Category Archives: Delaware Stem Cells

We know that Detroit Lions linebacker Paul Worrilow can play the game of football pretty well, but what you may not know is the kind of work he does off the field, according to Jeff Seidel of The Detroit Free Press.

During his sophomore year of college at the University of Delaware, Worrilow joined the Be The Match Foundation Registry to become a bone marrow donor.

Four months after doing so, he was matched with a 23-year-old woman who was dealing with leukemia.

While Worrilow does not know what happened to the woman and does not even know her name, he donated peripheral blood stem cells to her and said that the process is very quick and easy.

Its so simple. They do a cheek swab. You get put in the database, said Worrilow. If you match somebody, there are two ways to do it. You can donate actual bone marrow or do it like I did, peripheral blood stem cells.

Roughly one in 40 members will be called for additional testing, and only about one in 300 will be considered the best possible donor for a patient.

As far as actually donating peripheral blood stem cells or bone marrow, approximately one in 430 will do so.

Its not painful. Its a small part of your time, to have a great impact, a tremendous impact on another person and their family, said Worrilow. Its a no-brainer. You can have a great impact at such a small cost to yourself.

The Lions signed Worrilow, who played the first four years of his NFL career for the Atlanta Falcons, to a one-year deal this past March.

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Lions LB Paul Worrilow Making A Difference On And Off The Field - FanRag Sports (blog)

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Atlanta Falcons linebacker Paul Worrilow kisses his 15-month-old daughter, Julie, after the first day of training camp in Flowery Branch, Ga., on July 28, 2016.(Photo: Curtis Compton, Associated Press)

Height, weight: 6 feet, 230 pounds.

Joined the Lions:Worrilow, who turns 27 in May, agreed to a one-year contract with the Lions on Wednesday.

NFL career: He made the Atlanta Falcons in 2013 as an undrafted free agent after being a walk-on at Delaware. Worrilow was the Falcons' starting middle linebacker job in 2013-15. He led the team in tackles each of his first two seasons. Last season, the Falcons wanted to get faster at linebacker, so they drafted two, and Worrilow lost his job to rookie Deion Jones. Worrilow was relegated mostly tospecial teams in 2016 and played just four defensive snaps in the playoffs -- none in the Super Bowl.I know I can go and play good ball, Worrilow told the Atlanta Journal-Constitution. Whether if thats here or somewhere else.

Off the field:In 2011, he signed up for Delawares bone-marrow program. He underwent a six-hour procedure to donate peripheral blood stem cells to an anonymous 21-year-old leukemia patient.

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Lions LB Paul Worrilow gave stem cells to anonymous leukemia patient - Detroit Free Press

WITH THE FOUNDING of the Delaware Biotechnology Institute in 1999, the state and its academic and industrial leaders made the development of biotechnology, including stem cell research, within the state a priority. Delaware has no legislation in place to regulate or fund stem cell research, though the Delaware BioTechnology Institute at the University of Delaware is a statewide collaborative network to encourage research in biotechnology including stem cell research.

At present, no federal legislation in the United States is in place to regulate stem cell research (except by executive order to not allow federal funding for generation of new embryonic stem cell research and limiting research to specific embryonic stem cell lines); this leaves each state responsible for determining its own policy and funding for stem cell research.

Although passed by the Delaware Senate in March, in June 2007 the legislators in the Delaware House of Representatives defeated a bill (State Bill 5) regarding oversight and regulation of research for regenerative medicine and human cloning and establishing regulation of stem cell research on adult, embryonic, and umbilical cord blood cells. The defeat of this bill left Delaware with no laws governing stem cell research; therefore, research being done could continue.

The University of Delaware, located in Newark, was founded in 1743. The university offers a variety of academic programs in science and medicine, as well as other academic majors. One of the research groups in the chemical engineering department is focused on stem cell differentiation and understanding the cellular processes of regulation. Current research includes cancer biology and genetically linked illness. In cancer, biology researchers are studying embryonic development and cancer tumor growth processes in both mouse and human models; the role of bone matrix in the progression of cancer following metastasis from primary sites, with the possibility of molecular drug development for prevention or control of metastasis; the study of cell adhesion molecule role in metastasis; finding fast-growing versus slow-growing cell types for drug development for cancer inhibition; tissue engineering with polymeric and organic-inorganic hybrid materials; and synthesis of model peptides for the activation of pharmaceuticals at the target organ.

