Monthly Archives: June 2022

If youve changed your supplement routine since the pandemic, youre not alone. According to a 2020 survey conducted by the Council for Responsible Nutrition (CRN), more than 43 percent of dietary supplement users have switched things up. Among those who updated their regimens, 91 percent reported increasing their supplement intake, either by adding new supplements, taking the same supplements more regularly, or upping their dose(s). Overall immune support and health and wellness benefits are cited as the top reasons.

But while supplements are often seen as a method to ensure you meet your daily nutritional needs, they can create problems if youre not careful. Like drugs, dietary supplements can affect the way your body functions, which can cause adverse effects in some people, according to an article published in the May 2022 issue of U.S. Pharmacist.

So, how do you know if youre overdoing it with the supplements? Read on to find out.

[In general], a supplement is something youre not getting enough of through food, says Rohit Moghe, PharmD, CDCES, a pharmacist with Trinity Health Mid-Atlantic in Philadelphia, and member of the American College of Lifestyle Medicine (ACLM).

To fill in these nutrient gaps, many people turn to gummies, capsules, powders, tinctures, and even saline solutions delivered via needle (known as IV therapy).

In the Dietary Supplement Health and Education Act of 1994, Congress defined supplements as products (other than tobacco) that are intended to supplement the diet, contains one or more dietary ingredients (including vitamins, minerals, herbs, botanicals, amino acids, or other substances) or their constituents, is intended to be taken by mouth as a pill, capsule, tablet, or liquid, and is labeled as a dietary supplement.

While many people are able to meet their nutrient needs through their diet, others may benefit from supplements. Particularly those who face a greater risk of nutrient deficiencies, including those with higher requirements (like children, adolescents, and pregnant and lactating women), those who struggle to absorb nutrients (like older adults, obese individuals, and people with chronic conditions), and those who follow a restrictive diet (like vegans and vegetarians), according to an article published in January 2018 article in Nutrients.

For example, a vitamin B12 supplement may be a good idea for older adults and people who follow a vegan or vegetarian diet. Vitamin B12 helps keep your blood and nerve cells healthy, and plays an important role in making DNA, per theNational Institutes of Health (NIH). Its found naturally in animal foods, which means vegans and vegetarians may not get enough through diet alone. Older adults may also be deficient in vitamin B12, because many dont have enough hydrochloric acid in their stomach to absorb it, according to the NIH. Therefore, both groups might benefit from a vitamin B12 supplement.

A common concern about supplements is that the industry, in general, is under-regulated. Unlike medications, supplements dont have to be approved by the U.S. Food and Drug Administration (FDA) before theyre sold or marketed.

New legislation, proposed by Senate Majority Whip Dick Durbin, a Democrat from Illinois, and Sen. Mike Braun, a Republican from Indiana, aims to improve the safety of dietary supplements by requiring manufacturers to list their products with the FDA under the Dietary Supplement Listing Act of 2022 a bipartisan initiative. The new legislation, which refers to the Dietary Supplement Health and Education Act of 1994, points out that in 1994 there were about 4,000 dietary supplements marketed in the United States, but the industry has boomed and now 50,000 to 80,000 products are available.

In the meantime, consumers cant be sure the supplements theyre taking are safe or effective.

Even if a supplement is considered generally safe, it may not be safe for you. Most vitamins and minerals have a risk of harm with dosages, and the risk is based on the individual nutrient and patient, says Ravi Tripathi, MD, medical director of critical care services for the Ross Heart Hospital at The Ohio State University Wexner Medical Center in Columbus. When it comes to supplements and risks, there is no one size that fits all, he says.

For example, people with an inherited condition called hemochromatosis have to be careful with iron supplements, as hemochromatosis causes toxic levels of iron to build up in their bodies, notes theNIH. And while most people dont get enough potassium even when diet and supplements are combined, according to theNIH, people with chronic kidney disease can develop abnormally high levels of potassium in their blood. This condition, known as hyperkalemia, can cause serious heart problems if left untreated, according to theNational Kidney Foundation.

