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Vein grown from stem cells saves girl

Posted: June 15, 2012 at 3:14 am

Doctors in Sweden have replaced a vital blocked blood vessel in a 10-year-old girl using the first vein grown in a lab from a patient's own stem cells.

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A CPAP device, the Darth Vader-like mask used to ease breathing in sleep apnea sufferers, might be the least attractive thing a man can wear at night, but it could wind up improving his sex life, according to a new study released today at an annual meeting of sleep experts.

The successful transplant operation, reported online in The Lancet medical journal on Thursday, marks a further advance in the search for ways to make new body parts.

It could open the door to stem cell-based grafts for heart bypass and dialysis patients who lack suitable blood vessels for replacement surgery, and the Swedish team said it is now working with an undisclosed company to commercialize the process.

"I'm very optimistic that in the near future we will be able to get both arteries and veins transplanted on a large scale," said Suchitra Sumitran-Holgersson, professor of transplantation biology at the University of Gothenburg, and a member of the team that performed the operation in March 2011.

The advantage of using tissue grown from a patient's own cells is that there is no risk of organ rejection and hence no need for lifelong immunosuppressive drugs.

Four years ago, a 30-year-old woman received the world's first transplant of a tailor-made windpipe, grown in a similar way by seeding a stripped-down donor organ with her own stem cells. Other such trachea operations have followed since.

The latest case involved a young girl with an obstructed hepatic portal vein, which drains blood from the intestines and spleen to the liver. Its blockage can be fatal.

The team from the University of Gothenburg took a 9 cm (3.5 inch) section of groin vein from a deceased donor and removed all the living cells, leaving just a protein scaffold tube. Stem cells extracted from the girl's bone marrow were then injected onto the tube and two weeks later the graft was implanted.

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Doctors Use Stem Cells To Grow Vein For Young Patient

Posted: June 15, 2012 at 3:14 am

June 14, 2012

Brett Smith for redOrbit.com

A successful transplant operation in Sweden points to a medical future where your doctor can grow a transplant organ from your own cells, making organ donation a thing of the past.

Doctors have now successfully transplanted a vein grown with a patients own stem cells without complications or the need for immunosuppressants, according to a report published this week in The Lancet. The patient was a 10-year-old girl in Sweden who was suffering from a potentially fatal blockage in the vein which drains blood from the intestines and spleen to the liver.

Last March, a team of doctors at the University of Gothenburg decided to grow the new blood vessel used to bypass the blocked vein instead of using an invasive neck or leg surgery to extract one of her own.

The young girl in this report was spared the trauma of having veins harvested from the deep neck or leg with the associated risk of lower limb disorders, and avoided the need for a liver or multivisceral transplantation, Martin Birchall and George Hamilton of University College London wrote in The Lancet.

To start the procedure, doctors took a three-inch section of a cadaver groin vein and stripped it of all living cells, leaving only an inert protein structure. The team then injected it with blood-forming stem cells taken from the girls bone marrow. After growing the vein for two weeks in an incubator, the stem cells had multiplied and converted into vein wall cells, to create a biologically-engineered replacement. The new vein was then implanted into the patient a year ago.

The new stem-cells derived graft resulted not only in good blood flow rates and normal laboratory test values but also, in strikingly improved quality of life for the patient, the report said.

In noting the success of the transplant, the doctors reported that the patient grew 2 inches and gained 11 pounds over the following year. In addition, her parents said that she was more physically active, had improved articulated speech, and had concentrated better on her studies.

The only major complication was the slight constriction of the vein nine months after the operation, which was corrected in a follow-up procedure. During the course of following up on the operation, scientists found no antibodies for the donor vein in the girls blood. This meant her body was not rejecting the transplant because it was recognized as being made of her own cells.

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Six New U-M Stem Cell Lines Now Publicly Available

Posted: June 15, 2012 at 3:13 am

Six new U-M stem cell lines now publicly available to help researchers find treatments for disease

Lines in US registry will help studies on Huntingtons disease, hemophilia & more

Newswise ANN ARBOR, Mich. Six new human embryonic stem cell lines derived at the University of Michigan have just been placed on the U.S. National Institutes of Healths registry, making the cells available for federally-funded research.

U-M now has a total of eight cell lines on the registry, including five that carry genetic mutations for serious diseases such as the severe bleeding disorder hemophilia B, the fatal brain disorder Huntingtons disease and the heart condition called hypertrophic cardiomyopathy, which causes sudden death in athletes and others.

Researchers at U-M and around the country can now begin using the stem cell lines to study the origins of these diseases and potential treatments. Two of the cell lines are believed to be the first in the world bearing that particular disease gene.

The three U-M stem cell lines now in the registry that do not carry disease genes are also useful for general studies and as comparisons for stem cells with disease genes. In all, there are 163 stem cell lines in the federal registry, most of them without major disease genes.

