameness in the sport horse.

About VetStem Biopharma, Inc.VetStem Biopharma is a veterinarian-led Company that was formed in 2002 to bring regenerative medicine to the profession. This privately held biopharmaceutical enterprise, based near San Diego, California, currently offers veterinarians an autologous stem cell processing service (from patients own fat tissue) among other regenerative modalities. With a unique expertise acquired over the past 15 years and 17,000 treatments by veterinarians for joint, tendon or ligament issues, VetStem has made regenerative medicine applications a therapeutic reality. The VetStem team is focused on developing new clinically practical and affordable veterinary solutions that leverage the natural restorative abilities present in all living creatures. In addition to its own portfolio of patents, VetStem holds exclusive global veterinary licenses to a large portfolio of issued patents in the field of regenerative medicine.

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Stem Cell Therapy Michigan | Regenerative Medicine 248-216 …

Posted: February 27, 2019 at 11:42 am

Perhaps you have been intrigued about stem cell therapy. How can this natural powerhouse of healing potential help with your chronic pain? Did you know that your own stem cells can actually heal your own injuries? Its all true. You can learn more at The Michigan Center for Regenerative Medicine, where we specialize in stem cell therapy in Michigan.

As a leader in these advancements in the local community, we see more and more patients looking outside traditional treatments like surgery and pain medicine to address their chronic orthopedic and musculoskeletal conditions. Theyve become fed up with the medical communitys insistence that their painful condition can only be managed with Band-Aid fixes such as cortisone shots, medications and invasive surgery.

In order to get relief from pain and avoid addictive medications for your chronic pain or progressive disease, there is a safer, more effective and more affordable alternative. It is called stem cell therapy in Michigan. This is a virtually painless, straightforward process that involves injecting the cells right at the injury site to harness the most benefit.

Focusing on bone marrow aspiration procedures because those cells work best for the types of conditions we treat, The Michigan Center for Regenerative Medicine does all it can to remain in compliance with the FDA, which restricts techniques aimed at isolating fat cells. Thats why we work with bone marrow rather than fat, which also happens to have stem cells in it.

Essentially, stem cells from your own body can be used to heal your own injuries, ranging from plantar fasciitis and spinal disc herniations to osteoarthritis and tendonitis. It can even help with bursitis and rotator cuff damage. Bottom line is, theres an alternative out there that can bring you great comfort without reliance on addictive medication and expensive surgery.

Learn more today when you call The Michigan Center for Regenerative Medicine for your consultation at 248-216-1008.

Stem cell therapy in Michigan is gaining momentum among patients who are tired of treatment plans that only mask the pain. Yes, there is still a place for pills, surgery and cortisone injections in traditional medicine. However, were offering a better way to achieve relief from pain in many cases, through stem cell therapy in Michigan that addresses the underlying cause of the problem.

This therapy can also provide healing potential for a variety of conditions and diseases, such as spinal cord injuries, type one diabetes, Parkinsons disease, heart disease, Alzheimers disease, stroke, cancer, burn injuries and osteoarthritis, points out the Mayo Clinic.

Stem cell treatments can also:

When you visit us at The Michigan Center for Regenerative Medicine for your consultation on stem cell therapy in Michigan, Dr. Thomas S. Nabity, Jr. will go over the process in detail. He is board-certified in physical medicine, rehabilitation and pain medicine, leading the whole team here.

When planning, set aside two hours for the visit. If you want IV sedation, we will give it to you but most people only need a local anesthetic for mild discomfort. We will:

Thats all there is to it!

Find out more about this procedure through a consultation on stem cell therapy in Michigan. Contact The Michigan Center for Regenerative Medicine at 248-216-1008.

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Stem Cell Treatments Bloomfield Hills, MI | 248-216-1008

Posted: January 9, 2019 at 5:43 pm

Every year, more and more patients opt to fix their chronic orthopedic and musculoskeletal conditions with stem cell treatments over surface fixes that only mask the problem. Stem cell treatments are becoming more popular options for those tired of dealing with pain. How would you like to avoid addictive medications for your chronic pain or progressive disease with a safer and more effective alternative? Your own stem cells are packed with the power to bring healing potential to the forefront. The Michigan Center for Regenerative Medicine is a leading proponent of these advancements in the local community.

