Category Archives: Michigan Stem Cells

Stem Cell Therapy in Michigan

Thank you for visiting. Many people have been awaiting a practical way to get stem cells for various conditions. This site is intended to offer information so you can learn about current options, understand what stem cells are, and to allow you to determine if this stem cell therapy be for you.

The term Stem Cells refers to cells in your body that are lying dormant, and designed to regenerate or repair diseased tissues. Stem Cell Therapy refers to isolating and deploying stem cells into your body with the intention of regenerating the tissues they are designed to repair.

Your stem cells are your bodys natural healing cells. They are recruited by chemical signals emitted by damaged tissues to repair and regenerate your damaged cells. Stem cells derived from your own tissues may well be the next major advance in medicine. Allure Medical Spa has the technology to produce a solution rich with your own stem cells. Under investigational protocols these can be deployed to treat a number of degenerative conditions and diseases.

At this time, the cost of experimental stem cell treatments is not covered by insurance companies. We believe that our research is university quality. We are patient funded and we have no source of grants or pharmaceutical company funding. Although we are a for-profit organization, our goal is not to patent stem cell technology for corporate profit but rather to learn the medical potential of these cells and contribute to the science of regenerative medicine. We have set our fees very reasonably to lower the threshold of access to stem cell medicine. Our fee includes harvesting, isolating cells and deployment of your own cells. Also, under special conditions, your stem cells may be cryogenically stored for future treatments.

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Stem Cell Therapy Treatment at Allure Medical Spa in Michigan

Experts List

As a leading center of biomedical research, the University of Michigan has many scientists who have been attracted to the promising new frontier of stem cells. They hope to build new understanding of basic biology and perhaps improved medical treatments.

Across a wide array of topics, from repairing facial injuries to attacking cancer, all types of stem cell research are being done at Michigan, using both adult and embryonic stem cells from humans and animals. To see some recent press releases on their important work, please see In the News.

Here are a few of the U-M researchers exploring stem cells:

Professor and Chair, Cell and Developmental Biology Director, Center for Organogenesis

Engels lab studies the embryonic development of mammals to determine how tissues and organs are generated, and how embryonic cells are instructed to become specialized cells. He is interested in learning how chemical signaling between cells works and how, when it goes wrong, cancers and other diseases can occur. These studies have led to surprising insights into the developmental origin of the central and peripheral nervous system, the kidney, the cardiovascular system and blood.

Engel Lab >

Professor of Neurology in the Medical School Director, A. Alfred Taubman Medical Research Institute Director, JDRF Center for the Study of Complications in Diabetes Director, ALS Clinic

As one of the nations leading biomedical researchers Feldman is conducting groundbreaking work in ALS (Lou Gehrigs Diseases) and other neurological diseases. One of the most exciting new approaches to treating ALS involves stem-cell technology. Injecting stem cells into the spinal cords of rats with ALS has shown great promise in arresting the disease.

A. Alfred Taubman Medical Research Institute >

Donald A. Kerr Collegiate Professor of Oral Pathology Chair of the Department of Biologic & Materials Sciences Associate Professor of Dentistry and Biomedical Engineering

Krebsbachs research focuses on bone growth and bone marrow with the goal of being able to help human tissue heal itself better and regrow missing or damaged areas. He is currently studying how human embryonic stem cells differentiate into bone tissue, using both cell cultures and biomaterial scaffolds in animal models. His work also compares the activity of embryonic stem cells to adult stem cells. His long-term goal is to understand the signals that specify bone cell differentiation of hES cells and work towards some day being able to grow replacement bone.

Krebsbach Lab > Video Clip >

Assistant Professor, Center for Stem Cell Biology at the Life Sciences Institute Assistant Professor of Hematology-Oncology in the Medical School

Maillard investigates the signals regulating the development and function of blood-forming stem cells. He is studying how these cells are supported in fetal hematopoietic organs, such as the fetal liver, the main site of blood development during fetal life before migration of blood-forming stem cells into the bone marrow to improve or enhance their function after transplantation. In addition, it might provide insights into the function of stem cells in other contexts, including in cancerous tissues.

Associate Professor of Neurology in the Medical School Acting Director, Epilepsy Research Program

Dr. Parents research has focused for a decade on the role of adult stem cells in epilepsy and stroke. His laboratory, working with the Michigan Center for Human Embryonic Stem Cell Research at U-M, is attempting to repair stroke damage by transplanting neural progenitor cells derived from embryonic stem cells.

