Posted: July 13, 2014 at 2:45 am
Is there Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder?
Dr. Hemangi Sane from Neurogen Brain and Spine Institute show Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder. Published Paper on Autism Spectrum Disorder http://stem...
By: Neurogen Brain and Spine Institute
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Is there Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder? - Video
Posted: July 13, 2014 at 2:45 am
How safe is stem cell therapy for children affected with autism spectrum disorder
In conversation with Dr Alok Sharma (MS, MCh.) Professor of Neurosurgery Head of Department, LTMG Hospital LTM Medical College, Sion, Mumbai. Explains, How safe is stem cell therapy for...
By: Neurogen Brain and Spine Institute
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How safe is stem cell therapy for children affected with autism spectrum disorder - Video
Posted: July 13, 2014 at 2:45 am
Another Success: Treatment of Supraspinatus Tear with StemCells
In a previous blog I discussed the clinical success of rotator cuff repair using expanded stem cell therapy.
Today we had the opportunity to review MRI images of an elderly patient who also underwent the Regenexx procedure 2 years ago for a supraspinatus tear. ABis an 80y/o patient with neck, headache and shouder pain. Her shoulder pain wassevere and she was unable to lift her shoulder. She declined surgery and elected to proceed with mesenchymal stem cell therapy. Her own stem cells were injected into the rotator cuff tear under x-ray guidance.
To understand the differencesin pre and post MRIs, some basic MRIconcepts and anatomy is essential.
The image above is the patients pre-injection coronal MRI. The rotator cuff tendon is the area of interest. The rotator cuff is compromised of 4 principle muscles. Muscles have two parts: the muscle belly and the attachment of the muscle to bone(tendon). Tears in the rotator cuff commonly involve the tendon.
Above are ABs pre and post MRIs . On the left the rotator cuff tendon(red arrows) are bright in color and mottled in appearance. This means that its a full thicknesstear with severe degeneration. On the right is ABs MRI 2 year post stem cell injection. The rotator cuff tendon identified by the yellow arrowsis better organized and darker in color consistent with significant healing. This is consistent with her clinical improvement. She reports 100% improvement in pain and full range of motion.
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The rotator cuff is compromised of 4 principles muscles and theirtendons: supraspinatus, infraspinatus, subscapularis and teres minor. Collectively they stabilizethe jointand allow for movement . Tendons at the end of the rotator cuff muscles can become torn resulting in pain and restriction in motion. The majority of tears occur in the supraspinatus tendon. Typical presentation includes pain with impaired motion. Surgicaltreatment often involvesarthorscopic repair, subacromial decompression or use of an anchor to secure the tendon to the bone. Surgical complications included fatty atrophy, re-tears of the rotator cuff, infection and failure.
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stem cell therapy for rotator cuff tears | Stemcelldoc's ...
Posted: July 13, 2014 at 2:44 am
Im not betting on it, but if, by some miracle, Argentine winger Angel Di Maria is on the pitch against Germany Sunday in the 2014 World Cup final, get ready for another explosion of interest in stem cell therapy, a now familiar occurrence every time a famous athlete undergoes the treatment.
Di Maria, who either tore or strained a thigh muscle in Argentinas World Cup win over Belgium, is so determined to play in the final that, according to some reports, he is having the muscle injected with stem cells in the hope of healing by Sunday. (This Associated Press report from Thursday said he was practicing at 60 to 80 percent, so Im guessing were talking about a strain.)
If those reports are true, Di Maria will join a long line of elite athletes who have resorted to the unproven and possibly risky therapy. This kind of stem cell therapy is experimental in every sense of the word, according to the International Society for Stem Cell Research. There also is some evidence that the procedure can promote tumor growth or create an immune response to a patients own cells, or that injected stem cells might migrate to another part of the body.
Never mind. There is soccer to be played!
No one denies that stem cells hold promise as a therapy down the road, perhaps in as little as five or 10 years, says Kevin McCormack, communication director for the California Institute for Regenerative Medicine. With $3 billion supplied by voters in a 2004 ballot initiative, the organization is funding trials of the use of stem cell therapies for scarring after heart attacks, sickle cell anemia, leukemia and other conditions.
But for now, stem cells are known to be effective only for certain disorders of the blood, immune system and bone marrow. Beyond that, little has been proven, although clinics in the United States and around the world are offering the therapy and raking in bucks from desperate patients.
Di Maria may even see some benefits, McCormack said. In theory, they might [help] because they may have an anti-inflammatory effect or they may stimulate the bodys own natural healing, he said. But the problem is that they havent done any research to prove that.
The stem cells are harvested from a patients bone marrow and sometimes run through a centrifuge to concentrate them. Then they are injected into the damaged tissue.
For athletes, who are always looking for ways to prolong their careers and bounce back from injury, the fad began in 2010, when Major League pitcher Bartolo Colon had a slurry of stem cells that can turn into a variety of tissues injected into his injured elbow and shoulder. Within months, he was throwing 93 mile per hour fastballs for the New York Yankees. Later, Denver Broncos quarterback Peyton Manning, one of the most famous athletes in the United States, reportedly had stem cell therapy on his injured neck.
McCormack and others express concern that when pro athletes and other celebrities have unproven treatments, it sends the rest of us weekend warriors out in search of the same. Here a good bit of blame goes to us in the media. A 2012 analysis conducted for the journal Molecular Therapyshowed that 72.7 percent of the media coverage of athletes and stem cell therapy didnt address whether the treatment works, and 42 percent referred to alleged benefits. Only 5.7 percent of the stories brought up possible safety issues and risks.