Each of the lines was derived from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. The embryos carrying disease genes were created for reproductive purposes, tested and found to be affected with a genetic disorder, deemed not suitable for implantation and would have otherwise been discarded if not donated by the couples who donated them.

Some came from couples having fertility treatment at U-Ms Center for Reproductive Medicine, others from as far away as Portland, OR. Some were never frozen, which may mean that the stem cells will have unique characteristics and utilities.

The full list of U-M-derived stem cell lines accepted to the NIH registry includes:

UM9-1PGD Hemophilia B UM17-1 PGD Huntingtons disease UM38-2 PGD - Hypertrophic Cardiomyopathy (MYBPC3) UM15-4 PGD - Hydroxysteroid Dehydrogenase 4 Deficiency, a rare hormone disorder UM11-1PGD - Charcot-Marie-Tooth disease Type 1A UM4-6 no disease gene UM14-1 no disease gene UM14-2 no disease gene

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Six New U-M Stem Cell Lines Now Publicly Available

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Six new U-M stem cell lines now publicly available to help researchers find treatments for disease

Posted: June 15, 2012 at 3:13 am

Lines in US registry will help studies on Huntington's disease, hemophilia & more

ANN ARBOR, Mich., June 14, 2012 /PRNewswire-USNewswire/ --Six new human embryonic stem cell lines derived at the University of Michigan have just been placed on the U.S. National Institutes of Health's registry, making the cells available for federally-funded research.

U-M now has a total of eight cell lines on the registry, including five that carry genetic mutations for serious diseases such as the severe bleeding disorder hemophilia B, the fatal brain disorder Huntington's disease and the heart condition called hypertrophic cardiomyopathy, which causes sudden death in athletes and others.

Researchers at U-M and around the country can now begin using the stem cell lines to study the origins of these diseases and potential treatments. Two of the cell lines are believed to be the first in the world bearing that particular disease gene.

The three U-M stem cell lines now in the registry that do not carry disease genes are also useful for general studies and as comparisons for stem cells with disease genes. In all, there are 163 stem cell lines in the federal registry, most of them without major disease genes.

Each of the lines was derived from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. The embryos carrying disease genes were created for reproductive purposes, tested and found to be affected with a genetic disorder, deemed not suitable for implantation and would have otherwise been discarded if not donated by the couples who donated them.

Some came from couples having fertility treatment at U-M's Center for Reproductive Medicine, others from as far away as Portland, OR. Some were never frozen, which may mean that the stem cells will have unique characteristics and utilities.

The full list of U-M-derived stem cell lines accepted to the NIH registry includes:

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Six new U-M stem cell lines now publicly available to help researchers find treatments for disease

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Stem cell stroke trial promising

Posted: June 15, 2012 at 3:13 am

14 June 2012 Last updated at 10:45 ET By Pallab Ghosh Science correspondent, BBC News

Doctors in Scotland have said five stroke patients involved in an experimental stem cell treatment have shown signs of slight improvement.

They have stressed that it is too soon to tell whether the improvement is due to the therapy.

The medical team has talked about the first results of the treatment at a conference in Japan.

The procedure is controversial as brain cells from a foetus were originally used to create the stem cells.

A team, from Glasgow's Southern General Hospital, has been injecting the stem cells into the brains of stroke patients.

The trial began in November 2010. The participants are all men over the age of 60 who have been severely disabled by a stroke and have shown no sign of improvement for at least a year.

We hope to tease out over the next 18 months whether the improvement is due to the treatment

The doctors hope that the treatment will repair their damaged brain tissue and restore some of their movement and ability to speak.

The trail is at an early stage, and doctors are primarily looking to see that the treatment is safe. But they have found that five of the six patients treated so far have shown some slight signs of improvement.

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Six New UM Stem Cell Lines Now Publicly Available

Posted: June 15, 2012 at 3:13 am

ANN ARBOR Six new human embryonic stem cell lines derived at the University of Michigan have just been placed on the National Institutes of Healths registry, making the cells available for federally funded research.

UM now has a total of eight cell lines on the registry, including five that carry genetic mutations for serious diseases such as the severe bleeding disorder hemophilia B, the fatal brain disorder Huntingtons disease and the heart condition called hypertrophic cardiomyopathy, which causes sudden death in athletes and others.

Researchers at UM and around the country can now begin using the stem cell lines to study the origins of these diseases and potential treatments. Two of the cell lines are believed to be the first in the world bearing that particular disease gene.

The three UM stem cell lines now in the registry that do not carry disease genes are also useful for general studies and as comparisons for stem cells with disease genes. In all, there are 163 stem cell lines in the federal registry, most of them without major disease genes.

