Page 230«..1020..229230231232..240250..»

IN8bio Reports Second Quarter 2022 Financial Results and Provides Corporate Update

Posted: August 14, 2022 at 2:33 am

NEW YORK, Aug. 12, 2022 (GLOBE NEWSWIRE) -- IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company focused on discovering and developing innovative gamma-delta T cell therapies that utilize its DeltEx platform, today announced financial results and operational highlights for the quarter ended June 30, 2022. In addition, the Company provided an overview of recent corporate developments.

Continue reading here:
IN8bio Reports Second Quarter 2022 Financial Results and Provides Corporate Update

Posted in Global News Feed | Comments Off on IN8bio Reports Second Quarter 2022 Financial Results and Provides Corporate Update

Veru Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

Posted: August 14, 2022 at 2:33 am

MIAMI, Aug. 12, 2022 (GLOBE NEWSWIRE) -- Veru Inc. (NASDAQ: VERU), a biopharmaceutical company focused on developing novel medicines for COVID-19 and other viral and ARDS-related diseases and for the management of breast and prostate cancers, today announced the granting of inducement awards to five new employees. In accordance with NASDAQ Listing Rule 5635(c)(4), the award was made as a material inducement to the five employees’ entry into employment with the Company.

More here:
Veru Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

Posted in Global News Feed | Comments Off on Veru Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

Adamis Pharmaceuticals Announces Results of Annual Meeting of Stockholders

Posted: August 14, 2022 at 2:33 am

Meeting adjourned only with respect to reverse stock split proposal until September 8, 2022 Meeting adjourned only with respect to reverse stock split proposal until September 8, 2022

See the original post here:
Adamis Pharmaceuticals Announces Results of Annual Meeting of Stockholders

Posted in Global News Feed | Comments Off on Adamis Pharmaceuticals Announces Results of Annual Meeting of Stockholders

Plus Therapeutics Presents Positive Data from Ongoing ReSPECT™ Clinical Trials at the Annual Conference on CNS Clinical Trials and Brain Metastases

Posted: August 14, 2022 at 2:33 am

AUSTIN, Texas, Aug. 13, 2022 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (the “Company”), a clinical-stage pharmaceutical company developing innovative, targeted radiotherapeutics for rare and difficult-to-treat cancers, yesterday presented positive data from two ongoing clinical trials of its lead investigational drug, Rhenium-186 Nanoliposome (186RNL), in the treatment of recurrent glioblastoma (GBM) and leptomeningeal metastases (LM) at the 2022 Annual Conference on CNS Clinical Trials and Brain Metastases. The conference is co-sponsored by the Society for Neuro-Oncology (SNO) and the American Society of Clinical Oncology (ASCO) and is being held August 12-13, 2022 in Toronto, Canada.

Here is the original post:
Plus Therapeutics Presents Positive Data from Ongoing ReSPECT™ Clinical Trials at the Annual Conference on CNS Clinical Trials and Brain Metastases

Posted in Global News Feed | Comments Off on Plus Therapeutics Presents Positive Data from Ongoing ReSPECT™ Clinical Trials at the Annual Conference on CNS Clinical Trials and Brain Metastases

Winged Scapula – A Body Builders Woe: Causes, Signs And Treatment – Boldsky

Posted: August 14, 2022 at 2:33 am

Disorders Cure

oi-Dr Medha Gupta

The scapula is a triangular bone on both sides of the upper back region. It is a part of the shoulder girdle and is stabilized by 2 muscles, the trapezius and the serratus anterior.

The winged scapula is a pathological condition where the scapula's vertebral border (the part of the scapula facing the spine) shows an unusual prominence. It restricts movement and is painful.

Nerve injury due to compression, heavy load bearing, athletic activity, and overuse. Bony changes Alteration of the peri-scapular tissues

Glenohumeral condition - the glenohumeral joint of the shoulder girdle is the most mobile joint of the body. It experiences deterioration and inflammation, and can result in winging of the scapula.