Supplements can pose risks even in otherwise healthy people. According to theNIH, youre more likely to have side effects from dietary supplements if you take them at high doses or use many different supplements.

The symptoms from taking more supplementation that your body needs vary depending on the nutrient and the amount taken, and may only show up in blood tests. However, there are some physical signs to watch for. According to the May 2022U.S. Pharmacist article, general symptoms to look out for may include:

Why its good for you: Vitamin D (also known as the sunshine vitamin) helps your body absorb calcium, making it a key nutrient for bone health. Your body also needs vitamin D to carry messages between your brain and your body and fight off bacteria and viruses, according to the NIH.

Why you might be overdoing it: On the one hand, 40 percent of Americans are deficient in vitamin D, per blood tests (when serum levels are less than 50 nmol/L), according tofindings published in June 2018 in Cureus. The reason? Most of us arent getting enough sunlight exposure, notes the NIH. Taking a vitamin D supplement may help and the CRN survey shows this supplement is becoming more popular but its important to watch your dosage to ensure you dont get more than 100 micrograms (mcg) a day. According to the NIH, overdosing is almost always caused by taking supplements, as opposed to sunlight exposure or eating vitamin Drich foods.

Risks: Very high levels of vitamin D can cause nausea, vomiting, muscle weakness, pain, loss of appetite, dehydration, and kidney stones, per the NIH.

Why its good for you: Iron is a mineral your body needs to make hemoglobin, a protein in red blood cells that carries oxygen throughout your body, according to theNIH. It also helps your body make hormones.

Why you might be overdoing it: Iron supplements are often recommended for younger women to help offset iron lost during menstruation. But according to theCleveland Clinic, many women continue to take supplements containing iron after menopause, when menstruation stops and iron needs decrease.

Risks: Getting too much iron can cause gastrointestinal (GI) symptoms like constipation, nausea, vomiting, abdominal pain, and diarrhea, per the NIH. Overdosing on iron can also lead to inflammation of the stomach lining and ulcers. Although rare, extremely high doses of iron (in the hundreds or thousands of milligrams) can even cause organ failure, coma, convulsions, and death, according to the NIH.

Why its good for you: According to theNIH, vitamin A is important for vision, immune health, reproduction, growth, and development.

Why you might be overdoing it: Its pretty easy for most people to score plenty of vitamin A. If you eat cereal for breakfast and carrots or sweet potatoes at lunch, and then pop a supplement for eye health, youve probably gone over the recommended amount, says the Cleveland Clinic.

Risks: High levels of vitamin A can cause severe headaches, blurred vision, nausea, dizziness, muscle aches, and coordination issues, notes the NIH.

Why its good for you: Vitamin C, also known as ascorbic acid, acts as an antioxidant, helping to protect your body from free radical damage. According to theNIH, your body also needs vitamin C to make collagen, a protein thats important for wound healing.

Why you might be overdoing it: The CRN survey found that vitamin C supplements have seen a big boost since the pandemic. However, most people can get enough vitamin C through food. In fact, 1 cup of strawberries, chopped red pepper, or broccoli will provide the daily amount needed, per Mayo Clinic.

Risks: Taking too much vitamin C can cause diarrhea, nausea, and stomach cramps, according to Mayo Clinic. Vitamin C supplements may also interact with cancer treatments like chemotherapy and radiation therapy, per the NIH. In addition, a past study found that men who took vitamin C supplements had a higher risk for developing kidney stones.

Why its good for you: Calcium is a mineral that builds and maintains strong bones. It also plays a role in nerve function, circulation, and hormone release, according to theNIH.

Why you might be overdoing it: You may be tempted to load up on calcium supplements to protect your bones, but according to theCleveland Clinic, its surprisingly easy to overdo it. Especially if youre already getting calcium from your food.

Risks: Excess calcium has been linked to constipation, kidney stones, kidney failure, heart problems, and cognitive issues, according to the Cleveland Clinic.

