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Monthly Archives: July 2022
Geisinger’s Mobile Care Gap bus offers care to those with diabetes – Williamsport Sun-Gazette
Posted: July 11, 2022 at 2:19 am
Geisinger is hitting the road to make better health easier for people who have diabetes with its Mobile Care Gap bus. The bus is intended to reach those who have a care gap in their preventive health, according to a recent press release.
It offers critical services and screenings to help patients with diabetes manage their health.
The bus stops every Monday, Wednesday and Friday at different locations in the Geisinger footprint. Patients with care gap misses are contacted and scheduled for appointments on the bus no walk-ins are taken, the press release stated.
Staff members also assist in scheduling mammography and colorectal screening services. Three nurses on the bus each see up to 20 patients.
Services provided include height, weight and blood pressure checks, foot exams, diabetic retinopathy eye exams, nephropathy screening (urine collection) and any overdue lab work including phlebotomy services (A1c), according to the press release. Patients can also be vaccinated against pneumonia and flu, when needed.
In the midst of the COVID-19 pandemic, it closed the care gap on our diabetic population. Patients were missing critical yearly eye exams, kidney checks and blood tests used to monitor how well people are managing blood sugar levels, said Brandie ONeil, care gaps mobile nurse health coordinator. This highlighted the need for a full-service diabetic population care bus to provide patient care to those who need it most. It really turned into something special to be able to serve our patients with diabetes.
The team plans to continue care year-round. During the fall and winter months, when the bus may not be appropriate, the mobile nurses will go into clinics to continue closing diabetic care gaps, according to the press release.
Geisingers Mobile Care Gap bus is one of four mobile units in service. Patients served include those on Geisinger Health Plan, which includes Geisinger Gold (Medicare Advantage). Nurses also help patients identify resources to help them with any other health challenges theyre facing or offer enrollment in programs like Geisinger at Home and Geisinger 65 Forward.
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Geisinger's Mobile Care Gap bus offers care to those with diabetes - Williamsport Sun-Gazette
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Diabetes: The Exercise Prescription – KXLY Spokane
Posted: July 11, 2022 at 2:19 am
July 4, 2022 10:26 AM
Posted: July 4, 2022 10:26 AM
Updated: July 5, 2022 4:18 AM
Every time Natalie Wayne climbs a mountain or goes speed skating, sugar pills are part of her equipment. Wright, who lives in Wakefield, Rhode Island, is a certified diabetes educator, an exercise physiologist, and a self-proclaimed exercise nut who happens to have type 1 diabetes. In addition to climbing and skating, she likes to work out on a trampoline and, just to keep things interesting, swing on a trapeze. Wayne has to take steps to keep her blood sugar from crashing while she exercises, but diabetes has never slowed her down. She knows that a good workout boosts both her body and her mind.
Exercising can improve anyones health, but its especially valuable for people with diabetes. Exercise can be crucial for people with diabetes if they are also overweight, especially those with type 2 diabetes, whose weight is a likely contributor to their disease.
Wayne urges all her clients with diabetes to get regular exercise. It can be a tough sell, but she believes in her product. After all, regular exercise greatly reduces the risk of cardiovascular disease, by far the leading killer of people with diabetes. Exercising also helps to keep the body limber and ward off depression.
For many patients with type 2 diabetes, physical exertion can often rein in high blood sugar as effectively as a medication. Not only does exercise burn extra sugar in the blood, it also helps make the body more sensitive to insulin. While patients who have diabetes will still require medication, some people with type 2 diabetes who embrace exercise and a healthy diet may be able to reduce their medications (under the supervision of their physician).
In fact, the current guidelines from the American Diabetes Association stress that exercise can help patients control their blood sugar. In one study involving nearly 20,000 pediatric patients with type 1 diabetes, researchers concluded that regular physical activity was a major factor influencing the childrens ability to control their blood sugar.
If you have type 1 or type 2 diabetes, your doctor has probably already told you to exercise more. If not, its time to have a talk with your doctor about the safest and most effective way to incorporate regular exercise into your plans to stay healthy.
What type of exercise is best?
The American Diabetes Association recommends at least 150 minutes a week of moderate exercise thats just a little more than 20 minutes a day and two sessions of resistance exercises a week unless your doctor recommends against it. Theres no single plan that works for everyone. In general, the best exercises are the ones that youll actually do and enjoy. If youre otherwise in good health, theres no limit to the kinds of workout you can try. People with diabetes are out there playing football, climbing rock faces, and running marathons. Theyre also walking around the block and taking water aerobics classes and playing catch with their children. And theyre all doing something good for their bodies.
Why do I need to see my doctor before I start exercising?
Your doctor can help you choose the exercises that best fit your abilities and needs. Depending on your condition, certain activities may be discouraged. In some cases, physicians will recommend testing the health of a patients heart before allowing him or her to participate in a strenuous exercise program. If you have numbness in your feet, for example, jogging could cause sores or even fractures; your physician may recommend that you switch to swimming or cycling. If you have unusual symptoms when you exercise, such as severe shortness of breath or chest pain, further testing might be needed to make sure its safe to work out. Your doctor may recommend swimming, bike riding, or short walks instead.
Remember: Exercise is powerful therapy so powerful that you shouldnt try it without a little professional guidance. (After all, youd never start taking extra-strong diabetes pills without your doctors okay.) Your doctor can help you fit exercise into your overall health plan. You may need to adjust your medications, carry snacks or drinks, or tweak your diet to help prevent hypoglycemia (low blood sugar). This can happen to people with type 2 diabetes, but its much more common for people with type 1. If you have this type of diabetes, youll have to work especially closely with your doctor to find the right balance of exercise, diet, and medications.
No matter how careful they are, people with type 1 diabetes should expect a few setbacks. Their sugar levels might crash unexpectedly, briefly putting them back on the sidelines. With all of my book smarts and experience, sometimes things dont work out like they should, Wayne says. But tomorrow is a clean slate. Any diabetic who exercises should carry glucose tablets or some equivalent, such as Lifesavers, in case sugar level drops unexpectedly.
If youre having trouble controlling your blood sugar during exercise, your doctor may refer you to an exercise physiologist who is specially trained to treat diabetics.
What other precautions should I take?
Your doctor or exercise physiologist can give you safety tips for your particular workouts. Here are a few general guidelines:
Warm up with five to 10 minutes of gentle stretching and five to 10 minutes of light aerobic activity (such as walking or jogging in place).
