Monthly Archives: June 2020

Lately, there has been rising awareness among people regarding the therapeutic potential of stem cells for disease management. This is one of the key factors contributing to growth of the global stem cell therapy market.

Further, identification of new stem cell lines, research and development of genome based cell analysis techniques, and investment inflow for processing and banking of stem cell are some of the significant factors augmenting expansion rate of the global stem cell therapy market.

Meanwhile, limitations associated with traditional organ transplantation such as immunosuppression risk, infection risk, and low acceptance rate of organ by body are few features leading to adoption of stem cell therapy. Moreover, high dependency on organ donors for organ transplantation is paving opportunities for growth of the stem cell therapy.

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Moreover, expanding pipeline and development of drugs for new applications are driving growth of the global stem cells market. Growing research activities focused on augmenting the application array of stem cell will also widen the horizon of stem cell market. Researchers are consistently trying to develop novel methods for creating human stem cell in order to comply with the rising demand for stem cell production to be used for disease management.

Development of Advanced Treatment Method Augmenting Market Growth

Lately, various new studies, development of novel therapies, and research projects have come into light in the global stem cell therapy market. Some of these treatment have been by approved by regulatory bodies, while others are still in pipeline for approval of the treatment.

In March 2017, Belgian based biotech firm TiGenix has announced that its latest development- cardiac cell therapy AlloCSC-01 has reached in its phase I/II successfully. It has shown positive results. Meanwhile, the U.S. FDA has also approved the treatment method. If this therapy is well-accepted among the patients, then approximately 1.9 million AMI patients could be treated using the therapy.

Likewise, another significant development that has been witnessed is development novel stem cell based technology for treatment of multiple sclerosis (MS) and similar concerns associated with nervous system. The treatment is developed by Israel-based Kadimastem Ltd. Also, the Latest development has been granted a patent by reputed regulatory body.

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Some of the prominent companies operating in the global stem cell therapy landscape are Anterogen Co. Ltd., RTI Surgical, Osiris Therapeutics Inc., Holostem Terapie Avanzate S.r.l., JCR Pharmaceuticals Co. Ltd., MEDIPOST Co. Ltd., Pharmicell Co. Ltd., and NuVasive Inc.

Some of these firms are following various growth strategies such as mergers and acquisitions, strategic alliances, and collaborations, and product development in order to strengthen their foothold in the global market for stem cell therapy.

Dermatology Segment Holds Prominence in Stem Cell Therapy Market

Stem cell therapy, primarily is a regenerative medicine. It encourages the reparative response of damaged, dysfunctional, or diseases tissue with the help of stem cells and associated derivatives. The treatment method is replacing the conventional transplant methods.

Stem cell therapy method has wide array of application in the field of nervous system treatment, dermatology, bone marrow transplant, multiple sclerosis, osteoarthritis, hearing loss treatment, cerebral palsy, and heart failure. The method aids patients fight leukemia and similar blood related diseases.

Among all, dermatology segment is leading in the global stem cell therapy market. The segment is substantially contributing to growth of the market. Stem cell therapy reduces the after effects of general treatment for burns such as adhesion, infections, and scars among others.

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Meanwhile, rising number of patient suffering from diabetes and increase in trauma surgery cases are anticipated to accelerate the adoption of stem cell therapy in the dermatology segment.

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Stem Cell Therapy Market Grows on Back of Growing Awareness Regarding Regenerative Treatment Methods - BioSpace

Latest Research Report on Global Stem Cell Therapy Market to 2027 Global Analysis and Forecast by Type (Adult Stem Cell Therapy, Embryonic Stem Cell Therapy, Induced Pluripotent Stem Cell Therapy, Other Stem Cell Therapy); Treatment (Allogeneic, Autologous ); Application (Musculoskeletal, Dermatology, Cardiology, Drug Discovery and Development, Other Applications); End User (Hospitals and Specialty Clinics, Academic and Research Institutes).The research report provides deep insights into the global market revenue, parent market trends, macro-economic indicators, and governing factors, along with market attractiveness per market segment. The report provides an overview of the growth rate of the Stem Cell Therapy market during the forecast period, i.e., 20202027. Most importantly, the report further identifies the qualitative impact of various market factors on market segments and geographies. The research segments the market on the basis of product type, application, technology, and region. To offer more clarity regarding the industry, the report takes a closer look at the current status of various factors including but not limited to supply chain management, niche markets, distribution channel, trade, supply, and demand and production capability across different countries.

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Stem Cell Therapy Market In-Depth Analysis

Stem cells are preliminary body cells from which all other cells with specialized functions are generated. Under controlled environment in the body or a clinical laboratory, these cells divide to form more cells called daughter cells. Due to the advent of modern health science, these cells play a major role in understanding the occurrence of diseases, generation of advanced regenerative medicines, and drug discovery. There are certain sources such as embryo, bone marrow, body fats, and umbilical cord blood amongst others, where stem cells are generated. The globalstem cell therapy marketis driven by factors such as increasing awareness related to the stem cells therapy in effective disease management and growing demand for regenerative medicines. However, high cost related with stem cell therapy is likely to obstruct the growth of the stem cell therapy market during the forecast period. The growing research and development activities in Asia Pacific region is expected to offer huge growth opportunity for stem cell therapy market.

Some of the key players profiled in the study are MEDIPOST, Pharmicell Co., Inc., RichSource, BioTime Inc. (Lineage Cell Therapeutics, Inc.), Mesoblast Limited, Holostem Terapie Avanzate Srl, U.S. Stem Cell, Inc., Caladrius Biosciences, Inc., TiGenix NV, AlloSource, etc.