Experts often recommend speaking with your doctor before trying a supplement. Unfortunately, many physicians and nurse practitioners arent as knowledgeable in this area. I find many [healthcare professionals] are grossly unprepared to answer their patients questions, and they wind up telling them that supplements are a waste of money, when maybe theres a product that may actually work for your intended use, Dr. Moghe says.

If youre interested in adding a supplement to your diet, Moghe suggests talking with a physician trained in integrative medicine or nutritional medicine, a pharmacist, naturopath, or registered dietitian. You can check the directories of the National Board of Physician Nutrition Specialists and the American Board of Physician Specialties to find a healthcare professional who works for your needs.

Simple blood tests can reveal if youre deficient in specific nutrients, but the routine blood work at your annual physical doesnt typically include these tests, although some nutritional deficiencies can produce changes on these labs, according toRush University. Youll have to request these blood tests when you visit your doctor. A physician trained in integrative medicine and/or nutritional medicine, a pharmacist, naturopath, or registered dietitian may be able to offer suggestions and a tailored approach to getting the right levels of nutrients for you, and explore whether it makes sense to test for specific vitamin deficiencies given your unique lifestyle, diet, and health.

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Can You Take Too Many Supplements? - Everyday Health

Health experts warn that diabetes has become a silent epidemic in the U.S.and a silent killer. For the last two years, deaths from diabetes have hit record levels. It doesn't have to be this way. For many people, diabetes is preventable. Diabetes can lead to serious health complications like heart disease and stroke, so it's important to take steps to avoid developing the disease if possible. That includes avoiding the #1 root of diabetes. Read on to find out moreand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Diabetes is the body's inability to process sugar (glucose). Normally, when a non-diabetic person consumes sugar, their pancreas releases an enzyme called insulin to help cells convert and use sugar for energy. In a diabetic person, the pancreas either doesn't make insulin, or the body becomes resistant to insulin. Blood sugar can builds up in blood vessels, causing damage. This can lead to an increased risk of heart disease, stroke, blindness, even amputation.

Type 1 diabetes, once known as "juvenile diabetes," can develop at any age. But type 2 diabetes is the kind that has become epidemic in the United Statesup to 95% of people with diabetes have this typeand it's directly connected to diet and lifestyle choices. Experts predict one in 10 people will have diabetes by the year 2045.

There are many risk factors for type 2 diabetes, but one of the biggest is a poor diet high in processed foods and added sugar. They're closely relatedmany processed foods quickly break down into sugar. When the body is swamped with sugar, it can become resistant to insulin. The body isn't able to process glucose for energy, and serious health consequences can follow.

Eating this kind of diet increases your risk of being overweight or obese, a major contributor to diabetes. "You are more likely to develop type 2 diabetes if you are not physically active and are overweight or obese," says the National Institutes of Health. "Extra weight sometimes causes insulin resistance and is common in people with type 2 diabetes. The location of body fat also makes a difference. Extra belly fat is linked to insulin resistance, type 2 diabetes, and heart and blood vessel disease."

It's especially important to limit or avoid sugar-sweetened beverages, such as sodas, juices and sports drinks. The average American consumes the equivalent of 17 teaspoons of sugar a day, mainly through sugar-sweetened beverages, desserts and sweet snacks.

"A lot of the foods we eat are diabetogenic. What that means is they increase your risk for insulin resistance and diabetes," says Aaron Hartman, MD, a board-certified functional medicine and integrative medicine doctor in Richmond, Virginia, and assistant clinical professor of family medicine at Virginia Commonwealth University. "Sugars are one diabetogenic food. Processed carbohydrates are another. The first rule of thumb if you want to prevent diabetes is to eat real food." A diet rich in fruits and vegetables, whole grains, lean protein (especially fatty fish, like salmon) and good fats (like avocados, nuts and olive oil) may reduce your risk of diabetes and other chronic illnesses like heart disease and cancer.6254a4d1642c605c54bf1cab17d50f1e

To reduce your diabetes risk or manage your diabetes, increasing your physical activity is important. Exercise builds muscle and makes them more sensitive to insulin, so the body utilizes it better. "For people who have diabetesor almost any other disease, for that matterthe benefits of exercise can't be overstated," says Harvard Medical School. "Exercise lowers blood glucose levels and boosts your body's sensitivity to insulin, countering insulin resistance." Studies have found that all types of exercise help, but a combination of aerobic exercise and resistance training is particularly effective in reducing insulin resistance. Experts recommend aiming for 150 minutes of moderate-intensity exercise each week, including two sessions of resistance exercise.And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.