Proper footwear is essential, especially if you have poor circulation or numbness in your feet. A gel insert and polyester or poly-blend socks will help keep your feet comfortable, dry, and blister-free.
Check your feet carefully for blisters and other sores before and after exercise.
Dehydration can affect your sugar levels, so be sure to get plenty of fluids before, during, and after exercise. Water is often an excellent choice. Your doctor may suggest taking along some fruit juice or sugary sports drink if youre at risk for low blood sugar.
Wear a diabetes identification bracelet or tag. This precaution is especially important if theres a chance you could lose consciousness from hypoglycemia.
Getting started
People with diabetes are just like everyone else if theyre not used to breaking a sweat, it can be very hard to get started. Wayne motivates her clients by having them check their blood sugar before and after a walk. When they see the numbers drop, it really clicks, she says. If theyre still having trouble taking that first step, she encourages them to find a friend or family member wholl walk or jog or ride bikes with them. Its much easier to stick to an exercise routine if you dont have to do it alone.
Exercise isnt a miracle cure, but its still one of the best things you can do for your body. So talk to your doctor, get moving, and have fun.
References
Interview with Natalie Wayne, certified diabetes educator, exercise physiologist.
American Diabetes Association: Its a great time to get moving: https://www.diabetes.org/healthy-living/fitness
American Diabetes Association. Physical activity/exercise and diabetes mellitus. Diabetes Care. 26: S73-S77.
Diabetes and Physical Activity. American Association of Diabetes Educators, February 9, American Diabetes Association. Frequently asked questions about exercise.
American Diabetes Association. Position Statement: Physical Activity/Exercise and Diabetes. Diabetes Care. 27:S58-S62.
Herbst A et al. Effects of Regular Physical Activity on Control of Glycemia in Pediatric Patients With Type 1 Diabetes Mellitus. Archives of Pediatrics and Adolescent Medicine. Vol. 160:573-577. http://archpedi.ama-assn.org/cgi/content/full/160/
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Food Freezing Guide – North Dakota State University
Posted: July 11, 2022 at 2:18 am
Introduction
Freezing is one of the easiest, quickest, most versatile and most convenient methods of preserving foods. Properly frozen foods maintain more of their original color, flavor and texture and generally more of their nutrients than foods preserved by other methods.
Good freezer management is important. The following tips will help you get the most of your freezer dollar.
The condition of the food at the time of freezing will determine the final quality of the frozen food. Frozen food can be no better than the food was before it was frozen. Freezing does not sterilize foods as canning does. It simply retards the growth of microorganisms and slows down chemical changes that affect quality or cause food spoilage.
Freezing, heating and chemical compounds can control enzyme actions. Freezing slows enzyme activity so that many frozen foods, such as meats and many fruits, will keep satisfactorily with little or no further treatment.
Enzymes in vegetables are inactivated by heat during the recommended blanching process. Enzymes in fruits, causing browning and loss of vitamin C, are controlled by chemical compounds (antioxidants).
Oxygen in the air may cause flavor and color changes if the food is improperly packaged.
Microorganisms do not grow at freezer temperature, but most are not destroyed and will multiply as quickly as ever when the frozen food is thawed and allowed to stand at room temperature.
The formation of small ice crystals during freezing is desirable. Fast freezing is the most practical way to form small ice crystals. Large ice crystals associated with slow freezing tend to rupture the cells, causing an undesirable texture change.
Maintain temperature of 0 degrees Fahrenheit or less to keep frozen foods at top quality. The storage life of foods is shortened as the temperature rises. For example, the same loss of quality in frozen beans stored at 0 F for one year will occur in three months at 10 F, in three weeks at 20 F, and in five days at 30 F.
Fluctuating temperatures result in growth in the size of ice crystals, further damaging cells and creating a mushier product. Changes in temperature can also cause water to migrate from the product.
Improperly protected food will lose moisture, color, flavor and texture. Ice crystal evaporation from an area at the surface results in freezer burn, which is a dry, grainy, brownish area that becomes tough. Freezer burn does not render a food unsafe, only less desirable.
The prime purpose of packaging is to keep food from drying out and to preserve nutritive value, flavor, texture and color. Labels on packages will say if the product is suitable for freezer storage. A good packaging material should have the following characteristics:
The packaging you select will depend on the type of food to be frozen, personal preference and availability. For satisfactory results, do not freeze fruits and vegetables in containers larger than one-half gallon.
Packaging not sufficiently moisture/vapor-resistant for long-time freezer storage includes ordinary waxed paper and paper cartons from ice cream and milk.
Rigid containers are made of plastic, glass, aluminum and heavily waxed cardboard and are suitable for all packs. These are often reusable. Straight or tapered sides on rigid containers make it much easier to remove frozen foods.
Glass jars used for freezing should be made for the purpose. Regular glass jars may not withstand the extremes in temperature. Do not use regular, narrow-mouth canning jars for freezing foods packed in liquid. Expansion of the liquid could cause the jar to break at the neck.
Cans, such as shortening and coffee cans, are good for packaging delicate foods. Line the can with a food-storage bag and seal the lid with freezer tape because they are not airtight.
Baking dishes can be used for freezing, heating and serving. Dishes may be covered with a heavy aluminum foil taped with freezer tape. To reuse the baking dish after the food is frozen, wrap the food in casserole-wrap fashion.
Ice cube trays are good for freezing foods in small amounts. Freeze food until firm and then transfer to freezer bags.
Bags and sheets of moisture/vapor-resistant materials and heavy-duty foil are suitable for dry packed vegetables and fruits, meat, fish or poultry. Bags can also be used for liquid packs. Protective cardboard cartons may be used to protect bags and sheets from tearing and to make stacking easier.
Laminated papers made of various combinations of paper, metal foil and/or cellophane are suitable for dry packed vegetables and fruits, meats, fish and poultry. Laminated papers are also used as protective overwrap.
Keep a list of all the foods in the freezer. Update the list each time food you put food in or take it out of the freezer. Use of an inventory can prevent overstorage of foods and loss of quality.
See sample.
Most of the changes that appear during thawing are a result of freezing and storage. When food is thawed the ice crystals melt, the liquid is either absorbed back into the food or leaks out from the food. Slow, well-controlled thawing usually results in better return of moisture to the food and results in a food more like the original food than rapid thawing.