Neurodevelopment and Regeneration Laboratory >

Director, Michigan Center for Human Embryonic Stem Cell Research Professor of Cell and Developmental Biology

OSheas lab is focused on the cell-to-cell communication that occurs during formation of the nervous system. In particular, her group is interested in a protein, thrombospondin, that appears to be telling new nerve cells to migrate in specific ways to form parts of the brain. Embryonic stem cells are being used to study patterns of gene expression during formation of the retina in animal models.

She also heads the Michigan Center for hES Cell Research, which is an NIH-funded central resource for the U-M campus that helps researchers from many labs culture and work with human embryonic stem cell lines that are on the approved list for NIH-funding.

Michigan Center for Human Embryonic Stem Cell Research > OShea Lab > Video Clip >

Director of the MStem Cell Laboratories Professor of Ob/Gyn, Urology, and Molecular and Integrated Physiology

Dr. Smiths research in stem cell biology and derivation of new human embryonic stem cells incorporates over 20 years of: i) experience directing clinical embryology laboratories for treatments of infertility and/or preserving fertility; ii) investigating intracellular regulation of chromatin remodeling in oocytes and molecular regulators of embryo development; iii) integrating novel technologies developed in chemical and biomedical engineering, material sciences, and physics into basic and applied studies of gametes, embryos, and embryonic stem cells. Collectively, these skills and investigations result in translating basic discoveries into solutions for current practical short-comings of human embryonic stem cell isolation, culture, differentiation, and establishment of model systems for human diseases.

Gary Smiths profile >

Director, University of Michigan Comprehensive Cancer Center Professor of Internal Medicine

Dr. Wicha is at the forefront of research into cancer stem cells, the small number of cells within a tumor that are capable of fueling the tumors growth. His team was first to identify stem cells in a solid tumor, finding them in breast cancer. Recent research suggests cancer stem cells share some basic elements with embryonic stem cells, as well as with normal adult stem cells. Thus, in order to understand how cancer stem cells are regulated, scientists have to study and understand how these pathways work in embryonic stem cells. By studying embryonic stem cells, we can accelerate efforts to find a cure for cancer.

Press release on stem cells in breast cancer > Comprehensive Cancer Center >

Research Assistant Professor, Center for Stem Cell Biology, Life Sciences Institute Assistant Professor of Cell and Developmental Biology, Medical School

Yamashita is elucidating the process of stem cell division and its role in the age-related decline in organ repair and in the onset of some cancers and other proliferative disorders. She studies the division of stem cells to establish which ones go on to replace differentiated cells and which ones maintain the pool of stem cells for future division. Yamashita won a prestigious MacArthur Fellowship in 2011.

Yamashita Lab >

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University of Michigan Stem Cell Research | Experts List

ANN ARBOR, Mich. Five years ago this month, Michigan voters opened the door for a full range of stem cell research in the state. Today, that effort is well under way at the University of Michigan, and yielding results that are expanding knowledge of a wide range of diseases.

The Michigan ballot initiative approved in 2008 amended the state constitution, and allowed for the first time the production of new human embryonic stem cell (hESC) lines in Michigan.

Since that approval, U-M founded what is now known as the MStem Cell Laboratories, based in the Medical School, to derive hESCs using donated embryos that would otherwise have been discarded by couples undergoing fertility treatment.

U-M also established a framework and oversight panel to guide this work under the appropriate state and federal statutes and regulations.

In less than three years, the research has flourished, and researchers from U-M and other institutions are able to use U-M-derived hESCs in their work.

At the same time, a broad range of other stem cell research continues at U-M, including research on adult and induced pluripotent stem cells, cancer stem cells, and treatments and clinical trials based on delivering stem cells into the body. This includes a Phase II clinical trial investigating the use of stem cells in patients with Lou Gehrigs disease.

Weve been working hard to do what the people of Michigan asked us to do -- and were starting to see benefits in terms of scientific discoveries being made, says Gary Smith, Ph.D., who directs the MStem Cell lab and is a professor of obstetrics and gynecology; molecular and integrative physiology; and urology. He notes that hESC work and other types of stem cell work complement one another.

Key facts about human embryonic stem cell research at U-M since 2008s vote:

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Five years after Michigan vote on human embryonic stem ...

ANN ARBOR, Mich. -- Scientists have coaxed stem cells to grow the first three-dimensional mini lungs.

