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Monthly Archives: June 2022
New UCI-led study finds that your genetic sex determines the way your muscle talks to other tissues in your body – Newswise
Posted: June 4, 2022 at 2:17 am
Newswise Irvine, CA May 31, 2022 A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females. This new discovery provides insight into how muscle functions, such as exercise, promote healthy longevity, metabolism and improve cognition.
The study, titled, Genetic variation of putative myokine signaling is dominated by biologic sex and sex hormones, published in eLife, is the first to evaluate how genetic architecture influences muscle signaling to other tissues, highlighting that sex and estrogens are critical determinants of these processes.
Muscle is criticalfor maintaining metabolic state and disruption of musclefunction is a hallmark of diseases such as obesity, type 2 diabetes and cardiovascular disease, said senior author Marcus M. Seldin, PhD, assistant professor of biological chemistry at UCI School of Medicine.
Muscles secrete proteins called myokines, which play roles in a variety of processes by interacting with other tissues. Essentially, myokines allow skeletal muscles to communicate with organs such as the kidneys, the liver or the brain, which is essential for the body to keep its metabolic balance. Some of the process myokines are involved include inflammation, cancer, the changes brought about by exercise, and even cognition. Despite the clear relevance of myokines to so many physiological outcomes, the way these proteins are regulated and their effects are not well understood.
For this study, the research team performed a survey of genetic correlations focused on myokine gene regulation, muscle cell composition, cross-tissue signaling and interactions with genetic sex in humans. While expression levels of a majority of myokines and cell proportions within skeletal muscle showed little relative differences between males and females, nearly all significant cross-tissue enrichments operated in a sex-specific or hormone-dependent fashion; in particular, with estradiol. These sex- and hormone-specific effects were consistent across key metabolic tissues: liver, pancreas, hypothalamus, intestine, heart, visceral and subcutaneous adipose tissue. This study highlighted a few examples such as that muscle signals more to the pancreas in females, compared to males where liver is dominant.
We already know that skeletal muscle plays an integral role in coordinating physiologic homeostasis. In this study, we sought to understand how muscle interacts with metabolic tissues and illustrate the importance of considering the effects of genetic sex and sexual hormones when studying metabolism, said Seldin.
Moving forward, the research team plans to generate cell-based systems to evaluate some of the new hormones uncovered as part of this study and investigate why they signal differently between sexes.
This work was supported by the National Institutes of Health.
About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.
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New UCI-led study finds that your genetic sex determines the way your muscle talks to other tissues in your body - Newswise
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Pantea Kalhor’s Book The Gap: Simple Steps to Reclaim Your Health and Reverse Most Chronic Diseases is Now Available on Amazon and Online Bookstores….
Posted: June 4, 2022 at 2:17 am
Richmond Hill, Ontario, Canada June 3, 2022
Pantea Kalhor, the founder of Acechoice Publishing and Branding, 5 times amazon best-selling author, Functional Diagnostic Nutrition Practitioner, certified fertility and PTSD coach along with seven other health experts published her fifth book, The Gap: Simple Steps to Reclaim Your Health and Reverse Most Chronic Diseases.
Health gurus talk about different approaches to how to live a happy, healthy life by discovering healing opportunities in the body. The experts in this book explain how one can find true healing if research is extended, goes deeper, and looks at the big picture, at the body as a whole.
This book is the missing link, the piece of the puzzle that holds the answers youve been searching for. Its The Gap between chronic disease and your true recovery. said Pantea.
So many in the world today suffer from a myriad of conditions that are treated with a high consumption of medications over long periods of time. These only create a temporary relief from the pain and symptoms, and do not truly heal the root cause. With The Gap, readers are able to learn how the body, mind, and spirit connect. Discover how a high level of understanding about this interconnection can improve recovery from chronic pain.
Once again, Pantea has created a valuable resource for all who want to find answers to their health issues, a collaboration of experts who started off and highly trained medical and integrative medicine professionals that turned to natural, holistic practices to find the root causes of illness in their field. reviewed Angela Curtis, a best-selling author and editor.
Pantea Kalhor is also a show host, podcaster and the survivor of a Carjacking accident and unexplained infertility. Both traumas immensely affected her life and encouraged her to write four books regarding Mind-Body connection healing: Rules of Change for the Better, Naturally Conceived, PTSD Compass and The GAP. She helps women who are struggling with fertility issues remove their mental and physical blockers by filling the gap between mind and body connection.
To uncover the mystery surrounding chronic disease and to learn how your body can live healthier and longer, please visit https://acechoiceidea.com/funnel/the-gap/landing-page/ to read The Gap and download your freebies.
As the founder of Ace Choice Publishing & Branding: http://acechoiceidea.com, Pantea Kalhor also helps authors share their messages by supporting them in publishing and distributing their own book or becoming co-authors in their best seller books, and get featured in top media placements.
About Us: AceChoice Publishing and Branding helps authors write, publish, and distribute their books to bookstores and libraries. Authors learn how to publish and market their own book to the best ranking in amazon. They can also take the shortcut and only write 2500-3000 words by participating in our book projects, get connected with other coauthor experts and get high exposure in shows, podcasts, and media outlets. By getting help from Acechoice, authors can not only publish their books but also become speakers, be more visible in media and build their business foundations.To find out if you are eligible to participate in our book project, please visit the company website: http://acechoiceidea.com
Contact Info: Name: PANTEA KALHOREmail: Send EmailOrganization: AceChoice Publishing and BrandingAddress: 363 browndale crescentPhone: 14168805527Website: http://Acechoiceidea.com
Video URL: https://youtu.be/jQOfca1K_Bk
Release ID: 89075748
If you detect any issues, problems, or errors in this press release content, kindly contact [emailprotected] to notify us. We will respond and rectify the situation in the next 8 hours.
COMTEX_408130116/2773/2022-06-02T22:39:43
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Pantea Kalhor's Book The Gap: Simple Steps to Reclaim Your Health and Reverse Most Chronic Diseases is Now Available on Amazon and Online Bookstores....
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City of Angels to help NJ veterans regardless of situation – New Jersey 101.5 FM
Posted: June 4, 2022 at 2:17 am
Since 2008, City Of Angels has been helping people deal with addiction and recovery throughout New Jersey. They were instrumental in helping Artie Lange go into rehab.
Many times their founder Kevin Meara will be in studio talking about addiction or co-hosting one of our games only to hit the phone during a commercial break to help an addict trying to get help.
One night he sent chills down our spine when he pulled 23 holy cards out off his pocket representing the funeral he attended that month.
Now City of Angels is expanding to help out veterans with the Fr Vincent R Capodanno Veterans Research and Wellness Initiative at City Of Angels. Meara explains:
"For some time City of Angels has been working on an initiative to enhance our existing veteran's program -Warrior Down, No Vet Left Behind".