Key Benefits

The report profiles the key players in the industry, along with a detailed analysis of their individual positions against the global landscape. The study conducts SWOT analysis to evaluate strengths and weaknesses of the key players in the Stem Cell Therapy market. The researcher provides an extensive analysis of the Stem Cell Therapy market size, share, trends, overall earnings, gross revenue, and profit margin to accurately draw a forecast and provide expert insights to investors to keep them updated with the trends in the market.

Competitive scenario:

The study assesses factors such as segmentation, description, and applications of Stem Cell Therapy industries. It derives accurate insights to give a holistic view of the dynamic features of the business, including shares, profit generation, thereby directing focus on the critical aspects of the business.

Scope of the Report

The research on the Stem Cell Therapy market focuses on mining out valuable data on investment pockets, growth opportunities, and major market vendors to help clients understand their competitors methodologies. The research also segments the Stem Cell Therapy market on the basis of end user, product type, application, and demography for the forecast period 20212027. Comprehensive analysis of critical aspects such as impacting factors and competitive landscape are showcased with the help of vital resources, such as charts, tables, and infographics.

Promising Regions & Countries Mentioned in The Stem Cell Therapy Market Report:

Major highlights of the report:

All-inclusive evaluation of the parent market

Evolution of significant market aspects

Industry-wide investigation of market segments

Assessment of market value and volume in past, present, and forecast years

Evaluation of market share

Study of niche industrial sectors

Tactical approaches of market leaders

Lucrative strategies to help companies strengthen their position in the market

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Massive Growth Seen in Stem Cell Therapy Market 2020-2027 | In Depth Analysis with Top Key Players RichSource, Mesoblast Limited, TiGenix NV,...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Verve Therapeutics, a next-generation cardiovascular company developing medicines that safely edit the adult human genome to permanently reduce a persons risk of coronary heart disease, today announced that Sekar Kathiresan, M.D., co-founder and chief executive officer of Verve Therapeutics, will give a keynote presentation on the genetic basis for risk and resistance to coronary heart disease and gene editing as a promising new treatment approach at the ISSCR 2020 Virtual Annual Meeting on Saturday, June 27, 2020.

Dr. Kathiresans presentation titled, From reading the genome for risk to rewriting it for health, will be delivered during the Clinical Innovation & Gene Editing plenary session. The session will begin at 4:00 p.m. ET, with the keynote address at 5:45 p.m. ET. Dr. Kathiresan will discuss the discovery of cardioprotective genetic mutations, Verves approach to develop one-time gene editing medicines that mimic these protective mutations to treat coronary heart disease, and Verves progress with new preclinical data in non-human primates. The presentation will be available for on-demand viewing by registrants immediately following the presentation through July 31, 2020.

About Verve Therapeutics

Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. The company brings together human genetics analysis and gene editing two of the biggest breakthroughs in 21st century biomedicine to develop transformative therapies for coronary heart disease. Verve is developing medicines, administered once in life, to safely edit the genome of adults to permanently lower LDL cholesterol and triglyceride levels, and reduce the risk of coronary heart disease and heart attack. Founded by world-leading experts in cardiovascular medicine, human genetics and gene editing, Verve is backed by a top-tier syndicate of investors, including GV (formerly Google Ventures), ARCH Venture Partners, F-Prime Capital, Biomatics Capital, Wellington Management, Casdin Capital, and Partners Innovation Fund. Verve is headquartered in Cambridge, Massachusetts. For more information, visit http://www.VerveTx.com.

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Verve Therapeutics CEO Sekar Kathiresan, M.D., to Give Keynote Presentation at the International Society for Stem Cell Research (ISSCR) 2020 Virtual...

LOS ANGELES, United States: The global Stem Cell Characterization and Analysis Tool market is carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the global Stem Cell Characterization and Analysis Tool market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the global Stem Cell Characterization and Analysis Tool market. With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the global Stem Cell Characterization and Analysis Tool market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the global Stem Cell Characterization and Analysis Tool market.

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Leading players of the global Stem Cell Characterization and Analysis Tool market are analyzed taking into account their market share, recent developments, new product launches, partnerships, mergers or acquisitions, and markets served. We also provide an exhaustive analysis of their product portfolios to explore the products and applications they concentrate on when operating in the global Stem Cell Characterization and Analysis Tool market. Furthermore, the report offers two separate market forecasts one for the production side and another for the consumption side of the global Stem Cell Characterization and Analysis Tool market. It also provides useful recommendations for new as well as established players of the global Stem Cell Characterization and Analysis Tool market.

Key Players Mentioned in the Global Stem Cell Characterization and Analysis Tool Market Research Report:

Osiris Therapeutics, Inc., Caladrius Biosciences, Inc., U.S. Stem Cell, Inc., Astellas Pharma Inc., TEMCELL Technologies Inc., BioTime Inc., Cellular Engineering Technologies Inc., Cytori Therapeutics, Inc., BrainStorm Cell Therapeutics Inc.

Global Stem Cell Characterization and Analysis Tool Market Segmentation by Product:ServicesSoftwareInstrumentsAccessoriesConsumablesReagent and Assay Kits

Global Stem Cell Characterization and Analysis Tool Market Segmentation by Application:Neurological DisordersOrthopedic TreatmentsOncology DisordersDiabetesOther Therapeutic ApplicationsDrug Development and Discovery Embryonic Stem Cells Research

The global Stem Cell Characterization and Analysis Tool market is segmented to allow the readers to gain a detailed perspective of the important elements of the market. The products, technologies, and applications of the market are discussed in great depth. Analysts have studied the factors that are expected to help certain segments flourish while restraining the others. Technological advancements, increasing investments, and innovative approaches have also been discussed in the Stem Cell Characterization and Analysis Tool research report.