Each of the lines was derived from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. The embryos carrying disease genes were created for reproductive purposes, tested and found to be affected with a genetic disorder, deemed not suitable for implantation and would have otherwise been discarded if not donated by the couples who donated them.

Some came from couples having fertility treatment at UMs Center for Reproductive Medicine, others from as far away as Portland, Ore. Some were never frozen, which may mean that the stem cells will have unique characteristics and utilities.

The full list of UM-derived stem cell lines accepted to the NIH registry includes:

UM9-1PGD Hemophilia B

UM17-1PGD Huntingtons disease

UM38-2PGD- HypertrophicCardiomyopathy (MYBPC3)

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Six new stem cell lines now publicly available

Posted: June 15, 2012 at 3:13 am

ScienceDaily (June 14, 2012) Six new human embryonic stem cell lines derived at the University of Michigan have just been placed on the U.S. National Institutes of Health's registry, making the cells available for federally-funded research.

U-M now has a total of eight cell lines on the registry, including five that carry genetic mutations for serious diseases such as the severe bleeding disorder hemophilia B, the fatal brain disorder Huntington's disease and the heart condition called hypertrophic cardiomyopathy, which causes sudden death in athletes and others.

Researchers at U-M and around the country can now begin using the stem cell lines to study the origins of these diseases and potential treatments. Two of the cell lines are believed to be the first in the world bearing that particular disease gene.

The three U-M stem cell lines now in the registry that do not carry disease genes are also useful for general studies and as comparisons for stem cells with disease genes. In all, there are 163 stem cell lines in the federal registry, most of them without major disease genes.

Each of the lines was derived from a cluster of about 30 cells removed from a donated five-day-old embryo roughly the size of the period at the end of this sentence. The embryos carrying disease genes were created for reproductive purposes, tested and found to be affected with a genetic disorder, deemed not suitable for implantation and would have otherwise been discarded if not donated by the couples who donated them.

Some came from couples having fertility treatment at U-M's Center for Reproductive Medicine, others from as far away as Portland, OR. Some were never frozen, which may mean that the stem cells will have unique characteristics and utilities.

The full list of U-M-derived stem cell lines accepted to the NIH registry includes:

"Our last three years of work have really begun to pay off, paving the way for scientists worldwide to make novel discoveries that will benefit human health in the near future," says Gary Smith, Ph.D., who derived the lines and also is co-director of the U-M Consortium for Stem Cell Therapies, part of the A. Alfred Taubman Medical Research Institute.

"Each cell line accepted to the registry demonstrates our attention to details of proper oversight, consenting, and following of NIH guidelines," says Sue O'Shea, Ph.D., professor of Cell and Developmental Biology at the U-M Medical School, and co-director of the Consortium for Stem Cell Therapies.

U-M is one of only three academic institutions to have disease-specific stem cell lines listed in the national registry, says Smith, who is a professor in the Department of Obstetrics and Gynecology at the University of Michigan Medical School. The first line, a genetically normal one, was accepted to the registry in February.

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First stem cell vein implant helps young girl

Posted: June 14, 2012 at 6:13 pm

By Denise Mann HealthDay Reporter

THURSDAY, June 14 (HealthDay News) -- In what is being reported as a scientific first, Swedish doctors were able pair the groin vein of a dead donor with stem cells from a young girl and implant the healthy vein into the girl, improving both blood flow in her lower body and her quality of life.

The 10-year-old had a rare condition where her portal vein, which is located in the abdomen and tasked with carrying blood from the bowels and other abdominal organs to the liver, was blocked. If this vein is blocked, liver disease, heart failure and certain cancers may develop. The relatively rare condition may also cause weight loss, nausea and pain.

Details of the feat are published online June 14 in The Lancet.

U.S experts were quick to caution that the procedure has only been accomplished in one patient, but they agreed that it could be a game-changer with applications that go far beyond this particular condition.

In the procedure, the transplant team from the University of Gothenburg in Sweden first took a segment of the groin vein from a dead donor, and stripped it of all living cells. They then injected stem cells taken from the girl's own bone marrow into the remaining vein. Two weeks after this seeding, the newly grown graft was implanted in the girl.

There were no complications, and the procedure immediately restored normal blood flow. In the year following the operation, the girl grew taller and gained weight. Her blood flow later decreased, and she underwent a second vein replacement surgery a year after the first. Her quality of life has improved since the procedures, and she is now able to take increasingly long walks and participate in light gymnastics. Importantly, she is showing no sign of rejecting the new vein even though she is not taking any immunosuppressive drugs.

"The new stem cells-derived graft resulted not only in good blood flow rates and normal laboratory test values but also, in strikingly improved quality of life for the patient," wrote the team led by Dr. Michael Olausson, of Sahlgrenska University Hospital in Gothenburg. "The work also establishes the feasibility and safety of a novel paradigm for treatment, in cases of venous insufficiency, obstructed veins or inadequate autologous [from the patient] veins."