Kevin with two marines who were on the battlefield when Fr Capodanno was KIA
"We call that enhancement. The Father Vincent R Capodanno Veterans Research and Wellness Initiative at City of Angels or Father Vincents. The mission of our Initiative is to drive advances in and access to research and integrative medicine which addresses our veterans mental health and substance use disorders. Keeping with the service and sacrifice of Father Capodanno no veteran is denied access due to status, religion, or race.
"Born of our Warrior Down -No Vet Left Behind program, no veteran will ever receive a bill from Father Vincents. COA believes that wellness, through initiatives like integrative medicine, is the missing link to addressing mental health and substance use disorders."
attachment-Untitled design - 2022-06-02T132427.281
"When COA started in 2008, relapse was inconvenient, but now relapse is deadly. So its not rocket science that relapse can be prevented if recovery can be extended. Wellness concepts, including mental, physical and spiritual, can prevent relapse. Integrative medicine such as Hyperbarics and Ketamine Infusions, which promote neurogenesis and are supported by counseling, meditation, massage therapy, nutrition and yoga, are leading-edge."
Why was it named for Father Capodanno?
"It was something that I have no explanation for other than we were blessed by the Capodanno family, as Vinnie Capodanno (Father Vincent's namesake and a close friend) suggested we use his uncle's name."
attachment-Untitled design - 2022-06-02T132650.065
What made City of Angels take this on?
"Veteran addiction numbersmore veterans are dying from suicide than combat! This was an extension of our current veteran program Warrior Down, which was initiated when vets were coming home from Iraq and Afghanistan. It was simply the right thing to do!"
What can be done to fight mental illness?
'The number one thing to do is recognition followed by awareness. After that, if things arent working, do something different and we believe this is something different. This is leading-edge."
Vinnie Capodanno
How would you like City Of Angels to resemble St Judes?
"Every St Judes commercial states no child in need will be turned away. We believe every veteran in need should get the help they deserveits basic human compassion!"
Opinions expressed in the post above are those of New Jersey 101.5 talk show host Steve Trevelise only. Follow him on Twitter @realstevetrev.
You can now listen to Steve Trevelise On Demand! Discover more about New Jerseys personalities and what makes the Garden State interesting. Download the Steve Trevelise show wherever you get podcasts, on our free app, or listen right now.
Click here to contact an editor about feedback or a correction for this story.
See the Must-Drive Roads in Every State
A trip to New Jersey doesn't have to be all about the beach. Our state has some incredible trails, waterfalls, and lakes to enjoy.
From the Pine Barrens to the Appalachian Trail to the hidden gems of New Jersey, you have plenty of options for a great hike.Hikingis such a great way to spend time outdoors and enjoy nature, plus it's a great workout.
If you are going downhill and run into an uphill hiker, step to the side and give the uphill hiker space.Ahiker going uphill has the right of way unless they stop to catch their breath.
Always stay on the trail, you may see side paths, unless they are marked as an official trail, steer clear of them. By going off-trail you may cause damage to the ecosystems around the trail, the plants, and wildlife that live there.
You also do not want to disturb the wildlife you encounter, just keep your distance from the wildlife and continue hiking.
Bicyclists should yield to hikers and horses. Hikers should also yield to horses, but Im not sure how many horses you will encounter on the trails in New Jersey.
If you are thinking of bringing your dogon your hike, they should be leashed, and make sure to clean up all pet waste.
Lastly, be mindful of the weather, if the trail is too muddy, it's probably best to save your hike for another day.
Iasked our listeners for their suggestions of the best hiking spots in New Jersey, check out their suggestions:
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How To Get The Best Summer Look For Miami Pool And Boat Parties – Ocean Drive | Modern Luxury
Posted: June 4, 2022 at 2:17 am
Summer is around the corner, although sometimes it seems like we live in an eternal summer in the Magic City; however, pool and boat activities are back in full swing. And in a glamorous city like Miami, you have to look your best and have a fabulous time. Below you will find the best tips to serve a snatched body and face, wear the best outfit and relax. We have you covered, so get ready to enjoy the fun water activities and parties!
See Also: Capittana Capsule Swimwear Collection To Launch At Nikki Beach
There is nothing better than toning your body with a good workout and getting your body ready for the pool and the boat. Some may call it the revenge body because it will have some people talking about it. So below, we have some great recommendations for a much-needed workout. And if you don't like going to gyms, we have some fantastic outdoor destinations to start your fitness journey inside or outside.
Multiple Locations / Website
With multiple locations in South Florida, and the country, this is a great place to work on that summer body. Here not only will you find HIIT+ workouts,Group Classes, Affordable Personal Training, but also nutrition guidance using the latest technology and top notch fitness equipment.
Multiple Locations / Website
Anatomy provides a complete three-phase personal training system, performed by expertly trained Body Architects, to help members achieve their fitness goals. Here you will find hot and cold plunge pools, infrared and cold saunas, a eucalyptus steam room, and more. This gym is a holistic wellness experience for all members, making breaking a sweat even more enjoyable.
Arthur Lamb Jr. Road / Website
For those who love working in nature with fresh air and peacefulness, Virginia Key North Point Trails has options for everyone. The trail is a 4-mile loop that is different at every turn, with elevation and beautiful scenery.
1 Washington Ave / Website
Nothing gets more Miami than South Pointe Park. Here you can run, walk, meditate, and more if you are an outdoors lover while enjoying some of the most fantastic views of the city and the water. If you are lucky, you might wave to cruisers leaving the port. When you are ready to cool down, take a dip at the nearby beach.
Whether you choose to work out inside of a gym or outside, Miami will inspire you to get your body ready for the summer.
To look your best at the pool or on the boat, you need to give yourself new skin, to achieve this, there is nothing better and more accessible than exfoliating. Just be careful not to overdo it and ready the instructions before using some of the best exfoliators for the body, scalp, and face that we recommend below.
Price: $70 / Website
One of the best body scrubs on the market, the Detoxifying Body Scrub penetrates deeply to extract everything from clogged pores. Ingredients like Aloe vera moisturizes, and avocado softens skin to balance things out so it doesn't feel dry and tight after scrubbing. After using it, your skill will feel so smooth.
Price: $80 / Website
This is definitely a facial because it does, in fact, leave your skin looking like you just had a professional treatment. Credit a combination of alpha-hydroxy and beta-hydroxy acids (glycolic, tartaric, lactic, citric, and salicylic) for smoothing the texture of your skin and helping to minimize the appearance of fine lines and wrinkles. Because the product is specially formulated to have a pH of 3.5, it is especially effective without causing redness or sensitivity. It also includes a vial of the brand's organic marula luxury face oil.
Even if you tan under the sun, there is no limit to your summer glow. However, it's always better to protect your skin and fake-tan using the best products. So, to take that sun-kissed golden look to the next level, we have some recommendations that will have people wondering if you are a sun princess.
Price: $40 / Website
You can never go wrong with a St. Tropez tanning product. The fragrance noses at Givaudan were enlisted to create a powdery floral aroma that doesn't make you want to hold your breath until it's time to shower. After misting and blending it with a mitt, you should wait for one to three hours before rinsing it off for a light, medium, or dark tan. It dries instantly, so feeling sticky is never an issue. Eight hours after applying and rinsing, the results are tanned skin with no streaks just like your own skin, only healthier.