Thawing in the refrigerator is the safest thawing method. Food standing at room temperature gives microorganisms the opportunity for growth and activity.
See Thawing Fruits.
The basis for safety in refreezing foods is the temperature at which thawed foods have been held and the length of time they were held after thawing. You can safely refreeze foods that still contain ice crystals or if they are still cold, i.e. below 40 F, and have been held no longer than one or two days at this temperature after thawing. In general, if it is safe to eat it is safe to refreeze.
Unfortunately, you often dont know the time and temperature. In these cases, you need to consider the following points.
If the freezer will not be operational within a day or two:
Use dry ice if available. Twenty-five pounds of dry ice in a 10 cubic foot freezer should hold the temperature below freezing for two to three days with less than half a load and three to four days in a fully loaded cabinet if you obtain dry ice quickly following interruption of freezer operation.
Place dry ice on boards or heavy cardboard on top of packages. Open freezer only when necessary. Dont handle dry ice with bare hands as it will cause burns. When using dry ice be sure the room is ventilated.
If dry ice is not available, other options are to:
- Cover the freezer with layers of newspaper and blankets. Pin the blankets away from the air vent. The air vent must be open because the freezer needs air when electricity comes on. A blanket cover will help even when using dry ice.
- Find other freezer storage at a locker plant or with friends and neighbors. Transfer foods in insulated boxes or well-wrapped in layers of newspapers.
Refreezing needs to be done quickly. Clean the freezer before refilling. If the freezer has an adjustable temperature control, turn it to the coldest position.
Check each package or container of food. You often can check nonrigid containers without opening by squeezing to feel for ice crystals. If they need to be opened they should be carefully rewrapped.
Place the warmer packages against the refrigerated surface when possible, but leave space between packages for air circulation.
The quality of refrozen foods is diminished.
Label and use refrozen foods as soon as possible.
Foods that have defrosted have no remaining ice crystals. If defrosted foods have warmed above refrigerator temperature (40 F) they should not be refrozen, except for very high acid foods, such as fruits.
Many thawed foods, i.e. those still containing many ice crystals or a firm-to-hard core of ice in the center, may be safely refrozen.
Any signs of spoilage, off-odors or color in any food indicate you should dispose of the food without tasting.
Remember, however, that you cant rely on appearance and odor. Some foods may look and smell fine, but if theyve been at room temperature too long, food poisoning bacteria may have multiplied enough to cause illness.
Meats, such as beef, pork, veal, lamb and poultry can be refrozen when they are still firm with ice crystals. Meat still safe to eat can be cooked and refrozen. Discard meats if they have any signs of spoilage such as an off-color or off-odor.
Fruits usually ferment when they start to spoil, which will not make them dangerous to eat but will spoil the flavor. Defrosted fruits that smell and taste good can be refrozen.
Vegetables should be refrozen only if they contain plenty of ice crystals.
Shellfish, prepared foods or leftovers should not be refrozen if defrosted. If the condition of the food is poor or even questionable, get rid of it. It may be dangerous.
Never refreeze melted ice cream, cream pies, eclairs or similar foods.
Unfrosted cakes, uncooked fruit pies, breads and rolls can be refrozen.
The investment in the foods in the freezer may be significant, but so are the benefits of serving safe foods.
Recent studies have shown the nutrient content of frozen, fresh ready-to-eat and canned foods to be nearly comparable. Nutrient content is the highest when foods are preserved or eaten as soon after harvest as possible.
Fresh, tender vegetables right from the garden are best for freezing. If vegetables cannot be frozen immediately after harvesting, store them in the refrigerator to preserve freshness until they can be prepared and frozen.
See table 1, for approximate yield of frozen vegetables from fresh.
Not all vegetables freeze well. Be sure to contact your county extension office for information on recommended varieties of vegetables for North Dakota to ensure a good crop to fill the freezer.
Blanching is scalding the vegetables in water or in steam for a short time. It is a very important step in freezing vegetables because it slows or stops the action of enzymes. These enzymes are essential for growth and ripening. If the enzyme action is not stopped before freezing, the vegetables may continue maturing, develop off-flavors, discolor, or toughen so they may be unappetizing in a short time.
This heating process also wilts or softens vegetables and makes them easier to pack. Some microorganisms are killed and the color is brightened.
Blanching times vary with the size and kind of vegetable. The times recommended are just long enough to stop or destroy the enzymes. Be sure to follow the recommended blanching times.
Underblanching can stimulate the activity of some en-zymes and is worse than not blanching at all. Overblanching results in loss of vitamins, minerals, flavor and color.
Use a blancher that has a blanching basket and cover or fit a wire basket into a large kettle with a cover. A cheesecloth bag is another option. Use at least 1 gallon of water for each pound of vegetables. Put the vegetables into the basket or bag and lower the basket into the boiling water. Cover and start counting time immediately. Keep heat high and continue boiling for the time specified for the vegetable you are freezing. If boiling stops, you are blanching too large a quantity at one time.
The same water can be reused several times for blanching; just be sure to bring it back to a vigorous boil before adding vegetables.
Put 1 to 2 inches of water in a kettle and bring to a rolling boil. Suspend a thin layer of vegetables in a wire basket or cheesecloth over the rapidly boiling water. Cover, keep the heat on high, and steam blanch vegetables the time recommended in the table.
Microwave-blanched vegetables are not as acceptable as either water- or steam-blanched vegetables. Using the microwave for vegetable blanching does not save significant time. This is because the time required when using either water or steam is so short.
If you choose to use the microwave for blanching vegetables, check the oven manufacturers recommendations.
After vegetables are heated they should be cooled quickly and thoroughly to stop the cooking. After heating, plunge the basket of vegetables immediately into a large quantity of cold water. Change water frequently or use cold running water or ice water. If ice is used youll need about 1 pound of ice for each pound of vegetables. It takes about as long to cool the vegetables as it does to heat them. When vegetables are cool, remove from water and drain thoroughly.
When using rigid containers leave head space (see below). Food expands when it freezes, and the top may pop off the container if it is too full.
When using freezer bags, press air out of unfilled part of the bag, seal and freeze. If the bag has a twist closure, be sure to twist the bag and fold the bag back in a gooseneck before securing the twist. If this is not done, air will rush back into the bag.
Vegetables can be packed either solid or loose.