Michael Martin

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The #1 Source of Diabetes, According to Science Eat This Not That - Eat This, Not That

CHICAGO Eduardo Bruera, M.D., chair of Palliative Care Medicine at The University of Texas MD Anderson Cancer Center, has received the American Society of Clinical Oncology (ASCO) Walther Cancer Foundation Supportive Oncology Award. Bruera was formally recognized today at the 2022 ASCO Annual Meeting during the Mentorship and Career Development Roundtable.

The Walther Cancer Foundation Supportive Oncology Award is one of the highest honors presented by ASCO and Conquer Cancer, the ASCO Foundation. Endowed by the Walther Cancer Foundation, a private foundation that supports and promotes interdisciplinary and inter-institutional bench and clinical cancer research, the award and lecture were established to recognize a distinguished lecturer and leader who has made multiple, significant and enduring contributions to palliative and supportive care in oncology through the prevention, assessment and management of cancer- and treatment-related suffering.

I am honored to receive the award and to have ASCO recognize the importance of clinical and research programs aimed at alleviating the physical and psychosocial suffering associated with cancer, said Bruera, who holds the F.T. McGraw Chair in the Treatment of Cancer. We are committed to continuing our efforts to build upon these structures and processes for the benefit of our patients.

As an internationally renowned leader in the field, Bruera has made innumerable contributions to palliative and supportive care with significant impacts on the quality of life for patients with cancer and their families.

He established the Department of Palliative, Rehabilitation and Integrative Medicine at MDAnderson in 1999. Under his leadership, the department has become the largest clinical and academic palliative care program in the world, with an interdisciplinary outpatient Supportive Care Center and both inpatient and outpatient Palliative Care programs. These serve as a model for other institutions, nationally and internationally. The programs structures, processes and outcomes are shared with faculty and leaders of cancer centers across the country and have been reported in peer-reviewed journals and scientific meetings, including the ASCO Annual Meeting and ASCO Palliative Care Symposium.

Dr. Bruera is recognized as an outstanding clinician scientist, a dedicated leader and a passionate educator, said Peter WT Pisters, M.D., president of MD Anderson. Through his leadership, unwavering commitment and pioneering work, his profound contributions have increased the visibility and integration of palliative care into oncology care on a local, national and international level. We are proud that he is receiving this prestigious recognition by ASCO.

Throughout the course of Brueras distinguished career, he has pioneered practice-changing discoveries that have transformed the delivery of modern palliative care and helped to alleviate suffering for patients affected by cancer.

He developed methodologies and conducted research studies instrumental in establishing routine clinical practices in supportive and palliative care including patient-reported outcomes measurement, methylphenidate for opioid sedation and fatigue, opioid rotation and methadone for refractory pain. In addition, he established strategies for corticosteroids for fatigue and symptom control, assessment and management of delirium, opioids and oxygen for dyspnea, and the screening and management of chemical coping and opioid use disorders in cancer patients.

Bruera led numerous research studies aimed at improving the quality of life for cancer patients. He developed and validated the Edmonton Symptom Assessment Scale (ESAS) decades before patient-reported outcome measurements became fully accepted. The ESAS is designed to assist in the assessment of nine symptoms common in cancer patients and provides a clinical profile of symptom severity over time. The tool has been translated into 60 languages and is currently the most commonly used tool for symptom assessment of palliative care and cancer patients worldwide. Bruera made ESAS available free of charge for anyone to use.

Bruera has authored more than 1,075 papers in top peer-reviewed journals, such as The Lancet, Lancet Oncology, JAMA, JAMA Oncology, JAMA Internal Medicine, Journal of Clinical Oncology and Cancer, as well as co-authored Dying in America. Bruera is a frequently invited speaker at national and international scientific conferences, and he has delivered over 900 invited lectures to major cancer centers and supportive and palliative care congresses.