The university also participates in research with industry partners through the Delaware Biotechnology Institute to work on gene editing and repair that may lead to a cure for a number of devastating hereditary diseases.

There is also clinical collaboration with Christiana Care Health Services, through a National Institutes of Health National Center for Research Resources IDeA Network of Biomedical Research Excellence grant to Delaware. The core of the program is focused on innovative research in bio-medical imaging and in infrastructure to support expanded cancer research in Delaware. The network brings together state, academic, and industrial stakeholders to perform research and improve educational opportunities as a means of enhancing the biotechnology industry and promote jobs within the state.

The Delaware Biotechnology Institute was established at the University of Delaware in 1999 as a center of excellence in biotechnology and life sciences. The institute was created through funding from the state of Delaware, the National Institutes of Health, the National Science Foundation, and other government and private sources. The institutes research facility occupies land adjacent to the Delaware Technology Park, with laboratory space dedicated to plants, animals, human health, biomaterials, and bioinformatics, as well as office space and instrumentation. Though the institute is an academic division of the University of Delaware, it brings together professionals from other institutions statewide, including Delaware State University, Delaware Technical and Community College, Wesley College, Christiana Care Health System, Helen F. Graham Cancer Center, Alfred I. DuPont Hospital for Children, and Nemours Bio-medical Research for collaboration.

The institute brings together all the academic disciplines for the development of new technology. The field of biomaterials is an emerging technology area creating clinical therapies, medications, and bioelectronic devices through the networking of scientists in physical sciences and those in materials science and engineering. The institutes current research includes biosurface modifications to promote or prevent protein absorption, rapid separation and sensing of proteins, and cell and tissue engineering. An example of the type of integrated research occurring is the creation of nanofibers by controlling polymer shaping by the universitys department of Materials Science and Engineering and then the biology departments investigation of cell response, growth, and proliferation within the polymers.

The Delaware Technology Park, located in Newark, Delaware, is built on 40 acres adjacent to the University of Delaware and is dedicated to the creation of jobs and the growth of biotechnology and other high-tech industries in an environment with proximity (within 35 miles) to 30 educational institutions, as well as providing networking opportunities with other businesses in the park.

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Delaware (Stem Cell) - what-when-how

We are delighted to welcome Joshua Enszer, who has joined the Department of Chemical and Biomolecular Engineering as assistant professor of instruction, with responsibilities that cover teaching and academic innovation in the undergraduate program. His goal is to bring knowledge from the scholarship of teaching and learning to improve opportunities in the departments undergraduate courses. He hopes to apply some of his earlier work in the areas of game-based learning and metacognition to his new position at UD. Before starting at UD in August, Enszer was a lecturer in chemical engineering at the University of Maryland Baltimore County. Prior to that, he was interim program coordinator for first-year engineering at the University of Notre Dame. Enszer holds a bachelor of science degree in chemical engineering and mathematics from Michigan Technological University and a master of science degree and doctorate in chemical engineering from Notre Dame.

The Department of Chemical and Biomolecular Engineering at the University of Delaware invites applications for a tenure-track Assistant Professor position.

Wednesday, November 4, 2015 9:30 AM - 3:30 PM Rodney Room, Perkins Student Center REGISTER NOW

Allan Ferguson was in the very first engineering class taught by the late Jon Olson at the University of Delaware. "He was absolutely brilliant, and here we were, these young, malleable minds, ready to learn the really complex things he would teach us," the 1965 chemical engineering graduate recalls. "And then he gave the first exam." Ferguson flunked, but he wasnt the only one.

Thomas H. Epps, III, the Thomas and Kipp Gutshall Associate Professor of Chemical and Biomolecular Engineering at the University of Delaware, has been awarded the American Physical Societys 2016 John H. Dillon Medal for "significant advances in the control, characterization and understanding of polymer nanoscale structure and energetics." The medal recognizes outstanding research accomplishments by young polymer physicists who have demonstrated exceptional research promise early in their careers.