Solid pack: Put drained vegetables into freezer containers. Pack tightly to cut down on the amount of air in the container or bag. Seal and freeze.
Loose or tray pack: This enables you to pour out as much as you want from a large package. Spread the drained vegetables in a single layer on a tray and freeze. As soon as they are frozen, pour into rigid freezer containers or bags, seal and return to freezer. Remove as you need them.
Most frozen vegetables should be cooked without thawing them first. Corn on the cob is an exception it should be partially thawed so the cob is heated through by the time the corn is cooked. This takes about 10 minutes.
Do not overcook vegetables. Cook only until tender. Most vegetables have been partially cooked when blanched, so less cooking time is required than for fresh vegetables. Cook in a small amount of water; about cup is sufficient.
Note: The microwave oven does an excellent job of cooking frozen vegetables. Follow the manufacturers recommendations for times and power selections.
Most fruits can be frozen satisfactorily, but the quality of the frozen product will vary with the kind of fruit, stage of maturity and type of pack.
Select a variety suitable for freezing. Select fruits with a firm texture and well-developed flavor and treat them with respect. Wash small lots (2 to 3 quarts) at a time to avoid bruising. Wash through several changes of cold water, lifting produce out of the water so dirt will not settle back on the fruit. Do not let produce soak.
Fruits are prepared for freezing in about the same way as for serving. It is best to prepare enough fruit for only 2 to 3 quarts at one time.
If fruit is to be crushed, suit the method to the fruit. A wire potato masher, pastry fork or slotted spoon may be used to crush soft fruits. Firm fruits may be crushed more easily with a food chopper. A colander, food press or strainer is useful for making purees. Blenders and food processors tend to liquify the fruit too much.
Do not use galvanized ware with fruit or fruit juices because the acid in fruit dissolves the zinc, which is poisonous. Metallic off-flavors may result from the use of iron utensils, chipped enameled ware or tinware that is not well tinned.
Some fruits such as peaches, apples, pears and apricots darken quickly when exposed to air and during freezing.
While preparing, keep peeled, halved, quartered, sliced or diced fruits that turn dark in a solution of ascorbic acid. This procedure is also useful for preventing stem-end discoloration in cherries and grapes. You can get ascorbic acid in several forms:
Pure powdered form seasonally available among canners supplies in supermarkets. One level teaspoon of pure powder weighs about three grams. Use one teaspoon per gallon of water as a treatment solution.
Vitamin C tablets economical and available year round in many stores. Buy 500-milligram tablets; crush and dissolve six tablets per gallon of water as a treatment solution.
Commercially prepared mixes of ascorbic and citric acid seasonally available among canners supplies in supermarkets. Citric acid powder is sold in supermarkets, but it is less effective in controlling discoloration. If you choose to use these products, follow the manufacturers directions.
There are several types of fruit packs suitable for freezing: syrup pack, sugar pack, unsweetened pack, tray pack or sugar replacement pack.
Most fruits have a better texture and flavor if packed in sugar or syrup. Some can be satisfactorily packed without sweetening, but vitamin C losses are greatest when fruits are packed without sugar. The type of pack will depend on the intended use. Fruits packed in syrup are generally best for serving uncooked; those packed in dry sugar or unsweetened are best for most cooking purposes because there is less liquid in the product. Unsweetened packs and sugar replacement packs are often used by people on special diets.
The proportion of sugar to water used depends on the sweetness of the fruit and the taste preference of the user. A 40 percent syrup is recommended for most fruits. Lighter syrups are desirable for mild flavored fruits to prevent masking the flavor. Heavier syrups may be used for very sour fruits.
To make syrup, dissolve the sugar in lukewarm water until the solution is clear. Cool syrup before using.
Use just enough cold syrup to cover the prepared fruit after it has been settled by jarring the container (about 1/2 to 3/4 cup of syrup per pint). To keep the fruit under the syrup, place a small piece of crumpled waxed paper or other water resistant wrapping material on the top and press the fruit down into the syrup before closing, sealing and freezing.
Fruit can be packed dry. Place the clean fruit in the carton, cover and freeze, or cover with water containing ascorbic acid or packed in unsweetened juice. For fruit packed in water or juice, submerge fruit by using a small piece of crumpled water-resistant material as for syrup and sugar packs. Seal tightly and freeze.
Unsweetened packs generally yield a lower quality product than packs with sugar. However, some fruits such as raspberries, blueberries, scalded apples, gooseberries, currants, cranberries and rhubarb give a good quality without sugar.
Put fruit in a bowl or shallow pan. Sprinkle sugar over the fruit and mix gently until the juice is drawn out and the sugar is dissolved. Use a large spoon or pancake turner for mixing.
Soft sliced fruits, such as peaches, strawberries, plums and cherries will yield sufficient syrup for covering if the fruit is layered with sugar and allowed to stand for 15 minutes. Some whole fruits may be coated with sugar and frozen.
Pack fruit and juice into container. Place a small piece of crumpled water-resistant paper on top to hold fruit down in the juice. Seal and freeze.
This is a good pack for the fruits mentioned above in unsweetened pack section. Spread a single layer of prepared fruit on shallow trays. Freeze and package in freezer bags promptly. The fruit pieces remain loose. Later the bag may be opened, the needed amount taken out, and the bag reclosed and returned to the freezer.
Sugar substitutes can be used when freezing fruits. They will give a sweet taste but do not furnish the beneficial effects of sugar like color protection and thick syrup. Fruits frozen with sugar replacements will freeze harder and thaw more slowly than those preserved with sugar.