Previous research has focused on deriving lung tissue from flat cell systems or growing cells onto scaffolds made from donated organs.

In a study published in the online journal eLife the multi-institution team defined the system for generating the self-organizing human lung organoids, 3-D structures that mimic the structure and complexity of human lungs.

These mini lungs can mimic the responses of real tissues and will be a good model to study how organs form, change with disease, and how they might respond to new drugs, says senior study author Jason R. Spence, Ph.D., assistant professor of internal medicine and cell and developmental biology at the University of Michigan Medical School.

The scientists succeeded in growing structures resembling both the large airways known as bronchi and small lung sacs called alveoli.

Since the mini lung structures were developed in a dish, they lack several components of the human lung, including blood vessels, which are a critical component of gas exchange during breathing.

Still, the organoids may serve as a discovery tool for researchers as they churn basic science ideas into clinical innovations. A practical solution lies in using the 3-D structures as a next step from, or complement to, animal research.

Cell behavior has traditionally been studied in the lab in 2-D situations where cells are grown in thin layers on cell-culture dishes. But most cells in the body exist in a three-dimensional environment as part of complex tissues and organs.

Researchers have been attempting to re-create these environments in the lab, successfully generating organoids that serve as models of the stomach, brain, liver and human intestine.

The advantage of growing 3-D structures of lung tissue, Spence says, is that their organization bears greater similarity to the human lung.

The panel on the left is a cross section through an organoid, viewed through a microscope and stained to visualize the lung tissue. Lung tissue in organoids is organized in a similar manner to the adult lung, shown in the right panel.

To make these lung organoids, researchers at the U-Ms Spence Lab and colleagues from the University of California, San Francisco; Cincinnati Childrens Hospital Medical Center; Seattle Childrens Hospital and University of Washington, Seattle manipulated several of the signaling pathways that control the formation of organs.

First, stem cells the bodys master cells -- were instructed to form a type of tissue called endoderm, which is found in early embryos and gives rise to the lung, liver and several other internal organs.

Scientists activated two important development pathways that are known to make endoderm form three-dimensional tissue. By inhibiting two other key development pathways at the same time, the endoderm became tissue that resembles the early lung found in embryos.

In the lab, this early lung-like tissue spontaneously formed three-dimensional spherical structures as it developed. The next challenge was to make these structures expand and develop into lung tissue. To do this, the team exposed the cells to additional proteins that are involved in lung development.

The resulting lung organoids survived in the lab for over 100 days.

We expected different cells types to form, but their organization into structures resembling human airways was a very exciting result, says lead study author Briana Dye, a graduate student in the U-M Department of Cell and Developmental Biology.

The research has gained support from the National Heart, Lung and Blood Institute (NHLBI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the March of Dimes and the U-Ms Center for Organogenesis and Biological Sciences Scholars Program (BSSP).

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Reference: In vitro generation of human pluripotent stem cell derived lung organoids, eLife, DOI: http//dx.doi.org/10.7554/eLife.05098.001

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Scientists coax stem cells to form 3-D mini lungs ...

Cancer stem cells are the small number of cells within a tumor that drive the tumor's growth. These cells generally make up just 1% to 3% of all cells in a tumor Watch the video with Max Wicha, M.D., director emeritus of the University of Michigan Comprehensive Cancer Cancer and learn more about stem cell research

If you are having trouble viewing the video, watch it on our YouTube channel.

At the U-M Comprehensive Cancer Center, we believe treatments designed to target and destroy cancer stem cells will revolutionize how we treat cancer. Over the last 30 years, researchers have developed more effective treatments for cancers like childhood leukemia, Hodgkin's disease and testicular cancer.

Death rates for some common cancers, like breast and prostate cancer, have gone down due to advances in early detection and prevention. However, the survival rate for patients with many advanced cancers has not changed significantly for decades, and cancer is still the second-most common cause of death in the United States.

Instead of trying to kill all the cells in a tumor with chemotherapy or radiation, we believe it would be more effective to use treatments targeted directly at these so-called cancer stem cells. If the stem cells were eliminated, the cancer would be unable to grow and spread to other locations in the body.

The U-M Comprehensive Cancer Center is one of only a few research institutions in the United States and Canada that has made an institutional commitment to cancer stem cell research.

Organized teams of U-M scientists are studying cancer stem cells in many different types of cancer:

By working together and sharing information, Cancer Center scientists hope to make progress more rapidly than would be possible for individual scientists working alone.

