Molecular motors carry out vital functions in all eukaryotic cells. One of these, Cytoplasmic Dynein, is critical during mitosis, migration and cellular trafficking events. We are characterizing several signaling pathways that impinge on dynein function. Our current focus is on their importance in the adult mammalian nervous system and during colon carcinogenesis in mammals.
Publications Pandey JP, Smith DS.. 2011. A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons. Journal of Neuroscience. Nov 23;31(47):17207-19. http://www.jneurosci.org.pallas2.tcl.sc.edu/content/31/47/17207.long
Hebbar S, Mesngon MT, Guillotte AM, Desai B, Ayala R, Smith DS.. 2008. Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. Journal of Cell Biology. Sep 22;182(6):1063-71. http://jcb.rupress.org/content/182/6/1063.long
Hebbar S, Guillotte AM, Mesngon MT, Zhou Q, Wynshaw-Boris A, Smith DS.. 2008. Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene. Developmental Neuroscience. 30(1-3):157-70. http://www.ncbi.nlm.nih.gov.pallas2.tcl.sc.edu/pmc/articles/PMC3097246/?tool=pubmed
Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, Musacchio A, King SJ, Smith DS. . 2006. Regulation of cytoplasmic dynein ATPase by Lis1. Journal of Neuroscience. Feb 15;26(7):2132-9. http://www.jneurosci.org.pallas2.tcl.sc.edu/content/26/7/2132.long
D. Smith. 2003. Cdk5 in neuroskeletal dynamics. Neurosignals. Sep-Oct;12(4-5):239-51. http://content.karger.com.pallas2.tcl.sc.edu/produktedb/produkte.asp?DOI=74626&typ=pdf
Smith DS, Tsai LH.. 2002. Cdk5 behind the wheel: a role in trafficking and transport?. Trends in Cell Biology. Jan;12(1):28-36. http://www.sciencedirect.com.pallas2.tcl.sc.edu/science/article/pii/S096289240102181X
Smith DS, Greer PL, Tsai LH.. 2001. Cdk5 on the brain. Cell Growth and Differentiation. Jun;12(6):277-83. http://cgd.aacrjournals.org.pallas2.tcl.sc.edu/cgi/content/full/12/6/277
Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. 2000. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. Dec;28(3):697-711. http://www.sciencedirect.com.pallas2.tcl.sc.edu/science/article/pii/S0896627300001471
Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR.. 2000. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth and Differentiation. Dec;11(12):625-33. http://cgd.aacrjournals.org.pallas2.tcl.sc.edu/cgi/content/full/11/12/625
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