24-03-2012 07:46 This is the harvest of adipose tissue for combination with bone marrow aspirate concentrate for stem cell therapy
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Adipose harvest for stem cell therapy by Dr Adelson - Video
Posted: March 26, 2012 at 2:18 am
24-03-2012 07:46 This is the harvest of adipose tissue for combination with bone marrow aspirate concentrate for stem cell therapy
Follow this link:
Adipose harvest for stem cell therapy by Dr Adelson - Video
Posted: March 26, 2012 at 2:18 am
25-03-2012 10:22 Dr Adelson aspirates bone marrow for concentration for stem cell therapy for musculoskeletal pain conditions
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bone marrow aspiration for stem cell therapy by Dr Adelson - Video
Posted: March 25, 2012 at 7:51 pm
(RTTNews.com) - An important clinical trial, which evaluated the use of autologous bone-marrow-cell therapy in patients with chronic ischemic heart failure, has failed to meet the prespecified end points of improvement in most measures of heart function, according to the results presented at the American College of Cardiology 2012 Scientific Sessions.
The trial dubbed, FOCUS - a phase II study, is the largest study to date to investigate if a patient's own bone marrow cells improved myocardial perfusion, reduced left ventricular end-systolic volume or enhanced maximal oxygen consumption in patients with coronary artery disease or LV dysfunction, and limiting heart failure or angina. The FOCUS trial was undertaken by the National Heart, Lung, and Blood Institute-sponsored Cardiovascular Cell Therapy Research Network.
Ninety two patients with chronic ischemic heart disease , having a left ventricular ejection fraction of 45% or less, a perfusion defect by single-photon emission tomography, or SPECT, who were no longer candidates for revascularization, were enrolled in the trial. Sixty one patients in the study were administered bone marrow cells through transendocardial injections while thirty one patients were administered placebo.
An assessment of primary endpoints at 6 months has revealed that there is no statistically significant difference between the treatment group and placebo arm in left ventricular end-systolic volume assessed by echocardiography, maximal oxygen consumption, and reversibility on SPECT. The secondary outcomes, including percent myocardial defect, total defect size, fixed defect size, regional wall motion, and clinical improvement, also has not exhibited any difference between the two arms.
However, according to the study authors, exploratory analyses have revealed that left ventricular ejection fraction improved in the treatment group compared with the placebo group by 2.7%.
The authors, led by Emerson Perin, concluded that the findings provide evidence for further studies to determine the relationship between the composition and function of bone marrow product and clinical end points. Understanding these relationships will improve the design and interpretation of future studies of cardiac cell therapy, the authors noted.
The results were published online March 24 in the Journal of the American Medical Association.
For comments and feedback: contact editorial@rttnews.com
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Bone Marrow Stem Cell Therapy Trial - Clues, But No Answers
Posted: March 25, 2012 at 4:02 pm
(HealthDay News) -- A new method to prevent recurrence of deadly glioblastoma brain cancer shows promise, say U.S. scientists.
Radiation can temporarily shrink a glioblastoma tumor, but the cancer nearly always recurs within weeks or months. Few people with this type of brain cancer survive more than two years after diagnosis.
In a study on mice, Stanford University School of Medicine researchers found that blocking access to oxygen and nutrients prevents tumor recurrence.
The first step, they said, was discovering that tumors blasted with radiation use a secondary pathway to generate blood vessels needed for regrowth.
"Under normal circumstances, this pathway is not important for growth of most tumors," senior author Martin Brown, a professor of radiology, said in a Stanford news release. "What we hadn't realized until recently is that radiation meant to kill the cancer cells also destroys the existing blood vessels that nourish the tumor. As a result, it has to rely on a backup blood delivery pathway."
The Stanford team used a molecule called AMD3100 to block the secondary glioblastoma tumor growth process in mice.
The study was published online Feb. 22 in the Journal of Clinical Investigation. Read more...
Posted: March 25, 2012 at 4:02 pm
Biotechnology is undoubtedly the technology of the future for it not only presents exceptional opportunities, but also gives hope for a better future with better diagnosis and treatment of diseases. In terms of potential and growth, it is not much different from the mystical dragon, and since 2012 is the year of the dragon, it is expected that it would bring in loads of good news and prosperity for this new branch of science.
The good newsFor biotechnology, the last year has been strong and monumental with Tax Incentive Legislation being passed in Australia and a very strong and consistent growth in the sector which was recently followed by good news, the Senate Inquiry of the gene patents bill. Since the last year, the Australian Biotechnology has been included amongst the fifth most innovative biotech nations in the world (according to the Scientific American World View). This trend is continuing in the current year, as Australia has shown great potential in developing biotech related agricultural, medical and even environmental research.
