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Stem cell brain injections ease Parkinson's

Posted: March 18, 2012 at 10:00 pm

MONKEYS with Parkinson's disease-like symptoms have had their suffering eased by an injection of human embryonic stem cells (hESCs) into their brain.

Jun Takahashi of Kyoto University in Japan and colleagues injected these cells into monkeys whose brains had been damaged by a chemical that destroys dopamine-producing neurons and so causes Parkinson's symptoms.

Two monkeys received hESCs that had been matured into an early form of neural cell. Six months later, the monkeys had recovered 20 to 45 per cent of the movement they had lost before treatment. Post-mortems a year after treatment showed that the cells had developed into fully functioning dopamine-secreting neurons. Another monkey that received less-mature neural cells also showed improvements (Stem Cells, DOI: 10.1002/stem.1060).

"Monkeys starting with tremors and rigidity [began] to move smoothly, and animals originally confined to sitting down were able to walk around," says Takahashi.

The team says it will probably be four to six years before clinical trials in humans begin.

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Stem cell brain injections ease Parkinson's

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Infusion of stem cells could fix heart damage

Posted: March 18, 2012 at 10:00 pm

I had a large heart attack about two years ago. As a result, my cardiologist says that my heart only pumps half as well as a healthy heart.

Im on a number of medications to help my heart, but can you tell me if theres anyone studying a way to restore a weak heart like mine back to the way it was? T.Y., Scranton, Pa.

Dear T.Y.: A heart attack is the permanent damage and death of heart muscle resulting from a blockage to the blood vessel supplying that area.

Once an area of tissue is dead, it forms a permanent scar and its gone for good or so weve always thought.

The results from a small but very exciting study conducted by the Cedars-Sinai Heart Institute show that for the first time, heart attack patients who received an infusion of their own heart-derived stem cells were able to regrow healthy new heart muscle.

The Caduceus trial, just published online in the journal Lancet, involved 25 heart attack patients who, one year following their own stem cell infusion, showed a reduction in their heart attack scar size from 24 percent of their heart mass to only 12 percent. This represents a potential paradigm shift in our understanding of patients who are post-heart attack.

If this is successful when repeated on a larger study population, we may be able to help folks like you reverse the damage caused by a heart attack and dissolve your hearts scarring. Pretty exciting stuff!

My wife and I want to start a family in the near future.

Ive been taking Adderall for ADD, and am wondering if I need to stop it until my wife becomes pregnant. Does it affect the sperm? D.L., Flowery Branch, Ga.

Dear D.L.: There is nothing in the medical literature that shows taking a prescribed amphetamine like Adderall causes a reduction the sperm count, a reduction in sperm motility, sperm deformity or any damage to the genetic information contained within sperm.

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Stem cell agency ponders its future

Posted: March 18, 2012 at 10:00 pm

LOS ANGELES (AP) The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

So far, CIRM has spent some $1.3 billion on infrastructure and research. At the current pace, it will earmark the last grants in 2016 or 2017. Since most are multi-year awards, it is expected to stay in business until 2021.

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Hometownstations.com-WLIO- Lima, OH News Weather SportsCalifornia's stem cell agency ponders its future

Posted: March 18, 2012 at 10:00 pm

By ALICIA CHANG AP Science Writer

LOS ANGELES (AP) - The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

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Hometownstations.com-WLIO- Lima, OH News Weather SportsCalifornia's stem cell agency ponders its future

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California's stem cell agency ponders its future

Posted: March 18, 2012 at 10:00 pm

LOS ANGELES (AP) The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

So far, CIRM has spent some $1.3 billion on infrastructure and research. At the current pace, it will earmark the last grants in 2016 or 2017. Since most are multi-year awards, it is expected to stay in business until 2021.

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Genetic variation in East Asians found to explain resistance to cancer drugs

Posted: March 18, 2012 at 7:16 pm

Public release date: 18-Mar-2012 [ | E-mail | Share ]

Contact: Mary Jane Gore mary.gore@duke.edu 919-660-1309 Duke University Medical Center

DURHAM, N.C., AND SINGAPORE A multi-national research team led by scientists at Duke-NUS Graduate Medical School has identified the reason why some patients fail to respond to some of the most successful cancer drugs.