Stem cells are found in our blood to some degree, but mostly in our bone marrow and fat. As healing powerhouses, stem cells from your own body can be used to heal your own injuries. These injuries can include plantar fasciitis, spinal disc herniations, osteoarthritis, tendonitis, bursitis, whiplash, rotator cuff damage and more.

Because bone marrow stores house the stem cells that work better for the types of conditions we treat, we use those over ones from fat. In addition, we pride ourselves on staying in compliance with the FDA, which restricts techniques aimed at isolating fat cells. These are two main reasons why we focus on bone marrow aspiration procedures. These stem cell treatments in Bloomfield Hills MI are virtually painless, with a straightforward process that involves injecting the cells where they can do the most good right at the injury site.

If you are tired of living with pain and dont want to be relegated to using a Band-Aid approach to feeling good, we can help. Call The Michigan Center for Regenerative Medicine today for your consultation at 248-216-1008.

Stem cell treatments in Bloomfield Hills MI are accompanied by many benefits, allowing patients to finally adopt a treatment plan that doesnt simply mask the pain such as through pills and cortisone injections. Consequently, this treatment can truly address the underlying cause once and for all.

Specifically, it could provide a cure to help people suffering from any manner of conditions and diseases, such as spinal cord injuries, type one diabetes, Parkinsons disease, heart disease, Alzheimers disease, stroke, cancer, burn injuries, and osteoarthritis, points out the Mayo Clinic.

Stem cell treatments can also:

Dr. Thomas S. Nabity, Jr. is board-certified in physical medicine, rehabilitation and pain medicine, and he leads the team at The Michigan Center for Regenerative Medicine. When you come in for your consultation, we will go over in detail what the process entails, but heres a glimpse:

Harvested cells are isolated in an on-site lab using a centrifuge and flow cytometer. This allows us to gain the highest concentration of cells for the best results possible.The stem cells are then placed in a syringe and re-introduced into the targeted tissue. This takes place in one visit (usually about two hours), performed under either x-ray or ultrasound to ensure precise location for stem cell delivery. Most people only need a local anesthetic for mild discomfort. However, IV sedation is available for those who want it.

We would be happy to provide you with a consultation to answer your questions on stem cell treatments in Bloomfield Hills MI. Please call us now at 248-216-1008.

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Michigan Integrative Health Dr. Roy Picard, D.C.

Posted: December 27, 2018 at 8:41 pm

Human Umbilical Cell Tissue (HUCT) stem cell therapy is the most effective and ethical form of stem cell therapy available today for the care of musculoskeletal degeneration. At Michigan Integrative Health, we harvest stem cells from a healthy babys umbilical cord after its birth with complete consent of the healthy mother. These human umbilical stem cells, called Mesenchymal stem cells, then go through a testing process in an FDA-approved Stem Cell Cord Bank.

What is extraordinary about Mesenchymal stem cells is that they enable the human body to trigger its own innate healing abilities and regenerate and repair muscle, bone, cartilage, and tendons. The regenerative effectiveness of innovative stem cell therapy is enabling patients to gain relief and mobility without surgery or pain pills.

Stems cells are important anti-inflammatory agents that reinvigorate the bodys own cells, which go dormant in a dehydrated disc, and induce the dysfunctional cells to begin working again.

Discs work by producing proteins that attract water to keep discs healthy and hydrated. When the cells don't work properly due to injury or disease, they cant use those proteins causing them to dehydrate and lose their shock-absorbing capacity which in turn causes pain and suffering. Up until recently, people suffering chronic pain from degenerative disease faced invasive and risky treatment options like surgery and addictive pain medication.

This revolutionary form of healthcare, however, goes far beyond the traditional medical treatments as well as more advanced functional medicine methods like decompression and laser therapy. No other care other than stem cell therapy has the ability to repair and regenerate osteoarthritic bone damage and stimulate the regrowing and repairing of joint and tissue damage.

