Posted: August 3, 2013 at 4:46 am
Andrew Moreno - High School Stem Cell Research Intern - Summer 2013
This clip shows me weighing reagents for Xgal staining while I discuss some of the results I #39;ve gathered this summer. Visit our Through Their Lens page for p...
By: California Institute for Regenerative Medicine
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Andrew Moreno - High School Stem Cell Research Intern - Summer 2013 - Video
Posted: August 3, 2013 at 4:46 am
Michelle Tran - High School Stem Cell Research Intern - Summer 2013
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Michelle Tran ...
By: California Institute for Regenerative Medicine
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Michelle Tran - High School Stem Cell Research Intern - Summer 2013 - Video
Posted: August 3, 2013 at 4:46 am
Steven Wang - High School Stem Cell Research Intern - Summer 2013
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Steven Wang is...
By: California Institute for Regenerative Medicine
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Steven Wang - High School Stem Cell Research Intern - Summer 2013 - Video
Posted: August 2, 2013 at 9:08 pm
“Diane and Nancy, I'm shocked that
you are either unaware or do not acknowledge that there are studies
of oocyte retrieval surgeries that show very persuasively that the
potential harm from this procedure is manageable. While you refer to 'stories' of women being harmed--that's called anecdotal
evidence and is the antithesis of science--you ignore the established
research in this area, which makes it clear that you are reacting
hysterically rather than responding to empirical evidence. I would
suggest that you read the National Academies Press workshop report:
Assessing the Medical Risks of Human Oocyte Donation for Stem Cell
Research (http://www.nap.edu/catalog.php?record_id=11832).
It cites numerous studies, including a German study that examined the
outcome of approximately 380,000 oocyte retrieval surgeries during
2000-2004. For the procedures for which there was information, the
rate of complications was very low: only 0.002 percent—2 in every
100,000—had complications that required surgery to correct.
“Studies have also examined the
potential risks of retrieval for a woman's future fertility.
“According to one large study, the
rate of infection after oocyte retrieval was about 1 in every 200 IVF
cycles, and surgery is needed to treat pelvic abscesses in less than
1 in 1,000 IVF cycles.
“About five hundred egg donations
take place in Canada each year, according to the Canadian Fertility
and Andrology Society.The CFAS told me that, between 2001 and 2010,
only two donors in Canada, out of a total of 4,177 donations,
suffered from “severe” OHSS, which usually involves
hospitalization. Fourteen others had “moderate” OHSS. These
numbers are collected in a database called the Canadian Assisted
Reproductive Technologies Registry.
“So sure, you can find your 'stories' but they do not represent a scientific review of the available
data--you are trying to legislate based on fear. That's not science;
that's the dark ages, and it's exactly the tactics used by
anti-abortionists (and indeed by organizations like the Center for
Genetics and Society which opposes such beneficial advances as
mitochondrial replacement surgery).
“Furthermore, because women have a
set of two ovaries and two fallopian tubes, they can remain fertile
even if one set is damaged, and there is no evidence that both might
be threatened simultaneously by the side effects of retrieval
surgery.
“Today doctors have had two decades
of experience with the use of hormone treatments to maximize the
number of eggs that can be harvested from a woman, and they have
become quite proficient in the production of oocytes. During that
time they have also worked to improve the safety of the procedure and
decrease the potential risks. Despite these improvements some risk
will remain, because hormones have a powerful effect on the body—they
could not increase egg production so dramatically if this were not
true—and anything with a powerful effect on the body has the
potential for harmful side effects as well.
“Egg donations are done for a reason.
There are risks and benefits. For you to exaggerate the risks based
on 'stories' and ignore the evidence is unconscionable.
It's exactly what anti-abortion groups do and what opponents of
genetically modified foods do--you promote fear around manageable (or
in the case of GMOs, negligible) risk.
“Your call for 'further studies' is the age old technique of reactionaries trying to control other
people and impose their values on other people. You know darned well,
because of your fundamental ideological opposition to this procedure,
no study results could ever meet your standard of acceptability.
“You are trying to control other
women's bodies, claiming you have superior knowledge and
wisdom--those are pro-life talking points. Your views, and that of
the organizations that you represent, are illiberal.”