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Injured Argentine winger Angel Di Maria may be resorting to unproven stem cell therapy
Posted: July 13, 2014 at 2:44 am
For many years scientists have been trying to unravel mechanisms that guide function and differentiation of blood stem cells, those cells that generate all blood cells including our immune system. The study of human blood stem cells is difficult because they can only be found in the bone marrow in specialized "niches" that cannot be recapitulated in a culture dish. Now a group of scientists from Dresden led by stem cell researcher Prof. Claudia Waskow (Technische Universitt Dresden) was able to generate a mouse model that supports the transplantation of human blood stem cells despite the species barrier and without the need for irradiation. They used a mutation of the Kit receptor in the mouse stem cells to facilitate the engraftment of human cells.
In the new model human blood stem cells can expand and differentiate into all cell types of the blood without any additional treatment. Even cells of the innate immune system that can normally not be found in "humanized" mice were efficiently generated in this mouse. Of significance is the fact that the stem cells can be maintained in the mouse over a longer period of time compared to previously existing mouse models. These results were now published in the journal Cell Stem Cell.
"Our goal was to develop an optimal model for the transplantation and study of human blood stem cells," says Claudia Waskow, who recently took office of the professorship for "animal models in hematopoiesis" at the medical faculty of the TU Dresden. Before, Prof. Waskow was a group leader at the DFG-Center for Regenerative Therapies Dresden where most of the study was conducted.
The trick used by Claudia Waskow's team to achieve optimal stem cell engraftment was the introduction of a naturally occurring mutation of the Kit receptor into mice that lack a functional immune system. This way they circumvented the two major obstacles of blood stem cell transplantation: the rejection by the recipient's immune system and absence of free niche space for the incoming donor stem cells in the recipient's bone marrow. Space is usually provided by irradiation therapy, called conditioning, because it damages and depletes the endogenous stem cells and thus frees space for the incoming human cells. However, irradiation is toxic to many cell types and can lead to strong side effects. The Kit mutation in the new mouse model impairs the recipient's stem cell compartment in such a way that the endogenous blood stem cells can be easily replaced by human donor stem cells with a functional Kit receptor. This replacement works so efficiently that irradiation can be completely omitted allowing the study of human blood development in a physiological setting. The model can now be used to study diseases of the human blood and immune system or to test new treatment options.
The results from Prof. Waskow's group also show that the Kit receptor is important for the function of human blood stem cells, notably in a transplantation setting. Further studies will now focus on using this knowledge about the role of the receptor to improve conditioning therapy in the setting of therapeutic hematopoietic stem cell transplantation in patients.
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The above story is based on materials provided by Technische Universitt Dresden. Note: Materials may be edited for content and length.
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Opening-up the stem cell niche: Hematopoietic stem cell transplantation without irradiation
Posted: July 13, 2014 at 2:44 am
PUBLIC RELEASE DATE:
11-Jul-2014
Contact: Jia Liu liujia@genomics.cn BGI Shenzhen
July 3, 2014, Shenzhen, China Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.
The combination of stem cells and targeted genome editing technology provides a powerful tool to model human diseases and develop potential cell replacement therapy. Although the utility of genome editing has been extensively documented, but the impact of these technologies on mutational load at the whole-genome level remains unclear.
In the study, researchers performed whole-genome sequencing to evaluate the mutational load at single-base resolution in individual gene-corrected hiPSC clones in three different disease models, including Hutchinson-Gilford progeria syndrome (HGPS), sickle cell disease (SCD), and Parkinson's disease (PD).
They evaluated the efficiencies of gene-targeting and gene-correction at the haemoglobin gene HBB locus with TALEN, HDAdV, CRISPR/CAS9 nuclease, and found the TALENs, HDAdVs and CRISPR/CAS9 mediated gene-correction methods have a similar efficiency at the gene HBB locus. In addition, the results of deep whole-genome sequencing indicated that TALEN and HDAdV could keep the patient's genome integrated at a maximum level, proving the safety and reliability of these methods.
Through integrating the advantages of TALEN- and HDAdV-mediated genome editing, researchers developed a new TALEN-HDAdV hybrid vector (talHDAdV), which can significantly increase the gene-correction efficiency in hiPSCs. Almost all the genetic mutations at the gene HBB locus can be detected by telHDAdV, which allows this new developed technology can be applied into the gene repair of different kinds of hemoglobin diseases such as SCD and Thalassemia.
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A new genome editing method brings the possibility of gene therapies closer to reality
Posted: July 12, 2014 at 9:40 am
Bench to Bedside: Mesenchymal Stem Cells and ARDS, Part 2 - Michael Matthay
http://www.ibiology.org/ibioeducation/taking-courses/bench-to-bedside/mesenchymal-stem-cells-acute-respiratory-distress-syndrome.html In Part 1, Dr. Calfee b...
By: iBioEducation
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Bench to Bedside: Mesenchymal Stem Cells and ARDS, Part 2 - Michael Matthay - Video
Posted: July 12, 2014 at 9:40 am
Professor Alexander Seifalian explains stem cell technique"
Professor Alexander Seifalian explains stem cell technique"However, last year, eight years after the stem cell operation, the woman, then 28, ... Professor Alexander Seifalian explains stem...
By: jessi jess
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Professor Alexander Seifalian explains stem cell technique" - Video
Posted: July 12, 2014 at 9:40 am
Insight: Stem Cells promo
Australians are getting a number of unproven stem cell treatments at home and abroad. Many patients claim the therapies are changing their lives for the bett...
By: Insight SBS
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Insight: Stem Cells promo - Video
Posted: July 10, 2014 at 10:43 pm
Patient Testimonial 1
By: Plexus Neuro and Stem Cell Research Centre