We believe new treatments designed to target and destroy cancer stem cells could revolutionize the way physicians treat cancer. Our goal is to be the world's leader in research on cancer stem cells and in the development of new stem cell-based therapies for cancer patients.

Every organ and type of tissue in the body contains a small number of what scientists call "adult" or "tissue" stem cells. Since most cells in the body live for just a short time, the body needs to keep making new cells to replace them.

Adult stem cells ensure a continuous supply of new cells to replace old cells that wear out or are destroyed.

In 2003, U-M scientists were the first in the world to identify cancer stem cells in a solid tumor, finding them in breast tumors. Since then, other Cancer Center scientists have discovered and isolated cancer stem cells in pancreatic cancer (2007), in head and neck cancer (2007) and in an aggressive brain cancer called glioblastoma (2009).

Even under a microscope, there's no way to distinguish cancer stem cells from other malignant cells just by looking at them. To identify stem cells, scientists use specialized equipment to detect specific proteins on the cell's surface.

These proteins are not found on regular cancer cells. A biochemical assay developed at the U-M Cancer Center can identify breast cancer stem cells.

The ultimate test to prove that cells are true cancer stem cells is to inject cells from a human tumor into mice that are genetically engineered to lack a cancer-fighting immune system. If the mouse does not get cancer, scientists know the injected cells were not stem cells, because ordinary tumor cells will divide a few times and then die. But if the mouse develops a tumor with the same types of cells as the human tumor, scientists know that the injected cells were true cancer stem cells.

By analyzing the genes that are active in a patient's cancer stem cells and counting the number of stem cells in a tumor, physicians could identify patients at high risk for advanced, aggressive disease.

New therapies designed to target stem cells could eliminate cancer without the risks and side effects of current treatments that also destroy healthy cells in the body. Destroying cancer stem cells in the original tumor could reduce the risk of deadly metastasis, where malignant cells move from the primary tumor to other places in the body. Finally, by killing the cells driving the tumor's growth, treatments targeted at cancer stem cells could eliminate recurrences of the disease.

Scientists don't know for sure. Since chemotherapy and radiation kill cells that divide often, stem cells may be less vulnerable because they rarely divide. Some scientists believe cancer stem cells may have genetic mutations that make them resistant to damage from chemotherapy or radiation, or cancer stem cells may be able to repair DNA damage more rapidly than normal cells.

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Updated 06.2016

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October 16, 2015: Throughout October, Catholic churches across the country are celebrating Respect Life Month to draw attention to the worth of every human person. The theme this year is Every Life is a Gift, reminding all that their inherent worth cannot simply be reduced to their skills or level of productivity (Cardinal Sean OMalley). During his visit to the United States last month, Pope Francis spoke about the dignity of all persons, especially those on the margins or considered disposable. The Word from Lansing column this month delves further into the idea of finding life as a gift, even in the midst of profound struggles. In addition, Michigan Catholic Conference offers a few ideas of how to promote and care for human life. Read more

October 7, 2015: Federal legislation that seeks to reduce certain mandatory minimum sentences, reduce recidivism, and limit solitary confinement for juvenile offenders recently found favor with Archbishop Thomas Wenski, chairman of the USCCB Committee on Domestic Justice and Human Development , and Sister Donna Markham, president of Catholic Charities USA. While noting that Pope Francis visited a Correctional Facility during his recent stay in Philadelphia, Archbishop Wenski said We must try to ensure that sentences are just, while creating humane space in which individuals can restore their lives with the kind of support that reduces the chances that they will return to prison in the future. These reforms are a step in the right direction. The bi-partisan Sentencing Reform and Corrections Act of 2015 was introduced recently in the United States Senate. Read more

October 6, 2015: Each year, the month of October is designated as Respect Life Month by the U.S. Conference of Catholic Bishops (USCCB) in the Catholic Church. The goal of the month is to celebrate the gift of human life and to promote a culture that recognizes the dignity of all people. This years theme for the month, which kicks off with Respect Life Sunday on October 4th, is Every Life is Worth Living. Cardinal Sean OMalley, Archbishop of Boston and chairman of the Committee on Pro-Life Activities for the USCCB, issued a statement highlighting this theme, calling all lives a good and perfect gift, whether they last for a brief moment or for a hundred years. More information on Respect Life Month and the 20152016 Respect Life program materials