Dr. Bruera has been a longstanding preeminent leader in palliative and supportive care, said Christopher Flowers, M.D., division head ad interim of Cancer Medicine. His dedication and service in this field has had a tremendous impact on patients at MD Anderson and around the world, and he continues to advance research and initiatives to improve their lives.

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About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. The institutions sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 52 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is No. 1 for cancer in U.S. News & World Reports Best Hospitals rankings and has been named one of the nations top two hospitals for cancer since the rankings began in 1990. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).

2022 The University of Texas MD Anderson Cancer Center

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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ASCO honors Eduardo Bruera, MD, with Walther Cancer Foundation Supportive Oncology Award - EurekAlert

By Andrew L. Salner, MD, FACR, FASTRO

Medical Director, Hartford HealthCare Cancer Institute at Hartford Hospital

The number of cancer survivors living in the United States continues to increase each year as a result of updated early-detection practices and treatment advances, as well as aging of the population. In 2019, an estimated 17 million Americans were cancer survivors. According to researchers at the American Cancer Society, that number is expected to increase to some 22 million by the year 2030.

The most common diagnoses for female survivors are:

The most common diagnoses amongst male survivors are:

These numbers do not include the large number of patients who have experienced non-melanoma skin cancer (basal cell and squamous cell cancer) or non-invasive bladder cancer.

Of the 17 million survivors, over two-thirds were diagnosed and treated more than five years ago, and 18 percent have been surviving their disease for over 20 years. More than two-thirds of the survivors are age 65 or over, while 10 percent are younger than 50. Approximately 52 percent of survivors are female.

Cancer is a common disease some 43 percent of us will receive the diagnosis during our lifetime. As early detection and treatment continue to improve, the number of survivors will grow each year. The overall five year survival rate from a cancer diagnosis has increased from 49 percent in 1975, to 63 percent in 1995, to close to 70 percent today. While we celebrate these milestones, we realize we still have much more work to do in developing new prevention strategies, screening techniques and therapies. In addition, we also understand that cancer survivorship has associated with it a complex set of issues that require attention on many fronts.

Enduring a cancer diagnosis and therapy not only affects patients physically, it can also impact them emotionally, socially and spiritually. From the physical perspective, treatment can commonly disrupt a patients quality of life due to short and long term side effects including fatigue, pain, sleep disturbance and functionality. Emotional and psychological wellbeing may be impacted by fear of recurrence, anxiety, depression, concentration and memory issues. Social wellbeing may be impaired due to impacts on relationships with others, and issues of intimacy and sexuality. Spirituality may be impacted by ones enhanced hope and resilience or the impairment thereof due to despair.

Other challenges facing survivors include a slightly increased risk of second cancers, the importance of continued surveillance for the initial cancer diagnosis, and the possible presence of financial hardship as a result of the treatment journey, even when medical insurance is present, due to lost work opportunity and other associated costs.

Cancer survivors have an opportunity to help improve their quality of life and possibly reduce the risk of recurrence by adopting healthy behaviors such as:

Hartford HealthCare providers monitor patients for late effects of treatment, and suggest strategies to help cope with a wide array of these survivorship issues. In addition, specific resources are available to help patients overcome these obstacles. For example, a survivorship APRN helps patients by presenting a survivorship care plan designed to present a personalized list of potential issues for patients who so desire. Psychologists and social workers provide counseling to help patients deal with the emotional impact of the experience.

Other resources available include dietary counseling, smoking cessation and integrative medicine strategies such as massage therapy, yoga, acupuncture and Reiki, all designed to help deal with some of the physical and emotional effects of therapy. Your oncology team can help make the referrals for these services as needed.

Articles in our monthly newsletter will provide more detailed information as we dive into survivorship issues related to each type of cancer diagnosis and intervention. At the Hartford HealthCare Cancer Institute, we are committed to your long term wellness.