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Food Freezing Guide - North Dakota State University
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Stem Cell – National Human Genome Research Institute Home
Posted: July 11, 2022 at 2:17 am
A stem cell is a specific type of cell in the body that has the potential to form many different cell types. So stem cells generally are undifferentiated, and then the kind of cells that they make would become the more mature cells that you're familiar with. So generally, if you think about it, stem cell is the top brick in a big pyramid, and at the base of the pyramid are maybe four different kinds of cells that are derived from that stem cell. And you can see that not only do they mature as they head down the pyramid, but they get greater in number. So a very small number of stem cells can give rise to an enormous number of mature progeny. Now, there are several different kinds of stem cells. There are somatic stem cells. These are the ones that live in the adult organism. And people have stem cells in their bone marrow that give rise to all the different kinds of blood that they have. There are stem cells in the liver that give rise to hepatocytes and secretory cells. There are stem cells in neural tissue that give rise to neurons and astroglial cells and things like that. And muscle has stem cells. And there are many different kinds of stem cells that have been identified in adults. There are also embryonic stem cells, and these are derived from three and a half days in the mouse and about six- to eight-day embryos in people, and these are cells with even more potential than the adult cells, because an embryonic stem cell derived in the proper way can give rise to neural cells, muscle cells, and liver cells. And these are the three different general parts of an organism that happens during its development. So the very important thing to remember about stem cells is they need not only divide and proliferate to make these many, many mature progeny cells, they also need to assure that their own stem cell pool is not reduced. So it's kind of like if you're getting three wishes, your last wish should be for more wishes. So what stem cells do is they have two different kinds of divisions they can make. They can make what's called a symmetric division, where the stem cell divides and both cells stay undifferentiated in stem cells. Or they can make asymmetric division, in which one cell goes on to proliferate and differentiate into the progeny, and the other cell stays a stem cell. So in periods like after a bone marrow transplant, where the stem cell number has to expand, they make many more symmetric than asymmetric divisions. But in the regular time in your bone marrow, the stem cells make mostly asymmetric divisions, which keep the number of stem cells pretty standard.
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Stem Cell - National Human Genome Research Institute Home
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Induced Pluripotent Stem Cells (iPS) | UCLA Broad Stem Cell Center
Posted: July 11, 2022 at 2:17 am
iPSC are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that enables the development of an unlimited source of any type of human cell needed for therapeutic purposes. For example, iPSC can be prodded into becoming beta islet cells to treat diabetes, blood cells to create new blood free of cancer cells for a leukemia patient, or neurons to treat neurological disorders.
In late 2007, a BSCRC team of faculty, Drs. Kathrin Plath, William Lowry, Amander Clark, and April Pyle were among the first in the world to create human iPSC. At that time, science had long understood that tissue specific cells, such as skin cells or blood cells, could only create other like cells. With this groundbreaking discovery, iPSC research has quickly become the foundation for a new regenerative medicine.
Using iPSC technology our faculty have reprogrammed skin cells into active motor neurons, egg and sperm precursors, liver cells, bone precursors, and blood cells. In addition, patients with untreatable diseases such as, ALS, Rett Syndrome, Lesch-Nyhan Disease, and Duchenne's Muscular Dystrophy donate skin cells to BSCRC scientists for iPSC reprogramming research. The generous participation of patients and their families in this research enables BSCRC scientists to study these diseases in the laboratory in the hope of developing new treatment technologies.
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Induced Pluripotent Stem Cells (iPS) | UCLA Broad Stem Cell Center
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Global 3D Cell Culture Market To Be Driven By Growing Impact Of Economy On Regenerative Medicine, Emerging Applications Of Gene Therapy During The…
Posted: July 11, 2022 at 2:17 am
The new report by Expert Market Research titled, Global3D Cell Culture MarketReport and Forecast 2021-2026, gives an in-depth analysis of the global 3D cell culture market, assessing the market based on its segments like applications, technology type and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analyzing the market based on the SWOT and Porters Five Forces models.
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The key highlights of the report include:
Market Overview (2016-2026)
Forecast Historical Market Size (2020): USD 1.29 billion
Forecast CAGR (2021-2026): 16.3%
Forecast Market Size (2026): USD 3.2 billion
The numerous uses of 3D cell culture in drug screening, regenerative medicine, stem cell therapies, cancer research, and cell biology are propelling the global market for 3D cell culture forward. The industry benefits from the increased acceptance of 3D cell culture models as an alternative to in vivo testing, research and development of expanded cell culture systems, and growing demand for organ transplantation. With the onset of the coronavirus pandemic, the demand for 3D cell culture has increased significantly for the investigation and development of COVID-19 and other respiratory illnesses. Additionally, 3D cell cultures can provide desired outputs with greater efficiency in research and development, both in terms of quality and cost. These are the key driving factors anticipated to accelerate market growth in the forecast period.
Industry Definition and Major Segments
Three-dimensional cell culture is a culture environment that is artificially developed to allow biological cells to thrive and interact with the surrounding framework in all three dimensions. Unlike standard 2D cell cultures, in which cells grow in a flat monolayer on a plate, 3D cell culture allows cells to grow in all directions within a test-tube system.
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By technology, the market is divided into:
By application, the market is divided into:
By end users, the market is divided into:
By region, the industry is categorized into:
Market Trends
Globally increasing prevalence of chronic medical conditions is one of the primary reasons driving the markets growth. The industry is also benefiting from the growing preference for tailored medicines among healthcare professionals and patients. Three-dimensional cell cultures are widely employed in cancer research, stem cell research, drug discovery, toxicology testing, and tissue engineering. As the coronavirus disease (COVID-19) continues to spread around the globe, the use of scaffold-based 3D cell cultures for the development and bio-fabrication of antiviral medicines and new therapies has increased significantly. Furthermore, the development of advanced microfluidic-based three-dimensional cell cultures with enhanced cell viability, morphology, proliferation, and differentiation is assisting in the markets expansion. Additional factors, such as intensive research and development (R&D) in the realm of biotechnology, as well as the growing demand for effective alternatives to animal testing, are expected to propel the market forward.
North America is projected to remain dominant in the 3D cell culture market over the forecast period. This is because the government and commercial funding businesses in the region are willing to develop superior 3D cell culture models. Additionally, the sector is strengthened by the presence of multiple colleges and research organizations exploring various stem cell-based technologies throughout North America. Due to the increase of infrastructure development to expedite stem cell research in the regions growing economies such as India, China, Asia Pacific is expected to have the highest growth rate during the forecast period. The Chinese government has given grants for many R&D initiatives on human embryonic stem cells research, encouraging scientists to investigate the cells clinical potential. These factors are expected to boost the market during the forecast period as well.
Key Market Players
The major players in the market are 3D Biotek LLC, Advanced Biomatrix Inc., Avantor Inc., CN Bio Innovations Limited, Corning Incorporated, Emulate Inc., InSphero AG, Lonza Group AG, Merck KGaA, Promocell GmbH, and Synthecon Inc., among Others. The report covers the market shares, capacities, expansions, investments and mergers and acquisitions, among other latest developments of these market players.