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Michigan Integrative Health Dr. Roy Picard, D.C.

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Breast Cancer Stem Cells Stopping Them In Their Tracks …

Posted: November 23, 2018 at 1:47 pm

Image Source: Rgbstock.com / StariSob

Breast Cancer Stem Cells Stopping Them In Their Tracks

A growing area of cancer research, breast cancer stem cells were first identified in 2003 by scientists at the University of Michigan (UM) in the United States. With this article I will do my best to explain breast cancer stem cells, and offer some guidance about natural therapies that help to create healthy stem cells.

Healthy Stem Cells vs Breast Cancer Stem Cells

Think of healthy stem cells as mother cells that have the potential to become any type of cell in the body. One of the chief characteristics of stem cells is that they have the ability to self-renew or multiply while maintaining their potential to develop into other types of cells like blood cells or heart cells or bone cells. When the DNA of healthy stem cells becomes impaired or damaged, thats when they can become cancer stem cells.

Conventional cancer theory states that any cell in the body may undergo changes in their DNA sequences and become a rogue cancer cell. Researchers at the Ludwig Center at Stanford, however, postulate that our normal stem cells are the only cells that reproduce themselves and are therefore around long enough to accumulate all the necessary changes to produce cancer. 1

According to UM researchers, breast cancer stem cells (hereinafter BCSCs) are identified by a cell surface glycoprotein marker named CD44, which is responsible for cell to cell communication, cell adhesion and migration. Also on BCSCs are very low or no levels of a surface marker named CD24, another glycoprotein on the cell surface of most B lymphocytes, a white blood cell and part of the immune system. UM researchers discovered that just a few BCSCs were required for the growth and spread of breast cancer and that unless the BCSCs could be destroyed, tumors were likely to recur and spread to other parts of the body (called metastasis). 2

Although BCSCs comprise only a small population within a tumor, they are resistant to conventional chemotherapy and radiation therapy because BCSCs do not renew themselves through normal cell division as other cancer cells do. In fact, these therapies are known to stimulate BCSCs and make them grow faster. 3, 4

Let me repeat that. Chemotherapy and radiation do not kill BCSCs. Any cancer therapy that ignores BCSCs in favor of killing non-tumor causing daughter cells in order to shrink a tumor will not result in destroying the root of the cancer.

My friend Elyn Jacobs, a cancer strategist in New York City, advises: Dont be misled into thinking that tumor reduction guarantees that you are making progress with respect to overcoming the disease, as you may not be. Shrinking a tumor by killing the less damaging cancer cells (the non-stem cells) with chemo and/or radiation may NOT improve long term survival and may increase the likelihood that these cancer stem cells will metastasize, allowing them to regenerate tumors elsewhere in the body. So although you may get an 80% reduction in tumor bulk, you are not targeting the most dangerous of the cells. 5

The BRCA1 link

For those who have a mutation in the BRCA1 gene, this part may be of interest. As we know, the BRCA1 (or breast cancer 1) gene is a tumor suppressor gene, mutations in which are strongly linked to breast and ovarian cancers.

UM Cancer Center scientists have discovered that the BRCA1 gene regulates self-renewal of BCSCs. When the gene is mutated, BCSCs multiply abnormally.

So the task becomes clear we must take in the nutrients that help our stem cells and genes be as healthy as they can be. By doing this, we not only combat any BCSCs currently circulating in the body, we are also actively creating healthy cells and genes that have no damaged DNA.