Subacromial conditions refer to the impingement of the region close to the acromion process of the scapula, which results in the scapular prominence.

These factors cause muscle weakness, which results in the winged scapula.

Bodybuilding is a sport and a recreational activity mixed. It is the intentional growth of the muscles through resistance training and nutrition.

Despite producing aesthetically pleasing results, the strict training, diet, and postural changes are not without risk. It makes the body vulnerable to multiple musculoskeletal and nervous problems.

Besides bodybuilders, accidental weightlifting, gymnastics, and gym sessions can also result in the winged scapula.

1. Propped out scapula and shoulder deformity2. Restricted hand movements3. Pain4. Muscle spasms5. Fatigue

1. Immobilization using a brace or a sling

2. Anti-inflammatories for pain management

3. Physical therapy:

a. Serratus anterior injury:

Acute stage: Moderate medication and range-of-motion (ROM) exercises are recommended, along with enough rest and a sling.

Intermediate stage: Complete range-of-motion exercises are advised because the muscle is starting to heal at this stage.

Late stage: After the muscle has fully recovered, strengthening or rehabilitation exercises are started.

b. Trapezius injury:

It is advised to take medication and wear a shoulder brace until the pain subsides. Rehabilitative exercises, chiropractic therapy, and nerve stimulation sessions follow.

4. Integrative medicine:

It is a novel idea that has amazing effects on chronic pain. It entails mastering both the body and the mind. Therapies like yoga, meditation, tai chi, and qigong can help with this.

5. Surgical treatment:

When the discomfort is persistent and the deformity worsens, it is recommended to correct it surgically.

An orthopaedic surgeon will be your go-to doctor.

Full recovery is possible if wing scapula is discovered in its early stages. It can be avoided by engaging in well-planned and methodical athletic or exercise sessions.

disorders cure

Ashton Kutcher's Autoimmune Disorder Left Him Blind And Disabled: Know About Vasculitis Causes And Treatment

disorders cure

Rat Fever Reported In Karnataka: Know About The Causes, Symptoms, Treatment And Prevention

disorders cure

What Is Synesthesia? A Condition That Causes You To 'See Shapes When You Hear Music'

disorders cure

What Is Bell's Palsy? Causes, Symptoms, Complications And Treatment

disorders cure

Justin Bieber Diagnosed With Ramsay Hunt Syndrome: Know More About The Disease

disorders cure

What Is Onchocerciasis, Also Called 'River Blindness'? Symptoms And Causes

wellness

Govt Releases Monkeypox Guidelines On Detecting And Treating The Disease

disorders cure

What Is Exploding Head Syndrome, A Condition That Happens Only When You Sleep

disorders cure

Foreign Accent Syndrome (FAS): What Causes This Weird But Real Medical Condition?

disorders cure

What Is Flatfoot (Flat Feet)? Symptoms, Causes, Treatment And Can It Be Prevented?

disorders cure

Sleeping Beauty Syndrome, A Rare Disorder That Affects Men: Symptoms, Causes And Treatment

disorders cure

Expert Article: What Is Amenorrhea? Causes And Treatment

GET THE BEST BOLDSKY STORIES!

Allow Notifications

You have already subscribed

Story first published: Saturday, August 13, 2022, 12:18 [IST]

Read the original here:
Winged Scapula - A Body Builders Woe: Causes, Signs And Treatment - Boldsky

Posted in Integrative Medicine | Comments Off on Winged Scapula – A Body Builders Woe: Causes, Signs And Treatment – Boldsky

New UCI-led research reveals the circadian clock influences cell growth, metabolism and tumor progression – Newswise

Posted: August 14, 2022 at 2:33 am

Newswise Irvine, Calif., Aug. 10, 2022 In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression. Their research also reveals how disruption of the circadian clock impacts genome stability and mutations that can further drive critical tumor promoting pathways in the intestine.

The study, titled, Disruption of the Circadian Clock drives Apc Loss of Heterozygosity to Accelerate Colorectal Cancer, was published today in Science Advances.