About Us:
Expert Market Research is a leading business intelligence firm, providing custom and syndicated market reports along with consultancy services for our clients. We serve a wide client base ranging from Fortune 1000 companies to small and medium enterprises. Our reports cover over 100 industries across established and emerging markets researched by our skilled analysts who track the latest economic, demographic, trade and market data globally.
At Expert Market Research, we tailor our approach according to our clients needs and preferences, providing them with valuable, actionable and up-to-date insights into the market, thus, helping them realize their optimum growth potential. We offer market intelligence across a range of industry verticals which include Pharmaceuticals, Food and Beverage, Technology, Retail, Chemical and Materials, Energy and Mining, Packaging and Agriculture.
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Tevogen Bio Appoints Acclaimed Oncologist and Immunotherapy Expert Neal Flomenberg, M.D. as Chief Scientific Officer and Global Head of R&D – Yahoo…
Posted: July 11, 2022 at 2:16 am
WARREN, N.J., July 07, 2022--(BUSINESS WIRE)--Tevogen Bio, a late stage clinical biotechnology company specializing in developing cell and gene therapies in oncology, neurology, and virology, today announced the appointment of preeminent oncologist Neal Flomenberg, M.D. as Chief Scientific Officer (CSO) and Global Head of Research and Development. Dr. Flomenberg will lead the companys diverse and rapidly advancing research and development initiatives of its highly adaptable precision T cell product pipeline in oncology, neurology, and virology.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220707005531/en/
Acclaimed oncologist and immunotherapy expert, Neal Flomenberg, M.D. joins Tevogen Bio as Chief Scientific Officer and Global Head of R&D (Photo: Business Wire)
Most recently, Dr. Flomenberg served as Professor and Chairman of the Department of Medical Oncology and Deputy Director of Sidney Kimmel Cancer Center of Thomas Jefferson University & Hospital. Under his leadership, Jeffersons Department of Medical Oncology more than tripled in size, established a nationally recognized senior adult oncology program as well as an embedded Supportive Medicine and Survivorship Program. At Jefferson, Dr. Flomenberg also served as Director of the Hematologic Malignancies, Blood and Marrow Transplantation (BMT) Program.
Throughout his more than forty-year career, Dr. Flomenberg has maintained a longstanding interest in the immunogenetics and immunology of stem cell transplantation, with the goal of making transplantation safer and more widely available. As Chairman of Tevogens Scientific Advisory Board, he helped advance Tevogens lead investigational product, TVGN-489, through proof-of-concept clinical trial for treatment of high-risk COVID-19 patients. Trial enrollment is currently nearing completion.
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In his new capacity at Tevogen, Dr. Flomenberg will serve as member of the executive team and lead companys ambitious R&D initiatives, allowing for further advancement of its next generation precision T cell technology platforms. Dr. Flomenberg and his leadership team will operate out of Tevogens R&D Center located in Philadelphias Wanamaker building.
"There is no better person than Neal to lead the advancement of Tevogens highly promising genetically unmodified T cell technology platforms, which we believe will pave the way for the next era of personalized T cell therapeutics for large patient populations through convenience and affordability for the very first time," said Tevogen CEO Ryan Saadi, M.D., M.P.H. "A lifelong student of science, Neals compassionate nature, brilliant mind, and unwavering passion to innovate leading-edge medicines for the good of humanity are just a few of the characteristics that make him the ideal leader to realize the fullest potential of our R&D initiatives."
"I am thrilled to serve in this new role at Tevogen, a truly patient-centric company designed to achieve commercial success through its advanced science and efficient business model which ensure affordability. I have dedicated my career to increasing our understanding of blood cancers and the infections which plague these and other patient groups as well as the cellular immunologic approaches which might be used to address these problems," said Dr. Flomenberg. "Tevogens proprietary approach allows cellular immunotherapeutics to be developed with unprecedented specificity and precision while remaining affordable and broadly applicable. Applications range from acute viral infections such as COVID-19, to longer term consequences of infections such as Long-COVID and Multiple Sclerosis, to viral-induced and non-viral induced cancers," he added.
Dr. Flomenberg has been the recipient of numerous awards including: The Simon Gratz Award for Research Most Likely to influence Patient Care (2003), The Leukemia Lymphoma Society Contributions to Mankind Award (2006), The Pennsylvania State University Outstanding Science Alumnus Award (2006), Inaugural recipient of the Philadelphia Chapter of the Leukemia Lymphoma Societys Lifetime Achievement Award (2018), Thomas Jefferson Universitys Alumnus of the Year Award (2019), and Jeffersons Deans Lifetime Distinguished Service Award (2022).He received a Bachelor of Science degree from Penn State University and earned a Doctor of Medicine degree from Jefferson Medical College.
About Tevogens Next Generation Precision T Cell Platform
Tevogens next generation precision T cell platform is designed to provide increased specificity to eliminate malignant and virally infected cells, while allowing healthy cells to remain intact. Multiple targets are selected in advance with the goal of overcoming mutational capacity of cancer cells and viruses.
Tevogen is investigating its technologys potential to overcome the primary barriers to the broad application of personalized T cell therapies: potency, purity, production-at-scale, and patient-pairing, without the limitations of current approaches. Tevogens goal is to open the vast and unprecedented potential of developing personalized immunotherapies for large patient populations impacted by common cancers and viral infections.
The companys lead product, TVGN-489, is currently in clinical trial for high-risk COVID-19 patients at Jefferson University Hospitals in Philadelphia. TVGN-489 is a highly purified, genetically unmodified, off-the-shelf, allogeneic SARS-CoV-2-specific cytotoxic CD8+ T lymphocyte (CTL) product designed to detect targets spread across the entire viral genome.
Tevogen recently announced the initiation of the fourth and final dose level of its investigational T cell therapy for high-risk COVID-19 patients in the proof of concept clinical trial of TVGN-489. No dose limiting toxicities or treatment-related adverse events, including Cytokine Release Syndrome (CRS), have been observed to date in any of the dose cohorts.
About Tevogen Bio
Tevogen Bio is driven by a team of distinguished scientists and highly experienced biopharmaceutical leaders who have successfully developed and commercialized multiple franchises. Tevogens leadership believes that accessible personalized immunotherapies are the next frontier of medicine, and that disruptive business models are required to sustain medical innovation in the post-pandemic world.
Forward Looking Statements
This press release contains certain forward-looking statements relating to Tevogen Bio Inc (the "Company") and its business. These statements are based on managements current expectations and beliefs as of the date of this release and are subject to a number of factors which involve known and unknown risks, delays, uncertainties and other factors not under the Companys control that may cause actual results, performance or achievements to be materially different from the results, performance or other expectations implied by these forward-looking statements. Forward-looking statements can sometimes be identified by terminology such as "may," "will," "should," "intend," "expect," "believe," "potential," "possible," or their negatives or comparable terminology, as well as other words and expressions referencing future events, conditions, or circumstances. In any forward-looking statement in which the Company expresses an expectation or belief as to future results, there can be no assurance that the statement or expectation or belief will be achieved. Various factors may cause differences between the Companys expectations and actual results, including, among others: the Companys limited operating history; uncertainties inherent in the execution, cost and completion of preclinical studies and clinical trials; risks related to regulatory review and approval and commercial development; risks associated with intellectual property protection; and risks related to matters that could affect the Companys future financial results, including the commercial potential, sales, and pricing of the Companys products. Except as required by law, the Company undertakes no obligation to update the forward-looking statements or any of the information in this release, or provide additional information, and expressly disclaims any and all liability and makes no representations or warranties in connection herewith or with respect to any omissions herefrom.
View source version on businesswire.com: https://www.businesswire.com/news/home/20220707005531/en/
Contacts
Media: Katelyn JoyceCorporate Communications LeadT: 1 877 TEVOGEN, Ext 709Katelyn.joyce@tevogen.com
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Tevogen Bio Appoints Acclaimed Oncologist and Immunotherapy Expert Neal Flomenberg, M.D. as Chief Scientific Officer and Global Head of R&D - Yahoo...
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Rare study involving Arab children finds genetic factors linked to severe Covid-19 illness – The National
Posted: July 11, 2022 at 2:14 am
Scientists in Dubai have identified genetic factors that may put certain children at greater risk of having a potentially fatal reaction when infected with Covid-19.
Researchers used data from dozens of youngsters in Dubai and Jordan to determine what genetic variants increased the likelihood of them developing multisystem inflammatory syndrome in children (MIS-C).
Previous studies have highlighted the role genes play in causing MIS-C, but this new research is unusual in that it included many Arab children, who are often not included in large numbers in studies of this kind.
The work was led by scientists at Mohammed Bin Rashid University of Medicine and Health Sciences and Al Jalila Childrens Hospital, both in Dubai, and published in JAMA Network Open.
This is an important study not only because the findings show comprehensive genetic profiling of children with MIS-C, which is essential to characterise the genetic contribution to the disease, but also because patients of an Arab background have long been under-represented in genetic studies, Dr Walid Abuhammour, head of the paediatric infectious diseases department at Al Jalila Childrens Specialty Hospital, and study investigator, said.
In the US, children under 5 can now receive the Pfizer vaccine. AP
The study involved analysing the genes, clinical symptoms and other factors of 45 Arab and Asian children who developed MIS-C, and comparing them to 25 children who also had Covid-19 but did not develop MIS-C.
The children were treated at Al Jalila Childrens Specialty Hospital and the Jordan University Hospital between September 2020 and August 2021.
MIS-C involves a type of over-reaction of the immune system, known as a cytokine storm, that can affect multiple organs and result in death. The cytokine storm has also been associated with deaths from Covid-19 in adults.
Among the other institutions to have researched MIS-C is Boston Childrens Hospital, which released a study in September that identified genetic risk factors that all pointed to, the hospital said, underlying problems with immune regulation.
These variants caused the children to have what was described as an exaggerated response to viral infections, something that before the coronavirus emerged actually helped these individuals fight off infections. Particular chemical messengers in the body that stimulate the immune system were blamed for the over-reaction associated with MIS-C, as they could cause inflammation if released at the wrong time.
Like the Boston study last year, and others, the new research found that children who developed MIS-C were more likely to have particular rare genetic variants linked to the immune system.
Although clinical presentations and laboratory markers in this cohort were consistent with recently described MIS-C cohorts elsewhere, our analysis revealed significant enrichment of rare, likely deleterious [harmful] [genetic] variants, the study said.
These variants affect particular biochemical processes, the paper stated, that overlap with the currently characterised immunologic profile in patients with MIS-C.
The onset of the disease and resistance to treatment were also associated with genetic factors identified by the scientists.
The results of this research suggest that rare genetic factors play a role in MIS-C disease and highlight immune-related pathways which might become targets for intervention, Dr Ahmad Abou Tayoun, director of Al Jalila Children's Genomics Centre and associate professor of genetics at MBRU, said.
Hopefully, this will now prompt additional studies to functionally characterise some of the identified genes, and to expand genomic sequencing to more diverse populations to fully characterise the genetic landscape of this new disease entity.
The research was funded by the Al Jalila Foundation, which was founded by Sheikh Mohammed bin Rashid, Vice President and Ruler of Dubai.
As well as researchers at MBRU and Al Jalila Childrens Hospital, the study involved scientists at Dubai Health Authority, the University of Jordan and The Specialty Hospital in Amman.
Updated: July 10, 2022, 5:03 AM
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Apply ‘Apple thinking’ to genetic selection, ICMJ conference students told – Beef Central
Posted: July 11, 2022 at 2:14 am
YOUNG red meat industry stakeholders were told to treat tradition as an opportunity, during the 2022 Intercollegiate Meat Judging Association Conference in New South Wales last week.
At Charles Sturt Universitys Wagga Wagga campus, NSW prime lamb seedstock producer Tom Bull described how he moved on from industry tradition to succeed. He said the sheep industry in the 1990s was subjective: The show was king.
Tom Bull addressing the ICMJ conference in Wagga this week
The key for most breeders was trying to win a bit of felt and the whole industry was trying to win this bit of felt at a show and thats how it went.
It was all purebred, very wool-focused, lamb was a by-product and at that time lamb was declining in popularity, it was too fat, eye muscles were too small and consumption per capita was really declining.
Mr Bull said one of the most influential people on his career was a former Inghams Chicken employee who explained how the Inghams business was based on producing a meal for two at two different price points.
And then they would work back and find out what genetics and what feed they would need. Everything we have done since is trying to do that, he said.
He said he look at the sheep stud industry and thought: The best thing about the stud industry is they wont change. They are still going to show sheep, the average stud breeder is about 70 years of age, he said.
So then all of a sudden, really our business was based about looking at opportunities.