Natural Therapies To Combat Breast Cancer Stem Cells

Glyconutrients.The exterior of most healthy cells are covered densely with things that appear to be tiny little trees, called glycoforms or glycans. These glycoforms prevent viruses, bacteria and other enemies from entering the cell by blocking the entrance to the cells surface. The glycoforms of healthy cells are also responsible for assisting in cell-to-cell communication, indeed they play an intimate role in nearly every single human physiological process. Glycoforms can also hold onto an enemy cell for safekeeping until an immune cell comes to destroy it (kind of like a holding cell at the police department!). The objective is to create healthy glycans/glycoforms so that our cells are able to communicate effectively, and this helps in a myriad of ways, including the formation of healthy stem cells and immune cells. In order to create healthy glycans/glycoforms we need to be consuming at least 8 simple sugars, known as monosaccharides, from our diet and the problem is we are only consuming two glucose and galactose. The other 6 sugars are missing because of things like fertilizers, pesticides, GMOs, harvesting fruit and vegetables too early before they are completely ripe thus most of the all-important simple sugars are either missing or extremely depleted. We absolutely must supplement with glyconutrients in order to build healthy cells that do the jobs they were meant to do.

Foods/Herbs that Help. Cruciferous vegetables (and especially broccoli sprouts) contain particular phytochemicals such as sulfurophane which work in a myriad of ways to block the formation of BCSCs. 6 Curcumin literally hundreds of studies have been done on curcumin and its ability to kill cancer cells, but it also targets BCSCs and improves the sensitivity of certain chemotherapy drugs in estrogen receptor positive (ER+), progesterone receptor positive (PR+) and estrogen receptor negative (ER-) breast cancer cell lines. 7 One study also indicated that curcumin inhibited the migration of BCSCs, an important factor for metastasis. 8 Get it by using loads of turmeric in your cooking, by all means, but the best way is to supplement with it. Make sure that your supplement has been optimized for bioavailability by the addition of piperine and an oil, as they both improve absorption. Ginseng a chemical component called ginsenoside F2 derived from ginseng has been tested for its efficacy against BCSCs. Research found that ginsenoside F2 suppressed BCSC proliferation (rapid growth) and increased apoptosis (planned cell death). 4, 9 Raspberries (both red and black), and more specifically ellagic acid and ellagitannins, help our immune system find BCSCs by removing the protein that hides them from our immune system. While it may be tempting to take ellagic acid via a supplement, you must eat the berries because they contain the all-important ellagitannin complex within them. Raspberries also have many anti-mutagenic and anti-carcinogenic properties and are full of vitamins, minerals, antioxidants, they help reduce inflammation and encourage apoptosis. 10 Fermented soy products including soy sauce, miso, natto and tempeh have research indicating they help to reduce cancer symptoms, reduce chemotherapy side effects, decrease chemotherapy resistance, increase survival rates and improve cancer stem cell differentiation, suggesting reduced aggressiveness of cancer. 11

This by no means an exhaustive list, but the items listed above are definitely among the best things that are known to help create healthy stem cells rather than BCSCs.

Please do avoid all sugar, processed food (if it has a bar code, check out the list of ingredients carefully), preservatives, conventionally grown produce (always buy organic), chemically laden body products and cleaning products, drinking from plastic bottles and drinking tap water.

For more information about some more healing foods, check out my page Diet and Cancer.

Research:

1. The Stem Cell Theory of Cancer https://med.stanford.edu/ludwigcenter/overview/theory.html

2. http://www.mcancer.org/research/stem-cells/breast

3. Targeting Breast Cancer Stem Cells: http://www.sciencedirect.com/science/article/pii/S1574789110000517

4. Breast Cancer Stem Cells: A Novel Therapeutic Target http://www.clinical-breast-cancer.com/article/S1526-8209%2812%2900221-2/pdf

5. Cancer Stem Cells and Progression of Disease What You Need to Know Now http://elynjacobs.com/2015/07/08/cancer-stem-cells-and-progression-of-disease-what-you-need-to-know-now/

6. Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432495/

7. Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549178/#pone.0136694.ref009

8. Curcumin Inhibits Breast Cancer Stem Cell Migration By Amplifying the E-cadherin/-catenin Negative Feedback Loop http://www.stemcellres.com/content/5/5/116

9. Ginsenoside F2 Induces Apoptosis Accompanied By Protective Autophagy In Breast Cancer Stem Cells http://www.cancerletters.info/article/S0304-3835(12)00100-0/abstract

10. The Truth About Ellagic Acid and Red Raspberries http://jonbarron.org/article/truth-about-ellagic-acid-and-red-raspberries#.VKHrV14AGA