In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC).APC point mutations, deletions, and loss of heterozygosity (LOH) events have been reported in ~80 percent of human CRC cases, and it is these mutations that drive the initiation of intestinal adenoma development.

As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior, said Selma Masri, PhD, assistant professor of biological chemistry at UCI School of Medicine. Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. However, based on our findings, we now believe that disruption of the circadian clock plays an important role.

According to the National Institutes of Health, there has been an alarming rise in early-onset colorectal cancer among young individuals. Today, nearly 10 percent of CRC cases are now diagnosed in people younger than 50 years, and this trend is on a steady rise. Suspected risk factors include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock.

APC mutations are also associated with second hits in key oncogenic pathways, including Kras, Braf, p53, and Smad4, and these mutations drive progression to adenocarcinoma, collectively contributing to disease progression. Our findings now implicate circadian clock disruption in driving additional genomic mutations that are critical for accelerating colorectal cancer.

The circadian clock is an internal biological pacemaker that governs numerous physiological processes. Research in the Masri Lab is primarily focused on how disruption of the circadian clock is involved in the development and progression of certain cancer types. Researchers in the Masri Lab are actively pursuing further research aimed at defining how the circadian clock impacts other cancer types.

Financial support for this study was provided by the National Institutes of Health/National Cancer Institute, the Concern Foundation, the V Foundation for Cancer Research, the Care Research Coordinating Committee, Johnson and Johnson, and the UCI Chao Family Comprehensive Cancer Centers Anti-Cancer Challenge.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

Read more:
New UCI-led research reveals the circadian clock influences cell growth, metabolism and tumor progression - Newswise

Posted in Integrative Medicine | Comments Off on New UCI-led research reveals the circadian clock influences cell growth, metabolism and tumor progression – Newswise

Please and thank you: Cannabis startup Polite sells science-backed products to treat yourself – GeekWire

Posted: August 14, 2022 at 2:33 am

Some of Polites founders, left to right: Mary Brown Szomjassy, chief clinical officer; Yung Tan, CEO; Sue Tan, chief creative officer; Adam Melero, chief innovation officer; and Jeffrey Freeman Jr, chief growth officer. (Pax Bradford Photo)

The co-founders of Seattle-based cannabis and hemp product company Polite have multiple explanations for their startup name.

Its about self care that includes THC- and CBD-containing products that address specific health concerns. Its about replacing the naughty stereotype of marijuana with the nice alternative of their micro-dose products. It includes making science-backed claims about the tinctures, oral sprays, topical lotions and vaping devices that theyre selling.

The spirit of Polite is really about treating yourself well and treating others well, said Sue Tan, Polite co-founder and chief creative officer.

We use cannabis for mental, physical, [and] social health and when we feel better as people, she said, in turn that has a knock on effect on our partners, children, our families, our communities.

In January 2020, Polite launched its cannabis products containing THC, the intoxicating ingredient in marijuana. In April 2022 it began selling non-THC hemp goods with CBD. Products from both lines include a variety of cannabinoids the biologically active components of cannabis and hemp as well as other medicinal herbs.

We put the medical back into medical marijuana.

Polite distinguishes itself by its focus is on health-related products, in contrast to purely recreational use.

With the legalization of marijuana, patient-focused products were kind of ignored and thrown by the wayside, said Yung Tan, co-founder and CEO. The health and wellness piece disappeared, he said, so we put the medical back into medical marijuana.

The company is collaborating with physicians who study the outcomes for patients using these sorts of products and its applying this clinical information to develop its products. Polite partners with Seattles Advanced Integrative Medical Sciences (AIMS) Institute, a healthcare clinic that incorporates conventional and naturopathic approaches.

Its medical advisory board includes AIMS Institute co-founders Dr. Sunil Aggarwal and Dr. Leanna Standish. Both also hold positions at the UW School of Medicine and Bastyr University, a school of alternative medicine in Kenmore, Wash.

