Posted: November 2, 2012 at 11:41 am
FAQ-9 of 19: In Stem Cell Therapy Are There Any Contraindications for Stem Cells?
youtu.be There ARE some times and ways that stem cells should NOT be used, and this short video outlines them. For more personalized information, visit bit.ly or StemCell-Asia.info now.From:John PepperViews:0 0ratingsTime:00:54More inEducation
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FAQ-9 of 19: In Stem Cell Therapy Are There Any Contraindications for Stem Cells? - Video
Posted: November 2, 2012 at 11:41 am
FAQ-7 of 19: In Stem Cell Therapy How Long Do Benefits of Stem Cells Last?
youtu.be Briefly explaining how long the benefits of stem cell therapy last, when, why and for what conditions. For more detailed explanations, go to StemCell-Asia.info and find the #39;Apply Now #39; page, httpFrom:Harvey WallbangerViews:0 0ratingsTime:01:19More inEducation
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FAQ-7 of 19: In Stem Cell Therapy How Long Do Benefits of Stem Cells Last? - Video
Posted: November 2, 2012 at 11:41 am
FAQ-9 of 19: In Stem Cell Therapy Are There Contraindications for Stem Cells?
youtu.be Yes, there ARE some times and some ways that stem cells should NOT be used, so this short video outlines them for you. For more personalized information, visit bit.ly or StemCell-Asia.info now.From:Karridine1Views:0 0ratingsTime:00:54More inPeople Blogs
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FAQ-9 of 19: In Stem Cell Therapy Are There Contraindications for Stem Cells? - Video
Posted: November 2, 2012 at 11:41 am
Adult Stem Cells are the Secret To Youth Anti-Aging | NewHopeForAging.com
NewHopeForAging.com - Newest anti-aging tips revealed by top medical expert, Dr. Vincent Giampapa on the Today Show. Find out why adult stem cells are the best way to look 10 years younger, plus other secrets of youth. Dr. Giampapa is on the Medical Advisory Board for Jeunesse Global. Call for Free Samples 561.779.0000 or go to: NewHopeForAging.com Watch on YouTube youtu.beFrom:koniscavellaViews:1 0ratingsTime:03:45More inHowto Style
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Adult Stem Cells are the Secret To Youth
Posted: November 2, 2012 at 11:41 am
What Are Stem Cells...And How Do They Work | NewHopeForAging.com
NewHopeForAging - Dr. Nathan Newman, a Beverly Hills Plastic Surgeon, shows us what stem cells are and why we need them to look younger, stop aging and wrinkles. Find out what products contain adult stem cell technology and which ones don #39;t. The results can be amazing! Get your FREE samples at http or call: 561.779.0000. Watch on YouTube: youtu.beFrom:koniscavellaViews:1 0ratingsTime:02:21More inHowto Style
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What Are Stem Cells...And How Do They Work | NewHopeForAging.com - Video
Posted: November 2, 2012 at 11:41 am
Under fire from the Food and Drug Administration, the Houston-area company that facilitated Gov. Rick Perry's controversial 2011 stem-cell treatment has stopped providing doctors with the cells patients banked at its facility for the procedure.
In a response to an FDA warning that it is acting illegally by marketing the unlicensed therapy, Celltex Therapeutics Corp. wrote the federal agency this week that it has ceased enrolling patients in the clinical trials the state requires of stem-cell providers. Celltex was the Houston area's primary sponsor of such for-profit trials.
"We're telling potential patients that we will still bank their stem cells and will enroll them in trials once new investigational drug applications have been submitted and reviewed by the FDA," said Amdrea Ferrenz, Celltex's executive vice president and legal counsel. "We hope that will be in a matter of months."
Ferrenz called the FDA warning letter, publicly posted Tuesday, "a disappointment" but said it actually just moves up Celltex's plan to move into agency-approved trials targeting specific disease conditions. The Sugar Land company had been operating for nearly 18 months facilitating adult stem-cell procedures with little regulation.
The Texas Medical Board in July began requiring that any stem-cell procedure be reviewed for patient safety by a board expert at such evaluations. The board used by Celltex, Texas Applied Biomedical Services, last month received an FDA warning letter of its own, informing it the agency will withhold approval of all its reviews because of problems with the review board's operations, such as members with conflicts of interest.
FDA warning letters are considered big deals in drug regulation, the federal agency's principal means of achieving compliance. They include language that failure to take corrective action can result in company seizure or shutdown.
It is unclear if the FDA letters to Celltex and the review board will have an effect on the new medical board rules, meant to regulate the experimental therapy in the absence of oversight from the FDA. A medical board spokeswoman said this week that the board could reopen the matter at its November meeting.
