Takada, L. T. et al. Genetic prion disease: Experience of a rapidly progressive dementia center in the United States and a review of the literature. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 174(1), 3669 (2017).
PubMed PubMed Central Article Google Scholar
Minikel, E. V. et al. Quantifying prion disease penetrance using large population control cohorts. Sci. Transl. Med. 8(322), 322329 (2016).
Google Scholar
Ashwath, M. L., Dearmond, S. J. & Culclasure, T. Prion-associated dilated cardiomyopathy. Arch. Internal Med. 165(3), 338340 (2005).
Article Google Scholar
Itzhaki-Ben-Zadok, O., Orvin, K., Inbar, E. & Rechavia, E. Cardiomyopathy associated with Ceutzfeld-Jakob disease: A diagnosis of exclusion: A case report. Eur. Heart J. Case Rep. 4(1), 15 (2020).
PubMed PubMed Central Article Google Scholar
Cortelli, P. et al. Cardiovascular dysautonomia in fatal familial insomnia. Clin. Auton. Res. 1(1), 1521 (1991).
ADS CAS PubMed Article Google Scholar
Palma, J. A. et al. Cardiac autonomic impairment during sleep as a marker of human prion diseases: A preliminary report. Clin. Neurophysiol. 125(1), 208210 (2014).
PubMed Article Google Scholar
Garza, M. C., Monzn, M., Marn, B., Badiola, J. J. & Monlen, E. Distribution of peripheral PrP(Sc) in sheep with naturally acquired scrapie. PLoS ONE 9(5), e97768 (2014).
ADS PubMed PubMed Central Article CAS Google Scholar
Jewell, J. E., Brown, J., Kreeger, T. & Williams, E. S. Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease. J. Gener. Virol. 87(Pt 11), 34433450 (2006).
CAS Article Google Scholar
Balachandran, A. et al. Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): Early detection and late stage distribution of protease-resistant prion protein. Can. Vet. J. 51(2), 169178 (2010).
CAS PubMed PubMed Central Google Scholar
Bessen, R. A. et al. Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters. PLoS ONE 6(12), e28026 (2011).
ADS CAS PubMed PubMed Central Article Google Scholar
Mitchell, G. B. et al. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS ONE 7(6), e39055 (2012).
ADS CAS PubMed PubMed Central Article Google Scholar
Krasemann, S. et al. BSE-associated prion-amyloid cardiomyopathy in primates. Emerg. Infect. Dis. 19(6), 985988 (2013).
CAS PubMed PubMed Central Article Google Scholar
Trifilo, M. J. et al. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (N.Y.) 313(5783), 9497 (2006).
ADS CAS Article Google Scholar
Nico, P. B. et al. Altered behavioural response to acute stress in mice lacking cellular prion protein. Behav. Brain Res. 162(2), 173181 (2005).
CAS PubMed Article Google Scholar
Nico, P. B. et al. Impaired exercise capacity, but unaltered mitochondrial respiration in skeletal or cardiac muscle of mice lacking cellular prion protein. Neurosci. Lett. 388(1), 2126 (2005).
CAS PubMed Article Google Scholar
Klamt, F. et al. Imbalance of antioxidant defense in mice lacking cellular prion protein. Free Radical Biol. Med. 30(10), 11371144 (2001).
CAS Article Google Scholar
Beraldo, F. H. et al. Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J. Neurochem. 145(1), 6879 (2018).
CAS PubMed PubMed Central Article Google Scholar
Rambold, A. S. et al. Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J. 27(14), 19741984 (2008).
CAS PubMed PubMed Central Article Google Scholar
Dupiereux, I. et al. Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells. J. Neurosci. Res. 86(3), 653659 (2008).
CAS PubMed Article Google Scholar
Haigh, C. L. Brown, DR: Prion protein reduces both oxidative and non-oxidative copper toxicity. J. Neurochem. 98(3), 677689 (2006).
CAS PubMed Article Google Scholar
Resenberger, U. K., Winklhofer, K. F. & Tatzelt, J. Neuroprotective and neurotoxic signaling by the prion protein. Top. Curr. Chem. 305, 101119 (2011).