Tyrosine kinase inhibitor drugs (TKIs) work effectively in most patients to fight certain blood cell cancers, such as chronic myelogenous leukemia (CML), and non-small-cell lung cancers (NSCLC) with mutations in the EGFR gene.

These precisely targeted drugs shut down molecular pathways that keep these cancers flourishing and include TKIs for treating CML, and the form of NSCLC with EGFR genetic mutations.

Now the team at Duke-NUS Graduate Medical School in Singapore, working with the Genome Institute of Singapore (GIS), Singapore General Hospital and the National Cancer Centre Singapore, has discovered that there is a common variation in the BIM gene in people of East Asian descent that contributes to some patients' failure to benefit from these tyrosine kinase inhibitor drugs.

"Because we could determine in cells how the BIM gene variant caused TKI resistance, we were able to devise a strategy to overcome it," said S. Tiong Ong, M.B.B. Ch., senior author of the study and associate professor in the Cancer and Stem Cell Biology Signature Research Programme at Duke-NUS and Division of Medical Oncology, Department of Medicine, at Duke University Medical Center.

"A novel class of drugs called the BH3-mimetics provided the answer," Ong said. "When the BH3 drugs were added to the TKI therapy in experiments conducted on cancer cells with the BIM gene variant, we were able to overcome the resistance conferred by the gene. Our next step will be to bring this to clinical trials with patients."

Said Yijun Ruan, Ph.D., a co-senior author of this study and associate director for Genome Technology and Biology at GIS: "We used a genome-wide sequencing approach to specifically look for structural changes in the DNA of patient samples. This helped in the discovery of the East Asian BIM gene variant. What's more gratifying is that this collaboration validates the use of basic genomic technology to make clinically important discoveries."

The study was published online in Nature Medicine on March 18.

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California’s stem cell agency ponders its future

Posted: March 18, 2012 at 7:15 pm

LOS ANGELES (AP) The creation of California's stem cell agency in 2004 was greeted by scientists and patients as a turning point in a field mired in debates about the destruction of embryos and hampered by federal research restrictions.

The taxpayer-funded institute wielded the extraordinary power to dole out $3 billion in bond proceeds to fund embryonic stem cell work with an eye toward treatments for a host of crippling diseases. Midway through its mission, with several high-tech labs constructed, but little to show on the medicine front beyond basic research, the California Institute for Regenerative Medicine faces an uncertain future.

Is it still relevant nearly eight years later? And will it still exist when the money dries up?

The answers could depend once again on voters and whether they're willing to extend the life of the agency.

Several camps that support stem cell research think taxpayers should not pay another cent given the state's budget woes.

"It would be so wrong to ask Californians to pony up more money," said Marcy Darnovsky of the Center for Genetics and Society, a pro-stem cell research group that opposed Proposition 71, the state ballot initiative that formed CIRM.

Last December, CIRM's former chairman, Robert Klein, who used his fortune and political connections to create Prop 71, floated the possibility of another referendum.

CIRM leaders have shelved the idea of going back to voters for now, but may consider it down the road. The institute recently submitted a transition plan to Gov. Jerry Brown and the Legislature that assumes it will no longer be taxpayer-supported after the bond money runs out. CIRM is exploring creating a nonprofit version of itself and tapping other players to carry on its work.

"The goal is to keep the momentum going," board Chairman Jonathan Thomas said in an interview.

So far, CIRM has spent some $1.3 billion on infrastructure and research. At the current pace, it will earmark the last grants in 2016 or 2017. Since most are multi-year awards, it is expected to stay in business until 2021.

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Researcher Alert: California Stem Cell Agency To Alter How It Administers Grants

Posted: March 18, 2012 at 3:57 pm


Stem cell researchers and institutions throughout the state are likely to be affected by proposed changes – to be discussed online publicly Tuesday – dealing with how the California stem cell agency will handle its $3 billion in grants.

An important online session – open to all interested parties – comes up then, but advance registration is required.