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Going Beyond Treatment - Hartford HealthCare's Cancer Institute Fights for Survivors - Health News Hub

Michael Glick: ADI International Dentist of the Year for 2021

Michael Glick, Executive Director of Penn Dental Medicines Center for Integrative Global Oral Health, was named the Academy of Dentistry Internationals International Dentist of the Year for 2021. The award honors career contributions to dentistry, international education, and service.

Dr. Glick has been active with the FDI World Dental Federation since 2007, serving on multiple committees. He also had a leading role in establishing FDIs Vision 2020 and most recently was the primary author of its Vision 2030, giving guidance for a global interdisciplinary and integrative role for oral health. Dr. Glick served as Editor-in-Chief of The Journal of the American Dental Association from 2005 to 2020.

Dr. Glick served as Dean of the University at Buffalo, SUNY, School of Dental Medicine (2009-2015) where he remained as professor of oral diagnostic Sciences before coming to Penn Dental Medicine in 2021 to lead Penn Dental Medicines new Center for Integrative Global Oral Health (CIGOH). The schools first policy center, CIGOH is seeking to find creative solutions to address unmet oral health needs around the world through public policy, education, and research initiatives, collaborating across disciplines and across borders.

The ADI will present the award at its 2022 annual meeting (delayed a year due to the COVID-19 pandemic), to be held in November in San Antonio, Texas. Dr. Glick was also invited to present a continuing education lecture as part of the meeting.

The ADI is an international honor society for dentists dedicated to sharing knowledge in order to serve the dental health needs and to improve the quality of life of people throughout the world.This transnational organization is devoted to the advancement of dentistry throughout the world and to the elevation of dental standards by continuing education. There are chapters and fellows in over 80 countries around the world.

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Michael Glick: ADI International Dentist of the Year for 2021 - U Penn

TORONTO--(BUSINESS WIRE)--Cybin Inc. (NEO:CYBN) (NYSE American:CYBN) (Cybin or the Company), a biopharmaceutical company focused on progressing Psychedelics to Therapeutics, is pleased to announce the publication of a peer-reviewed article introducing EMBARK, a model of psychedelic-assisted psychotherapy that integrates leading clinical approaches to promote effective facilitation and supportive healing with psychedelic medicines.

Its a pleasure to see our work published in this respected journal. In developing EMBARK, we looked at 17 models of psychedelic-assisted psychotherapy, and we noticed that many are missing critical elements: a focus on ethics, on human relationships, on the body as a site of somatic healing, and on evidence-based practices. We designed EMBARK to overcome some of these limitations as an integrative model of psychedelic therapy. Wed like to honor the contributions of many teachers and leaders in the field who have helped chart this course, said Alex Belser, PhD, EMBARKs co-creator and Cybins Chief Clinical Officer.

The article was published on June 2, 2022 in the peer-reviewed journal Frontiers in Psychology and is titled, Models of Psychedelic-Assisted Psychotherapy: A Contemporary Assessment and an Introduction to EMBARK, a Transdiagnostic, Trans-Drug Model. Written by EMBARKs co-creators, Bill Brennan, PhD and Alex Belser, PhD, Cybins Chief Clinical Officer, the article provides a detailed overview of EMBARK to the academic and clinical communities. Frontiers in Psychology is the largest journal in the field of psychology.

We are excited to present our model to the field in a way that highlights its thoughtfulness and responsiveness to current concerns in psychedelic research. We have listened carefully to what has worked, and what has been found lacking, and offer EMBARK as an innovative step forward, said Bill Brennan, PhD, EMBARKs co-creator.

The article also provides an overview of EMBARKs six clinical domains (Existential-Spiritual, Mindfulness, Body Aware, Affective-Cognitive, Relational, and Keeping Momentum) and highlights the strengths and limitations of existing psychedelic-assisted psychotherapy approaches and evidence-based therapies. The article is the first of a series of publications aimed at presenting EMBARK as an open-source model of practice and training for therapists and facilitators supporting psychedelic-based treatments.