The company has competition. CBD products almost by definition are health-related. Other medically focused cannabis brands include Aunt Zeldas and Marys Brands. But the sector does seem to give less priority to medical applications. A search on the cannabis platform Leafly, for example, doesnt provide a clear path to finding low-dose THC-containing products for health needs.

Polite founders say their goal is to help customers discover which formulations and doses work best for meeting their health needs. That includes products to address chronic pain and inflammation, sleep, stress and anxiety, digestion and immunity, energy and focus, and joint and muscle pain.

It focuses on cannabis educational outreach to the public, healthcare workers, and budtenders who work in marijuana retail stores and often have only their personal experience to draw upon when recommending products.

This issue is, forgive the pun, truly grassroots, said Sue Tan. You have patients going to their healthcare providers and saying, Im going to try this [cannabis product], whether you believe in it or not, because Im out of options. Everything else has failed me.'

While the company is engaged in research into cannabinoids, it is not conducting rigorous FDA-approved clinical trials and is not publishing studies in peer-reviewed journals. It does employ outside laboratories to test its products for ingredient concentrations and contaminants such as pesticides.

The companys aesthetic and name are trying to walk the line of respectability aiming to offer products that people would be comfortable providing to ailing elderly parents or leaving out on their nightstand while not appearing intimidatingly pharmaceutical.

Polite is a brand within a parent company called Canvas Therapeutics, which has a second brand called Revida Labs. In addition to Sue and Yung Tan, who are siblings, Canvas other co-founders are Mary Brown Szomjassy, Jeffrey Freeman Jr., Adam Melero, Melissa Durkee, Mike Szomjassy and Suan Teo.

Prior to founding cannabis companies, Yung Tan was a corporate attorney at firms including Perkins Coie and a senior investment banker at banks such as Citigroup and Deutsche Bank. Sue Tan has done design work internationally and co-authored a book on innovation. Brown Szomjassy has a background in education and been a consultant in cannabis health education for 14 years.

Polites cannabis products are available in Washington and Arizona, two of the states where recreational marijuana is legal. The hemp items are sold nationally.

The company, which has approximately 15 employees, has been bootstrapped and not received outside financial support. As it expands its national and international customer base, the team will be pursuing capital from investors, said Yung Tan.

Read more here:
Please and thank you: Cannabis startup Polite sells science-backed products to treat yourself - GeekWire

Posted in Integrative Medicine | Comments Off on Please and thank you: Cannabis startup Polite sells science-backed products to treat yourself – GeekWire

Cannabis Increasingly Used for Menopause Symptom Relief. Is It Safe? – Healthline

Posted: August 14, 2022 at 2:33 am

More women are turning to medical cannabis to seek relief from menopause and perimenopause symptoms, research suggests.

For instance, a 2020 study shows that about 1 in 4 female veterans use cannabis to treat menopause symptoms.

And now, new research, recently published in the journal Menopause, suggests that the number of both menopausal and perimenopausal women using medical cannabis for symptom relief could be much higher.

This study suggests that medical cannabis use may be common in midlife women experiencing menopause-related symptoms, said Dr. Stephanie Faubion, medical director of the North American Menopause Society, in a press release.

Still, experts caution that the effects of cannabis on menopause symptoms like anxiety, depression, sleep, and pain have not yet been fully established.

Healthcare professionals should query their patients about the use of medical cannabis for menopause symptoms and provide evidence-based recommendations for symptom management, Faubion added.

The new study involved more than 250 perimenopausal and postmenopausal women who were recruited through targeted ads about womens health and cannabis use.

Over 83% of study participants said they regularly used cannabis to treat menopause-related symptoms, which was defined by researchers as at least once per month.

The study shows that cannabis was most commonly used to ameliorate sleep and mood or anxiety issues. The majority of participants (84%) said they smoked cannabis for symptom relief, with 78% of participants reporting the use of edibles.

Despite the seemingly positive findings, the study has a built-in bias since participants were recruited because of their interest in cannabis.

