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Second, this report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRCs Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report:

Fred Alt, Howard Hughes Medical Institute, Harvard Medical School

Fred Appelbaum, Fred Hutchinson Cancer Research Center

Daniel Callahan, The Hastings Center

R. Alta Charo, University of Wisconsin Law School

Carolyn Compton, McGill University

William Danforth, Washington University

Neal First, University of Wisconsin

Barbara Gastel, Texas A&M University

John Gerhart, University of California, Berkeley

Paul Gilman, Celera Genomics

Micheline Mathews-Roth, Harvard Medical School

Martin Raff, University College London

Nathan Rosenberg, Stanford University

Evan Snyder, Boston Childrens Hospital

Virginia Weldon, Monsanto Company

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations nor did they see the final draft of the report before its release. The review of this report was overseen by Ronald Estabrook of the University of Texas Southwestern Medical Center and Floyd Bloom of the Scripps Research Institute. Appointed by the

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