11. Managing Immunity In Resistant Cancer Patients Correlates To Survival: Results and Discussion of a Pilot Study http://www.ncbi.nlm.nih.gov/pubmed/25961344

The Trophoblast and the Origins of Cancer By Dr Nicholas Gonzalez

GET MY BEST TIPS on getting through breast cancer and preventing recurrences by signing up for my free e-newsletters and e-books on the right. You can also like me on Facebook (Marnie Clark, Breast Health Coach) to get my inspirational snippets, news and updates. I promise to do my utmost to keep you informed and empowered on your healing journey and beyond.

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Stem Cell Treatments MI | Michigan Center for Renerative …

Posted: November 2, 2018 at 7:40 am

How would you like to avoid addictive medications for your chronic pain or progressive disease with a revolutionary, safe and effective alternative? Our own stem cells could provide the answers. Found mainly in our bone marrow and fat, stem cells are powerhouses of healing potential. Imagine being able to use your own stem cells to heal injury! The process itself is relatively simple, which involves isolating the stem cells, concentrating them into a syringe and injecting them where they can do the most good.

Here at The Michigan Center for Regenerative Medicine, we utilize the bone marrow stores over fat for a couple of different reasons. First, they work better for the types of conditions we treat. Second, the FDA restricts techniques aimed at isolating fat cells. Because we pride ourselves on our strict compliance with the FDA, we focus on bone marrow aspiration procedures. Virtually painless, stem cell treatments in Michigan have been used here to successfully treat conditions such as spinal disc herniations, osteoarthritis, tendonitis, bursitis, rotator cuff damage, whiplash, plantar fasciitis and much more.

Tired of pain? Looking to avoid dependence on medication or reduce your chances of surgery? We can help. To find out more, call The Michigan Center for Regenerative Medicine today for your free consultation at 248-216-1008.

Stem cell treatments in Michigan carry with them many benefits, not the least of which is to finally incorporate a treatment plan that doesnt simply mask the pain such as through pills and cortisone injections, but that truly addresses the underlying cause.

Stem cell treatments can:

Dr. Thomas S. Nabity, Jr., board-certified in physical medicine, rehabilitation and pain medicine, will conduct the procedure with his team. Harvested cells are isolated in an on-site lab using a centrifuge and flow cytometer to achieve the highest concentration of cells possible.The stem cells are then placed in a syringe and re-introduced into the targeted tissue. This all happens on the same day, performed under either x-ray or ultrasound to ensure precise location for stem cell delivery.The entire procedure takes two hours from start to finish, usually only requiring local anesthetic. However, IV sedation is available if you want it.

Scientifically proven regenerative medicine could be your solution. Every year, more and more patients opt to fix their chronic orthopedic conditions with stem cell treatments over invasive surgery. Are stem cell treatments in Michigan right for you?

We would be happy to provide you with a free consultation to answer your questions on stem cell treatments in Michigan. Please call us now at 248-216-1008.

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Michigan Stem Cell Therapy – Foot HealthCare Associates

Posted: November 2, 2018 at 7:40 am

*Absolutely Ethical NO fetal tissue Amniotic Material only from live birth*

Stem cell grafts can be used for effective long-term treatment of:

Regenerative medicine offers solutions and hope for painful medical conditions that are resistant to traditional treatments and greatly enhance the resolution and healing for painful injuries. Therefore, there is the potential to fully heal the body by stimulating the tissues and joints to heal themselves. Regenerative medicine holds the hope of repairing damaged tissue by stimulating the body to heal from within.

Derived from the placental tissue of healthy donors after live elective Cesarean Delivery, Amniotic Stem Cells are formed from the same blastocyst that form the human fetus and Maternal placenta. Furthermore, Amniotic Stem Cellshave a remarkable ability to form into many different types of cells. They act as an internal repair center, dividing endlessly to replenish other cells. After dividing, the stem cell will do one of two things: Become another stem cell or become another type of needed specialized cell (muscle, skin, blood, brain, etc). Stem cells are the building blocks that allow us to go from a single cell organism into a complex multicellular unit.