In the world of catalytic science and technology, the hunt is always on for catalysts that are inexpensive, highly active, and environmentally friendly. Recent efforts have focused on combining two metals, often in a structure where a core of one metal is surrounded by an atom-thick layer of a second one.

Wilfred Chen, Gore Professor of Chemical Engineering at the University of Delaware, is the recipient of the American Institute of Chemical Engineers (AIChE) 2015 D.I.C. Wang Award for Excellence in Biochemical Engineering. Chen is cited for the creative application of molecular techniques in engineering proteins and microbes to perform an extraordinary range of biotechnological tasks for bioremediation, biocatalysis, biofuel production, bioseparation and biosensing.

Polymer nanocomposites are used in a wide range of applications, from automobile parts and tires to high-tech electronics and solar cells. As with traditional composites, the properties of nanocomposites can be tailored to the requirements of specific applications, but achieving those properties can be challenging.

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University of Delaware Chemical Engineering

[12/2014] Stephanie Luff wins one of the two runner up poster Awards at this years 43rd Annual Philadelphia Workshop on Hemostasis, Thrombosis and Atherosclerosis. Congratulations Stephanie!

[4/2014] E. Terry Papoutsakis receives the Delaware Bio Academic Research Award, sponsored by Delaware IDeA Network of Biomedical Research Excellence (INBRE). The award recognizes significant contributions to the advancement of life science research at an academic or medical research institution in the state. (read more)

[10/2012] E.T. Papoutsakis received the 2012 James E. Bailey Award at the 2012 AIChE annual meeting, Pittsburgh, PA. (read more)

[06/2012] Stefan Gaida won best poster award for "tools and methods development" at the Metabolic Engineering IX Conference (An ECI Conference Series) in Biarritz, France.

[08/08/2011] 2011 ACS Fellow E. Terry Papoutsakis has been selected as 2011 American Chemical Society (ACS) Fellow.

Genomics, systems and synthetic biology, and metabolic engineering applied to stem-cell bioengineering and biorefining. The Papoutsakis Group focuses on the study and modification of regulatory networks that control key cellular programs such as stem-cell differentiation and plasticity or prokaryotic sporulation and stationary-phase phenomena. This research contributes to the understanding of cellular processes of both fundamental and industrial interests - such as stem-cell bioengineering or the link between sporulation, solvent production and stress response in solventogenic clostridia for biofuel production and biorefinery applications - and involves interdisciplinary work in the areas of systems biology, metabolic engineering, experimental and computational genomics, stem-cell biology, and hematology. By combining state-of-the-art microarray and genomic analysis techniques with molecular biological tools and cellular physiology, the Papoutsakis Group aims to unravel the exquisitely crafted interplay of cellular processes that allow the exploration of cells for beneficial applications from Regenerative Medicine to Industrial Biotechnology.

The Papoutsakis Research Group is an active, vibrant and collaborative team of educators, students, researchers and scientists. The group is comprised of PhD and other graduate students, postdoctoral fellows, a lab manager, undergraduate and visiting students, occasionally visiting scientists, and Papoutsakis administrative coordinator. Our mission is to carry out world-class, forward-looking, genomic-based research in the context of bioengineering, biochemical engineering and more broadly modern biology. Based at the Delaware Biotechnology Institute at the University of Delaware, the Papoutsakis Research Group is dedicated to initiating and supporting the best of front line research and technology within the ever-changing and wide-ranging scope of the molecular life sciences. click here to learn more

The research facilities for the Group are in laboratories in the Delaware Biotechnology Institute, which is a state-of-the art research facility for modern research in the biological sciences and bioengineering. Click here to learn more

[12/13] Venkataramanan, K. P., Jones, S. W., McCormick, K. P., Kunjeti, S. G., Ralston, M. T., Meyers, B. C., & Papoutsakis, E. T. (2013). The Clostridium small RNome that responds to stress: the paradigm and importance of toxic metabolite stress in C. acetobutylicum. BMC genomics, 14(1), 849.