Leigh Turner, a University of Minnesota bioethicist who writes frequently about stem-cell tourism and in February complained to the FDA that Celltex is "a potential danger to patients" and not in compliance with federal law, said he thinks it's "highly unlikely" that Celltex could quickly meet FDA requirements for research trials. He said Celltex would need to make a dramatic reconfiguration considering all the deficiencies an FDA inspection found in April.
Those included numerous basic manufacturing problems, all reiterated in the warning letter. Ferrenz said Celltex is eager to meet with FDA officials to learn what they still want to know beyond the "tons of information" the company has already sent.
Celltex had argued stem-cell injections are like bone marrow transplants and not subject to the FDA's jurisdiction. But in its warning letter, the FDA said Celltex's processing "alters the original relevant characteristics" of the cells and hence doesn't meet its requirement that living cells only be "minimally manipulated." It categorized the stem cells stored and treated at Celltex as biologic drugs.
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Sugar Land company ceases supplying stem cells
Posted: November 2, 2012 at 11:41 am
ScienceDaily (Nov. 1, 2012) An injection of banked sperm-producing stem cells can restore fertility to male primates who become sterile due to cancer drug side effects, according to researchers at the University of Pittsburgh School of Medicine and Magee-Womens Research Institute. In their animal study, which was published today in Cell Stem Cell, previously frozen stem cells restored production of sperm that successfully fertilized eggs to produce early embryos.
Some cancer drugs work by destroying rapidly dividing cells. As it is not possible to discriminate between cancer cells and other rapidly dividing cells in the body, the precursor cells involved in making sperm can be inadvertently wiped out leaving the patient infertile, said senior investigator Kyle Orwig, Ph.D., associate professor, Department of Obstetrics, Gynecology and Reproductive Medicine, Pitt School of Medicine, and an investigator at Magee-Womens Research Institute.
"Men can bank sperm before they have cancer treatment if they hope to have biological children later in their lives," he said. "But that is not an option for young boys who haven't gone through puberty, can't provide a sperm sample, and are many years away from thinking about having babies."
Even very young boys, though, have spermatogonial stem cells in their testicular tissue that are poised to begin producing sperm during puberty. To see whether it was possible to restore fertility using these cells, Dr. Orwig and his team biopsied the testes of prepubertal and adult male macaque monkeys and cryopreserved the cells from the small samples. The monkeys were then treated with chemotherapy agents known to impair fertility.
A few months after chemotherapy treatment, the team re-introduced each monkey's own spermatogonial stem cells back in to his testes using an ultrasound-guided technique. Sperm production was established from transplanted cells in nine out of 12 adult animals and three out of five prepubertal animals after they reached maturity. In another test, spermatogonial stem cells from other unrelated monkeys were transplanted into infertile animals, which created sperm with the DNA fingerprint of the donor to allow easy tracking of their origin. In lab tests, sperm from transplant recipients successfully fertilized 81 eggs, leading to embryos that developed to the morula and blastocyst stages, which are the stages that normally precede implantion in the mother's uterus. Donor parentage was confirmed in seven of the embryos.
"This study demonstrates that spermatogonial stem cells from higher primates can be frozen and thawed without losing their activity, and that they can be transplanted to produce functional sperm that are able to fertilize eggs and give rise to early embryos," Dr. Orwig said.
The findings are encouraging because several centers in the U.S. and abroad already are banking testicular tissue for boys in anticipation that new stem cell-based therapies will be available in the future to help them achieve pregnancy and have their own biological children.
"These patients and their families are the pioneers that inspire our research and help drive the development of new medical breakthroughs," Dr. Orwig said. He directs the Fertility Preservation Program in Pittsburgh, a unique collaboration between Magee-Womens Research Institute, Magee-Womens Hospital of UPMC, Children's Hospital of Pittsburgh of UPMC, and the University of Pittsburgh Cancer Institute that offers education and treatment options for children as well as adult men and women who are at risk of becoming infertile due to medical problems including cancer.
"Many questions remain to be answered," Dr. Orwig noted. "Should we re-introduce the spermatogonial cells as soon as treatment is over, or wait until the patient is considered cured of his disease, or when he is ready to start a family? How do we eliminate the risk of cancer recurrence if we give back untreated cells that might include cancer cells? These are issues we still must work through, but this study does show us the concept is feasible."
Co-authors of the paper include lead author Brian P. Hermann, Ph.D., David K. Cooper, M.D., Ph.D., Angus W. Thomson, Ph.D., D. Sc., Gerald P. Schatten, Ph.D., and others from the University of Pittsburgh School of Medicine, as well as collaborators from the Oregon National Primate Research Center, University of California at Davis, ITxM Diagnostics in Pittsburgh, and CaridianBCT.