If psychedelics are ever to be integrated into modern clinical medicine, the usage protocols are as important as the medicines themselves. In this respect Cybin is a leader. Cybin has assembled a faculty of top-notch therapists to lead its EMBARK program, which incorporates a multi-dimensional approach to therapies that enable them to be tailored to a variety of patient needs. With the implementation of EMBARK, Cybin is setting high standards for the future of psychedelic therapy, said Dennis J. McKenna, Ph.D., Founding Board Member of Heffter Research Institute and President and Principal Founder of McKenna Academy of Natural Philosophy.

The article can be accessed online here.

Cybins upcoming clinical trials evaluating the Companys proprietary psychedelic-based molecules CYB003 and CYB004 for treating major depressive disorder, alcohol use disorder, and anxiety disorders will use EMBARK to support study participants.

About CybinCybin is a leading ethical biopharmaceutical company, working with a network of world-class partners and internationally recognized scientists, on a mission to create safe and effective therapeutics for patients to address a multitude of mental health issues. Headquartered in Canada and founded in 2019, Cybin is operational in Canada, the United States, the United Kingdom and Ireland. The Company is focused on progressing Psychedelics to Therapeutics by engineering proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens for mental health disorders.

Cautionary Notes and Forward-Looking Statements

Certain statements in this press release constitute forward-looking information. All statements other than statements of historical fact contained in this press release, including, without limitation, statements regarding Cybins future, strategy, plans, objectives, goals and targets, and any statements preceded by, followed by or that include the words believe, expect, aim, intend, plan, continue, will, may, would, anticipate, estimate, forecast, predict, project, seek, should or similar expressions or the negative thereof, are forward-looking statements. Forward-looking statements in this news release include statements regarding the Companys proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens to potentially treat psychiatric disorders.

These forward-looking statements are based on reasonable assumptions and estimates of management of the Company at the time such statements were made. Actual future results may differ materially as forward-looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results, performance, or achievements of the Company to materially differ from any future results, performance, or achievements expressed or implied by such forward-looking statements. Such factors, among other things, include: implications of the COVID-19 pandemic on the Companys operations; fluctuations in general macroeconomic conditions; fluctuations in securities markets; expectations regarding the size of the psychedelics market; the ability of the Company to successfully achieve its business objectives; plans for growth; political, social and environmental uncertainties; employee relations; the presence of laws and regulations that may impose restrictions in the markets where the Company operates; and the risk factors set out in the Company's management's discussion and analysis for the period ended December 31, 2021 and the Company's listing statement dated November 9, 2020, which are available under the Company's profile on http://www.sedar.com and with the U.S. Securities and Exchange Commission on EDGAR at http://www.sec.gov. Although the forward-looking statements contained in this news release are based upon what management of the Company believes, or believed at the time, to be reasonable assumptions, the Company cannot assure shareholders that actual results will be consistent with such forward-looking statements, as there may be other factors that cause results not to be as anticipated, estimated or intended. Readers should not place undue reliance on the forward-looking statements and information contained in this news release. The Company assumes no obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors, should they change, except as required by law.

Cybin makes no medical, treatment or health benefit claims about Cybins proposed products. The U.S. Food and Drug Administration, Health Canada or other similar regulatory authorities have not evaluated claims regarding psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds. The efficacy of such products has not been confirmed by approved research. There is no assurance that the use of psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds can diagnose, treat, cure or prevent any disease or condition. Rigorous scientific research and clinical trials are needed. Cybin has not conducted clinical trials for the use of its proposed products. Any references to quality, consistency, efficacy and safety of potential products do not imply that Cybin verified such in clinical trials or that Cybin will complete such trials. If Cybin cannot obtain the approvals or research necessary to commercialize its business, it may have a material adverse effect on Cybins performance and operations.

Neither the Neo Exchange Inc. nor the NYSE American LLC stock exchange have approved or disapproved the contents of this news release and are not responsible for the adequacy and accuracy of the contents herein.

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Cybin Announces Publication in Frontiers in Psychology Journal Introducing EMBARK, an Integrative Model of Psychedelic Therapy - Business Wire