Today, surgeons may approach such cases by harvesting veins from a patient's neck or leg to re-route around a blockage elsewhere. This can be traumatic and is associated with its own set of risks and complications. In addition, not everyone has healthy veins that can be used in this manner. This is where the new stem cell vein grafting procedure could play an important role.

"This is an interesting article and an exciting first step," said Dr. Scott Pilgrim, an attending pediatric cardiologist at Steven and Alexandra Cohen Children's Medical Center of New York, in New Hyde Park. "If this outcome turns out to be reproducible and is studied in a larger, defined population with a well-designed, controlled trial, I feel this advance could be a watershed moment in developing new, novel strategies for vascular and cardiothoracic surgeons."

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Doctors Use Stem Cells To Grow Vein For Young Patient

Posted: June 14, 2012 at 6:12 pm

June 14, 2012

Brett Smith for redOrbit.com

A successful transplant operation in Sweden points to a medical future where your doctor can grow a transplant organ from your own cells, making organ donation a thing of the past.

Doctors have now successfully transplanted a vein grown with a patients own stem cells without complications or the need for immunosuppressants, according to a report published this week in The Lancet. The patient was a 10-year-old girl in Sweden who was suffering from a potentially fatal blockage in the vein which drains blood from the intestines and spleen to the liver.

Last March, a team of doctors at the University of Gothenburg decided to grow the new blood vessel used to bypass the blocked vein instead of using an invasive neck or leg surgery to extract one of her own.

The young girl in this report was spared the trauma of having veins harvested from the deep neck or leg with the associated risk of lower limb disorders, and avoided the need for a liver or multivisceral transplantation, Martin Birchall and George Hamilton of University College London wrote in The Lancet.

To start the procedure, doctors took a three-inch section of a cadaver groin vein and stripped it of all living cells, leaving only an inert protein structure. The team then injected it with blood-forming stem cells taken from the girls bone marrow. After growing the vein for two weeks in an incubator, the stem cells had multiplied and converted into vein wall cells, to create a biologically-engineered replacement. The new vein was then implanted into the patient a year ago.

The new stem-cells derived graft resulted not only in good blood flow rates and normal laboratory test values but also, in strikingly improved quality of life for the patient, the report said.

In noting the success of the transplant, the doctors reported that the patient grew 2 inches and gained 11 pounds over the following year. In addition, her parents said that she was more physically active, had improved articulated speech, and had concentrated better on her studies.

The only major complication was the slight constriction of the vein nine months after the operation, which was corrected in a follow-up procedure. During the course of following up on the operation, scientists found no antibodies for the donor vein in the girls blood. This meant her body was not rejecting the transplant because it was recognized as being made of her own cells.

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Jets safety LaRon Landry’s rehab speeding along thanks to advanced medicine

Posted: June 14, 2012 at 6:11 pm

The left Achilles tendon that forced LaRon Landry to miss most of the last two seasons with the Washington Redskins is totally healed and, remarkably, no surgery was required.

LaRon Landry hopes to add some lumber to New Yorks secondary. (Nick Wass - Associated Press) The New York Jets safety spurned advice to go under the knife, instead opting for alternative medicine. And so far, so good. Landry joined his new teammates at minicamp this week, and, although he could not practice, his progress has Coach Rex Ryan giddy.

LaRon is way ahead of where our trainers thought hed be, Ryan told the teams Web site on Wednesday. Weve just got to be smart the next couple of days that he doesnt overdo things. Hes on the right track and we feel good about it.

Landrys secret? A stem cell treatment called AminoMatrix and a couple of platelet-rich plasma transfusions. PRP treatments are becoming increasingly popular for athletes looking to avoid surgery. Tiger Woods used them to recover from a knee injury.

Im progressing and things are looking real well I was kind of shocked myself, Landry said. I cant wait to get back out there and be with the team.

Landrys bulging biceps and muscular physique were as familiar as his massive hits in the Washington secondary. In February, Landry tweeted a photo of himself in which he looked particularly large, leading to some public speculation about steroid use. In a Twitter conversation with a concerned Redskins fan, Landry defended his weight, which was up to 218 pounds in March.

Of the injuries that prematurely ended his 2011 season, Landry said the Achilles is totally healed and that hes waiting for the heel bone that is connected to the tendon to fully heal.

When he returns, hell join former Dolphin Yeremiah Bell and Eric Smith to form a formidable trio of safeties for the Jets secondary.

I think these guys can do a lot more than just go in there and blast you on the running game, Ryan said of Landry and Bell. Landry, when hes healthy, is a 4.3-something-in-the-40 type of guy. Hes got tons of God-given ability.

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