Posted: August 2, 2013 at 7:05 pm
“Dr. Diane Tober and Prof. Nancy
Scheper-Hughes are 'pro choice' social scientists who are
concerned about the absence of any evidence-based medicine on the
long term effects of hyper-stimulation for oocyte (egg) production in
young women research subjects. We are not concerned about abortion,
right to life, or obstructing needed and valuable research on
stem cells. We are concerned about the safety for potential research
subjects who are being actively recruited to participate in
invasive medical procedures without any medical research
studies on the possible risks and consequences of egg multiplication
and extraction. We are on record that we fully support stem
cell research but not at the expense of unprotected egg donors.”
Posted: August 2, 2013 at 6:46 pm
Aug. 1, 2013 McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.
It is hoped this discovery will lead to lowering the amount of bone marrow needed for a donation while increasing regeneration and lessening rejection in the recipient patients, says principal investigator Mick Bhatia, professor and scientific director of the McMaster Stem Cell and Cancer Research Institute.
In a paper published online today by the journal Cell Stem Cell, his team reports that human stem cells (HSC) residing in the end (trabecular region) of the bones display the highest regenerative ability of the blood and immune system.
"Like the best professional hockey players, our findings indicate blood stem cells are not all equal," said Bhatia. "We now reveal the reason why -- it's not the players themselves, but the effect the arena has on them that makes them the highest scorers."
Bone marrow transplants have been done for more than 50 years and are routine in most hospitals, providing a life saving treatment for cancer and other diseases including leukemia, anemia, and immune disorders.
Bhatia, who also holds a Canada Research Chair in Human Stem Cell Biology, said that cells surrounding the best blood stem cells are critically important, as these "stem cell neighbors" at the end of the bone provide the unique instructions that give these human blood stem cells their superior regenerative abilities.
The research was funded by the Canadian Institutes of Health Research and Ontario Cancer Research Institute.
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Researchers find home of best stem cells for bone marrow transplants
Posted: August 2, 2013 at 6:46 pm
Albany, New York (PRWEB) August 02, 2013
According to a new market report published by Transparency Market Research "Stem Cells Market (Adult, Human Embryonic , Induced Pluripotent, Rat-Neural, Umbilical Cord, Cell Production, Cell Acquisition, Expansion, Sub-Culture)- Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018," the market for stem cells was valued at USD 26.23 billion in 2011 and is expected to reach an estimated value of USD 119.51 billion in 2018, growing at a CAGR of 24.2% from 2012 to 2018.
Related Report : Dental Equipment Market http://www.transparencymarketresearch.com/dental-devices-market.html
The market growth is majorly attributed to therapeutic research activities led by government support worldwide owing to the growing number of patients with chronic diseases across the globe. In addition, rising awareness of regenerative treatment options and growing importance of stem cell banking services are also fostering the growth of the market. Apart from these, development of medical tourism hubs in developing nations such as India and China and in turn migration of patients from developed nations such as the U.S., and Europe for quality treatment at significantly lower prices will also serve the market as a driver especially for the Asian stem cells market.
Related Report : Biosensors Market http://www.transparencymarketresearch.com/biosensors-market.html
Stem cells market will be driven by rising proportion of patients with neurological and other chronic conditions and rising disposable incomes of patients induced by economic growth of Asian regions in the next five years In addition, increasing dependence on stem cells for drug discovery and screening will boost the growth of the market in future. Increased outsourcing of contract research and clinical trials to developing Asian regions will further encourage growth of the stem cells market.
Adult stem cells held majority share of the overall stem cells market in 2011 at over 80%. This is due to less laborious procedure of harvesting, and less probability of contamination during expansion and sub-culture of adult stem cells. However, fewer post-transplant complications and lesser risk of graft vs. host reaction from the recently introduced induced pluripotent stem cells will lead to its rapid inclusion in research activities and help the global induced pluripotent stem cells market to grow at a relatively faster CAGR during the forecast period.
Browse the full report with TOC at http://www.transparencymarketresearch.com/stem-cells-market.html.
Regenerative medicine dominated the stem cells market by applications in 2011, and is expected to maintain its leading position till 2018. Considerable research activities and the resultant developed therapies in neurology will drive the stem cells market in the forecast period.
North America was the market leader of the total stem cells market in 2011 and is expected to maintain its leading position till 2018. North American market is a center for stem cells research owing to greater support offered by federal government, and higher affordability of treatment in the region.
Continue reading here:
Stem Cells Market Research Report Published by Transparency Market Research
Posted: August 2, 2013 at 6:46 pm
TORONTO Stem cells from bone marrow have been helping people with diseases like leukemia to rebuild a healthy blood system for half a century. But now Canadian researchers have determined that not all stem cells are created equal and that might lead to better bone marrow transplants for more patients.