CAS PubMed Article Google Scholar
Turnbaugh, J. A., Westergard, L., Unterberger, U., Biasini, E. & Harris, D. A. The N-terminal, polybasic region is critical for prion protein neuroprotective activity. PLoS ONE 6(9), e25675 (2011).
ADS CAS PubMed PubMed Central Article Google Scholar
Zhang, B. et al. Prion protein protects against renal ischemia/reperfusion injury. PLoS ONE 10(9), e0136923 (2015).
PubMed PubMed Central Article CAS Google Scholar
Zocche-Soprana, H., Canes-Souza, L., Debbas, V. & Martins Laurindo, F. R. Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. Exp. Toxicol. Pathol. 63(3), 229236 (2011).
PubMed Article CAS Google Scholar
Zanetti, F. et al. The cellular prion protein counteracts cardiac oxidative stress. Cardiovasc. Res. 104(1), 93102 (2014).
CAS PubMed Article Google Scholar
Keller, G., Binyamin, O., Frid, K., Saada, A. & Gabizon, R. Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?. Neurobiol. Dis. 124, 5766 (2019).
CAS PubMed Article Google Scholar
Casini, S., Verkerk, A. O. & Remme, C. A. Human iPSC-derived cardiomyocytes for investigation of disease mechanisms and therapeutic strategies in inherited arrhythmia syndromes: Strengths and limitations. Cardiovasc. Drugs Therapy 31(3), 325344 (2017).
Article Google Scholar
Giacomelli, E. et al. Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease. Cell Stem Cell 26(6), 862-879.e811 (2020).
CAS PubMed PubMed Central Article Google Scholar
Koivumki, J. T. et al. Structural immaturity of human iPSC-derived cardiomyocytes: In silico investigation of effects on function and disease modeling. Front. Physiol. 9, 80 (2018).
PubMed PubMed Central Article Google Scholar
Bellin, M. et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J. 32(24), 31613175 (2013).
CAS PubMed PubMed Central Article Google Scholar
Paci, M., Casini, S., Bellin, M., Hyttinen, J. & Severi, S. Large-scale simulation of the phenotypical variability induced by loss-of-function long QT mutations in human induced pluripotent stem cell cardiomyocytes. Int. J. Mol. Sci. 19, 11 (2018).
Article CAS Google Scholar
Rebs, S., Sedaghat-Hamedani, F., Kayvanpour, E., Meder, B. & Streckfuss-Bmeke, K. Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation. Stem Cell Res. 47, 101901 (2020).
CAS PubMed Article Google Scholar
Bosman, A. et al. Perturbations of heart development and function in cardiomyocytes from human embryonic stem cells with trisomy 21. Stem Cells (Dayton, Ohio) 33(5), 14341446 (2015).
CAS Article Google Scholar
Foliaki, S. T. et al. Pathogenic prion protein isoforms are not present in cerebral organoids generated from asymptomatic donors carrying the E200K mutation associated with familial prion disease. Pathogens 9, 6 (2020).
Article Google Scholar
Baiardi, S. et al. Phenotypic diversity of genetic Creutzfeldt-Jakob disease: A histo-molecular-based classification. Acta Neuropathol. 2021, 5 (2021).
Google Scholar
Asante, E. A. et al. Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins. J. Gen. Virol. 90(Pt 3), 546558 (2009).
CAS PubMed PubMed Central Article Google Scholar
Foliaki, S. T. et al. Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases. Mol. Brain 14(1), 156 (2021).
CAS PubMed PubMed Central Article Google Scholar
Miele, G., Jeffrey, M., Turnbull, D., Manson, J. & Clinton, M. Ablation of cellular prion protein expression affects mitochondrial numbers and morphology. Biochem. Biophys. Res. Commun. 291(2), 372377 (2002).
CAS PubMed Article Google Scholar
Faris, R. et al. Cellular prion protein is present in mitochondria of healthy mice. Sci. Rep. 7, 41556 (2017).
ADS CAS PubMed PubMed Central Article Google Scholar
Flnes, I. H. et al. Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease. Acta Neuropathol. Commun. 8(1), 50 (2020).
PubMed PubMed Central Article CAS Google Scholar
Paterson, A. W., Curtis, J. C. & Macleod, N. K. Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria. J. Neurochem. 105(1), 177191 (2008).
CAS PubMed Article Google Scholar
Forkink, M. et al. Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V. Biochem. Biophys. Acta. 1837(8), 12471256 (2014).
CAS PubMed Google Scholar
Li, N. et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 278(10), 85168525 (2003).
CAS PubMed Article Google Scholar
Poleggi, A. et al. Age at onset of genetic (E200K) and sporadic Creutzfeldt-Jakob diseases is modulated by the CYP4X1 gene. J. Neurol. Neurosurg. Psychiatry 89(12), 12431249 (2018).
PubMed Article Google Scholar
Baylin, S. B. & Jones, P. A. Epigenetic determinants of cancer. Cold Spring Harb. Perspect. Biol. 8, 9 (2016).
Article CAS Google Scholar
Ilango, S., Paital, B., Jayachandran, P., Padma, P. R. & Nirmaladevi, R. Epigenetic alterations in cancer. Front. Biosci. (Landmark Ed.) 25, 10581109 (2020).
CAS Article Google Scholar
Mitrov, E. et al. Genetic Creutzfeldt-Jakob disease affected monozygotic twins: Analysis of survival time, age at death and possible exogenous risk factors. J. Clin. Neurosci. 66, 191195 (2019).
PubMed Article Google Scholar
Simon, E. S. et al. Creutzfeldt-Jakob disease profile in patients homozygous for the PRNP E200K mutation. Ann. Neurol. 47(2), 257260 (2000).
CAS PubMed Article Google Scholar
Groveman, B. R. et al. Sporadic creutzfeldt-jakob disease prion infection of human cerebral organoids. Acta Neuropathol. Commun. 7(1), 90 (2019).
PubMed Article Google Scholar
Henderson, D. M. et al. Rapid antemortem detection of CWD prions in deer saliva. PLoS ONE 8(9), e74377 (2013).
ADS CAS PubMed PubMed Central Article Google Scholar
See the original post here:
Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function | Scientific Reports - Nature.com
- New Atlas of Rare Stem and Progenitor Cells Reveals New Cell Types - Inside Precision Medicine - March 28th, 2024
- Instructing iPS cell-derived mesenchymal stem cells to inhibit abnormal bone formation in FOP - Medical Xpress - March 28th, 2024
- GLP podcast: GE crops have lived up to the hype; Growing 'mini' organs from stem cells; How do we solve right-wing ... - Genetic Literacy Project - March 28th, 2024
- Exosomes and Stem Cells Are the Future of Anti-Aging - NewBeauty Magazine - March 28th, 2024
- Stem cells: past, present, and future - PMC - National Center for ... - March 19th, 2024
- Stem cells: a comprehensive review of origins and emerging clinical ... - March 19th, 2024
- Biology of stem cells: an overview - PMC - National Center for ... - March 19th, 2024
- What are Stem Cells? - Types, Applications and Sources - BYJU'S - March 19th, 2024
- Stem Cell - The Definitive Guide | Biology Dictionary - March 19th, 2024
- Colossal Creates Elephant Stem Cells for the First Time in Quest to Revive the Woolly Mammoth - Singularity Hub - March 19th, 2024
- Florida congresswoman sued the Pentagon over stem cells. One problem: her husband's stocks - Raw Story - January 23rd, 2024
- Can Stem Cells Improve Knee Pain or Are They A Waste of Money? - Bloomberg - January 23rd, 2024
- Stem cells used to successfully treat arthritis in gorilla at Budapest zoo - University of Sheffield News - January 23rd, 2024
- A computational model of stem cells' internal mechanism to recapitulate spatial patterning and maintain the self ... - Nature.com - January 23rd, 2024
- Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells - EurekAlert - January 6th, 2024
- 'I couldn't just give up on my dad' | Round Rock son donates stem cells to father battling leukemia - KVUE.com - January 6th, 2024
- Closing in on the ultimate quest to regenerate insulin in pancreatic stem cells - Medical Xpress - January 6th, 2024
- Ask the doctors: Research being conducted on using stem cells to treat diabetes - The Spokesman Review - January 6th, 2024
- Regenerative Medicine and COPD: Generating Functional Lungs from Pluripotent Stem Cells - Medriva - January 6th, 2024
- What is a stem cell? YourGenome - December 2nd, 2023
- Stem cell transplant - NHS - December 27th, 2022
- Stem cells: a brief history and outlook - Science in the News - December 27th, 2022
- RUDN Physician And Russian Scientists Investigate Long-term Effects Of Treating Diabetic Ulcers With Stem Cells - India Education Diary - December 27th, 2022
- Stem Cell Basics | STEM Cell Information - National Institutes of Health - December 2nd, 2022
- Neural stem cell - Wikipedia - November 24th, 2022
- Donate Stem Cells | Bone Marrow Donation - American Cancer Society - November 24th, 2022
- Stem Cells- Definition, Properties, Types, Uses, Challenges - November 6th, 2022
- Brothers from Karnataka, Prapul and Prajwal donated their stem cells, save two blood cancer patients - APN News - November 6th, 2022
- Getting These Stem Cells Treatments: Crippled Ronnie Coleman Gives a Positive Update on His Ability to Walk - EssentiallySports - October 21st, 2022
- Cornell Prof Explains Relevance of Creating Mouse Embryos from Stem Cells - Cornell University The Cornell Daily Sun - October 13th, 2022
- Human neuron clusters transplanted into rats offer new tool to study the brain : Shots - Health News - NPR - October 13th, 2022
- The neuroprotective effects of dental pulp stem cells and erythropoietin in mice hippocampus after ischemia-reperfusion - Newswise - October 13th, 2022
- A $7 million grant to grow stem cell research - Swinburne University of Technology - October 13th, 2022
- Stem Cell Manufacturing Global Market Report 2022: Widespread Product Utilization in Effective Disease Management, Personalized Medicine, and Genome... - October 13th, 2022
- Brennand named Elizabeth Mears and House Jameson Professor of Psychiatry - Yale News - October 13th, 2022
- American Academy of Stem Cell Physicians to Offer Licensed Physicians Board Examination in Regenerative Medicine - BioSpace - October 13th, 2022
- Stem Cells - alsa.org - October 4th, 2022
- Mouse embryo models built from stem cells take shape in a dish - Nature.com - October 4th, 2022
- Growth in Cell and Gene Therapy Market - Pharmaceutical Technology Magazine - October 4th, 2022
- Therapeutic Solutions International Identifies CD103 Expressing Dendritic Cells and Exosomes Thereof as Novel Mechanism for JadiCell Mesenchymal Stem... - October 4th, 2022
- Aileron Therapeutics Announces Oral Presentation of Non-Clinical Data Demonstrating ALRN-6924 Protected Human Hair Follicles and Their Stem Cells from... - October 4th, 2022
- Research Shows Promise for Directing Later Lines of Therapy for Hodgkin Lymphoma - Targeted Oncology - October 4th, 2022
- How To Eat Your Way to Better Health According to a Doctor - Eat This, Not That - September 25th, 2022
- Phio Pharmaceuticals Announces Preclinical Data Demonstrating PH-762 Enhances Persistence of T cells for Tumor Cell Killing as Presented by Helmholtz... - September 25th, 2022
- Types of blood cancer: Leukemia, lymphoma, and more - Medical News Today - September 25th, 2022
- September: er-blood | News and features - University of Bristol - September 25th, 2022
- Here Is Why You Heal Slower As You Age - Health Digest - September 25th, 2022
- Global Single Cell Analysis Market is Projected to Grow at a CAGR of 15.1% By 2032: Visiongain Reports Ltd - Yahoo Finance UK - September 25th, 2022
- Findings explain exceptional auditory abilities in Williams-Beuren Syndrome - EurekAlert - September 25th, 2022
- Finding the potency in planarians | Communications Biology - Nature.com - September 16th, 2022
- Life-Saving Innovations in Cancer-Fighting Stem Cell Transplants and Pioneering Research in HIV, Autism and Cerebral Palsy to be Featured at World... - September 16th, 2022
- Treating Cancer with Oncolytic Viruses - BioPharm International - September 16th, 2022
- Israel's Profuse Technology Raises $2.5M for Technology That Lowers Cost of Cultured Meat - The Spoon - September 16th, 2022
- Stem Cells Used to Grow Mouse Embryo - BioTechniques - September 8th, 2022
- Largest Gift in UCSD History to Fund Stem Cell Research on Space Station - Times of San Diego - September 8th, 2022
- Global Induced Pluripotent Stem Cells Market (2022 to 2027) - Growth, Trends, Covid-19 Impact and Forecasts - ResearchAndMarkets.com - Business Wire - September 8th, 2022
- Health on the Frontlines: The Healing Power of Stem Cells - Dans Papers - September 8th, 2022
- Top 3 grants in regenerative medicine: July 2022 - RegMedNet - September 8th, 2022
- Childhood leukemia treatment 2022: Where we are now and what it takes - EurekAlert - September 8th, 2022
- Treatment Choices for AML Were Increasingly Influenced by Immunological Responses - Physician's Weekly - September 8th, 2022
- BioRestorative Therapies to Present at the H.C. Wainwright 24th Annual Global Investment Conference on September 14 - StreetInsider.com - September 8th, 2022
- Global Recombinant Cell Culture Supplements Market Report 2022: Increasing Need for Immunotherapies and Stem Cell and Regenerative Medicines Presents... - September 8th, 2022
- CAR-T Beyond CGTs In Development In 2022 - BioProcess Online - September 8th, 2022
- ADOCIA Announces First Cell Therapy Preclinical Proof of Concept of AdoShell Islets for the Treatment of Type 1 Diabetes - Business Wire - September 8th, 2022
- Synthetic Mouse Embryo with Brain and Beating Heart Grown from Stem Cells - Genetic Engineering & Biotechnology News - August 30th, 2022
- Utilization of Modified Induced Pluripotent Stem Cells as the Advance | OPTH - Dove Medical Press - August 30th, 2022
- Rise In Number Of CROS In Various Regions Such As Europe Is Expected To Fuel The Growth Of Induced Pluripotent Stem Cell Market At An Impressive CAGR... - August 30th, 2022
- Brush Up: Hematopoietic Stem Cells and Their Role in Development and Disease Therapy - The Scientist - August 30th, 2022
- Regenerative Properties of the Newborn Heart Offers Hope for Those With Congenital Heart Disease - The Epoch Times - August 30th, 2022
- Kanpur hospital is Indias first to perform fat-derived stem cell transplant for diabetic patients - India Today - August 30th, 2022
- Scientists Just Genetically Edited a Million Years of Evolution Into Mouse DNA - ScienceAlert - August 30th, 2022
- Canadian Blood Services Stem Cells for Life - August 22nd, 2022
- Scientists say they have created 'embryos' without sperm or eggs - Medical News Today - August 22nd, 2022
- Many stem cell lines used for research and therapies carry large number of mutations, Cambridge researchers find - Cambridge Independent - August 22nd, 2022
- Scientists hope to revive extinct mammal through stem cells and gene-editing in a first - The Mirror - August 22nd, 2022
- Stem cell therapy in capsule form - Malaya - August 22nd, 2022
- Cell Culture Technician Pluripotent Stem Cell Biology and Genome Editing job with UNIVERSITY OF SOUTHAMPTON | 305107 - Times Higher Education - August 22nd, 2022
- Long COVID-19 and other chronic respiratory conditions after viral infections may stem from an overactive immune response in the lungs - The... - August 5th, 2022
- Self-organized anteroposterior regionalization of early midbrain and hindbrain using micropatterned human embryonic stem cells - Newswise - July 27th, 2022
- Synthetic Stem Cells Market 2022 Size, Share, Future Plans, Competitive Landscape and Forecast to 2030 This Is Ardee - This Is Ardee - July 27th, 2022