Price: $60 / Website
This quick and easy self-tanning concentrate works with any moisturizer or body butter to produce a natural-looking, hydrated, and golden tan. It provides all-day hydration thanks to naturally derived raspberry seed oil, vitamin E, and aloe vera. It's easy to use, and you will look so good after using it. P.s., don't forget to use the face version of this wonderfould product.
To keep your skin looking fresh, you always have to moisturize. And sometimes, being under the sun and with salty water around you, your skin can dry out, which is why this step is essential. Below, we present you with some of the best moisturizers to look like you came out of a facial treatment at a luxurious spa.
Price: $60 / Website
This lightweight, clarifying water cream contains hydrating nutrients and pore-refining botanicals that promote healthy aging and smooth, balanced skin. Whether you are prone to dry skin, or you simply want to give your skin an extra boost of hydration, this is a great alternative.
Price: $39 / Website
The skin-perfecting goodness of Glow Recipe's Refillable Plum Plump Hyaluronic Cream is further proof that it is one of the Internet's buzziest brands with the brightest formulas. The whipped gel-cream gets its gorgeous lavender color from three different types of plums (kakadu, illawara, and Burdekin) and its intense moisture-replenishing powers from five different weights of hyaluronic acid.
Before anything else, apply your SPF. People often forget this crucial step in their skincare routine, but if you want to protect your skin from the sun, and make it look extra fresh, DO NOT skip it. Below you will find some great recommendations so you can enjoy the pool or the boat while protecting your skin.
Price: $19.99 / Website
It is known that most sunscreens containing only physical UV blockers are notorious for being harder to spread and more visible on the skin than those containing chemical UV filters, Blue Lizard's Sensitive Mineral Sunscreen SPF 50+ formula spreads and absorbs well. This sunscreen, which has both zinc oxide and titanium dioxide, provides broad-spectrum UVA and UVB protection. Blue Lizard claims that this fragrance-free formulation is sweat and water-resistant for 80 minutes (the highest such claim allowed by the FDA). It comes in bottles that change color (from white to blue) when exposed to harmful UV light.
Price: $49 / Website
Powered by SynchroShieldTM Technology, this lightweight, invisible protective veil provides maximum protection for active, outdoor activities when it detects water, sweat, or heat*. This sunscreen lotion applies evenly and protects against UVA/UVB rays, pollutants, and dryness. This SPF always makes it to the best lists, so it is a must-have and key to protecting your skin.
To some, the summer is bikini season. With all the great tips you will find here to get yourself ready to enjoy those pool and boat activities, it is only appropriate to show up with the best swimwear. Below you will find two great boutiques in Miami to meet all of your bikini needs.
1006 Lincoln Road / Website
Beach Bunny celebrates every woman's style in an undeniably playful way, from classic silhouettes to ultra glamorous pieces.
475 Biltmore Way / Website
If you want swimwear that makes you look luxurious while still keeping the fresh and fun vibe of swimwear, this is the boutique for you. Here you will find quality pieces and a wide variety for every day you go to the pool or the boat.
A pair of perfect sunglasses will only enhance your summer activities. They will also keep you looking fly while protecting your eyes, so find some fashionable sunnies that up your game below.
Price: $50 / Website
This Quay bestseller is perfect for the pool, the boat, and beyond. And because square sunglasses have been in for a while, these pairs will make you look fabulous. Also, during the sunset, they will blend perfectly with the colors of the sky.
Price: $163 / Website
You can never go wrong with some classic Rayn Ban sunglasses, and these are the perfect ones for every summer activity. They will make you look classy but trendy at the same time.
To finish off the perfect outfit, you need the ideal shoes. And although you can use any comfortable shoes you have at home, we have some great recommendations to up your pool and boat activities vibes. But regardless, you can wear those iconic sandals you have at home because you will probably not need them that much anyway.
Price: $140 / Website
The Arizona Soft Footbed Sandal from Birkenstock combines fashion and function. These sandals' iconic double strap uppers are crafted from premium suede leather. The Soft Footbed design offers lightweight cushioning with an additional layer of soft foam inserted between the cork midsole and suede liner for maximum support and comfort. Available in multiple colors, these sandal is a great option.
Price: $248 / Website
Tory Burch's logo-emblazoned Miller sandals are a good option for a flip flop with a little more oomph. The circular logo at the top is so fashionable, it keeps your foot in place a little better than traditional flip-flops. They come in a variety of classic colors and on-trend patterns.
Don't forget to top your look with your favorite jewelry pieces and a classic big hat perfect for an Instagram photo shoot.
Lastly, before you enjoy any pool or boat activities, you should take some time to relax, whether the day before or the same day before your activities. Because getting ready for fun activities requires a clear mind and relaxation to have an even better time enjoying the summer. Relaxing is part of a healthy balance wherever you go to a spa or meditate. We have you covered with some fantastic options!
Multiple Locations / Website
This internationally recognized spa and fitness superbrand and total well-being hot spot will help you relax, look and feel your best to prepare you for the pool and boat activities. And during Spa Month in Miami, exhale has some fantastic deals, so your relaxation doesn't stop. Don't forget to check it out with multiple locations throughout the region.
1901 NE 168th St. / Website
Helia House, located in North Miami Beach, embodies energy and vitality. It's a place to heal, reconnect with yourself, and find refuge from the daily chaos. Helia House was envisioned and designed by Dr. Elizabeth Trattner, a wellness and beauty expert who specializes in Chinese and Integrative medicine. A perfect place to relax and get your mind and body ready for summer activities.
Photography by: Courtesy Anna Demianenko/ Unsplash, Angello Pro/Unsplash, bruce mars/Unsplash, Amplitude Magazin/Unsplash, Drew Dau/ Unsplash, Poko Skincare/Unsplash, Onela Ymeri/Unsplash, Arturo Rivera/Unsplash, Charlota Blunarova/Unsplash, Jakob Owens/Unsplash, engin akyurt/ Unsplash
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How To Get The Best Summer Look For Miami Pool And Boat Parties - Ocean Drive | Modern Luxury
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Animal shelter gives out 29 more pallets of pet food, supplies with help from Marines – The San Diego Union-Tribune
Posted: June 4, 2022 at 2:17 am
Community events in North County...
CARLSBAD
Marine Protected Areas subject of talk at lagoon
Batiquitos Lagoon hosts a presentation on California Marine Protected Areas, 10 a.m. Saturday June 11 led by Angela Kemsley. The free, family event will focus on 124 marine protected areas in California that are a type of underwater park, including 11 in San Diego County that protect sandy shores, tide pools, kelp forests, submarine canyons, and lagoons, such as Batiquitos. Meet at the picnic tables next to the Nature Center, 7380 Gabbiano Lane. Visit Batiquitoslagoon.org.
Summer concert at La Costa Spa & Resort
The next Live summer concert series continues with Tris Imboden Yacht Stars 7:30 p.m. Saturday June 11 at Omni La Costa Spa & Resort, 2100 Costa Del Mar Road. Self parking is free; valet $25, Cocktails and beverages sold. Tickets are $60-$250 at tix.com/ticket-sales/apaulomusic/2914/event/1262879.
ENCINITAS
Monthly Bird Watch at botanic garden
The San Diego Botanic Garden hosts its next monthly Monday bird walk at 8 a.m. Monday June 6 led by birding specialists at the garden, Quail Gardens Drive and Ecke Ranch Road. which is a hot spot for native and migrating birds. Visit sdbgarden.org.
Last week of orchid show
San Diego Botanic Gardens second annual spring orchid showcase, World of Orchids continues through June 12 in the 8,000 square foot, glass-enclosed Dickinson Family Education Conservatory. Garden admission is $12-$18, including access to the Gardens 37 acres; free for members of SDBG and other gardens participating in the American Horticultural Societys Reciprocal Admissions Program. Reserve an entrance date and time at sdbgarden.org.
ESCONDIDO
Computer tutoring for seniors offered
The Senior Service Council Escondido holds registration for computer tutoring 9 to 11:30 a.m. Friday June 10 at 728 N Broadway. One-on-one tutoring is offered for PCs, tablets, and smartphones (Android and iPhone). Fee is $10/hr or three sessions for $25. Visit escondido-senior-services.org.
Sikes Adobe 150th anniversary celebration
San Diegito River Park and the Friends of Sikes Adobe will hold a celebration of the 150th anniversary of the Sikes Adobe Historic Homestead. The Open House is from 10:30 a.m. to 1:30 p.m. June 5 at the Sikes Adobe, 12655 Sunset Drive. Free festivities will include the history of the Sikes homestead and early agriculture in North County, recognition of the descendants of the Sikes family, and tours of the adobe home and gardens. Email leana@sdrp.org or call (858) 674-2270, ext.14.
Assistance League recruiting volunteers
The Assistance League of Inland North County is recruiting volunteers to join in their mission to support local children and families. The nonprofits largest programs are Operation School Bell, which serves 100 schools in nine county school districts, and the McKinney-Vento Programs for homeless students in Vista, Escondido and Poway. The nonprofit also helps neighboring Assistance League chapters clothe children of military families at Camp Pendleton. A new program began this year with the state-subsidized child care centers in Escondido called Growing Minds. Members work with children ages 3 to 5 with reading and other projects to prepare them for kindergarten. The group runs an all-volunteer thrift shop at 2068 E. Valley Parkway in Escondido, open from 10 a.m. to 4 p.m. Tuesdays and Fridays. Visit assistanceleague.org/inland-north-county or email alinc.membership@gmail.com.
FALLBROOK
Knights of Columbus holds golf tourney
The Knights of Columbus Chapter 3162 hosts the 10th Annual Scramble Charity Golf Tournament and Silent Auction fundraiser June 13, with a 1 p.m. shotgun start at The Golf Club of California, 3742 Flowerwood Lane. Tournament proceeds will benefit the historic Mission San Luis Rey Parish and the Semper Fi Fund/Americas Fund Camp Pendleton Unit which provides financial support to combat wounded, ill & injured members of armed services & their families. Register at kofc3162.org/golf.
NORTH COUNTY
Upcoming blood drives
The San Diego Blood Bank will hold blood drives in the following parking lots:
Target 10 a.m. to 3 p.m. Friday, June 10 at 3150 Business Park Drive.
Park Circle noon to 5 p.m. Saturday, June 11 at 27679 Park Circle Way, Valley CenterHarvest Park.
Vallecitos Water District 7 a.m. to noon June 13 at 201 Vallecitos de Oro, San Marcos.
Donors will receive a San Diego Padres Blood Drive T-shirt while supplies last.
Call (800) 469-7322 or visit sandiegobloodbank.org.
Widows/widowers support group offers social activities
The Catholic Widows and Widowers of North County support group fosters friendships through various social activities and will hold these events.
Tuesday June 7: Lunch, Dominics Italian Restaurant, Oceanside Harbor.
Thursday June 9: Walk, Buena Vista Park, Vista with lunch to follow La Casa De Los Alambres, Vista.
June 14: Lunch, The Grill at St Marks Golf Club, San Marcos.
June 16: Bowling, Bowlero, San Marcos and meal afterward.
June 18: Coastal Communities Concert Band, Carlsbad and meal afterward at Blue Water Grill, Carlsbad.
June 22: Happy Hour/Dinner La Tapatia, Escondido.
June 26: Mass, Mission San Luis Rey, Oceanside with meal to follow, Upper Crust Pizza, Oceanside.
June 29: Tour Museum of Making Music with lunch to follow at Karl Strauss Brewing Co., Carlsbad.
Reservations are required at (760) 696-3502.
Virtual Cancer Survivors Day Wednesday
Scripps MD Anderson Cancer Center will host a virtual Cancer Survivors Day event for cancer survivors, families, friends and the community 4 p.m. to 6 p.m. Wednesday, June 8. The program will focus on living life well and will include welcome remarks by Scripps MD Anderson medical director Thomas Buchholz, M.D., followed by a cancer patient story by author Catherine Datte. Robert Bonakdar, M.D., of Scripps Center for Integrative Medicine, will discuss using mindfulness meditation to help cope with stress. There will be a mindfulness and stretch break led by Scripps fitness instructor, followed by a discussion on nutrition and fitness for wellness. Free. Advance registration required at (800) 727-4777 or https://www.scripps.org/events/scripps-md-anderson-cancer-survivors-day-virtual-event-june-8-2022.
I Hate Hamlet at Scripps Ranch Theatre
Scripps Ranch Theatre continues Season 42 with the comedy I Hate Hamlet by Paul Rudnick, directed by Phil Johnson. The production runs through June 12 on the campus of Alliant International University. Performances are 8 p.m. Fridays and Saturdays and 2 p.m. Sundays. Tickets are $10-$39.
Meals on Wheels holds in-person gala Saturday
Meals on Wheels San Diego County will host its in-person Reach for the Stars Galaxy Gala from 5:30 p.m. to 10 p.m. Saturday June 11 at the Sheraton Hotel & Marina, 1380 Harbor Island Drive, Mission Bay for the County-wide community . Highlights include Attendees cocktail reception, a silent auction, and Chef Appetizer Showcase. The evening will close with dancing to live music from local funk, soul and R&B band, Lust for Life. General admission tickets are $250. Visit sandiegomealsonwheels.org.
Dance Troupe seeks new members
The Toe Tappers senior dance group is recruiting experienced tap dancers who enjoy rehearsing and performing for audiences. The group entertains at special events throughout San Diego. Dancers rehearse in North County on Monday and Thursday mornings. Call (760) 845-5705.
OCEANSIDE
Grand opening of library bookstore Thursday
The Friends of the Oceanside Public Library hold a grand opening of Jane & Evies Used Books, a Friends of the Oceanside Public Library Bookstore 11 a.m. to 2 p.m. Thursday, June 9 at 323 North Coast Highway. The celebration will include a ribbon-cutting ceremony at noon, guest speakers, light refreshments and giveaways. The stores name honors the late Jane Cheadle and Evie Magaa, Friends who devoted many years of service to the Library and community. Visit oplfriends.org or call (760) 435-5560.
Pride by the Beach fest Saturday
The North County LGBTQ Resource Centers Pride by the Beach annual festival is noon to 6 p.m. Saturday June 11, at 300 N. Coast Hwy. This years theme is Together. The free alcohol and tobacco-free event features local speakers, music, entertainment and education zone. Oceanside Unified School District Superintendent Dr. Julie Vitale will deliver the keynote address. The Los Angeles queer pop group Boi Band BOI will be the headline. All-female salsa band Sabrosas Latin Orquesta, rapper Tony Ocean, Lana Segi aka theholyrainbowclub and local drag queens will also perform. Visit ncresourcecenter.org.
Fishing enthusiasts meet Friday
The Senior Anglers of Escondido meets 9:30 a.m. Friday June 10 and will host Dr. Jay Grossman, a local dermatologist for 35 years, for a presentation on Maximizing protection when enjoying outdoor activities during sunlight conditions. The club is open to fishing enthusiasts age 50 and above, and meets at the Park Avenue Community Center, 210 Park Ave. Visit senioranglersofescondido.net.
Veterans group meets Monday
The Veterans Association of North Countys Veterans Advisory Committee meeting is noon to 1 p.m. Monday in the VANC Resource Center, 1617 Mission Ave. The speakers include Jaime Salome, assistant director for Ft. Rosecrans and Miramar National Cemetery; Sin Kook, student outreach & recruitment specialist-Workshops for Warriors and Lindsay Livingston, outreach coordinator at the Steven A. Cohen Military Family Clinic at VVSD Oceanside. Visit vanc.me.
Brother Benno Thrift Shop open
The Brother Benno Thrift Shop is open from 10 a.m. to 5 p.m. Wednesdays through Saturdays at 3955 Mission Ave. Donations are being accepted at the store from 10 a.m. to 2 p.m. Tuesdays and Thursdays and 10 a.m. to noon Saturdays. Visit brotherbenno.orgCQ or call (760) 967-7505.
Summer reading program begins
Oceanside Public Library kicks off its Summer Reading program for children, teens, and adults. All ages earn prizes and can attend literacy-based, educational and fun events through Aug. 6. This years theme is Read Beyond the Beaten Path. Sign up at oceansidepubliclibrary.org. Other area libraries are also offering Summer Reading programs.
POWAY
Senior patrol volunteers sought
The San Diego County Sheriffs Department stations in Poway and 4S Ranch are looking for adults to join the Senior Volunteer Patrol. Duties include traffic control, patrolling neighborhoods in Poway and 4S Ranch, checking on homes of residents on vacation, and checking on the welfare of residents as part of the Sheriffs Departments You Are Not Alone program. Volunteers must be at least 50 years old, a U.S. citizen or legal resident who has applied for citizenship, and have a valid California drivers license and car insurance. Volunteers must be of good moral character with no felony convictions and attend a two-week Senior Volunteer Patrol Academy. Volunteers typically work up to five hours a week. Call (858) 232-8000. For information about the Senior Volunteer Patrol program in other parts of San Diego, visit sdsheriff.gov/recruitment/senior-volunteer-patrol.
RANCHO BERNADO
Historical Society gives talk on book Measures to Missiles
The Rancho Bernardo Historical Society Speakers Series presents a free talk 11 a.m. Saturday, June 11 at the Rancho Bernardo History Museum in the Bernardo Winery. Historian and author Vincent Rossi will discuss his new book, From Measures to Missiles, the story of a government laboratory that developed the first U.S. guided missiles. Visit rbhistory.org.
RANCHO BERNARDO
Republican womens group hosts Senator Jones
The Rancho Bernardo Republican Women Federated hosts guest speaker State Senator Brian Jones at its luncheon/meeting 11 a.m. to 1:45 p.m. June 17 at the Bernardo Heights Country Club, 16066 Bernardo Heights Pkwy. Cost is $30 for two course lunch. Jones will discuss legislative measures he has authored and supported. He recently completed a project with the Warrior foundation - Freedom Station to provide disabled parking for the residents and their families. Register and RSVP by Friday June 10th to rbrwf.org.
RANCHO SANTA FE
Reunion Gala benefits Seacrest Village care for seniors
The Seacrest Foundations Womens Auxiliary presents the 44th annual gala on Saturday June 12 outdoors at a private residence and vineyard in Rancho Santa Fe. Highlights of the Reunion Gala include champagne and cocktail reception, a three course wine-paired dinner overlooking the vineyard, and entertainment. auction and Fund-a-Need Program. Proceeds support the Seacrest Village Resident Assistance Fund, which provides charitable care for residents in need. Visit seacrestfoundation.org.
SAN MARCOS
Bingo on Mondays at senior center
The San Marcos Senior Activity Center, at 111 Richmar Ave., hosts bingo from 12:30 to 2 p.m. Mondays. The cost is $1 per card. Prizes include snacks, decorations and household items. Participants can also have lunch at 11:30 a.m. before bingo. Suggested lunch contribution for ages 60 and older is $4; cost for ages 59 and younger is $5. Lunch reservations must be made by 2 p.m. the Friday before bingo at (760) 744-5535, ext. 3607, or visit the Lunch Desk.
Writing group meets Wednesdays
The San Marcos Writers Critique Group meets from 1 to 4 p.m. Wednesdays via Zoom for serious writers to critique each others writings. Basic requirements include a computer with video, audio and Internet and a commitment to participate every week for four months. The group splits the $16 monthly cost between members. Participants read their pieces and receive constructive critique. Email rmdellorfano@gmail.com.
Summer Soiree concert Saturday
Pacific Coast Harmony will present Summer Soire, a concert of modern four-part harmony music 3:15 p.m. June 12 at the Rancho Santa Fe Community Center, 5967 La Grenada. The music spans the Great American Songbook, Broadway theater and film, popular traditional pieces and beyond. In addition to the chorus, there will be several special quartet appearances. The concert will follow a reception from 2:30 p.m. to 3:15 p.m. with beer, wine and hors doeuvres and a silent auction. Tickets are $25 at the door or pacificcoastharmony.bpt.me.
VISTA
Rodgers and Hammersteins Cinderella staged at the Moonlight
The opening of Moonlightss production of Rodgers and Hammersteins Cinderella has been postponed from Wednesday June 8 to Friday June 10 because of COVID cases in the cast and the production runs through June 25 at the Moonlight Amphitheatre, 1250 Vale Terrace Drive. The romantic musical offers a fresh take and surprising twists on the tale. Gates open at 6:30 p.m. for dining and picnicking, curtain at 8 p.m. Table reservations on the Moonlight Patio are $5 per person, including early entry at 6 p.m. Bread and Cheese Eatery returns as the Moonlights concessionaire. Patrons holding tickets for the Wed.., June 8 performance will be rescheduled to June 14 and those with tickets for Thurs.., June 9 will be rescheduled to June 21. Patrons unable to move into the new dates can call VisTix at (760) 724-2110. Tickets are $17-$61 with additional general lawn discounts for seniors, students, and the military at moonlightstage.com.