Regional segmentation is an essential part of the Stem Cell Characterization and Analysis Tool research report. It analyzes the various regions that the market is segmented on the basis of and evaluates the various influencers. Changing political scenarios, impact of national budgets, governing polices, and importance given to global policies by certain regions and countries has also been discussed in this part of the Stem Cell Characterization and Analysis Tool research report.

Report Objectives Analyzing the size of the global Stem Cell Characterization and Analysis Tool market on the basis of value and volume Accurately calculating the market shares, consumption, and other vital factors of different segments of the global Stem Cell Characterization and Analysis Tool market Exploring key dynamics of the global Stem Cell Characterization and Analysis Tool market Highlighting important trends of the global Stem Cell Characterization and Analysis Tool market in terms of production, revenue, and sales Deeply profiling top players of the global Stem Cell Characterization and Analysis Tool market and showing how they compete in the industry Studying manufacturing processes and costs, product pricing, and various trends related to them Showing the performance of different regions and countries in the global Stem Cell Characterization and Analysis Tool market Forecasting the market size and share of all segments, regions, and the global market.

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Table of Content

1 Market Overview of Stem Cell Characterization and Analysis Tool1.1 Stem Cell Characterization and Analysis Tool Market Overview1.1.1 Stem Cell Characterization and Analysis Tool Product Scope1.1.2 Market Status and Outlook1.2 Global Stem Cell Characterization and Analysis Tool Market Size Overview by Region 2015 VS 2020 VS 20261.3 Global Stem Cell Characterization and Analysis Tool Market Size by Region (2015-2026)1.4 Global Stem Cell Characterization and Analysis Tool Historic Market Size by Region (2015-2020)1.5 Global Stem Cell Characterization and Analysis Tool Market Size Forecast by Region (2021-2026)1.6 Covid-19 Impact on Key Regions, Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.1 North America Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.2 Europe Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.3 China Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.4 Rest of Asia Pacific Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.5 Latin America Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.6.6 Middle East & Africa Stem Cell Characterization and Analysis Tool Market Size YoY Growth (2015-2026)1.7 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth1.7.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections1.7.2 Covid-19 Impact: Commodity Prices Indices1.7.3 Covid-19 Impact: Global Major Government Policy

2 Covid-19 Impact on Stem Cell Characterization and Analysis Tool Market Overview by Type2.1 Global Stem Cell Characterization and Analysis Tool Market Size by Type: 2015 VS 2020 VS 20262.2 Global Stem Cell Characterization and Analysis Tool Historic Market Size by Type (2015-2020)2.3 Global Stem Cell Characterization and Analysis Tool Forecasted Market Size by Type (2021-2026)2.4 Services2.5 Software2.6 Instruments2.7 Accessories2.8 Consumables2.9 Reagent and Assay Kits

3 Covid-19 Impact on Stem Cell Characterization and Analysis Tool Market Overview by Application3.1 Global Stem Cell Characterization and Analysis Tool Market Size by Application: 2015 VS 2020 VS 20263.2 Global Stem Cell Characterization and Analysis Tool Historic Market Size by Application (2015-2020)3.3 Global Stem Cell Characterization and Analysis Tool Forecasted Market Size by Application (2021-2026)3.4 Neurological Disorders3.5 Orthopedic Treatments3.6 Oncology Disorders3.7 Diabetes3.8 Other Therapeutic Applications3.9 Drug Development and Discovery Embryonic Stem Cells Research

4 Covid-19 Impact on Global Stem Cell Characterization and Analysis Tool Competition Analysis by Players4.1 Global Stem Cell Characterization and Analysis Tool Market Size (Million US$) by Players (2015-2020)4.2 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Stem Cell Characterization and Analysis Tool as of 2019)4.3 Date of Key Manufacturers Enter into Stem Cell Characterization and Analysis Tool Market4.4 Global Top Players Stem Cell Characterization and Analysis Tool Headquarters and Area Served4.5 Key Players Stem Cell Characterization and Analysis Tool Product Solution and Service4.6 Competitive Status4.6.1 Stem Cell Characterization and Analysis Tool Market Concentration Rate4.6.2 Mergers & Acquisitions, Expansion Plans