The companies of Australian Biotech are confident that the New Year would definitely be the best and until now with tremendous growth in the sector it has proved this. Even the new startup biotech companies in Australia now stand a better chance with the Tax Incentive’s 45% refundable component, even the large corporations would now be able to reduce their R&D expenses by as much as 10%. Such a healthy growth favoring environment has allowed the Australian Biotech companies to make a mark globally and have a steadily rising status even in the competitive markets of US and Europe.
ConclusionThe Australian Biotech industry now needs to revamp itself and embrace a more authentic and transparent management. There should be better communication between the management and the stakeholders. The opportunities are in plenty and the industry environment very supportive, hence the companies should make the most of it and truly let the biotech dragon rise in this year of the dragon.
Posted: March 25, 2012 at 4:02 pm
INTERNATIONAL STEM CELL CORPORATION AND SUBSIDIARIES (A Developmental Stage Company) Consolidated Balance Sheets (in thousands, except share data) | |||||||||||||||||
December 31, | |||||||||||||||||
2011 | 2010 | ||||||||||||||||
Assets | |||||||||||||||||
Current assets | |||||||||||||||||
Cash and cash equivalents | $ | 1,337 | $ | 5,782 | |||||||||||||
Accounts receivable | 140 | 739 | |||||||||||||||
Inventory, net | 1,268 | 856 | |||||||||||||||
Prepaid assets | 274 | 228 | |||||||||||||||
Total current assets | 3,019 | 7,605 | |||||||||||||||
Property and equipment, net | 1,420 | 1,296 | |||||||||||||||
Intangible assets, net | 1,282 | 986 | |||||||||||||||
Deposits and other assets | 16 | 40 | |||||||||||||||
Total assets | $ | 5,737 | $ | 9,927 | |||||||||||||
Liabilities and Stockholders' Equity | |||||||||||||||||
Current liabilities | |||||||||||||||||
Accounts payable | $ | 885 | $ | 583 | |||||||||||||
Accrued liabilities | 752 | 545 | |||||||||||||||
Deferred revenue | 189 | 760 | |||||||||||||||
Convertible debt and advances | 250 | 250 | |||||||||||||||
Warrants to purchase common stock | 38 | 2,400 | |||||||||||||||
Total liabilities | 2,114 | 4,538 | |||||||||||||||
Stockholders' Equity | |||||||||||||||||
Series D Preferred stock, $0.001 par value 50 shares authorized, 43 issued and outstanding for 2011 and 2010 | - | - | |||||||||||||||
Series A Preferred stock, $0.001 par value 5,000,000 shares authorized, 500,000 issued and outstanding for 2011 and 2010, liquidation preferences of $615,000 and $585,000 in 2011 and 2010, respectively | 1 | 1 | |||||||||||||||
Series B Preferred stock, $0.001 par value 5,000,000 shares authorized, 300,000 issued and outstanding for 2011 and 2010, liquidation preferences of $367,000 and $349,000 in 2011 and 2010, respectively | 0 | 0 | |||||||||||||||
Series C Preferred stock, $0.001 par value 3,000,000 shares authorized, 2,000,000 issued and outstanding for 2011 and 2010, liquidation preferences of $2,387,000 and $2,267,000 in 2011 and 2010, respectively | 2 | 2 | |||||||||||||||
Common stock, $0.001 par value 200,000,000 shares authorized, 80,036,315 and 74,771,107 issued and outstanding for 2011 and 2010, respectively | 80 | 75 | |||||||||||||||
Subscription receivable on common stock | - | (5 | ) | ||||||||||||||
Additional paid-in capital | 63,995 | 56,170 | |||||||||||||||
Deficit accumulated during the development stage | (60,455 | ) | (50,854 | ) | |||||||||||||
Total stockholders' equity | 3,623 | 5,389 | |||||||||||||||
Total liabilities and stockholders' equity | $ | 5,737 | $ | 9,927 | |||||||||||||
INTERNATIONAL STEM CELL CORPORATION AND SUBSIDIARIES (A Developmental Stage Company) Consolidated Statements of Operations (in thousands, except per share data) | ||||||||||||||||||||||
Year Ended December 31, | Inception (August 17, 2001) through December 31, 2011 | |||||||||||||||||||||
2011 | 2010 | |||||||||||||||||||||
Product sales | $ | 4,532 | $ | 1,568 | $ | 7,631 | ||||||||||||||||
Royalties and license | - | - | 135 | |||||||||||||||||||
Total revenue | 4,532 | 1,568 | 7,766 | |||||||||||||||||||
Development expenses | ||||||||||||||||||||||
Cost of sales | 1,618 | 725 | 3,334 | |||||||||||||||||||
Research and development | 4,434 | 3,374 | 18,294 | |||||||||||||||||||
Marketing | 1,475 | 860 | 3,874 | |||||||||||||||||||
General and administrative | 8,360 | 7,071 | 31,684 | |||||||||||||||||||
Total development expenses | 15,887 | 12,030 | 57,186 | |||||||||||||||||||
Loss from development activities | (11,355 | ) | (10,462 | ) | (49,420 | ) | ||||||||||||||||
Other income (expense) | ||||||||||||||||||||||
Settlement with related company | - | - | (93 | ) | ||||||||||||||||||
Miscellaneous | (163 | ) | (26 | ) | (180 | ) | ||||||||||||||||
Dividend and interest income | 1 | 28 | 94 | |||||||||||||||||||
Interest expense | - | (14 | ) | (2,225 | ) | |||||||||||||||||