Theres no value in terms of its numbers or validity, Dr. Felice Gersh, an OB-GYN and founder of the Integrative Medical Group in Irvine, California, told Healthline.

But it does bring up the important subject about the suffering that women go through in menopause with no assistance from the medical establishment.

Gersh said that very few of her patients report using cannabis to treat menopause symptoms.

I call cannabis green medicine, Gersh said. This is a potential tool, but we have no data on efficacy or safety. It really is a medication that should be talked about with a physician, and patients should realize that there are more tested options, like hormone therapy.

According to Gersh, the new research has possibly overestimated the use of cannabis.

Still, a prior 2020 study suggests that 1 in 4 female veterans used cannabis to treat menopause. In fact, the researchers found that more women were using cannabis to treat menopause symptoms than were using hormone therapy or other traditional types of menopause symptom management.

This is disturbing because hormone therapy is the most effective therapy we have for menopause symptoms, and the benefits typically outweigh the risks for women in their 50s and within 10 years of menopause, Faubion told Healthline. Cannabis, on the other hand, is not a proven therapy for menopause.

Dr. Aaron Gelfand, an OB-GYN at ChoicePoint, an addiction treatment center in New Jersey, explained that numerous physiological systems are thought to be influenced by the endocannabinoid system, which is activated by plant-based cannabinoids like CBD and THC. These systems include:

According to Gelfand, cannabis is also used to help treat anxiety and depression, sleep, and even vaginal dryness among menopausal women.

The amygdala is responsible for emotions, behavior, and motivation, Gelfand told Healthline. During menopause, all of these are heightened. Upon taking cannabis in any form, the response is suppressed, causing less anxiety and depression.

Still, Gelfand said using cannabis to aid sleep may have mixed results in people experiencing menopause.

While THC usually has a sedative effect, it can also have a stimulating impact on certain users, particularly those who are new to [cannabis] use or who are taking greater amounts, he explained. In these circumstances, smoking [cannabis] before bed may make it harder to fall asleep.

Conversely, Gelfand said that at smaller doses, CBD seems to encourage alertness. At greater concentrations, however, CBD may induce sleepiness.

As for treating vaginal dryness, Gelfand pointed out that the use of CBD-containing products in the vaginal or vulvar tissues has not been supported by any well-controlled clinical research.

If Gersh were to recommend cannabis for menopause symptom relief, she said she prefers hemp-based products like CBD over products containing THC, the main psychoactive ingredient found in cannabis.

CBD and other cannabinoids like THC bind with receptors in the brain that are associated with memory, cognitive function, and pain.

Women who are going through menopause often find relief from common symptoms of menopause for exactly that reason, Mitchell H. Stern, president and CEO of California-based cannabis producer Burning Bush Nurseries told Healthline.

Some CBD brands have begun to cater to the unique needs of this emerging market by infusing their products with things like hibiscus, sage, and other natural herbs that have been helping menopausal women find relief for thousands of years, he added.

Experts have cautioned that the purported benefits of using cannabis to treat menopausal symptoms require further study.

While there has not been adequate research into the use of cannabis for menopausal symptoms, I would be reluctant to advise the use of cannabis with THC for this purpose, Dr. David Culpepper, clinical director of Telehealth company LifeMD, told Healthline.

In my experience, most of the anti-inflammatory and other health benefits patients receive from cannabis products come not from THC, but from CBD, which is a benign, non-psychoactive compound. Its possible that women using cannabis for menopause are reaping the benefits of the CBD, while unnecessarily intoxicating themselves with THC.

As with other experts, Culpepper recommended that people experiencing menopause try CBD to help relieve their symptoms instead of cannabis products containing THC.

The proliferation of medical cannabis in the United States has contributed to an increasing number of menopausal and perimenopausal women using the drug to treat their associated symptoms.

But some experts say these numbers may be overestimated, and caution that research on safety and effectiveness is still limited.

Until more rigorous research is conducted, experts recommend hormone therapy as a first-line treatment or may suggest trying CBD products as an alternative.