5 Company (Top Players) Profiles and Key Data5.1 Osiris Therapeutics, Inc.5.1.1 Osiris Therapeutics, Inc. Profile5.1.2 Osiris Therapeutics, Inc. Main Business and Companys Total Revenue5.1.3 Osiris Therapeutics, Inc. Products, Services and Solutions5.1.4 Osiris Therapeutics, Inc. Revenue (US$ Million) (2015-2020)5.1.5 Osiris Therapeutics, Inc. Recent Development and Reaction to Covid-195.2 Caladrius Biosciences, Inc.5.2.1 Caladrius Biosciences, Inc. Profile5.2.2 Caladrius Biosciences, Inc. Main Business and Companys Total Revenue5.2.3 Caladrius Biosciences, Inc. Products, Services and Solutions5.2.4 Caladrius Biosciences, Inc. Revenue (US$ Million) (2015-2020)5.2.5 Caladrius Biosciences, Inc. Recent Development and Reaction to Covid-195.3 U.S. Stem Cell, Inc.5.5.1 U.S. Stem Cell, Inc. Profile5.3.2 U.S. Stem Cell, Inc. Main Business and Companys Total Revenue5.3.3 U.S. Stem Cell, Inc. Products, Services and Solutions5.3.4 U.S. Stem Cell, Inc. Revenue (US$ Million) (2015-2020)5.3.5 Astellas Pharma Inc. Recent Development and Reaction to Covid-195.4 Astellas Pharma Inc.5.4.1 Astellas Pharma Inc. Profile5.4.2 Astellas Pharma Inc. Main Business and Companys Total Revenue5.4.3 Astellas Pharma Inc. Products, Services and Solutions5.4.4 Astellas Pharma Inc. Revenue (US$ Million) (2015-2020)5.4.5 Astellas Pharma Inc. Recent Development and Reaction to Covid-195.5 TEMCELL Technologies Inc.5.5.1 TEMCELL Technologies Inc. Profile5.5.2 TEMCELL Technologies Inc. Main Business and Companys Total Revenue5.5.3 TEMCELL Technologies Inc. Products, Services and Solutions5.5.4 TEMCELL Technologies Inc. Revenue (US$ Million) (2015-2020)5.5.5 TEMCELL Technologies Inc. Recent Development and Reaction to Covid-195.6 BioTime Inc.5.6.1 BioTime Inc. Profile5.6.2 BioTime Inc. Main Business and Companys Total Revenue5.6.3 BioTime Inc. Products, Services and Solutions5.6.4 BioTime Inc. Revenue (US$ Million) (2015-2020)5.6.5 BioTime Inc. Recent Development and Reaction to Covid-195.7 Cellular Engineering Technologies Inc.5.7.1 Cellular Engineering Technologies Inc. Profile5.7.2 Cellular Engineering Technologies Inc. Main Business and Companys Total Revenue5.7.3 Cellular Engineering Technologies Inc. Products, Services and Solutions5.7.4 Cellular Engineering Technologies Inc. Revenue (US$ Million) (2015-2020)5.7.5 Cellular Engineering Technologies Inc. Recent Development and Reaction to Covid-195.8 Cytori Therapeutics, Inc.5.8.1 Cytori Therapeutics, Inc. Profile5.8.2 Cytori Therapeutics, Inc. Main Business and Companys Total Revenue5.8.3 Cytori Therapeutics, Inc. Products, Services and Solutions5.8.4 Cytori Therapeutics, Inc. Revenue (US$ Million) (2015-2020)5.8.5 Cytori Therapeutics, Inc. Recent Development and Reaction to Covid-195.9 BrainStorm Cell Therapeutics Inc.5.9.1 BrainStorm Cell Therapeutics Inc. Profile5.9.2 BrainStorm Cell Therapeutics Inc. Main Business and Companys Total Revenue5.9.3 BrainStorm Cell Therapeutics Inc. Products, Services and Solutions5.9.4 BrainStorm Cell Therapeutics Inc. Revenue (US$ Million) (2015-2020)5.9.5 BrainStorm Cell Therapeutics Inc. Recent Development and Reaction to Covid-19

6 North America Stem Cell Characterization and Analysis Tool by Players and by Application6.1 North America Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)6.2 North America Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

7 Europe Stem Cell Characterization and Analysis Tool by Players and by Application7.1 Europe Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)7.2 Europe Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

8 China Stem Cell Characterization and Analysis Tool by Players and by Application8.1 China Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)8.2 China Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

9 Rest of Asia Pacific Stem Cell Characterization and Analysis Tool by Players and by Application9.1 Rest of Asia Pacific Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)9.2 Rest of Asia Pacific Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

10 Latin America Stem Cell Characterization and Analysis Tool by Players and by Application10.1 Latin America Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)10.2 Latin America Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

11 Middle East & Africa Stem Cell Characterization and Analysis Tool by Players and by Application11.1 Middle East & Africa Stem Cell Characterization and Analysis Tool Market Size and Market Share by Players (2015-2020)11.2 Middle East & Africa Stem Cell Characterization and Analysis Tool Market Size by Application (2015-2020)

12 Stem Cell Characterization and Analysis Tool Market Dynamics12.1 Covid-19 Impact: Industry Trends12.2 Covid-19 Impact: Market Drivers12.3 Covid-19 Impact: Market Challenges12.4 Porters Five Forces Analysis

13 Research Finding /Conclusion

14 Methodology and Data Source14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Disclaimer14.4 Author List

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Stem Cell Characterization and Analysis Tool Market Analysis Report, Region, Application, Trends, Competitive Market Share and Forecast to 2026 -...

Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut.

Cells in the lining of the small intestine are replaced around every five days, the quickest rate for any organ in the body. This fast replacement helps the lining cope with the damage it suffers as a result of breaking down food and absorbing nutrients.

This process, which is important for the healthy functioning of the small intestine, is supported by the stem cells in a part of the small intestine called the crypt.

In their study, published in Gastroenterology, the researchers found two genes, MTG8 and MTG16, which are highly expressed in cells that have just left the stem cell zone. These genes 'switch off' signals that keep these cells in a multipotent or 'immature' state, leading them to start to differentiate.

When the team analysed intestinal tissue and small intestine organoids grown from mice lacking these genes, they found there were many more stem cells, indicating that the process of differentiation was impeded.

Anna Baulies, lead author and postdoctoral training fellow in the Stem Cell and Cancer Biology lab at the Crick says: "These genes maintain the flow of cells which are needed for the healthy functioning of the small intestine, starting the stem cells on the road to become enterocyte cells which are needed to absorb nutrients."

Importantly, by working with human small intestine organoids, the researchers also found that while the stem cells are still in the crypt, these genes are repressed by a key developmental pathway, Notch signalling. This ensures the stem cells do not differentiate too early.

Vivian Li, senior author and group leader of the Stem Cell and Cancer Biology lab at the Crick says, "Understanding the role these genes play in healthy tissue will also help us to understand how the intestine regularly regenerates and also if these genes are a helpful or harmful force in the presence of disease."

"For example, loss of these genes may increase the number of stem cells and contribute to colorectal cancer progression. Further study on the underlying mechanism might be helpful to limit the number of stem cells in the cancer."