[11/13] Wang Q, Venkataramanan KP, Huang H, Papoutsakis ET and Wu C. Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress BMC Systems Biology. 2013, 7:120.

[1/13] Zingaro, KA, Papoutsakis, ET, 2012. GroESL overexpression imparts Escherichia coli tolerance to i-, n-, and 2-butanol, 1,2,4-butanetriol and ethanol with complex and unpredictable patterns. Metab. Eng. (Download PDF)

[1/13] Jiang, J, Papoutsakis, ET, 2012. Stem-cell niche based comparative analysis of chemical and nano-mechanical material properties impacting ex vivo expansion and differentiation of hematopoietic and mesenchymal stem cells. Adv. Healthc. Mater. (Download PDF)

[11/12] Nicolaou, SA, Gaida, SM, Papoutsakis, ET. 2012. Exploring the combinnatorial genomic space in Escherichia coli for ethanol tolerance. Biotechnol. J. (Download PDF)

[11/12] Al Hinai, M, Fast, AG, Papoutsakis, ET, 2012. Novel system for efficient isolation of Clostridium double-crossover allelic exchange mutants enabling markerless chromosomal gene deletions and DNA integration. Appl. Environ. Microbiol. 78(22):8112-8121. (Download PDF)

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Cultivation & Storage

Our cell culture consumables with tissue culture (TC)-treated surface allow optimal attachment and homogeneous growth of stem cells. The New Brunswick CO2 incubators provide the ideal environment for growing stem cells in culture. The speed adjustment of our Easypet helps to handle cells very carefully and precisely.

For transfection of cells, e.g. for reprogramming, Eppendorf offers a broad range of manipulation devices. A variety of general lab equipment is available to facilitate the set-up, starting with manual or automated pipetting devices and centrifuges that fit your needs.

Our Mastercyclers guarantee convenient and extremely fast PCR runs. In addition the gradient function can be used to optimize the PCR condition very easily and establish reliable protocols. With the Detection equipment further analysis such as UV/Vis absorption or fluorescence detection can be conducted.

Controlled bioreactors can be the key to establish and optimize reproducible cultivation processes and to scale up from T-flasks and plates. The Eppendorf DASbox and DASGIP Parallel Bioreactor Systems offer precisely controlled environments for stem cell cultivation.

Our single-use bioreactors with working volumes of up to 40 L enable clinical-scale production of stem cells and facilitate validation. New Brunswick BioCommand SCADA Software can be chosen with security, event logs, and audit-trail capabilities to be compatible with the FDA 21 CFR Part 11 requirements.

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Stem Cells - Eppendorf

Apr 29, 2010 | Contact Author | By: Katie Schaefer

Mibelle Biochemistrylauncheda new stem cell active basedon alpine rose.PhytoCellTec Alp Rose (INCI:Rhododendron Ferrugineum Leaf Cell Culture Extract (and) Isomalt (and) Lecithin (and) Sodium Benzoate (and) Lactic Acid (and) Water (aqua)) is said to protect skin against UV stress, increase skin stem cell vitality, boost epidermal regeneration and improve skin barrier function.

Alpine roses are Swiss flowersthat grow at altitudes of up to 3,200 m. In this environment, they must adapt to extreme conditions such as the cold, UV and dryness. The leaves of these roses, therefore, were sourced to create an active thatprotects skin stem cells against environmental stress factors and improves their function.

Skin's ability toprotect the human body from the environment relies heavily on the renewal and repair of the skin barrierby the epidermal stem cells. But environmental changes and aging impair the skin barrier leading to a drier, more fragile skin and accelerated aging.

To createthe active, the companyemployed itsPhytoCellTec technology to obtainthe stem cells from alpine rose leave, which wereincorporated in a water-soluble powder. Thesealpine rose stem cells contain epigenetic factors and metabolitesthat are able to preserve the human skin stem cells function. After creating the active, the company used its Progenitor Cell Targeting technology,to show thattheingredientincreases the vitality of epidermal stem cells by helping them to maintain their stem cell characteristics and protects these stem cells against environmental stress.