If you are experiencing symptoms associated with menopause or perimenopause, ask your doctor about the safest treatment options available to help you find relief.

See the original post here:
Cannabis Increasingly Used for Menopause Symptom Relief. Is It Safe? - Healthline

Posted in Integrative Medicine | Comments Off on Cannabis Increasingly Used for Menopause Symptom Relief. Is It Safe? – Healthline

Acupuncture therapy in pets – DVM 360

Posted: August 14, 2022 at 2:33 am

This nonpharmacological form of treatment, rooted in Eastern medicine, can help with a variety of conditions

Tabitha, an 18-year-old, sweet-natured feline was struggling to move comfortably around the household. Her owner had exhausted many of the options offered to help ease the pain she was experiencing from her arthritic joints. Acupuncture was suggested to Tabithas owner and, despite being a slight skeptic about the true benefits this treatment could offer, she scheduled a first acupuncture appointment for Tabitha.

Tabitha was a very cooperative patient and seemed to enjoy her acupuncture visits. After about 6 sessions, Tabithas owner noticed a little pep her step and improved movement with less stiffness. The treatments were continued over the course of the year, and the owner observed that Tabithas daily life improved as she began to groom better, sleep more comfortably, navigate into the litter box with more ease, and had an increased appetite. Amazingly, Tabitha did not require any pain medications while receiving her acupuncture treatments, and she was able to celebrate her 22nd birthday. Tabitha was a model display of the true benefits acupuncture could provide to our furry companions.

Acupuncture has been around for thousands of years. This treatment originated in China, and traditional Chinese veterinary medicine not only includes the practice of acupuncture but also herbal medicine, food therapy, and Tui na (medical manipulation). Approximately 173 acupoints exist in animals and 361 in humans. Acupuncture generally involves the insertion of thin sterile needles into discrete and specific points on the body to cause a therapeutic effect. There are other methods utilized to enhance the effects of acupuncture, including electrical stimulation and moxibustion. Moxibustion utilizes dried plant materials called moxa, which are burned near the surface of the skin to help with treatment of certain conditions. Electroacupuncture uses a mild and gentle electric current to pass between the needles placed, causing a stimulation to help enhance the effects of acupuncture for certain conditions.

In terms of the effectiveness of acupuncture, there have been several studies that have demonstrated that the stimulation of acupoints leads to the release of -endorphins, serotonin, and other neurotransmitters. Studies have further indicated that acupuncture can help with pain relief, promotion of tissue healing processes, regulation of gastrointestinal motility, immunoregulation, anti-inflammatory effects, and hormone regulation.

The best part of acupuncture therapy is that the treatment is extremely safe and rarely causes any adverse effects. Some results can be seen immediately, but others will require several treatments. Most animals handle the acupuncture needles very well and often even show a relaxation effect from placement of some of the points. The body has many channels that interconnect and can be stimulated through acupuncture therapy. Many veterinarians who practice acupuncture can use these channels to help several areas of the body, with only a few acupoints.

To become a certified veterinary acupuncturist, a practicing veterinarian must undergo extensive training to understand the history of acupuncture, the proper diagnosis of a patient, and the channels and meridians used in acupuncture therapy. There are several tests these trained professionals must complete to become proficient and certified.

In practice, I will often have owners offer an animals favorite treat or meal to make it a positive experience during acupuncture sessions. Most sessions will last between 15 and 30 minutes. Some of the most common conditions acupuncture is used for in animals includes musculoskeletal and neurologic injuries, gastrointestinal disorders, allergic dermatitis, lick granulomas, epilepsy, and chronic pain conditions.

For those interested in pursuing this treatment for a pet, I would recommend finding a certified veterinary acupuncturist nearby. They will want to review your pets full medical history and perform a thorough examination prior to any acupuncture treatments. The acupuncturist may also suggest diet changes or herbal medicine to treat your pets underlying issues.

I have found the most success with an integrative approach to treating my patients using elements from both traditional Western medicine (eg, radiographs, ultrasound, antibiotics) and Eastern medicine (eg, acupuncture, herbs). We are fortunate, at the present time, to have numerous options available to help our animals live longer and more comfortable lives.

Dana Koch, VMD, CVA, MLAS is medical director of the HousePaws hospital in Morrisville, Pennsylvania, which offers acupuncture services. She received her veterinary degree from the University of Pennsylvania and a masters degree in laboratory animal medicine from Drexel University, both located in Philadelphia.

Here is the original post:
Acupuncture therapy in pets - DVM 360

Posted in Integrative Medicine | Comments Off on Acupuncture therapy in pets – DVM 360

New UCI-led study reveals computation-guided approach to suppressing cancer tumor growth – EurekAlert

Posted: August 14, 2022 at 2:33 am

image:Peter Kaiser, Department of Biological Chemistry, UC Irvine, School of Medicine and Chao Family Comprehensive Cancer Center view more

Credit: UCI School of Medicine

Irvine, CA Aug. 10, 2022 A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers. This approach was successful both in vitro and in vivo. This strategy can increase chemical diversity of p53 corrector molecules for clinical development.

The tumor suppressor p53 is one of the most powerful mechanisms organisms use to protect themselves from cancer. Elephants have multiple copies of the p53 gene and rarely get cancer. Humans have only one copy and it is the most mutated gene found in human cancer. Diverse therapeutic approaches are actively pursued to target this pathway.

Interestingly, a large fraction of p53 alterations are missense mutations, where the genetic code of the p53 is altered in a way that produces a different amino acid than it would normally, explained Peter Kaiser, PhD, professor and chair of the Department of Biological Chemistry at the UCI School of Medicine. This results in abundance of mutant p53 protein levels in tumors that are, in principle, amenable to a corrector drug approach.

Published in Cell Chemical Biology, the study identified small drug-like compounds that act through a well-defined mode of action; do not require covalent attachment, induction of redox imbalance, or metal binding; and have selective anti-cancer activities on tumors with p53 missense mutations. This research provides a framework for p53 reactivation compound discovery that can help to increase chemical diversity and improve pharmacological properties necessary for translation of pharmaceutical p53 mutant reactivation to the clinic.

This study successfully demonstrates the feasibility and efficacy of pharmaceutical reactivation of mutant p53, said Kaiser. These findings are encouraging given the large number of cancer patients with p53 mutations that could benefit from such drugs.

This study involved the application of an ensemble-based virtual screening approach, developed in the laboratory of Rommie Amaro, professor and endowed chair in the Department of Chemistry and Biochemistry at UC San Diego, which has the potential to identify compounds with increased cancer killing potential and with a broad spectrum of activity across a panel of p53 mutants. The researchers showed that their compounds bind mutant p53 and change mutant p53 conformation to wild type-like structures. This restores p53 DNA binding activity to activate the p53 transcriptional response, which in turn prevents tumor progression in mouse models selectively for tumors with a p53 missense mutation.

Challenges remain to define exact mechanisms and develop highly active corrector drugs for mutated p53 and future experiments are needed to optimize pharmacological properties to progress towards clinical therapeutics.

The study was supported by the National Institutes of Health and the Department of Defense.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

Cell Chemical Biology

Experimental study

Cells

Discovery of compounds that reactivate p53 mutants in vitro and in vivo

10-Aug-2022

Authors of this manuscript, including Amaro, R. E., Baronio, R., Demir, O., Kaiser, P., Lathrop, R. H., Salehi-Amiri, S.-F., Wassman, C., are listed as inventors on the patent, "mall molecules to enhance p53 activity", US20160193214 A1, United States. (Approved: March 2017). The patent describes compounds reported in this manuscript.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Here is the original post:
New UCI-led study reveals computation-guided approach to suppressing cancer tumor growth - EurekAlert

Posted in Integrative Medicine | Comments Off on New UCI-led study reveals computation-guided approach to suppressing cancer tumor growth – EurekAlert

Page 230«..1020..229230231232..240250..»