The signal that these genes repress, Wnt signalling, also keeps stem cells in a multipotent state in many other tissues, including the skin, stomach, liver and brain. These findings could therefore help other research into stem cell differentiation outside of the small intestine.

The researchers will continue this work, looking to understand more about the mechanism these two genes use to regulate stem cell differentiation and regeneration.

Reference:Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., . . . Li, V. S. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology. doi:10.1053/j.gastro.2020.06.012

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Drivers of Healthy Gut Maintenance Uncovered - Technology Networks

With a full devotion and dedication this superior GLOBAL HUMAN EMBRYONIC STEM CELL MARKET report is presented to the clients that extend their reach to success. Market parameters covered in this advertising report can be listed as market definition, currency and pricing, market segmentation, market overview, premium insights, key insights and company profile of the key market players. Each parameter included in this GLOBAL HUMAN EMBRYONIC STEM CELL MARKET business research report is again explored deeply for the better and actionable market insights. Geographical scope of the products is also carried out comprehensively for the major global areas which helps define strategies for the product distribution in those areas.

TheGlobal Human Embryonic Stem Cell Marketstudy with 100+ market data Tables, Pie Chat, Graphs & Figures is now released by Data Bridge Market Research. The report presents a complete assessment of the Market covering future trend, current growth factors, attentive opinions, facts, and industry validated market data forecast till 2026. Delivering the key insights pertaining to this industry, the report provides an in-depth analysis of the latest trends, present and future business scenario, market size and share ofMajor Players such as Arizona Board of Regents, STEMCELL Technologies Inc, Cellular Engineering Technologies, CellGenix GmbH, PromoCell GmbH, Lonza, Kite Pharma, Takeda Pharmaceutical Company Limited, BrainStorm Cell Limited., CELGENE CORPORATION, Osiris Therapeutics,Inc, U.S. Stem Cell, Inc and amny More

Global human embryonic stem cell market estimated to register a healthy CAGR of 10.5% in the forecast period of 2019 to 2026. The imminent market report contains data for historic year 2017, the base year of calculation is 2018 and the forecast period is 2019 to 2026. The growth of the market can be attributed to the increase in tissue engineering process.

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Market Dynamics:

Set of qualitative information that includes PESTEL Analysis, PORTER Five Forces Model, Value Chain Analysis and Macro Economic factors, Regulatory Framework along with Industry Background and Overview.

Global Human Embryonic Stem Cell Market By Type (Totipotent Stem Cells, Pluripotent Stem Cells, Unipotent Stem Cells), Application (Regenerative Medicine, Stem Cell Biology Research, Tissue Engineering, Toxicology Testing), End User (Research, Clinical Trials, Others), Geography (North America, Europe, Asia-Pacific, South America, Middle East and Africa) Industry Trends and Forecast to 2026

Global Human Embryonic Stem Cell Research Methodology

Data Bridge Market Research presents a detailed picture of the market by way of study, synthesis, and summation of data from multiple sources.The data thus presented is comprehensive, reliable, and the result of extensive research, both primary and secondary. The analysts have presented the various facets of the market with a particular focus on identifying the key industry influencers.

Major Drivers and Restraints of the Human Embryonic Stem Cell Industry

Complete report is available (TOC) @https://www.databridgemarketresearch.com/toc/?dbmr=global-human-embryonic-stem-cell-market

The titled segments and sub-section of the market are illuminated below:

By Type

By Application

By End User

Top Players in the Market are:

Some of the major companies functioning in global human embryonic stem cell market are Arizona Board of Regents, STEMCELL Technologies Inc, Cellular Engineering Technologies, CellGenix GmbH, PromoCell GmbH, Lonza, Kite Pharma, Takeda Pharmaceutical Company Limited, BrainStorm Cell Limited., CELGENE CORPORATION, Osiris Therapeutics,Inc, U.S. Stem Cell, Inc, Waisman Biomanufacturing, Caladrius, Pfizer Inc., Thermo Fisher Scientific, Merck KGaA, Novo Nordisk A/S, Johnson & Johnson Services, Inc and SA Biosciences Corporation among others.

How will the report help new companies to plan their investments in the Human Embryonic Stem Cell market?

The Human Embryonic Stem Cell market research report classifies the competitive spectrum of this industry in elaborate detail. The study claims that the competitive reach spans the companies of.

The report also mentions about the details such as the overall remuneration, product sales figures, pricing trends, gross margins, etc.

Information about the sales & distribution area alongside the details of the company, such as company overview, buyer portfolio, product specifications, etc., are provided in the study.

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Some of the Major Highlights of TOC covers:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2: Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3: Human Embryonic Stem Cell Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

Chapter 4: Human Embryonic Stem Cell Market, By Region

Chapter 5: Company Profile

Business Overview

Financial Data

Product Landscape

Strategic Outlook

SWOT Analysis

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GLOBAL HUMAN EMBRYONIC STEM CELL MARKET Analysis 2020 With COVID 19 Impact Analysis| Leading Players, Industry Updates, Future Growth, Business...

Global Bone Marrow-Derived Stem Cells (BMSCS) Market research report delivers comprehensive analysis of the market structure along with estimations of the various segments and sub-segments of the market. This study also analyzes the market status, market share, growth rate, sales volume, future trends, market drivers, market restraints, revenue generation, opportunities and challenges, risks and entry barriers, sales channels, and distributors. The company profiles of all the chief and dominating market players and brands who are taking steps such as product launches, joint ventures, mergers and acquisitions are mentioned in the report. With the use of SWOT analysis and Porters Five Forces analysis which are two of the standard, prominent and full-proof methods, this Global Bone Marrow-Derived Stem Cells (BMSCS) Market report is been framed.