September 28, 2015: Last week, Pope Francis visited the United States, drawing the attention of Catholics and non-Catholics alike. During his seven days in the country, he ate with the homeless, visited with Catholic schools students and immigrants, and blessed and greeted prisoners in a correctional facility. Pope Francis also met with President Obama, U.S. Congress, and the United Nations to bring a message of peace, cooperation, and hope to the political dialogue. Throughout his visit, he highlighted the dignity of the human person, including the poor and the immigrant, emphasized a concern for the environment and protection against a throwaway culture, promoted the importance of religious liberty, and spoke about the beauty and goodness of marriage. The U.S. Conference of Catholic Bishops offers video on demand of all of the papal events, as well as text of his speeches and homilies from Washington DC, New York City, and Philadelphia. Read more

Photo credit USCCB

September 24, 2015: This morning, Pope Francis addressed a joint session of Congress in Washington, D.C., making history as the first pope to ever do so. During his speech, Pope Francis highlighted the valuable contributions of four Americans of faith Abraham Lincoln, Martin Luther King Jr., Dorothy Day, and Thomas Merton to public life and to the common good. He encouraged the crowd to renew the spirit of fraternity and solidarity and to pass laws based on a concern for all people, speaking to issues along the broad spectrum of Catholic Social Teaching. Other speeches from Pope Franciss visit the United States, such as his address at the White House and midday prayers with the bishops, are also available at USCCBs website

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Michigan Catholic Conference: Home

Michigan Stem Cell Amendment, Proposal 2 (2008), also known as "Cure Michigan," was on the November 2008 ballot in Michigan as an initiated constitutional amendment, where it was approved.

The amendment enacted the allowance of the donation of embryos produced in fertility clinics that would otherwise be discarded, and the allowance of researchers to create embryonic stem cell cultures to study disease. It would allow government funding of stem-cell research. Human cloning would continue to be illegal.

After the approval of Proposal 2, the University of Michigan began to receive several inquiries from potential donors, however the acceptance of embryos was delayed because according to the university they needed time to conduct ethical, legal and medical reviews. In December 2009, the university announced that they have established procedures and expect to begin new lines of stem cells by mid-2010. The university's research is said to focus on studying specific diseases.

Also in December 2009, the Michigan State Senate announced that they plan on deciding on proposed state guidelines for embryonic stem cell research. The proposed guidelines are opposed by university researchers and Proposal 2 (2008) supporters.[1] According to stem cell researchers the proposed bill contradicts the intention of Proposal 2 and "would prevent the donation of embryos with known genetic defects that scientists most want to study."[2]

A total of six bills have been proposed to modify Proposal 2, however, in February 2010 the proposals stalled in the Senate. Majority Leader Mike Bishop said he was concerned that the amendments could "lead to job losses and may not reflect voters' intent in voting for the amendment."[3]

According to reports, the proposed changes include:[3]

Results according to the Michigan Secretary of State[4]

The initiative is sponsored by the Stem Cell Research Ballot Question Committee (BCQ). The same committee tried to get a similar stem cell initiative on the 2006 ballot but failed to collect sufficient signatures. Former Speaker Rich Johnson and former Congressman Joe Schwarz have been supporters of the initiative as well.[5]

The group believes that stem-cell research could lead to cure for Parkinson's, spinal cord injuries, and juvenile diabetes.

Former President Bill Clinton endorsed Proposal 2 and is helping to raise money for the campaign to pass the measure.[6]

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Michigan Stem Cell Amendment, Proposal 2 (2008 ...

For Donors

You have made embryos for fertility purposes and you no longer wish to use those embryos for reproduction. Or you may be making embryos for reproductive purposes that will be tested for genetic normalcy and those embryos found to have genetic abnormalities will not be used for implantation. You have been directed to this document because of your interest in freely donating embryos. You know and agree that any donation will be without compensation. No one has forced you to consider or make a donation. This document will aid you in thinking about and possibly donating those embryos for a human stem cell research project within the newly established MStem Cell Laboratories at the University of Michigan. The MStem Cell Laboratories is a group of physicians and scientists who are attempting to derive or develop new human embryonic stem cell lines for research on treatments and cures for medical diseases.

