Public release date: 13-Feb-2012
[ | E-mail | Share ]
Contact: Sally Stewart
sally.stewart@cshs.org
310-248-6566
Cedars-Sinai Medical Center
Results from a Cedars-Sinai Heart Institute clinical trial show that treating heart attack patients with an infusion of their own heart-derived cells helps damaged hearts re-grow healthy muscle.
Patients who underwent the stem cell procedure demonstrated a significant reduction in the size of the scar left on the heart muscle by a heart attack. Patients also experienced a sizable increase in healthy heart muscle following the experimental stem cell treatments.
One year after receiving the stem cell treatment, scar size was reduced from 24 percent to 12 percent of the heart in patients treated with cells (an average drop of about 50 percent). Patients in the control group, who did not receive stem cells, did not experience a reduction in their heart attack scars.
The study appears online at http://www.thelancet.com and will be in a future issue of the journal's print edition.
"While the primary goal of our study was to verify safety, we also looked for evidence that the treatment might dissolve scar and regrow lost heart muscle," said Eduardo Marb?n, MD, PhD, the director of the Cedars-Sinai Heart Institute who invented the procedures and technology involved in the study. "This has never been accomplished before, despite a decade of cell therapy trials for patients with heart attacks. Now we have done it. The effects are substantial, and surprisingly larger in humans than they were in animal tests."
"These results signal an approaching paradigm shift in the care of heart attack patients," said Shlomo Melmed, MD, dean of the Cedars-Sinai medical faculty and the Helene A. and Philip E. Hixon Chair in Investigative Medicine. "In the past, all we could do was to try to minimize heart damage by promptly opening up an occluded artery. Now, this study shows there is a regenerative therapy that may actually reverse the damage caused by a heart attack."
The clinical trial, named CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to Reverse ventricUlar dySfunction), was part of a Phase I investigative study approved by the U.S. Food and Drug Administration and supported by the National Heart, Lung, and Blood Institute.
As an initial part of the study, in 2009, Marb?n and his team completed the world's first procedure in which a patient's own heart tissue was used to grow specialized heart stem cells. The specialized cells were then injected back into the patient's heart in an effort to repair and re-grow healthy muscle in a heart that had been injured by a heart attack.
The 25 patients -- average age of 53 -- who participated in this completed study experienced heart attacks that left them with damaged heart muscle. Each patient underwent extensive imaging scans so doctors could pinpoint the exact location and severity of the scars wrought by the heart attack. Patients were treated at Cedars-Sinai Heart Institute and at Johns Hopkins Hospital in Baltimore.
Eight patients served as controls in the study, receiving conventional medical care for heart attack survivors, including prescription medicine, exercise recommendations and dietary advice.
The other 17 patients who were randomized to receive the stem cells underwent a minimally invasive biopsy, under local anesthesia. Using a catheter inserted through a vein in the patient's neck, doctors removed small pieces of heart tissue, about half the size of a raisin. The biopsied heart tissue was then taken to Marb?n's specialized lab at Cedars-Sinai, using methods he invented to culture and multiply the cells.
In the third and final step, the now-multiplied heart-derived cells ? approximately 12 million to 25 million ? were reintroduced into the patient's coronary arteries during a second, minimally invasive [catheter] procedure.
Patients who received stem cell treatment experienced an average of 50 percent reduction in their heart attack scars 12 months after infusion while patients who received standard medical management did not experience shrinkage in the damaged tissue.
"This discovery challenges the conventional wisdom that, once established, scar is permanent and that, once lost, healthy heart muscle cannot be restored," said Marb?n, The Mark S. Siegel Family Professor.
The process to grow cardiac-derived stem cells involved in the study was developed earlier by Marb?n when he was on the faculty of Johns Hopkins University. The university has filed for a patent on that intellectual property and has licensed it to a company in which Dr. Marb?n has a financial interest. No funds from that company were used to support the clinical study. All funding was derived from the National Institutes of Health and Cedars-Sinai Medical Center.
###
About the Cedars-Sinai Heart Institute
The Cedars-Sinai Heart Institute is internationally recognized for outstanding heart care built on decades of innovation and leading-edge research. From cardiac imaging and advanced diagnostics to surgical repair of complex heart problems to the training of the heart specialists of tomorrow and research that is deepening medical knowledge and practice, the Cedars-Sinai Heart Institute is known around the world for excellence and innovations.
[ | E-mail | Share ]
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Follow this link:
First-of-its-kind stem cell study re-grows healthy heart muscle in heart attack patients
- Stem Cell Research Documentary [Last Updated On: April 1st, 2011] [Originally Added On: April 1st, 2011]
- Human Embryonic stem cell research [Last Updated On: April 2nd, 2011] [Originally Added On: April 2nd, 2011]
- Obama Ends Funding Ban for Stem Cell Research [Last Updated On: April 3rd, 2011] [Originally Added On: April 3rd, 2011]
- Cardiovascular Therapies: Spotlight on Stem Cell Research - Douglas Boyd [Last Updated On: April 14th, 2011] [Originally Added On: April 14th, 2011]
- Court Lifts Ban On Federal Funding For Stem Cell Research [Last Updated On: April 30th, 2011] [Originally Added On: April 30th, 2011]
- US appeals court lifts stem cell research ban [Last Updated On: April 30th, 2011] [Originally Added On: April 30th, 2011]
- Stem Cell Research: A Father's Fight [Last Updated On: May 8th, 2011] [Originally Added On: May 8th, 2011]
- Politics: President Obama on Stem Cell Research [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- Trailer for Mapping Stem Cell Research: Terra Incognita [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- The Politics and Promise of Stem Cell Research [Last Updated On: May 24th, 2011] [Originally Added On: May 24th, 2011]
- Robert Klein: Stem Cell Research [Last Updated On: May 30th, 2011] [Originally Added On: May 30th, 2011]
- ICL Forum: Stem Cell Research [Last Updated On: May 30th, 2011] [Originally Added On: May 30th, 2011]
- McCain Favors Embryonic Stem Cell Research [Last Updated On: June 1st, 2011] [Originally Added On: June 1st, 2011]
- UC-Irvine's Stem Cell Program and Stem Cell Basics [Last Updated On: June 3rd, 2011] [Originally Added On: June 3rd, 2011]
- Stem Cells and Parkinson's Disease [Last Updated On: June 7th, 2011] [Originally Added On: June 7th, 2011]
- The Ethics of Embryonic Stem Cell Research [Last Updated On: June 7th, 2011] [Originally Added On: June 7th, 2011]
- The Next Frontier in Stem Cell Research [Last Updated On: June 7th, 2011] [Originally Added On: June 7th, 2011]
- Adult Stem Cell Research Far Ahead of Embryonic [Last Updated On: June 8th, 2011] [Originally Added On: June 8th, 2011]
- Frost Over The World - Stem Cell Research and Turkey -26 Oct [Last Updated On: June 8th, 2011] [Originally Added On: June 8th, 2011]
- Inside Story - Obama to end stem cell research ban - March 9 - Part1 [Last Updated On: June 10th, 2011] [Originally Added On: June 10th, 2011]
- Forbes Discusses Stem Cell Research [Last Updated On: June 12th, 2011] [Originally Added On: June 12th, 2011]
- Cardiovascular Therapies: Spotlight on Stem Cell Research - Yung-Wei Chi [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- Stem cell vision study [Last Updated On: June 19th, 2011] [Originally Added On: June 19th, 2011]
- Alzheimer's Stem Cell Research Patient Advocate Spotlight: The Faces of Neurodegenerative Disease [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- Deafness: Spotlight on Stem Cell Research - Karen Doyle [Last Updated On: July 2nd, 2011] [Originally Added On: July 2nd, 2011]
- Alzheimer's Disease: Spotlight on Stem Cell Research - Leeza Gibbons [Last Updated On: July 3rd, 2011] [Originally Added On: July 3rd, 2011]
- HIV/AIDS: Spotlight on Stem Cell Research - John Zaia [Last Updated On: July 6th, 2011] [Originally Added On: July 6th, 2011]
- Spotlight on Cancer Stem Cell Research [Last Updated On: July 9th, 2011] [Originally Added On: July 9th, 2011]
- Spotlight on Basic Stem Cell Research - Irv Weissman [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- Alzheimer's Disease: Spotlight on Stem Cell Research - Rod Shankle [Last Updated On: July 15th, 2011] [Originally Added On: July 15th, 2011]
- Huntington's Disease: Spotlight on Stem Cell Research 2007 - Han Keirstead [Last Updated On: July 16th, 2011] [Originally Added On: July 16th, 2011]
- Deafness: Spotlight on Stem Cell Research - Ebenezer Yamoah [Last Updated On: July 19th, 2011] [Originally Added On: July 19th, 2011]
- Diabetes: Spotlight on Stem Cell Research - Peter Butler [Last Updated On: July 27th, 2011] [Originally Added On: July 27th, 2011]
- Huntington's Disease: Spotlight on Stem Cell Research 2007 - Robert Pacifici [Last Updated On: July 27th, 2011] [Originally Added On: July 27th, 2011]
- Arthritis: Spotlight on Stem Cell Research - Introduction [Last Updated On: August 3rd, 2011] [Originally Added On: August 3rd, 2011]
- Parkinson's Disease: Spotlight on Stem Cell Research - Jeff Bronstein [Last Updated On: August 15th, 2011] [Originally Added On: August 15th, 2011]
- Stem Cell Research: Huntington's Disease [Last Updated On: August 16th, 2011] [Originally Added On: August 16th, 2011]
- Parkinson's Disease: Spotlight on Stem Cell Research - Arnold Kriegstein [Last Updated On: August 20th, 2011] [Originally Added On: August 20th, 2011]
- Stemcell Research and Aging - Panel 1 [Last Updated On: September 17th, 2011] [Originally Added On: September 17th, 2011]
- The EU and stem cell research [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- Batten Disease: Spotlight on Stem Cell Research - A Father's Story [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- Kerri Kimler: What I'll be telling people back in Texas about the World Stem Cell Summit [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Stem Cell Research Funding Halt [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- The Skin Gun stem cell research [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Roman Reed: What all patient advocates at the World Stem Cell Summit should know [Last Updated On: October 4th, 2011] [Originally Added On: October 4th, 2011]
- Stem Cell Research, Ethics and Religion [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- US divided over stem cell research reversal - 09 Mar 09 [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Stem cell symposium [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- CIRM: Progress and Promise in Stem Cell Research [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- UCSF opens stem cell research building [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- StemCONN 2011, The Latest in Stem Cell Research [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Adult and Non-Embryonic Stem Cell Research Conference at Notre Dame [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Ethics of Stem Cell Research (1) [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Stemcell Research and Aging - Panel 2 [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- The Vatican Initiative in Support of Adult and Alternative Stem Cell Research [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Governor Tim Pawlenty Discusses Stem Cell Research [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- Stem Cell Research: Macular Degeneration [Last Updated On: October 12th, 2011] [Originally Added On: October 12th, 2011]
- stem cell research - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Regenerative Medicine and Applications of Stem Cell Research - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Embryonic stem cell Research Update - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Mapping Stem Cell Research: Terra Incognita - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Myelin Repair Foundation on Stem Cell Research - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- CIRM Bridges Award: Building California's Stem Cell Research Workforce - Video [Last Updated On: October 16th, 2011] [Originally Added On: October 16th, 2011]
- Narendra Modi on MOU in Education , sickle cell and stem-cell research - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Disgraced scientist claims coyote clone - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Talking research: New stem cell trial for MS - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Gayle Atteberry - Cloning [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- Cardiovacular Therapies: Spotlight on Stem Cell Research - Welcome - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- UC Merced Stem Cell Research Addresses Health Problems - Video [Last Updated On: October 19th, 2011] [Originally Added On: October 19th, 2011]
- Whitney Seshie Stem Cell Research - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- Michael J. Fox Embryonic Stem Cell Research - Video [Last Updated On: October 22nd, 2011] [Originally Added On: October 22nd, 2011]
- Advances in Stem Cell Research: Shinya Yamanaka - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- Stem Cell Research (featuring Ron Paul) - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- Stem Cell Research in MS - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- Stem Cell Research Presentation - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- Embryonic Stem Cell Research - Video [Last Updated On: October 31st, 2011] [Originally Added On: October 31st, 2011]
- Is stem cell research a growing concern .flv - Video [Last Updated On: November 3rd, 2011] [Originally Added On: November 3rd, 2011]
- Arthritis: Spotlight on Stem Cell Research - Bill Robinson - Video [Last Updated On: November 4th, 2011] [Originally Added On: November 4th, 2011]
- Stem Cell Research (Pro side) - Video [Last Updated On: November 4th, 2011] [Originally Added On: November 4th, 2011]