Global Bone Marrow-Derived Stem Cells (BMSCS) Market By Service Type (Sample Preservation and Storage, Sample Analysis, Sample Processing, Sample Collection and Transportation), Application (Personalized Banking Applications, Research Applications, Clinical Applications), Country (U.S., Canada, Mexico, Germany, Italy, U.K., France, Spain, Netherland, Belgium, Switzerland, Turkey, Russia, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia- Pacific, Brazil, Argentina, Rest of South America, South Africa, Saudi Arabia, UAE, Egypt, Israel, Rest of Middle East & Africa), Market Trends and Forecast to 2027

By providing an absolute overview of the market, Global Bone Marrow-Derived Stem Cells (BMSCS) Market report covers various aspects of market analysis, product definition, market segmentation, key developments, and the existing vendor landscape. Such market insights can be accomplished with this comprehensive Global Bone Marrow-Derived Stem Cells (BMSCS) Market research report which takes into account all the aspects of current and future market. The report provides wide-ranging analysis of the market structure along with the estimations of the various segments and sub-segments of the market. This Global Bone Marrow-Derived Stem Cells (BMSCS) Market research report delivers an analytical measurement of the main challenges faced bythe business currently and in the upcoming years.

Bone marrow-derivedstem cells(BMSCS) marketis expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to growing at a CAGR of 10.4% in the above-mentioned forecast period. Increasing awareness regarding the benefits associates with the preservation of bone marrow derived stem cells will boost the growth of the market.

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The major players covered in the bone marrow-derived stem cells (BMSCS) market report are CBR Systems, Inc, Cordlife Sciences India Pvt. Ltd., Cryo-Cell International, Inc.ESPERITE N.V., LifeCell International Pvt. Ltd., StemCyte India Therapeutics Pvt. Ltd, PerkinElmer Inc, Global Cord Blood Corporation., Smart Cells International Ltd., Vita 34 among other domestic and global players. Market share data is available for Global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Some of the factors such as introduction of novel technologies for the preservation of stem cells and their storage, surging investment that will help in research activities leading to stem cells benefits, adoption of hemotopoietic stem cell transplantation system will accelerate the growth of the bone marrow-derived stem cells (BMSCS) market in the forecast period of 2020-2027. Various factors that will create opportunities in the bone marrow-derived stem cells (BMSCS) market are increasing occurrences of various diseases along with rising applications in emerging economies.

Large cost of operation and strict regulatory framework will restrict the growth of bone marrow-derived stem cells (BMSCS) market in the above mentioned forecast period. Ethical concern leading to stem cells will become the biggest challenge in the market growth.

Global Bone Marrow-Derived Stem Cells (BMSCS) Market By Service Type (Sample Preservation and Storage, Sample Analysis, Sample Processing, Sample Collection and Transportation), Application (Personalized Banking Applications, Research Applications, Clinical Applications), Country (U.S., Canada, Mexico, Germany, Italy, U.K., France, Spain, Netherland, Belgium, Switzerland, Turkey, Russia, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia- Pacific, Brazil, Argentina, Rest of South America, South Africa, Saudi Arabia, UAE, Egypt, Israel, Rest of Middle East & Africa), Market Trends and Forecast to 2027

Global Bone Marrow-Derived Stem Cells (BMSCS) Market Scope and Market Size

Bone marrow-derivedstem cells(BMSCS) market is segmented on the basis of service type and application. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Thisbonemarrow-derived stem cells (BMSCS) market report provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on bone marrow-derived stem cells (BMSCS) market contactData Bridge Market Researchfor anAnalyst Brief, our team will help you take an informed market decision to achieve market growth.

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Bone Marrow-Derived Stem Cells (BMSCS) Market Country Level Analysis

Bone marrow-derivedstem cells(BMSCS) market is analysed and market size insights and trends are provided by country, service type and application as referenced above.

The country section of the bone marrow-derivedstem cells(BMSCS) market report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as consumption volumes, production sites and volumes, import export analysis, price trend analysis, cost of raw materials, down-stream and upstream value chain analysis are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure Growth Installed Base and New Technology Penetration

Bone marrow-derived stem cells (BMSCS) market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipments, installed base of different kind of products for bone marrow-derived stem cells (BMSCS) market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the bone marrow-derived stem cells (BMSCS) market. The data is available for historic period 2010 to 2018.

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Key Highlights of Report

Competitive Landscape and Bone Marrow-Derived Stem Cells (BMSCS) Market Share Analysis

Bone marrow-derived stem cells (BMSCS) market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related to bone marrow-derived stem cells (BMSCS) market.

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About Data Bridge Market Research:

Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

Contact:

Data Bridge Market Research

US: +1 888 387 2818

UK: +44 208 089 1725

Hong Kong: +852 8192 7475

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Global Bone Marrow-Derived Stem Cells (BMSCS) Market (COVID 19 Impact Analysis) Data Highlighting Major Vendors, Promising Regions, Anticipated Growth...

Cambridge-based Magenta Therapeutics announced today that it has entered a non-exclusive research and clinical collaboration agreement with Beam Therapeutics. The goal is to evaluate the potential use of MGTA-117, Magentas novel targeted antibody drug conjugate (ADC) for the conditioning of patients with sickle cell disease and beta-thalassemia.

Conditioning is necessary to prepare a patients body to receive edited cells. Existing conditioning regimens rely on nonspecific chemotherapy or radiation. MGTA-117 precisely targets only hematopoietic stem and progenitor cells, sparing immune cells. It has also shown high selectivity, potent efficacy, and wide safety margins.