Thealpine rose active is recommended for:advanced stem cell cosmetic formulas, face and body care to protect stem cells against environmental stress and every weather formulations. Formulators can incorporate the active:at 0.41%, by dissolving it into the aqueous phase andby adding itpre-solved during the cooling phase (<60 C). The active is dissolvable at up to 20% in water and it is stable up to 60C for a short time.

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Z-COTE LSA provides broad-spectrum protection from long wave UVA rays and medium wave UVB rays by physically scattering, reflecting and absorbing solar radiation.

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Alpine Rose Leaf Extract for Environmental Protection for ...

DELAWARE STATE UNIVERSITY JULY 619, 2015 Learn about the business aspects of protecting plants and animals while exploring careers in agribusiness. Students will live on the Delaware State University (DSU) campus in Dover and learn about a variety of administrative professions from university professors and agriculture employees. Contact: Harry Thayer, (302) 857-6434, hthayer@desu.edu http://www.desu.edu DSU, founded in 1891 as the State College for Colored Students, takes pride in its heritage as one of the countrys first land-grant educational institutions, rooted early on in agriculture and education. DSUs current population includes a 76-percent African American enrollment and an increasing number of Caucasian, Hispanic, Asian, and other international students.

ARE YOU... a middle or high school student looking for a unique summer internship with an opportunity to live and study on a college campus? a high school student looking to improve your resume for college? a teacher looking for opportunities to expand your students view of agriculture? a parent looking for learning opportunities for your teen? Look no further the U.S. Department of Agriculture (USDA) offers you an opportunity of a lifetime. WHAT IS AGDISCOVERY? AgDiscovery is a summer outreach program to help teenagers learn about careers in plant and animal science, wildlife management, and agribusiness. The program allows students to live on a college campus and learn about agriculture from university professors, scientists, and administrative professionals who work for the U.S. Government in a variety of fields. They study the life cycles and habits of insects (entomologists); research micro-organisms, such as bacteria and viruses (biotechnologists); examine cells and tissues under a microscope to identify diseases (plant pathologists); work to conserve and manage wild animals and their habitats (wildlife biologists); carry out animal health programs (veterinarians); provide education on the humane care and treatment of animals (veterinarians and animal care inspectors); and manage the business aspects of protecting plants and animals (agribusiness). This 2- to 4-week summer outreach program for 2015 targets middle and high school students1 who are interested in learning more about plants, animals, and agribusiness. Students chosen to participate in AgDiscovery will gain experience through hands-on labs, workshops, and field trips. Students will also participate in character- and team-building activities and a variety of workshops.

WHO SPONSORS AGDISCOVERY? USDAs Animal and Plant Health Inspection Service (APHIS) partners with various universities and colleges to deliver the AgDiscovery program. Many of the Federal Governments professional plant scientists, biotechnologists, veterinarians, and wildlife biologists work for APHIS. The agency funds AgDiscovery each year, and partner universities host program participants on their local campuses. In 2015, there are 17 universities participating in AgDiscovery: Alcorn State University, Delaware State University, Florida Agricultural and Mechanical University, Fort Valley State University, Iowa State University, Kentucky State University, Lincoln University in Missouri, North Carolina State University, South Carolina State University, Tuskegee University, University of Arizona, University of Arkansas at Pine Bluff, University of Hawaii at Manoa, University of Illinois at Urbana-Champaign, University of Maryland at College Park, University of Maryland Eastern Shore, and Virginia State University. Each universitys AgDiscovery program focuses on a specific area of interest to our Nations agriculture, such as plant health, entomology, veterinary science, animal care, biotechnology, and agribusiness. AgDiscovery is a unique opportunity for students to gain a first-hand look at the many career paths open to them in the agricultural sciences. For those interested in an agricultural career, AgDiscovery is a great way to get started. Read on to learn more about this years program, including dates, locations, cost information, eligibility, and how to apply.

http://www.aphis.usda.gov/publications/aphis_general/2014/bro_ag_discove...

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DSU AgDiscovery 2015 - Investing in the Future of American ...