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Male fertility can be restored after cancer treatment, researchers find
Posted: November 2, 2012 at 11:41 am
STILL SMILING: Becca Graham is the UK's first child to have her stem cells banked from her teeth, after her dentist father removed them in his Glasgow surgery. Picture: PA
Becca Graham's parents Callum and Heather decided to freeze and store their daughter's milk teeth so the youngster can take advantage of future medical advances in stem cell research.
Stem cells from bone marrow and umbilical cord blood have been used for decades to treat leukaemia and other blood-related diseases.
Teeth are an "incredible source" of stem cells, Mr Graham said, and researchers are studying how they could be used to treat a number of diseases and conditions including diabetes, spinal cord injuries, stroke and liver problems.
Becca, who lives in East Kilbride, South Lanarkshire, had her two wobbly front teeth removed by her father at his Glasgow dental practice.
The dental pulp from the milk teeth will be collected, frozen and stored for 30 years or more until needed. Becca said the extraction was "a little bit sore" but that her real concern was about the tooth fairy.
"I wrote a wee letter to her to explain and she sent me back 5," she said with a toothless grin.
Doctors have already used dental cells to regenerate dental bone and treat periodontal disease, said Mr Graham, from Queen's Drive Dental Practice in Glasgow.
The dentist and his wife started to think about banking stem cells around the time of Becca's birth but were too late to arrange for cells to be taken from the umbilical cord.
They got the idea of using their daughter's teeth after seeing a leaflet for cell banking company Precious Cells at the surgery. Father-of-three Mr Graham said: "There's been an awful lot of research lately regarding stem cells and how to deliver them and use them to cure diseases, leukaemia, diabetes and cancers. We had been looking for a way to store stem cells when Rebecca was born. We'd heard all about it and thought it was a good idea.
Posted: November 2, 2012 at 11:41 am
1 November 2012 Last updated at 23:09 ET By James Gallagher Health and science reporter, BBC News
Boys left infertile by childhood cancer treatment may one day be able to produce healthy sperm by using stored stem cells, monkey research suggests.
Chemotherapy and radiotherapy can kill tumours and the cells which make sperm.
A study, published in the journal Cell Stem Cell, extracted sperm-producing stem cells before cancer treatment and later placed them back into the monkey.
Sperm which could fertilise an egg were produced, which experts labelled a "milestone" in research.
Most men who have cancer treatment which could affect their fertility can choose to freeze sperm before their treatment starts. This is not an option for patients who have not yet gone through puberty.
These are issues we still must work through, but this study does show us the concept is feasible
However, they do have the spermatogonial stem cells which would start to produce sperm in their teenage years.
The researchers at the University of Pittsburgh and the Magee-Womens Research Institute took samples of the stem cells from macaques and stored them in a freezer.
The monkeys were then given a chemotherapy drug.
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Stem cell op may 'restore sperm'
Posted: November 2, 2012 at 11:41 am
Washington, November 2 (ANI): An injection of banked sperm-producing stem cells can restore fertility in male primates who become sterile due to the side effects of cancer drugs, researchers say.
In the animal study by researchers at the University Of Pittsburgh School Of Medicine And Magee-Womens Research Institute, previously frozen stem cells restored production of sperm that successfully fertilized eggs to produce early embryos.
Some cancer drugs work by destroying rapidly dividing cells. As it is not possible to discriminate between cancer cells and other rapidly dividing cells in the body, the precursor cells involved in making sperm can be inadvertently wiped out leaving the patient infertile, said senior investigator Kyle Orwig from Magee-Womens Research Institute.
"Men can bank sperm before they have cancer treatment if they hope to have biological children later in their lives," Orwig said.
"But that is not an option for young boys who haven't gone through puberty, can't provide a sperm sample, and are many years away from thinking about having babies," he said.
Even very young boys, though, have spermatogonial stem cells in their testicular tissue that are poised to begin producing sperm during puberty.
To see whether it was possible to restore fertility using these cells, Dr. Orwig and his team biopsied the testes of prepubertal and adult male macaque monkeys and cryopreserved the cells from the small samples. The monkeys were then treated with chemotherapy agents known to impair fertility.
A few months after chemotherapy treatment, the team re-introduced each monkey's own spermatogonial stem cells back in to his testes using an ultrasound-guided technique. Sperm production was established from transplanted cells in nine out of 12 adult animals and three out of five prepubertal animals after they reached maturity.
In another test, spermatogonial stem cells from other unrelated monkeys were transplanted into infertile animals, which created sperm with the DNA fingerprint of the donor to allow easy tracking of their origin.
In lab tests, sperm from transplant recipients successfully fertilized 81 eggs, leading to embryos that developed to the morula and blastocyst stages, which are the stages that normally precede implantion in the mother's uterus. Donor parentage was confirmed in seven of the embryos.
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Sperm-producing stem cell jab 'may restore male fertility after cancer treatment'