Beam has demonstrated the ability to edit individual DNA bases in hematopoietic stem cells with little impact on the viability of edited cells, relative to unedited cells, using its novel base editing technology. MGTA-117 and Beams base editors could advance treatment in patients with sickle cell disease or beta-thalassemia.

We believe patients will benefit from a more precise process to remove hematopoietic stem cells and prepare them to receive genetic medicines, said Jason Gardner, D.Phil., president and chief executive officer, Magenta Therapeutics. Magenta has developed targeted ADCs as the preferred modality for our conditioning programs, and we have designed MGTA-117 specifically to optimize it for use with a genetically-modified cell product delivered in a transplant setting. Beams next-generation base editing technology complements our next-generation conditioning approach very well, and we are excited to combine these strengths to address the still-significant unmet medical needs of the sickle cell and beta-thalassemia patient communities.

This is not the only collaboration agreement Magenta has entered as of late. On June 11, the company announced that it had entered a clinical collaboration agreement with the National Marrow Donor Program (NMDP)/Be The Match to evaluate the use of MGTA-145, a CXCR2 agonist.

MGTA-145 works in combination with plerixafor, a CXCR4 antagonist, to leverage the physiological mechanism of stem cell mobilization into peripheral blood. It has achieved all safety and activity endpoints to date.

Magenta is delighted to build upon its successful partnership with NMDP/Be The Match through this clinical collaboration, said John Davis Jr., M.D., M.P.H., M.S., Head of Research & Development and Chief Medical Officer, Magenta. The NMDP/Be The Match team brings unparalleled experience in stem cell transplant, operating the largest and most diverse marrow registry in the world, with a global network of 187 transplant centers. We are excited to collaborate with them to explore MGTA-145 in allogeneic transplant, which makes up nearly half of the transplants that take place each year in the U.S. and Europe. MGTA-145 mobilizes robust numbers of functional stem cells in a single day, allowing donors to potentially avoid multiple visits to infusion centers or hospitals, which has been a major concern for donors during the COVID-19 pandemic. The large number of functional cells may also result in faster recovery and improved outcomes for patients undergoing a life-saving allogeneic transplant.

Under the collaboration agreement, Magenta and NMDP/Be The Match will conduct a Phase 2 clinical trial of MGTA-145 to mobilize and collect hematopoietic stem cells from donors. These stem cells will then be given to patients with blood cancers who need a stem cell transplant. Magenta will retain all commercial rights to MGTA-145.

There is a significant need for new medicines for stem cell mobilization for patients and stem cell donors, and this need is only exacerbated during the COVID-19 pandemic as donors in particular prefer to avoid the hospital setting, said Steven Devine, M.D., Chief Medical Officer, NMDP/Be The Match. Clinical data generated with MGTA-145 to date suggest that its robust mobilization of functional stem cells in a single day could improve both the donor experience and patient outcomes. We are pleased to partner with Magenta to further transform the practice of stem cell transplant. We look forward to initiating this Phase 2 study.

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Magenta and Beam to Further Explore MGTA-117 - PharmaLive

Our company has built a platform to produce high-quality cells and tissues for regenerative medicine. That pursuit involves multiple disciplines, which means everyone here is an expert in a different language. Some of us are fluent in stem-cell biology, others in optical engineering, others in machine learning. When we started the company it wasnt possible to do biology and engineering under the same roof. When we finally moved into a shared space we were able to learn each others lexicons, and we became more strongly aligned. And now that were all working separately, the bonds created in that process have helped us deal with things. We cant discuss technical details at our desks anymore, but weve learned new ways of working together. Its important to stay in sync as a team, and in a covid-19 world thats never felt more true.

TIM O'CONNELL

Founded Blendoor, a job-search platform that hides candidates names and photos in the initial stages to reduce unconscious bias.

I started coding at 13, and that has gotten me pretty far in my career (Stanford, MIT, Microsoft). I once viewed humanities and social science education as nice-to-haves but not need-to-haves. It wasnt until I came face to face with the harsh realities of inequity and the paradox of meritocracy that I realized that artificial intelligence is far from solving many of our most challenging problems as a human race (for example, xenophobia, sexism, racism, homophobia, impostor syndrome, and unconscious bias).

The externalities that influence creativity, adoption, and scale are often more important than the innovation itself. To be a successful innovator one has to be really in tune with whats happening in the world on a global scale (or be really lucky, or better yet both). Venture capital has shortened the learning curve for some innovators, but bias has limited access to venture capital for many. Unconscious bias is like an odorless gasits imperceptible to most, but pervasive and deadly.

To optimize the innovation ecosystem, institutions must invest more in leveling the playing field. Today and for much of the documented past, innovation has been reserved for the children of middle- and upper-class parents. (Research the founders of companies valued at over $1 billion.) We laud the proverb Necessity is the mother of invention, but the people who grow up needing the most, independent of their intelligence, are often left out of the innovation game. As with all games, the best players emerge when the barriers to entry are low, the rules/standards are equally enforced, and there is high transparency across the board.

Audre Lorde once wrote: The masters tools will never dismantle the masters house.

I am a short, melanin-enriched, queer female on planet Earth. In some ways its easier to be innovative when youre invisible, but at some point, you need tools to scale: capital, team, mentorship. The one thing I know now that I wish I had known earlier is that my path toward getting the tools I need looks a lot different from the paths of others. Its not better nor worsesimply different. The hardest part is carving it out. Now that I know my path isnt blockedrather, it just didnt existIm way better equipped to win.

COURTESY PHOTO

Founded DotLab, which makes diagnostic tests focused on womens health.

About a decade ago I worked at the White House Office of Science and Technology Policy, whose goal was to speed up the commercialization of technologies being developed in federally funded labs. While there I saw that some of the most important work done by the government involved things the media paid no attention tofor example, the way it could use investments in research and development to fuel private--sector innovation.