Stem cell treatment takes advantage of the bodys ability to repair itself. The amniotic stem cells can jump-start the healing process by creating the cells the damaged tissues need.

Surgeries canbe painful and require an extended rehabilitation time. Conversely, regenerative medicine procedures such as stem cell therapy allow the body to heal itself by providing building blocks to stimulate the bodys natural healing processes.

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Articles and Reference:

Basic Information

Amniotic Fluid as a rich source of mesenchymal Stromal cells for Transplantation Therapy

Amniotic Fluid Pathways& Functions

Gensano Education Link

http://www.MichiganPodiatry.com

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Cancer Stem Cell Research | University of Michigan Rogel …

Posted: November 2, 2018 at 7:40 am

What are adult stem cells?

Every organ and tissue in the body contains a small number of what scientists call adult stem cells or progenitor cells. These cells have three characteristics in common:

1). Adult stem cells can renew themselves through cell division for long periods of time.

2). Adult stem cells retain the ability to give rise to several (but not all) types of cells in the body.

3). Different types of adult stem cells give rise to different specialized cells. Pancreatic stem cells, for example, are the ancestors of insulin-producing islet cells in the pancreas. Hematopoietic stem cells develop into all the different types of cells in the human blood and immune systems.

Cancer stem cells are a type of adult or progenitor cell found in most types of cancer. These cells generally represent just 1% to 3% of all cells in a tumor, but they are the only cells with the ability to regenerate malignant cells and fuel the growth of the cancer.

No. Embryonic stem cells are primitive cells that form inside an early embryo. These cells also can be generated in a laboratory dish during a process called in-vitro fertilization. Four to five days after a human egg is fertilized by sperm, the dividing mass of cells is called a blastocyst. Scientists can remove the inner cell mass from the blastocyst and grow stem cells in a culture dish in the laboratory. Under the right conditions, these stem cells will retain the ability to divide and make copies of themselves indefinitely. Unlike adult stem cells, embryonic stem cells have the ability to give rise to any of the more than 200 different types of cells in the human body.

Cancer research focuses on stem cells present in malignant tumors. Researchers believe current cancer treatments sometimes fail because they don't destroy the cancer stem cells. Think of cancer as a weed: the stem cells are the root while the remaining majority of the cells are the part of the weed above ground. If you remove only the leaves but not the root, the weed will grow back. The same is true for cancer: if you do not kill the cancer stem cells, the cancer is likely to return.

In some cancer types, we are doing a good job. Most cancers when caught early can be successfully treated. But doctors still struggle to treat advanced cancers and some cancer types, such as pancreatic cancer, still have incredibly dismal survival rates. Other cancers, such as head and neck cancers, are often resistant to current therapies, making less-invasive treatments more difficult. In addition, current chemotherapies cause severe side effects because they target all rapidly dividing cells. Treatments that target only cancer stem cells would cause fewer side effects for patients.

Cancer stem cells were first identified in leukemia. U-M researchers discovered the first cancer stem cells in solid tumors, finding them in breast cancer. Since then, cancer stem cells have been identified in brain, colon, head and neck, pancreas and central nervous system tumors. Work is ongoing to identify stem cells in other tumor types.

Researchers take samples of tumors removed from patients during surgery, always with the patient's informed consent. The cells within the tumor are then sorted based on their expression of certain cell markers on their surface. Sorted cells can be injected into mice, which are then watched for new tumor growth. When only specific sorted cells form new tumors, researchers then test those cells for properties of stem cells.

The next step is to understand how cancer stem cells work and identify drugs that will kill the stem cells without harming normal cells.

The work on cancer stem cells is still in early stages, primarily taking place in the laboratory and early clinical trials. U-M is conducting clinical trials of experimental therapies targeted at cancer stem cells in multiple myeloma, pancreatic cancer and breast cancer. Initial results are positive, but additional trials in a larger number of patients will be necessary. If these new drugs are proven to be safe and effective, they could become the first approved cancer treatments to be developed as a result of cancer stem cell research.

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