5K Fun Run and Walk to support mental and physical health
Vista Community Clinics fourth annual 5K Fun Run and Walk is June 12 at Brengle Terrace Park, 1200 Vale Terrace Dr. The new course is scenic and has plenty of areas for participants to explore. All ages are welcome and this family-friendly event allows each participant to set their own pace. Check in is 7 to 10 a.m. on day of race. At the end of the race, the clinic team will have swag, continental breakfast snacks, and information on the clinics mental and physical health services. Registration fee is $12. http://www.vistacommunityclinic.org/vcc5k/.
City provides free breakfast, lunch to kids
The City of Vista is providing free, nutritional breakfast and lunch to children, 18 and under during its summer day camp program at Jim Porter Recreation Center in Brengle Terrace Park, 1200 Vale Terrace Drive. Meals are served weekdays from Monday June 13 through August 12. Breakfast is served 9 to 9:30 a.m. Lunch is 12 to 12:45 p.m. On the Independence Day holiday July 4, meals will not be available. Call (760) 643-5272.
Annual Alley Art Festival Saturday
The 6th Annual Alley Art Festival, a free community event with live entertainment, art demonstrations, food trucks, artist market and puppet parade, is 11 a.m. to 4 p.m. Saturday June 11 at Green Oak Ranch, 1237 Green Oak Road. Artists will exhibit a range of works from contemporary to traditional, including kinetic artworks and sculptures to puppetry and paintings. Visit artinvista.org.
LINDA MCINTOSH U-T
If your nonprofit would like to submit a listing or photos of events that have happened recently, please email northcounty@sduniontribune.com. Include the name of the group, date and time of event, address, cost and contact information for readers within the email text. Photos should be sent as JPEGs. Include the names of those in the photos from left to right along with the photo credit and permission from the photographer to use the photo in The San Diego Union-Tribune
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Animal shelter gives out 29 more pallets of pet food, supplies with help from Marines - The San Diego Union-Tribune
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The Coaching Industry Expands Beyond The Field Of Play Into Healthcare Education – Forbes
Posted: June 4, 2022 at 2:17 am
Health education and coaching continues to grow as a professional path.
Coaches are seeing more opportunities than ever, including educators and administrators who choose to expand their know-how into adjacent industries of healthcare, EdTech, human resources, and wellness organizations.
The higher education community recognizes the importance of a carryover model, demonstrated by Vanderbilts coaching program for the Center for Student Wellbeing inside their nursing school. Additionally, Harvard Medical School is exploring the need for certified health and wellness coaches in hospitals across the country.
Education and healthcare continue to strengthen their sometimes unintentional and coincidental relationship, often borrowing approaches to support better outcomes.
To gain a perspective on the approach, this reporter sat down with Integrative Nutrition Certified Health Coach, Kevin Ellis, a.k.a the Bone Coach, to learn more about how education has evolved coaching, as a profession, from the traditions of the athletic field to careers of study and impact.
Ellis was diagnosed with osteoporosis at the young age of 30, decades before its typical onset. Left with shrinking bone density and a lifetime of pharmaceutical dependence, he took ownership of his health and, in turn, developed a coaching network to address solutions more holistically.
Beginning Diagnosis
Rod Berger: Describe your diagnosis and your journey during the initial stages?
Kevin Ellis: It's pretty shocking when someone hears that a 30-year-old male has osteoporosis. Very weak porous bones are usually associated with someone later in life. Its a more common condition found in women 55 years and much older. Its very uncommon for a 30-year-old active male who's a former Marine to be diagnosed with the condition.
Kevin Ellis, Integrative Nutrition Certified Health Coach, changing lives through health education ... [+] and coaching.
I had suffered from celiac disease for years, where gluten damages the villi in the intestine. I couldn't absorb nutrients and my body started raking those nutrients like calcium from my bones to serve other purposes. My body was tapping into its own reserves in my bones, causing osteoporosis in my early 30s.
All the doctors failed to recognize the connection and thanks to a physician's assistant recommending a bone density exam, it was discovered. After doctors painted a future filled with broken bones and medication, I realized I needed to figure some things out.
I started down this path of reading, researching and consulting with many different people. I needed a plan in place to be there for my wife and kids to have an active future. I made progress, improving my health and my bones.
Coaching Onset
Berger: When we think about healthcare, or our own health, there's so much education that goes into it. I wonder if we have the correct information to understand and comprehend our bodies and what proper functioning looks and feels like.
Ellis: Pharmaceutical intervention may address the symptom but might not address the underlying root cause. I took the holistic approach, addressing bone loss issues to get the right plan in place. I became an integrative nutrition coach and started coaching people one-on-one. I noticed similar issues with diet, digestion, absorption, lab testing, stress, sleep and exercise.
I then realized that this could be repeated for multiple people for greater benefit and turned it into a program that we call the Stronger Bone Solution. I brought in a team of experts, highly credentialed people that are some of the best in their fields. I mentioned how an audience of underserved people would benefit from building stronger bones and would they want to be a part of it. These experts were immediately on board. Many of them were in women's health and understood the need.
Berger: It says a lot that these individuals, already the best in their fields, found your mission and story so compelling to dive into the mix.
Ellis: The team is fantastic. Many are in the natural health field. Theres an educator at the Institute for Functional Medicine, a functional medicine practitioner, a doctor of physical therapy, whos an adviser to the National Osteoporosis Foundation (NOF), and the American Bone Health organization. We have a Harvard Ph.D. who focuses on stress and sleep, a dietitian, who's also a chef and a university professor, and then we have a whole team of coaches underneath.
Weve helped people in over 1,500 cities worldwide and thousands of people. Our business and coaching programs are on an upward trajectory. Many people understand there is more to it than just whats in a pill.
Connection to Marines and Father
Berger: Not everyone is driven to take what theyve learned and apply it to help others. Is there something in your DNA going back to when you chose to be in the Marine Corps thats always had that element of service inside you?
Ellis: My health journey started before I was even born. When my mother was five months pregnant, my father was told he had cancer and two months after I was born, he passed away. He was 35 years old. I had this fear that I was going to follow in his footsteps to an early grave and not have the opportunity to watch my kids grow up and experience the joys of being a dad.
My father was a Marine, survived combat in Vietnam, but ended up getting cancer from Agent Orange used in the war. I went into the Marines because I thought it would make my dad proud. But also do good in the world and help people. I was in the Marine Corps for five years and brought a very close personal connection to my father, a way to say goodbye to him. After Afghanistan, I decided it was time to move forward with my life and went to school to get an education. But unfortunately, that was when my health took a turn for the worse.