In 2009, the Obama administration released the Strategy for American Innovation. The idea behind it was to establish the critical nature of federal government support for R&D. In particular it stressed the spillover effects, or the idea that investments in such research end up being beneficial to people unrelated to the original investment. Or to put it another way, R&D investment is a public good. Analyses at the time suggested that in order to produce economic growth we should be doubling or quadrupling our R&D investments. Instead that spending has since been slashed, especially in basic research.

President Obama also launched a Lab to Market Initiative meant to speed the path to market for technologies stemming from government--funded research. There were also pilot programs designed to increase the use of government-funded R&D facilities by entrepreneurs, create incentives to commercialization, and improve, among other things, the impact of the Small Business Innovation Research (SBIR) program.

My own company, DotLab, ended up being a beneficiary. We develop novel molecular diagnostic tests for prevalent yet underserved diseases affecting womens health. Its notoriously difficult for this field of early--stage diagnostics to attract private investment, because of unclear regulatory pathways, low reimbursement rates, or resistance to change among physiciansor all of the above. Many promising diagnostic technologies never make it to patients because its so hard for these types of companies to get financing. A grant from the SBIR was critical to our early success. I cant be sure that wed be here today without it.

COURTESY PHOTO

Founded Ubiquitous Energy, which makes transparent solar cells that can be put on windows or device screens.

I used to imagine innovators as individuals, as most people probably dothe genius inventor divining solutions in a lab or garage. But this picture that people have is not only wrong; it hinders our ability to innovate effectively.

Eight years ago I cofounded Ubiquitous Energy, a company based on an innovation Id helped to launch from an MIT laba transparent solar cell that promised new ways of deploying solar technology, like windows that generate energy or consumer devices powered by their own displays. I learned that in the messy, scrappy world of tech startups, the key to innovation is to make it a team sport.

Taking any innovation from the lab to commercial reality requires engaging with all sorts of people. You need to work with engineering, R&D, business development, and sales teams, as well as investors, advisors, and customers. By thoughtfully designing teams and carefully tending to the connections among them, you ensure that innovation doesnt happen in a vacuum. If you isolate the engineering team you risk creating an innovative technology that doesnt have a customer. If you listen only to the customer you might conceive of a product that cant practically be made. Neglect investors and you can find yourself with a business plan that nobody wants to fund.

Working among people with competing priorities takes more effort. It means encouraging communication so theyre aware of each others needs as they generate new ideas. You have to find a way to invite these ideas in, make it okay for people to disagree respectfully, and encourage the flow of ideas among the various groups. You need each person to focus on his or her task, but not so much that it creates boundaries and kills any sense of creativity in the group.

Ive found that viewing innovation as a team sport instills a creative culture that makes an organization better. The innovations that result are far greater than anything that might have come from any one person operating independently.

CHRIS SCIACCA / IBM RESEARCH

Founded Somalias first incubator and start-up accelerator; now at IBM Research.

People tend to think innovation can be neatly placed into two categories: incremental or disruptive. They also assume that the only category that really matters is the disruptive kind, where you dramatically transform markets or introduce a novel product. And yes, disruptive innovations in CRISPR, quantum computing, or batteries are undoubtedly worth the headlines.

But Ive learned that there is immense value in incremental innovation. When you improve an existing product to cut costs, or when you make that product more efficient or user friendly, thats what pays the bills. And in fact those little innovations can give you the needed tailwind to go after the disruptive ideas, which can take years to incubate and bring to fruition. Never underestimate the importance of incremental improvements.

TIM O'CONNELL

Cofounded Imprint Energy, which is developing thin, flexible, and safe print- able batteries.

As a CEO of a startup, you get used to hearing no. You also face an endless succession of what feel like earth--shattering crises, like nearly running out of cash, losing a key customer, discovering a widespread product failureor having to shut down operations because of a global pandemic. But it turns out that these disasters can actually be good for you. In fact, Im not sure you can innovate without them. Heres what all our crises have taught me.

Its good to be uncomfortable. We once had a key customer request a battery capability that wed never deployed before. The customer made it clear that if we couldnt develop this capability theyd be less confident in our product. We wrestled with the risks, not least of which was the potential embarrassment if we couldnt meet the customers needs. We knew wed face many technical problems with no obvious solutions if we tried to pull it off. Yet we decided to try to satisfy the customer, even if it wasnt obvious at first how we could get it done. A few weeks later we delivered something beyond what the customer had asked for, and weve since grown this capability into a powerful sales tool and potential revenue streamnot to mention it strengthened our relationship with the customer.

Short-term failure is good. A few years ago our company began to scale up our manufacturing output in response to a customers need. In the process we discovered aberrations we hadnt seen during smaller-scale production. Our team dived into failure analysis, and we finally attributed the problem to a single material within the battery. Wed used this material for years, but now we needed a replacement. Once we deployed that change, the battery quality, reliability, and manufacturability drastically improved.

Its okay to be vulnerable. One of my hardest days as Imprints CEO was the day I found out I was pregnant. We were in the middle of raising a funding round, we had begun scaling our manufacturing output, and I had been traveling nonstop for a year. Until that day, I had assumed that my role as CEO was to exude strength and confidence. With the mounting pressure I was harder on myself than I needed to be, and now I had the added stress of being pregnant. I decided to acknowledge to my team that I was overwhelmed. They rallied together and found ways to operate more efficiently and communicate more effectively, supporting me to focus my time and leverage on our most pressing goals. This gave me not only the space to plan for the companys future, but also the resiliency to prepare for my own new normal: leading while becoming a first-time mother.

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Six tales from the trenches of running a startup - MIT Technology Review