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Researchers are keen to compare induced pluripotent stem cells (pictured) with their embryonic cousins.

SILVIA RICCARDI/SPL

The US Supreme Courts decision last week to throw out a lawsuit that would have blocked federal funding of all research on human embryonic stem cells cleared the gloom that has hung over the field for more than three years. Yet the biggest boost from the decision might go not to work on embryonic stem (ES) cells, but to studies of their upstart cousins, induced pluripotent stem (iPS) cells, which are created by reprogramming adult cells into a stem-cell-like state.

At first glance, iPS-cell research needs no help. Researchers flocked to the field soon after a recipe for deriving the cells from adult mouse cells was announced in 2006, partly because this offered a way to skirt the thorny ethical issues raised by extracting cells from human embryos. But the real allure of iPS cells was the promise of genetically matched tissues. Adult cells taken from a patient could be used to create stem cells that would, in turn, generate perfectly matched specialized tissues replacement neurons, say for cell therapy. Although the number of published papers from iPS-cell research has not yet caught up with that of ES-cell work (see Inducing a juggernaut), US funding for each approach is now roughly matched at about US$120 million a year.

C. T. Scott et al. Cell 145, 820826 (2011)

But, as iPS cells crop up in ever more labs, ES cells generally cheaper, better behaved and backed by an extra decades worth of data promise to have an important supporting role. Ever since iPS cells were described, researchers have been trying to understand just how similar they are to ES cells. iPS cells begin with different patterns of gene expression, and they can also acquire mutations during the reprogramming process, which means that every iPS cell must be thoroughly evaluated before it can be used in any study. Human ES cells will always be the standard to which other cells will be compared, says Roger Pedersen, who studies how stem cells retain embryo-like states at the University of Cambridge, UK.

Federally supported ES-cell research was shut down in the United States on 23August 2010, a year after a lawsuit was filed by two opponents of human ES-cell research, and remained frozen for more than two weeks (see Fifteen years of controversy). Many investigators shied away from the field for fear of having to shut down again. The Supreme Courts move has reassured investigators such as Candace Kerr, who studies early development of the brain at the University of Maryland School of Medicine in Baltimore. As a young scientist working towards tenure, she felt particularly vulnerable to the threat of ES-cell funding being stopped. So she switched to iPS cells in 2010, while the lawsuit was working its way through the US court system. With the litigation over, she says she need not hesitate or fear adding to her work with experiments using ES cells, which she finds much easier to prompt into neurons than iPS cells. I am excited and relieved by this decision, she says.

The tussles over whether or not US federal funds can be used for research involving human embryonic stem cells have a long history.

November 1998 Paper announces the isolation of embryonic stem (ES) cells from human embryos.

August 2001 US President George W. Bush restricts federal funding for work on human ES cells to a few extant lines.

Original post:
Court lifts cloud over embryonic stem cells

This custom made, cutting edge spa treatment at the BODY Spa at BODY of Santa Fe allows clients to experience the tightening effects of a facelift without the expense or intrusion of surgery. Using technologies such as cryogenic stem cells, ultrasonic, LED light and

Santa Fe, NM (PRWEB) November 15, 2012

After a careful skin analysis, the BODY Natural Facelift begins with a deep cleansing, utilizing either microdermabrasion or a 100% organic herbal enzyme peel, followed by the application of ECOCERT certified Plant Stem Cells (Naturopathica products) or Cryogenic stem cells developed by the DNA Health Institute utilizing pure bovine origin stem cells (from the first trimester embryonic fluid of organic grass fed cows in France)*. The cells been proven to slow cellular aging and counteract a variety of skin problems leaving skin more hydrated, better nourished, less aged, and more radiant. The Natural Facelift treatment is applied with either the plant based products from Naturopathica or DNA Health Institute products.

BODY of Santa Fes highly trained therapists then custom design a blend of cutting edge, non-invasive therapies to amplify collagen and microcurrent to tighten skin and firm and tone facial muscles. LED light is then used to stimulate collagen and correct skin damage followed by ultrasonic therapy to deeply hydrate. Skin is left glowing and healthy with noticeable results after only one treatment.

I created the BODY Natural Face Lift to give our clients an alternative to plastic surgery, said BODY owner Lorin Parrish. As time passes, every cell loses strength and becomes more independent as its surrounding tissue deteriorates and runs slower and rougher. Cells need other cells for information, support, nourishment and direction; for skin to work the way it does, every cell must work in perfect unison with its surrounding tissue.

The BODY Natural Facelift is appropriate for all skin types and skin tones and is available for body treatment areas including the derriere, thighs, stomach, underarms, and chest. The BODY Natural Facelift is $175 for a 90-minute session and a series of 10 sessions is available for $1495. For more information about the Natural Facelift or to make spa reservations, please visit http://www.bodyofsantafe.com or call (505) 986-0362.

*The humane process of extracting bovine embryonic fluidrich in nutrients and stem cellshappens during carefully calculated specific timeline (within the first trimester of the bovines pregnancy) to achieve maximum amounts of stem cells, which have not become specific to the bovine composition, but contain the DNA information to influence and support human skin.

For press inquiries, contact:

Jennifer Hinsley

JLH Media

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BODY of Santa Fe Unveils the BODY Natural Facelift: Innovative Facial Mimics the Effect of a Facelift Using Stem Cell ...