The proposals are wide-ranging and detailed. The nearly 500 recipients of CIRM grants should examine them closely in addition to any persons seriously interested in California stem cell affairs. The changes deal with such subjects as milestones for research grants, indirect costs, travel costs, withholding payments for failure to file a progress report and much, much more.

Here is a link to the main page for all this, which has instructions on how to register for the online session along with links to the changes and their rationale.

(Editor's note: This item was filed from the Rio Sabana in the Darien in Panama when we found a weak Internet cellular link. We are still underway so postings are unlikely between now and later this month.)

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Researcher Alert: California Stem Cell Agency To Alter How It Administers Grants

Posted: March 18, 2012 at 3:56 pm


Stem cell researchers and institutions throughout the state are likely to be affected by proposed changes – to be discussed online publicly Tuesday – dealing with how the California stem cell agency will handle its $3 billion in grants.

An important online session – open to all interested parties – comes up then, but advance registration is required.

The proposals are wide-ranging and detailed. The nearly 500 recipients of CIRM grants should examine them closely in addition to any persons seriously interested in California stem cell affairs. The changes deal with such subjects as milestones for research grants, indirect costs, travel costs, withholding payments for failure to file a progress report and much, much more.

Here is a link to the main page for all this, which has instructions on how to register for the online session along with links to the changes and their rationale.

(Editor's note: This item was filed from the Rio Sabana in the Darien in Panama when we found a weak Internet cellular link. We are still underway so postings are unlikely between now and later this month.)

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

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‘Father of stem-cell research’ Dr. James Till feted for discovery's 50th anniversary

Posted: March 18, 2012 at 2:57 am

Shinan Govani Mar 17, 2012 7:30 AM ET | Last Updated: Mar 16, 2012 5:35 PM ET

How many scientific breakthroughs does one man need to make to get a plus-one around here? That small little matter one thats foiled lesser men constituted one of the lighter moments in the way-serious commemoration that took place last week at the inaugural Renew the World Gala. Guest of honour Dr. James Till known to some as one of the fathers of stem-cell research had, we were told, demurely inquired beforehand if it was, oh, OK if his wife tagged along for the big black-tie. I think we know what the answer was. (This wasnt one of those admit one kind of thingies.)

In the words of my sometime party proxy Pasquale Casullo: There were scientists. There were celebrities. There were philanthropists. And, oh, luxury automobiles, too! Attending the dinner that went down at the Mercedes-Benz dealership in the east end, he took in a night effectively marking the made-in-Toronto 50th anniversary of the landmark discovery of Dr. Till and his colleague, the late Ernest McCulloch. Swirling amongst the cell-supporters and humble-as-pie lab-coat set, Im told, were the likes of Chantal Kreviazuk, Robert Herjavec, Michael Burgess, Damon Allen, Monika Schnarre, Stacey McKenzie, Trish Stratus, Melissa Grelo, Keshia Chant, Heather Hiscox and many more.

The event raised $1.2-million for the Canadian Stem Cell Foundation, which as the crowd that night was told, supports the work being done to use stem cells to rebuild damaged tissue in many parts of the body, such as the eyes, pancreas and brain. Also in the works: clinical trials for possible new treatments for cancer, blindness, multiple sclerosis, spinal cord injury, etc.

The humility-soaked octogenarian cutie that is Dr. Till ended up leaving the joint with the biggest Q-rating uptick, with more than one person admitting later to a crush on the seasoned biophysicist. In the words of one who was there: Hes too good to be true. The most genuine and modest person Ive ever met.

Renew the World, indeed!

SCENE! HEARD!

Here! There!

A party is in the works next month to mark the 25th anniversary of Centro, the respectable resto on Yonge where newlyweds Conrad Black and Barbara Amiel used to conspire, and, in its hey-est-day, was the place people would go to gawk at everyone from Quincy Jones to Tony Bennett to Michael Jordan to Julio Iglesias!

Taking a break to brunch while in town shooting their TV series XIII: Stuart Townsend, Aisha Tyler. Spotted at The Drake last Sunday.

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