The Marine Corps provided a foundation for me to create a business that would reach, help and serve people.
Coaching Models and Mentoring
Berger: The coaching model is growing in many areas, from education and healthcare to executive coaching and personal coaching. Please talk about the why you feel a coaching model works well with traditional practice inside medicine?
Ellis: Coaches compress time and you will always want to work with someone who condenses the process. I saw an intervention gap in osteopenia and osteoporosis and I decided to utilize the skills I attained and apply them broadly.
I'm very oriented around systems, processes, and templates. The idea with our clients and coaching teams is to eliminate inefficiencies that they may experience in a conventional model where you go to your doctor, spend 15 minutes, book another appointment for eight months to a year out, without needed support along the way.
In our model, we lay out a plan for the individual. Then, every day of the week, we give support along the way with the experts who know how to help you best in a round-robin fashion. It changes the way people get information. When you can get people the correct information they need faster, it has the potential to achieve faster results.
Berger: It feels like going through this kind of coaching process would help develop a sense of agency. Is that something you have noticed?
Ellis: Good coaches don't create dependencies; they empower, educate and help you become your own best advocate. A doctor can cause dependency for some people. A coach helps with concurrencies. Its about reducing dependencies and increasing concurrencies to move a person forward on their best health path.
Most physicians are not people who came into their practice to just prescribe medication and not care about the patient. On the contrary, most want to help people. So we avoid creating a situation where this adversarial relationship of us vs. them mentality exists.
We work together to create a partnership in our healthcare. A doctor may have an education or training in a specific area and help with critical needs. But there are other things they're not going to help you with during a 15-minute consultation. We give our clients tools to share with their physicians to make bone health support easy, including tests to run. We add the science and when results come back, we give clients the guides and tools to sit down with their physician. It's a partnership with the physician.
Mentor a Million
Berger: How do you see serving underserved communities? Is there even more opportunity to dive in even deeper with this kind of support?
Ellis: I'm in the process of developing a program called Mentor a Million. I want to mentor a million kids and teach them how to be good, kind, contributing members of society and teach them good values. I want my business, Bone Coach, to create internship opportunities for these kids so they can work in a purpose-driven organization that's contributing to the betterment of society.
Its my long term vision and it's all going to come together. I can see it clear as day. In my eyes, I'm already mentoring a million kids, but we just haven't crossed paths yet.
According to the 2021 U.S. Health Coaching Market Report the health and wellness industry market has ballooned to $4.2 trillion supporting an exploding market of health coaches to the tune of over $7 billion.
The Annals of Family Medicine projects a shortfall of primary care physicians of nearly 50,000 providers by 2025. The industry is starting to explore health coaching not as a substitute, but as a vital response to expanding health care needs.
Schools and universities have been found to be feeder systems into this sector. Education, writ large, will most likely be looked at as the training grounds to support new interventions and career pathways.
Ellis might just be a reflection of a person and career path that current students explore in the future supporting industry personnel shortages and individual health needs across the country.
Interviews have been edited and condensed for clarity.
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The Coaching Industry Expands Beyond The Field Of Play Into Healthcare Education - Forbes
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Gene therapy to terminate tachyarrhythmias – DocWire News
Posted: June 4, 2022 at 2:16 am
This article was originally published here
Expert Rev Cardiovasc Ther. 2022 Jun 2. doi: 10.1080/14779072.2022.2085686. Online ahead of print.
ABSTRACT
INTRODUCTION: To date, the treatment option for tachyarrhythmia is classified into drug therapy, catheter ablation, and implantable device therapy. However, the efficacy of the antiarrhythmic drugs is limited. Although the indication of catheter ablation is expanding, several fatal tachyarrhythmias are still refractory to ablation. Implantable cardioverter-defibrillator increases survival, but it is not a curable treatment. Therefore, a novel therapy for tachyarrhythmias refractory to present treatments is desired. Gene therapy is being developed as a promising candidate for this purpose, and basic research and translational research have been accumulated in recent years.
AREAS COVERED: This paper reviews the current state of gene therapy for arrhythmias, including susceptible arrhythmias, the route of administration to the heart, and the type of vector to use. We also discuss the latest progress in the technology of gene delivery and genome editing.
EXPERT OPINION: Gene therapy is one of the most promising technologies for arrhythmia treatment. However, additional technological innovation to achieve safe, localized, homogeneous, and long-lasting gene transfer is required for its clinical application.
PMID:35655364 | DOI:10.1080/14779072.2022.2085686
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Gene therapy to terminate tachyarrhythmias - DocWire News
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Global Cell and Gene Therapy Markets, Analysis & Forecasts, 2016-2021, 2021-2026F, 2031F – Benzinga – Benzinga
Posted: June 4, 2022 at 2:16 am
Dublin, May 30, 2022 (GLOBE NEWSWIRE) -- The "Cell and Gene Therapy Global Market Report 2022: By Product, By Application, By End-User" report has been added to ResearchAndMarkets.com's offering.
The global cell and gene therapy market is expected to grow from $6.58 billion in 2021 to $8.57 billion in 2022 at a compound annual growth rate (CAGR) of 30.2%.
The growth is mainly due to the companies resuming their operations and adapting to the new normal while recovering from the COVID-19 impact, which had earlier led to restrictive containment measures involving social distancing, remote working, and the closure of commercial activities that resulted in operational challenges.
The market is expected to reach $21.33 billion in 2026 at a CAGR of 25.6%.
Major players in the cell and gene therapy market are Gilead Sciences, Bristol-Myers Squibb, Novartis AG, Amgen, Merck, Organogenesis Holdings, Dendreon, Vericel, Bluebird Bio and Fibrocell Science.
The cell and gene therapy market consist of sales of cell and gene therapies by entities (organizations, sole traders and partnerships) that develop cell and gene therapies. Cell therapy refers to the transfer of intact, live cells that are originated from autologous or allogenic sources and gene therapy refers to the introduction, removal, or change in the genome for treating diseases. The market consists of revenue generated by the companies developing cell and gene therapy products by the sales of these products.
The main types of products in cell and gene therapy are cell therapy and gene therapy. Gene therapy is a branch of medicine that focuses on modifying the genetic material of cells to achieve a therapeutic effect or to heal disease by repairing or reconstructing damaged genetic material. The different applications include oncology, dermatology, musculoskeletal, others and involves various sectors such as hospitals, ambulatory surgical centers, cancer care centers, wound care centers, others.
Steady investment and consolidation in cell and gene therapies contributed to the growth of the cell and gene therapy (CGT) market. After recognizing the potential of the CGT market, 16 out of the 20 largest biopharma companies by revenue, added CGT products to their portfolio.
For instance, Merck invested $109 million in viral vector and gene therapy manufacturing in April 2020. Moreover, 12% of industrial clinical pipeline products and at least 16% of preclinical pipeline products consist of CGT. Steady investment and consolidation in CGT production capacity led to an increase in production capacity and also contributed to the growth of the market.