Stem cells can be found inside embryos about five days after the embryos have been formed by the union of sperm and egg. These stem cells have the unique ability to form any kind of human cell. Investigators within the MStem Laboratories are interested in generating new human embryonic stem cell lines from normal embryos and from embryos known to have genetic abnormalities (eg. Huntingtons Disease or Spinal Muscular Atrophy). An embryonic stem cell line is a group of unspecialized cells that can be grown indefinitely in laboratory dishes and that can be induced to form any type of specialized cells for the treatment or study of disease. Studies of genetically normal and abnormal human embryonic stem cell lines may help in understanding the development of diseases, in testing treatments, and in potentially discovering new treatments and cures.

To learn more, view this presentation on the basics of human embryonic stem cell production.

There are two sources of embryos that can be donated to the University of Michigan for human embryonic stem cell research:

PLEASE NOTE: MStem Cell Laboratories periodically closes its donation program for frozen embryos no longer needed for reproduction to maintain an appropriate inventory/usage balance. We are currently not accepting donations for frozen embryos no longer needed for reproduction. Please check back for a change in the current open/closed status of the donation program. If you have any further questions, please contact the MStem Cell Study Coordinator at 734-649-6557 or mstemcell@med.umich.edu.

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University of Michigan Stem Cell Research | Embryo Donation

MStem Cell Laboratories

The University of Michigan is a long-time leader in the study of stem cells. So when voters in Michigan passed a 2008 state constitutional amendment allowing the production of new embryonic stem cells, the University was poised to quickly become a leader in this emerging and potent field of medical research. With the formation of the Consortium for Stem Cell Therapies (CSCT) in early 2009, the University created a multi-disciplinary team of leading researchers from across campus. As part of the U-M Medical School, the CSCT became responsible for the derivation, storage and distribution of new induced pluripotent stem cells and human embryonic stem cells.

Today, the division of the CSCT working with human embryonic stem cells is known as MStem Cell Laboratories. MStem Cell is one of only a handful of academic institution-based programs in the country dedicated to the derivation of disease affected stem cells. The MStem Cell Laboratories mission is to produce unique stem cells that will accelerate our understanding of specific human disorders and lead to eventual therapies and cures. The development of innovative technologies for the growth of stem cells is at the forefront of efforts. Bringing the global research community the best tools to improve future study potential and shorten the time span from initial discovery to clinical application is the goal.

A lot has been accomplished in the last few years. Researchers at MStem Cell Laboratories have already produced ten genetically normal and 17 disease-affected embryonic stem cell lines, providing new and invaluable resources to scientists at the U-M and throughout the global research community.

In this emerging field of medical research and clinical care, MStem Cell Laboratories are working on innovations to more rapidly move new stem cell therapies through the human trials process, and on to clinic use. In an exciting collaboration with chemical engineers and material scientists in the U-M College of Engineering, they have developed a new fully-synthetic artificial surface for the growth of stem cellsthe first of its kindwhich prevents tissue contamination from foreign feeder cells. Until now, mouse feeder cells have been the growth surface for stem cells. This non-human cell-cell interaction with human stem cells contaminates the human cells with mouse proteins and has meant a mandatory fifteen-year wait period between Phase I (safety) and Phase II (efficacy) human trials investigating stem cell replacement therapies. The new synthetic or xeno-free growth surface was designed to eliminate that lengthy gap.

Adrenoleukodystrophy - 2 lines Aneuploidy Aniridia (PAX6) - 2 lines Charcot-Marie-Tooth disease, Type 1 - 2 lines Duchenne Becker Muscular Dystrophy, XX carrier Fragile X Syndrome Hemophilia B Huntington's disease Hydroxysteroid Dehydrogenase Deficiency Hypertrophic Cardiomyopathy Multiple Endocrine Neoplasia, Type 2A Marfan Syndrome Spinocerebellare Ataxia, Type 3 Turner Syndrome

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University of Michigan Stem Cell Research | Stem Cell ...

Scientists from the University of Michigan have grown the first 3D mini lungs from stem cells. The study, published in eLife, compliments other developments in the field such as growing mainly 2D structures and building lung tissue from the scaffold of donated organs.

The advantage of growing 3D structures is that their organisation bears greater similarity to the human lung. The scientists succeeded in growing structures resembling both the large proximal airways and the small distal airways

Lead author Dr Jason Spence says:

"We expected different cells types to form, but their organisation into structures resembling human airways surprised us and is a very exciting result."

Ingredients

Embryonic stem cells

Proteins involved in lung development

Growth factors

Inhibitors of intestine development

Growing media

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How to grow a human lung