Scientists at Hamiltons McMaster University have discovered that stem cells located in bone marrow at the ends of bones are superior at regenerating blood cells, including immune system cells, than those found in the shafts of bones.
They all do the job, but theyre a little bit different, said principal researcher Mick Bhatia, scientific director of the Stem Cell and Cancer Research Institute at McMaster.
They have to regenerate the blood system, otherwise we cant even consider them a stem cell, said Bhatia, explaining that stem cells give rise to other cell types and are also capable of renewing themselves.
He likened these superior-performing stem cells, and their durability over time, to elite athletes.
You can have someone who can run and get to the Olympics, but there are ones that run that speed for a lot longer and a lot faster, he said. It makes them all professional athletes, but there are different gradients.
Bhatia said it turns out that what boosts their quality is whats going on at the ends of bones, which supply whats known as a niche, or home, for the regenerative cells.
Bone-making cells that make up this niche send chemical messages to the stem cells that allows them to perform differently from those in the middle of the bone.
Its not the athletes themselves, but the effect the arena has on them, he said.
In studies employing specially bred mice and donated samples of human bone removed as part of unrelated surgeries, Bhatias team found stem cells from bone ends regenerate better and last longer than those elsewhere along the bone.
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Best blood stem cells found in bone ends: study
Posted: August 2, 2013 at 6:46 pm
DUBLIN--(BUSINESS WIRE)--
Research and Markets (http://www.researchandmarkets.com/research/mqlqdz/mesenchymal_stem) has announced the addition of the "The Mesenchymal Stem Cells (MSC) Product Market 2013" report to their offering.
Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, beta-pancreatic islets cells, and potentially, neuronal cells. MSCs are of intense therapeutic interest because they represent a population of cells with the potential to treat a wide range of acute and degenerative diseases.
MSCs are advantageous over other stem cells types for a variety of reasons: they avoid the ethical issues that surround embryonic stem cell research, and repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogenic transplantation. MSCs reduce both the risks of rejection and complications of transplantation. Recently, there have been advances in the use of autologous mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, bone fractures, and more.
Trend analysis of grant activity, scientific publication rates, and patent applications trends reveal that global research activity involving mesenchymal stem cells (MSCs) increased 112% from 2009 to 2010, and 116% from 2010 to 2011. Of most interest is that this rate of growth accelerated throughout 2011, making mesenchymal stem cells the fastest growing area of stem cell research.
Because mesenchymal stem cell researchers represent a rapidly growing, well-funded research community, this report presents strategies for research supply companies to use to develop high-demand products for this community. A key element of this report is a survey of mesenchymal stem cell (MSC) researchers.
This survey reveals critical findings that include:
- Preferred Tissue Source for MSCs
- Preferred Species Source for MSCs
- MSC Product Preferences
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Research and Markets: The Mesenchymal Stem Cells (MSC) Product Market 2013 - The fastest growing area of stem cell ...
Posted: August 2, 2013 at 6:46 pm
File photo of frozen vial of human embryonic stem cells. THE ASSOCIATED PRESS/Paul Sancya
Stem cells from bone marrow have been helping people with diseases like leukemia to rebuild a healthy blood system for half a century. But now Canadian researchers have determined that not all stem cells are created equal and that might lead to better bone marrow transplants for more patients.
Scientists at Hamiltons McMaster University have discovered that stem cells located in bone marrow at the ends of bones are superior at regenerating blood cells, including immune system cells, than those found in the shafts of bones.
They all do the job, but theyre a little bit different, said principal researcher Mick Bhatia, scientific director of the Stem Cell and Cancer Research Institute at McMaster.
They have to regenerate the blood system, otherwise we cant even consider them a stem cell, said Bhatia, explaining that stem cells give rise to other cell types and are also capable of renewing themselves.
He likened these superior-performing stem cells, and their durability over time, to elite athletes.
You can have someone who can run and get to the Olympics, but there are ones that run that speed for a lot longer and a lot faster, he said. It makes them all professional athletes, but there are different gradients.
Bhatia said it turns out that what boosts their quality is whats going on at the ends of bones, which supply whats known as a niche, or home, for the regenerative cells.
Bone-making cells that make up this niche send chemical messages to the stem cells that allows them to perform differently from those in the middle of the bone.
Its not the athletes themselves, but the effect the arena has on them, he said.
Read more here:
Best stem cells for bone marrow transplant at bone ends: study
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