Limited reimbursements preventing patients from receiving treatments are expected to limit the growth of cell and gene therapy (CGT market. In 2019, Trinity Life Sciences, a life sciences solution provider, researched national and large regional commercial health insurance plans in the US.
It found that the confluence of increasing price, patient volume and number of CGTs on the market is likely to change the reimbursement model for CGTs and impact payer budgets by 5-10%. Payers realize that financing needs to be generated for cost management due to the uncertainty surrounding reimbursement of ancillary costs. Limited reimbursements and uncertain insurance plans are preventing patients from receiving high-cost CGT, which is expected to limit market growth.
Chimeric antigen receptor (CAR) T-cell therapy is shaping the cell and gene therapy (CGT) market. (CAR) T-cell therapy is a combination of cell and gene therapy in which T cells are collected from the patient's blood and are genetically engineered to produce modified receptors at their surface, known as chimeric antigen receptors (CARs). These modified T cells with special structures (receptors) are reinfused into the patient.
Then, the modified receptors of T cell help in targeting the surface antigen of the cancer cell that ultimately results in the killing of tumor cells in patients. In 2020, the US-FDA approved Bristol-Myers Squibb's two CAR-T cell therapies to treat lymphoma and multiple myeloma and is set to be launched.
Currently, FDA approved CAR-T cell therapy treatments like Tisagenlecleucel for the treatment of B-cell precursor acute lymphoblastic leukemia (ALL) in children and Axicabtagene ciloleucel for the treatment of adult patients with relapsed or refractory large B-cell lymphoma.
Key Topics Covered:
1. Executive Summary
2. Cell and Gene Therapy Market Characteristics
3. Cell and Gene Therapy Market Trends And Strategies
4. Impact Of COVID-19 On Cell and Gene Therapy
5. Cell and Gene Therapy Market Size And Growth5.1. Global Cell and Gene Therapy Historic Market, 2016-2021, $ Billion 5.1.1. Drivers Of The Market 5.1.2. Restraints On The Market 5.2. Global Cell and Gene Therapy Forecast Market, 2021-2026F, 2031F, $ Billion 5.2.1. Drivers Of The Market 5.2.2. Restraints On the Market
6. Cell and Gene Therapy Market Segmentation6.1. Global Cell and Gene Therapy Market, Segmentation By Product, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion
6.2. Global Cell and Gene Therapy Market, Segmentation By Application, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion
6.3. Global Cell and Gene Therapy Market, Segmentation By End User, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion
7. Cell and Gene Therapy Market Regional And Country Analysis7.1. Global Cell and Gene Therapy Market, Split By Region, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion 7.2. Global Cell and Gene Therapy Market, Split By Country, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion
Companies Mentioned
For more information about this report visit https://www.researchandmarkets.com/r/1mm93h
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Global Cell and Gene Therapy Markets, Analysis & Forecasts, 2016-2021, 2021-2026F, 2031F - Benzinga - Benzinga
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Roche SMA drug approved in youngest infants, challenging Novartis and Biogen – BioPharma Dive
Posted: June 4, 2022 at 2:16 am
Dive Brief:
Treatment of SMA has transformed over the six years since Biogen first gained approval for Spinraza. The disease was previously considered fatal for many babies born with the mutation that causes it. Even for those with less severe forms of the disorder, there were lifelong disabilities that often required use of a wheelchair or mechanical ventilation.
Until Evrysdi's latest approval, Spinraza was the only drug approved for all patients. Novartis' Zolgensma, which replaces the defective genes to stimulate production of an important muscle protein, is approved for children younger than 2 years old. The company has faced setbacks in trying to complete the clinical studies necessary to win approval in patients older than that.
With SMA's incidence estimated as once per every 10,000 births, the three drugmakers are all targeting a small group of patients with their treatments. While oral and therefore more convenient, Evrysdi must be taken every day. Spinraza, by comparison, is administered once every four months after a two-month loading period through the more invasive intrathecal injection. Zolgensma is intended to be a one-time treatment, although with the long-term safety of gene therapy still unclear, some parents could be more cautious about using it for their babies.
Spinraza is the biggest seller, with $473 million in sales in the first quarter of 2022, compared to $363 million for Zolgensma and about $236 million for Evrysdi. When the two Swiss drugmakers reported earnings, Novartis disclosed that Zolgensma had been used in about 2,000 patients worldwide and Roche said Evrysdi had been used in more than 5,000. (Roche's number includes those treated in clinical trials and compassionate use, however.)
Sales of both Zolgensma and Evrysdi are growing, at the apparent expense of Spinraza, sales of which shrank by 9% in the first quarter compared to the same period last year.
With all three drugs now approved for use in the youngest infants and two of the three available more widely, a new question is how these treatments might be used in sequence. All three, however, are costly: Zolgensma's one-dose list price is around $2 million, while Spinraza's list price is $375,000 a year at the maintenance dose and Evrysdicosts $340,000 annually.
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Roche SMA drug approved in youngest infants, challenging Novartis and Biogen - BioPharma Dive
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Gene Therapy Cell Culture Media Market Size, Scope and Forecast | Fujifilm Holdings Corporation, HiMedia Laboratories Pvt., Ltd, Lonza Group Ltd,…
Posted: June 4, 2022 at 2:16 am
New Jersey, United States TheGene Therapy Cell Culture Media Marketreport is the result of extensive and expert research into theGene Therapy Cell Culture Mediaindustry. TheGene Therapy Cell Culture MediaMarketreport explains what the market is all about, the market prognosis, several segmentations, and everything that falls under the markets umbrella. It also looks at major and secondary market drivers, market share, potential sales volume, regional analysis, and the markets key segments. The research also includes key variables that contribute to the markets growth as well as elements that might stifle the markets growth. The professionals at VM Reports applied precise research techniques and other analyses.
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Key Players Mentioned in the Gene Therapy Cell Culture Media Market Research Report:
Fujifilm Holdings Corporation, HiMedia Laboratories Pvt., Ltd, Lonza Group Ltd, Sartorius AG, Thermo Fisher Scientific Inc., Merck KGaA, Danaher Corporation, Takara Holdings Inc., Novartis International AG, Bio-Techne Corporation.
Gene Therapy Cell Culture MediaMarket Segmentation:
Gene Therapy Cell Culture Media Market, By Media Type
Serum-containing Media Serum-free Media Stem Cell Media Specialty Media Chemically Defined Media
Gene Therapy Cell Culture Media Market, By End User
Biotechnology & Pharmaceutical Industry Academic Institute Research Laboratory
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Gene Therapy Cell Culture Media Market Report Scope
Key questions answered in the report:
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3. Which product and application will take a lions share of the Gene Therapy Cell Culture Media market?
4. What are the drivers and restraints of the Gene Therapy Cell Culture Media market?
5. Which regional market will show the highest growth?
6. What will be the CAGR and size of the Gene Therapy Cell Culture Media market throughout the forecast period?
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