Posted: May 7, 2014 at 11:45 am
Knee arthritis 9 months after stem cell therapy by Dr Harry Adelson
Carol describes her outcome from stem cell therapy by Dr Harry Adelson for her arthritic knee http://www.docereclinics.com.
By: Harry Adelson, N.D.
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Knee arthritis 9 months after stem cell therapy by Dr Harry Adelson - Video
Posted: May 7, 2014 at 11:44 am
PUBLIC RELEASE DATE:
6-May-2014
Contact: Sally Stewart sally.stewart@cshs.org 310-248-6566 Cedars-Sinai Medical Center
LOS ANGELES (EMBARGOED UNTIL NOON ET ON MAY 6, 2014) Investigators at the Cedars-Sinai Heart Institute whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans have identified components of those stem cells responsible for the beneficial effects.
In a series of laboratory and lab animal studies, Heart Institute researchers found that exosomes, tiny membrane-enclosed "bubbles" involved in cell-to-cell communication, convey messages that reduce cell death, promote growth of new heart muscle cells and encourage the development of healthy blood vessels.
"Exosomes were first described in the mid-1980s, but we only now are beginning to appreciate their potential as therapeutic agents. We have found that exosomes and the cargo they contain are crucial mediators of stem cell-based heart regeneration, and we believe this might lead to an even more refined therapy using the 'active ingredient' instead of the entire stem cell," said Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.
"The concept of exosome therapy is interesting because it could potentially shift our strategy from living-cell transplantation to the use of a non-living agent," he added. "Stem cells must be carefully preserved to keep them alive and functioning until the time of transplant, and there are some risks involved in cell transplantation. In contrast, exosome therapy may be safer and simpler and based on a product with a longer shelf life."
In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells. Exosomes also produced the same post-heart attack benefits in mice, decreasing scar size, increasing healthy heart tissue and reducing levels of chemicals that lead to inflammation. Even when exosomes were injected in mice after heart attack scars were well-established, and traditionally viewed as "irreversible," they brought about multiple structural and functional benefits.
Exosomes transport small pieces of genetic material, called microRNAs, that enable cells to communicate with neighboring cells to change their behavior. The researchers pinpointed one such microRNA one that is especially plentiful in cardiac stem cell exosomes as responsible for some of the benefits. It is likely, they believe, that this and other microRNAs in the exosomes work together to produce the regenerative effects.
"The exosomes appear to contain the signaling information needed to regenerate healthy heart tissue, they are naturally able to permeate cells, and they have a coating that protects their payloads from degradation as they shuttle from cell to cell," said Marbn, senior author of an article in the May 6, 2014 Stem Cell Reports. "Injecting exosomes derived from specialized cardiac stem cells may be an attractive alternative to the transplantation of living cells."
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Cedars-Sinai researchers identify how heart stem cells orchestrate regeneration
Posted: May 7, 2014 at 11:44 am
Valencia, spain (PRWEB) May 07, 2014
Cell Science International Conference is being organized to broaden the scope of the research in the field of Tumorogenesis, Recombinant DNA technology, Cancer cell development and signaling pathway, Evolution of cancer, Genetic engineering and Gene therapy, Tumor suppressor genes, Tissue Engineering, Stem cell treatment, Bioinformatics and Computational biology, Bio Ethics and Patent Rights.
Eminent speakers including Stewart Sell, University of Albany, USA, Sudhakar Akul Yakkanti, SRI International, USA, and Diana Anderson, University of Bradford, UK will be joining their peers at Cell Science-2014, an International Conference 2014 to share their upcoming researches and experience in the field of Cell Science.
James L Sharely, Director of The Adult Stem Cell Technology Centre, LLC, USA organizes a symposium on Stem Cell DNA Segregation and Genetic Fidelity. Ornella Parolini, President, International Placenta Stem Cell Research (IPLASS) holds another symposium on Fetal-derived Stem cells: Characteristics and Applications during Cell Science-2014.
The GID Group, Inc. that manufactures and distributes versatile tissue processing system, sterile disposable canister like GID 700 and GID SVF-1 exhibits its products and services during the conference.