Change in market value of warrants | 2,335 | (2,501 | ) | (1,395 | ) | |||||||||||||||||
Sublease income | 11 | 252 | 309 | |||||||||||||||||||
Total other income (expense) | 2,184 | (2,261 | ) | (3,490 | ) | |||||||||||||||||
Loss before income taxes | (9,171 | ) | (12,723 | ) | (52,910 | ) | ||||||||||||||||
Provision for income taxes | - | - | 7 | |||||||||||||||||||
Net loss | $ | (9,171 | ) | $ | (12,723 | ) | $ | (52,917 | ) | |||||||||||||
Dividend on preferred stock | (430 | ) | (1,561 | ) | (7,968 | ) | ||||||||||||||||
Net loss applicable to common stockholders | $ | (9,601 | ) | $ | (14,284 | ) | $ | (60,885 | ) | |||||||||||||
Net loss per common share-basic and diluted | $ | (0.12 | ) | $ | (0.21 | ) | n/a | |||||||||||||||
Weighted average shares-basic and diluted | 77,320 | 68,762 | n/a | |||||||||||||||||||
Source:
http://intlstemcell.blogspot.com/feeds/posts/default?alt=rss
Posted: March 25, 2012 at 4:02 pm
The Vatican has cancelled a controversial scientific conference that would have featured scientists, including the president of the California stem cell agency, who support human embryonic stem cell research.
The conference reportedly created a "scandal" in the Vatican, according to a report by David Kerr of the Catholic News Agency. Kerr wrote,
"'I am infinitely relieved that the Church has avoided a major blunder which would have confused the faithful for decades to come,'” said one member of the Pontifical Academy who asked for anonymity in commenting to (the Catholic News Agency)."
The Catholic church opposes hESC research because of its belief that it destroys human life.
The conference would have taken place at the Vatican April 25-28 and included an audience with the pope. In addition to an appearance by CIRM's Alan Trounson, the key lecture was scheduled to have been given by George Daley of Harvard.
Kerr quoted the member of the Vactican's Pontifical Academy for Life as saying,
"The Holy Spirit has certainly shown to be present through those faithful members who drew attention to the ambiguity of the choice of speakers. I hope and pray that a review will be affected of the basis on which these congresses are planned."
Kerr also quoted another anonymous member of the academy as saying that the presence of speakers such as Trounson and Daley was "a betrayal of the mission of the academy and a public scandal."
Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss
Posted: March 25, 2012 at 4:02 pm
The California Stem Cell Report is concluding its coverage today of the meeting of the governing board of the directors meeting of the California stem cell agency.
No decisions were made on the general direction of future funding -- basic research and training vs development of therapies. Some of the directors differed sharply on the issues, however. We will have more on this subject later.
Here are slides from the presentation on the progress report on the agency's $230 million disease team round. One $19 million grant was cancelled.
Progress Report: Disease Team Grants by California Stem Cell Agency
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Posted: March 25, 2012 at 4:02 pm
A California stem cell researcher, who must remain anonymous, made the following emailed comment today on the progress report on the $230 million in disease team grants from the California stem cell agency and termination of a $19 million grant.
"I'm impressed that CIRM is following through on monitoring the huge disease team grants and has actually curtailed the funding of one that didn't meet a key milestone. I hope that makes the other grant holders nervous! Too many scientists (in my humble opinion) forget that they need to do what they said they'd do- or - if the first plan fails, have the expertise and desire to adapt and find another way to reach the goals."
Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss
Posted: March 25, 2012 at 4:02 pm
The $3 billion California stem cell agency announced today that it has hired Kevin McCormack, currently media relations manager at California Pacific Medical Center in San Francisco, as its new director of communications.
CIRM Chairman Jonathan Thomas told the agency's directors at their meeting this morning in Sacramento that the appointment comes "not a moment too soon." Thomas told directors last June that the agency was engaged in a "communications war." Directors have been concerned about the lack of media coverage of the agency, which is largely below the radar of the mainstream media.
Thomas said that McCormack has "lots of experience" in media crisis management and "pressure cooker situations."
McCormack also served as media relations manager, Division of Research at Kaiser Permanente, and was a health/medical producer at KRON-TV in San Francisco.
The agency did not immediately release McCormack's salary. He will begin work April 2.
Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss