Axol Bioscience Introduces CiPA-Validated Human Stem Cell-Derived Ventricular Cardiomyocytes to Help Improve Drug Discovery – Business Wire

CAMBRIDGE, England & EDINBURGH, Scotland--(BUSINESS WIRE)--Axol Bioscience Ltd. (Axol), an established provider of iPSC-derived cells, media, and characterization services for life science discovery, today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation. Using this assay, the cells were shown to be suitable for measuring cardiotoxicity, offering scientists a robust cardiac model for drug discovery and screening.

Axols human iPSC-derived ventricular cardiomyocytes are manufactured at scale according to strict quality control standards using ISO 9001-accredited quality management systems, providing a continuous source of cells from the same genetic background for use in multiple experiments. This offers a physiologically relevant in vitro research model of human heart cells to reliably and repeatably test drug candidates for cardiotoxicity at scale.

With the advent of human iPSC-derived cardiomyocytes, the US Federal Food and Drug Administration Agency (FDA) launched a working group to assess the utility of these cells in reproducing cardiotoxicity in a dish, known as CiPA*. The assay tests cells with 28 compounds that are known to be cardiotoxic and induce the fatal arrhythmia Torsades de Pointes. Clyde Biosciences, a CRO that specializes in cardiotoxicity assays, used this assay to validate Axols cardiomyocytes for cardiac safety testing. Using these cells could help researchers to identify unsuitable drug candidates earlier in the drug discovery process and improve the number of promising pre-clinical drug candidates that translate through to clinical trials and to patients.

Liam Taylor, CEO, Axol Bioscience, said: Scientists need cells and reagents they can rely on to make meaningful assessments of drug candidate toxicity, before progressing candidates to the clinic.

Were both excited and proud to demonstrate the suitability of our human iPSC-derived ventricular cardiomyocytes for toxicity testing. Axols stringent quality control standards mean we have the capability to produce reliable, validated cells that scientists can use to assess a compounds cardiac liability and, ultimately, help to improve the drug discovery process.

Prof. Godfrey Smith, CSO, Clyde Biosciences, added: As a core member of the CiPA initiative, were pleased to have supported Axols cell development and helped the team assess the performance of its cardiomyocytes. Having run the CiPA protocol on Clydes proprietary CellOPTIQ platform, and provided analysis and interpretation of the data, we confirm our data indicates that Axols cardiomyocytes meet the requirements for predictive in vitro pro-arrhythmia screening.

For further information about Axols human iPSC-derived cardiomyocytes, please visit: https://axolbio.com/cells/cardiovascular-system/

Dr. Jamie Bhagwan, Group Leader, Axol Bioscience will present data describing the development of Axols iPSC-derived cardiomyocytes alongside Clyde Biosciences Prof. Godfrey Smith at a free-to-attend webinar on June 9th, at 6 PM BST / 1 PM ET / 10 AM PT. Register here: https://register.gotowebinar.com/register/1085358037527496720?hss_channel=lcp-

Axol will also be attending the International Society for Stem Cell Research (ISSCR) Annual Meeting in San Francisco, USA from June 1518, 2022. Visit booth 440 to learn more.

* About CiPA: https://cipaproject.org/about-cipa/#About

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Axol Bioscience Introduces CiPA-Validated Human Stem Cell-Derived Ventricular Cardiomyocytes to Help Improve Drug Discovery - Business Wire