The Organizing Committee welcomes you to attend Cell Science-2014 which includes Ornella Parolini, IPLASS (International Placenta Stem Cell Society), Italy; Sudhakar A Yakkanti, Stanford Research Institute (SRI) International, USA; Stewart Sell, University of Albany, USA; Valles Marti, University of Valencia, Spain; LilianSoraya, University of Valencia, Spain; James L. Sherley, The Adult Stem Cell Technology Center, LLC, USA; Diana Anderson, University of Bradford, UK; Shiaw-Yih (Phoebus) Lin, Anderson Cancer Center The University of Texas, USA; Behjatolah Monzavi Karbassi, University of Arkansas for Medical Sciences, USA.
Cell Science-2014 official partners include The Adult Stem Cell Technology Center, LLC USA and the International Placenta Stem Cell Research (IPLASS).
The three day conference will be hosting significant sessions like Keynote forum, speaker Sessions, Poster sessions, awards and Exclussive session on Successful Postdoctoral Fellowship training.
In addition to this, Soraya L Valles, University of Valencia, Spain organized a pre-conference workshop on NeuroSceince at Salon de Grados, Faculty of Medicine Valencia, Spain on February 25th, 2014 thus promulgating this pragmatic conference.
OMICS Publishing Group hosts 350 Open Access, Online ScientificJournals and hosts more than 100 Scientific Conferences worldwide. With 30,000 strong editorial board members drawn from academics, research and industries, OMICS Group Journals will publish the best papers presented in Cell Science- 2014.
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OMICS Groups Cell Science & Stem Cell Research Congress to Explore the Recent Developments
Posted: May 6, 2014 at 9:46 pm
Stem Cells from Humans
PENNSYLVANIA - For the first time ever, cloning technologies are being used to make stem cells that are genetically matched to adult patients. Of course scie...
By: NextNewsNetwork
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Stem Cells from Humans - Video
Posted: May 6, 2014 at 9:45 pm
Persuasive Speech-Jared Volz-Stem Cell Research FOC
Persuasive Speech for Fundamentals of Oral Communications over Stem Cell Research.
By: Jared Volz
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Persuasive Speech-Jared Volz-Stem Cell Research FOC - Video
Posted: May 6, 2014 at 7:49 am
Dental Talk Show - Dental Stem Cells, Dental Show Preview Competition News
Host Nick Peters discusses Stem cell research and how the use of Stem Cells from Teeth are showing promising potential in the use of Stroke Therapy due to there likeness of Brain Neurons. #DentalNe...
By: NIck Peters
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Dental Talk Show - Dental Stem Cells, Dental Show Preview & Competition News - Video
Posted: May 6, 2014 at 1:58 am
Dental Talk Show - Dental Stem Cells, Dental Show Preview Competition News
Host Nick Peters discusses Stem cell research and how the use of Stem Cells from Teeth are showing promising potential in the use of Stroke Therapy due to there likeness of Brain Neurons. #DentalNe...
By: NIck Peters
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Dental Talk Show - Dental Stem Cells, Dental Show Preview & Competition News - Video
Posted: May 6, 2014 at 1:58 am
JACKSONVILLE, Fla. -
Hemorrhagic stroke is responsible for more than 30 percent of all stroke deaths. It happens when a weakened blood vessel ruptures and bleeds into the brain.
Its something Jon Galvan experienced five years ago when he almost died from a hemorrhagic stroke while at work.
"I was typing away and I felt a pop in my head," Galvan said.
He was able to recover, but Dr. Abba Zubair, medical director of transfusion medicine and stem cell therapy at Mayo Clinic, Florida, said not everyone is as fortunate.
"If it happens, you either recover completely or die," Zubair said. "Thats what killed my mother."
Zubair said he wants to send bone marrow derived stem cells to the international space station.
"Based on our experience with bone marrow transplant, you need about 200 to 500 million cells," Zubair said.
But conventionally grown stem cells take a month. Experiments on earth have shown that stem cells will grow faster in less gravity.
"Five to ten times faster, but it could be more," Zubair said.
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Health Beat: Growing stem cells in space: Medicine's next big thing?
Posted: May 6, 2014 at 1:58 am
Durham, NC (PRWEB) May 05, 2014
A new study released today in STEM CELLS Translational Medicine demonstrates the regenerative effects of mesenchymal stem cells (MSC) on the anal sphincter. The work could have implications for the 11 percent of the population suffering fecal incontinence due to an injury or disease.
Massarat Zutshi, M.D., and Levilester Salcedo, M.D., led the research team made up of their colleagues at the Cleveland Clinic (Cleveland, Ohio) as well as those from Summa Cardiovascular Institute and Northeast Ohio Medical University (Akron, Ohio).