The first was use of objective data, performance recording data, he said.
We were one of the first people in Lambplan in 1994 and using data, and that was not the done thing, its all about the eye, 50 years trying to train your eye how to pick a sheep.
The other one that really came up was to use composite sheep, again not the done thing purebred sheep, you cant taint the breed, you cant register them with your breed society, he said.
Mr Bull said he applied Apple thinking people dont know what they need, I didnt know I needed an iPhone.
It was really that Apple thinking, trying to think ahead, trying to work out what people need and I think thats really where our opportunities (are) performance recording, self-replacing flocks.
You could see the whole Australian lamb industry was based on Merino sheep, because we were wool-focused, wool is king, he said.
So really all we tried to do was go, why not have specialist meat flocks? We used to say, why not have the Angus cow of the Australian lamb industry.
Mr Bull said seven breeds were put together to develop the Primeline Maternal.
Every agent, every buyer was saying No, you cant do that. Within five years we broke the Australian ram sales record selling composite rams, and as lambs, half the age of the other fellows, he said.
So I think when I look at the industry, tradition is what got me ahead.
As young people, see that as an opportunity, dont see that as a threat, he said. The tradition of the industry is what enabled us to actually grow.
Mr Bull said the beef sector had applied IBISWorld founder Phil Ruthvens message at a Holbrook Meat Profit day in 2000 that the meat industry needed to become a wine industry.
You need provenance, you need point of difference. What actually happened we saw the beef industry take that up brands emerged, certified Angus beef, the Wagyu juggernaut was just starting to roll and then you look at whats happened since that time, he said.
The whole (southern) industrys been painted black based on one thing eating quality.
The beef industry is about brands now.
His favourite beef brand is Rangers Valley WX5. I know how it will eat it eats the same every time.
But Mr Bull said lamb is still just lamb.
Were where beef was 20-something years ago, but lamb is just lamb, there is no point of difference, some eats good, some eats bad. But what do you reckon my next opportunity is? Eating quality.
Mr Bull said looking at intramuscular fat, with an Australian average of 4.2pc,
The 46 year-old Lampro principal who said he still thinks he is 20, advised his audience to use their time wisely.
One minute you are thinking, you know, worrying about bar night and the next minutes youve got kids and farms and everything else.
His first job after his University of Sydney degree was working in the boning room of an American company Superior Farms trying to substitute US lamb with Australian product.
It was great because I actually understood about meat, it was probably one of the best things I ever did.
After Superior Farms left Australia, he stayed in the processing sector and was involved with the Viascan technology that measured the meat yield of carcases. He eventually became the marketing manager for Australia and New Zealand.
As it happened, New Zealand took it up and Australia to a limited degree.
He then headed home and briefly had a business processing his own wool into doonas, eventually marketing them nationwide through Grace Bros. (now Myers).
It was really good experience, learnt a lot, lost a lot of money, learned a lot about Underbelly One because all the people I had to deal with I felt were Mafia in Melbourne.
Mr Bull said he started Lambpro with five stud ewes in 1991 and now ran 10,500 sheep and will sell 400 rams this year.
And 1.1 million or nearly 5 percent of Australias lambs are now sired by our rams that come off our farm.
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Genetic test could tell millions of NHS patients if their hip or knee surgery will fail – iNews
Posted: July 11, 2022 at 2:14 am
Millions of people waiting for hip and knee surgery could soon be told whether their operation is likely to fail after scientists discovered a link between genetics and early failure of joint replacements.
In a world first, British researchers have found that DNA signals in saliva and blood samples are linked to an adverse reaction to the cobalt chrome materials in most joint implants.
It is thought a test to identify those patients who will have an adverse reaction to cobalt chrome will take at least two years before it can be rolled out but once in place should reduce the number of failed operations drastically.
About 15 per cent of Britons have these genetic characteristics, which make the immune system attack tissue around the material, causing pain and swelling, in a process similar to how a patient rejects an organ transplant.
Until now experts did not know what was causing the problem, which meant doctors had no way of telling if a patient would react badly to their new joint or not.
The research could lead to patients having more choice about what type of joint implant they decide on to boost their chance of success, which would transform the way orthopaedic surgery is carried out around the world.
In a trial, more than 600 patients who underwent joint-replacement surgery in the past 10 years were tested using saliva swabs and blood tests.
A computer analysed the data and revealed those patients who suffered complications carried specific genes. The team believe they can use this testing system to spot who would be at risk.
Currently, around 10 per cent of the population in the UK will have a joint surgically replaced in their lifetime, as a proven way to treat joint ailments such as arthritis. But as populations around the world grow older and heavier, this is leading to more joint replacement being performed, with some five million surgeries carried out across the world each year a number which is forecast to double over the next two decades.
The majority of patients are satisfied with the results of their surgery if joint replacements are successful they last between 15 and 25 years but a significant number of joint replacements fail early following adverse immune responses, leading to potentially dangerous and costly repeat surgery.
Patients with a genetic sensitivity to cobalt chrome usually have a second procedure within months of the first, using alternative materials.
The international study led by Newcastle University and published in Nature Communications Medicine, is the culmination of 14 years research by Dr David Langton, managing director at ExplantLab, a Newcastle-based organisation that investigates the links between genetics and the performance of medical devices which took part in the study.
Dr Langton said: Through our research we have been able to demonstrate that a significant percentage of patients carry a genotype that makes it more likely for them to have a reaction to a joint replacement made of a cobalt chrome component.
Our findings are a big step towards offering patients more choice about what type of joint implant they decide on, and helping them to make informed decisions about the risks involved.
Of the 6.4 million people currently on the waiting list for treatment on the NHS in England, more than 730,000 require orthopaedic surgery. Cobalt chrome is used in over 95 per cent of knee replacements, but alloys such as titanium and ceramic metals can be used as alternative, according to surgeons.
Tony Nargol, consultant orthopaedic surgeon at North Tees and Hartlepool NHS Foundation Trust, whose surgical team worked closely with Dr Langton, said: This exciting discovery comes as a result of the close working relationship our fantastic staff have had with Mr Langton and his team, as well as health staff from organisations across the world.
This work will help provide a practical way for health professionals to help patients in selecting the best type of implants for their individual bodies. It will mean better outcomes for our patients and could transform the quality of care we provide to our patients.
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Genetic test could tell millions of NHS patients if their hip or knee surgery will fail - iNews
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