Researchers have grown a miniature human intestine in    laboratory mice for the first time as part of a research    project, which claims to one day be able to cure intestinal    diseases by using a patient's own    tissue cells.  
    In a     study published in Nature Medicine, researchers    from Cincinnati    Children's Hospital Medical Centre in the US state of Ohio    said that this method "provides a new way to study the many    diseases and conditions that can cause intestinal failure, from    genetic disorders appearing at birth to conditions that strike    later in life, such as cancer and Crohn's disease."  
    In the first step, stem cells were bioengineered to grow    "organoids" of functioning human intestinal tissues from    pluripotent stem cells. These were transplanted into the    mouse's kidney capsule, which was given a blood supply.  
    The mice in question were also genetically engineered in order    to prevent the risk of their immune systems rejecting the    implanted human tissue.  
    Six to eight weeks after the transplantation, the ball of cells    had already grown larger than a regular mouse kidney. The    researchers noted that they had replicated almost all of the    tissue variations normally found within a human intestine, and    that these were capable of digesting and absorbing food.  
    According to the researchers, this procedure has created a new    model for studying intestinal disorders and diseases. As, while    this latest research grows human organs from scratch, it also    supports the idea that whole organs, built from complex    arrangements of tissues, can be generated within the patient's    body.  
    Researchers noted in the paper that studies carried out on    animals often do not produce the same    results in people. Yet they suggest that this research may    offer alternatives to animal testing in the future, as well as    produce better laboratory models of diseased tissues for drugs    testing, and speed up the development of new medicines and    treatments.  
    "These studies support the concept that patient-specific    cells can be used to grow intestines,"    said Michael Helmrath, who led the study, adding that the    research "advanced the longer-term aim of growing tissues that    can replace damaged human intestine."  
    An advantage of using the patient's own tissues in the    treatment process is that it eliminates both the risk of    transplant rejection, and the expense of needing to take    life-long drugs to prevent this    rejection.  
    While this latest research represents a step forward in terms    of stem cell and organoid research at the Cincinnati Children's    Hospital, researchers added that it could still take several    years before lab grown tissue replacements are incorporated    into medical practices.  
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Miniature human intestine grown in mice for first time