None of the current therapies for treating fecal incontinence are efficacious in the long-term or without complications related to the surgery or the device, Dr. Zutshi said. However, she added, adipose tissue, muscle and mesenchymal stem cells (MSC) have been shown to improve functioning of the heart and the urinary sphincter in animal models, leading researchers to test their effects in regenerating the anal sphincter, too.
In this most recent study the Zutshi/Salcedo team wanted to see how a single intramuscular (IM) injection of MSCs compared to a series of intravenous (IV) treatments. They used rats that had undergone an excision of 25 percent of their anal sphincter complex. Twenty-four hours after injury, one group received a single IM injection of stem cells directly into their anal sphincters. A second group began a series of six consecutive daily treatments delivered by IV through their tail veins, as did a group of non-injured animals. Another group of injured animals received no stem cells.
Anal pressures were recorded prior to injury, then again at 10 days and five weeks after treatment. Ten days after the IM treatment, resting and peak pressures were significantly increased in the injured groups compared to the control group that received no treatment. At five weeks, the anal pressures of the two groups of injured rats receiving treatments were almost on par with the non-injured group.
Both IM and IV MSC treatment after injury cause increase in anal pressures sustained at five weeks even though fewer cells were injected IM, Dr. Zutshi concluded. The MSC-treated groups showed less scarring than PBS treatment, with the IV infusion group showing the least scarring.
Since MSC delivered IM or IV both resulted in functional recovery, the IM route may be preferable as fewer cells seem to be needed.
This research demonstrates the regenerative effects of mesenchymal stem cells on the injured anal sphincter and, because fewer cells were needed for intramuscular injections, may direct the course of future clinical trials, said Anthony Atala, M.D., editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.
The full article, Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells, can be accessed at http://www.stemcellstm.com.
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Stem Cells Could Be the Answer for Treating Fecal Incontinence After Injury or Disease
Posted: May 6, 2014 at 1:58 am
Researchers have found a new source of stem cells that produce fat tissue, findings presented today at the European Congress of Endocrinology in Wrocaw, Poland, show. This unique in vitro human stem cell model of brown fat tissue could aid studies into how fat tissue develops and the development of new anti-obesity drugs.
There are two types of fat tissue found in humans: white adipose tissue (WAT) that accumulates lipids, and brown adipose tissue (BAT) that can burn lipids to produce heat. BAT is mainly found in babies, although recent studies show that adults may retain a small amount of BAT. BAT is considered important in obesity research as it represents a potential pathway by which the body can control metabolism by burning excess lipids to produce heat. Previously there have been no in vitro human models to aid research into BAT tissue development.
A team from the University of Florence in Italy studied patients with a rare tumor called pheochromocytoma. This tumor is found in the adrenal glands and causes the release of excess levels of the hormones adrenaline and noradrenaline. The team removed tumors from eight patients and examined the fat tissue that surrounded them. They found that, in addition to the WAT present in healthy people, pheochromocytoma patients also had some tissue with molecular markers for BAT cells present.
From this tissue, the team isolated and characterized brown adipose stem cells and compared their properties to precursor WAT cells from the same patient. Using gene expression analysis, immunophenotyping and differentiation tools, they found the two cell types had different properties, in particular in their potential to differentiate into BAT cells, thus indicating a different developmental pathway for the two types of fat cell.
This is an exciting discovery, said Professor Michaela Luconi, who led the research. Obesity is now a huge, worldwide health issue and we urgently need new treatment strategies to tackle it. Brown adipose tissue has long been seen as a potential target for new anti-obesity treatments as it is able to control metabolic rate and burn excess fat molecules.
Our research has characterized the first in vitro human model for brown adipose stem cells from a novel source. Our theory is that the excess adrenaline produced by this rare tumor may have induced the expansion of the brown adipose stem cell component present in this depot of white adipose tissue. We now need to carry out further work to see if this theory is correct and whether the process can be reproduced in the lab.
The team are currently unable to produce mature BAT cells from the brown adipose stem cells, but now plan to study how they can improve this differentiation process. This model has huge potential to allow us to learn more about how different types of fat cell develop, said Professor Luconi. Greater understanding of this process will aid us in designing and testing specific anti-obesity drugs targeting white to brown cells conversion.
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The above story is based on materials provided by European Society of Endocrinology. Note: Materials may be edited for content and length.
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New source of fat tissue stem cells discovered
