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Hair Loss Cure One Step Closer To Reality; Scientists Grow …

Posted: October 19, 2015 at 5:47 pm

The average American loses up to 100 hairs every day, and its perfectly normal. But imagine if that number increased into uncontrollably high volumes of rapid hair loss to the point of partial or complete baldness? Researchers from Sanford-Burnham Medical Research Institute believe theyve just taken a giant step toward a solution to the inevitability of balding for certain genetically susceptible people. They published their findings, which provide hope for the newly balding,in the journal PLOS ONE.

"We have developed a method using human pluripotent stem cells to create new cells capable of initiating human hair growth," said the studys lead author Dr. Alexey Terskikh, an associate professor in the Development, Aging, and Regeneration Program at Sanford-Burnham, in a press release. The method is a marked improvement over current methods that rely on transplanting existing hair follicles from one part of the head to another. Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn't limited by the availability of existing hair follicles."

Human dermal papillae cells grown from stem cells. Photo courtesy of Sanford-Burnham Medical Research Institute

The promise of a successful human stem cell hair growth trial could one day lead to the benefit of the 50 million men and 30 million women who are affected by hair loss in the United States. This could be a game changer for those who are completely bald and dont have the option of conventional hair transplant surgeries that other partially bald people can benefit from. If the treatment's success goes beyong the petri dishes, it could even open doors for those suffering from the auto-immune disease alopecia areata, which occurs when the immune system mistakenly attacks hair follicles, causing baldness.

"In adults, dermal papilla cells cannot be readily amplified outside of the body and they quickly lose their hair-inducing properties," Terskikh said. "We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice."

The technique uses pluripotent stem cells, which can be turned into almost any type of cell in the body. Terskikh and his team of researchers were able to transform them into dermal papilla cells, which are responsible for regulation hair growth in humans. Once they injected the mice with the stem cells and saw hair grow, they knew they were on the path to success.

"Our next step is to transplant human dermal papilla cells derived from human pluripotent stem cells back into human subjects," Terskikh said. "We are currently seeking partnerships to implement this final step."

Source: Terskikh A V, Gnedeva K, Vorotelyak E, Cimadamore F, Cattarossi G, and Giusto E, et al. Derivation of Hair-Inducing Cell from human Pluripotent Stem Cells. PLOS ONE. 2015.

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Stem Cells and Development – Mary Ann Liebert, Inc.

Posted: October 19, 2015 at 5:47 pm

Editor-in-Chief: Graham C. Parker, PhD

Latest Impact Factor* is 3.727 *2014 Journal Citation Reports published by Thomson Reuters, 2015

Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings.

Stem Cells and Development coverage includes:

Stem Cells and Development is under the editorial leadership of Editor-in-Chief Graham C. Parker, PhD, Wayne State University School of Medicine, Children's Hospital of Michigan; Senior Editor Hal E. Broxmeyer, PhD, Indiana University School of Medicine; and other leading investigators. View the entire editorial board.

An Official Journal of the British Society for Gene and Cell Therapy

Audience: Cell and developmental biologists, molecular biologists, regenerative medicine researchers, tissue development specialists, and genetic engineers, among others

Stem Cells and Development provides Instant Online publication 72 hours after acceptance.

The views, opinions, findings, conclusions and recommendations set forth in any Journal article are solely those of the authors of those articles and do not necessarily reflect the views, policy or position of the Journal, its Publisher, its editorial staff or any affiliated Societies and should not be attributed to any of them.

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StemEnhance Increase Adult Stem Cells from Bone Mirrow

Posted: October 19, 2015 at 5:47 pm

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Stem Cell Therapy For Treating Canine Osteoarthritis | The …

Posted: October 19, 2015 at 5:47 pm

Weekend hikes gradually turn into strolls around the block. Joyful games of fetch or Frisbee are rare. Even standing up after a nap becomes a daunting task for your faithful friend.

Anyone who has had a lifelong canine companion has also had the difficult experience of watching that companion age, becoming increasingly stiff and less interested in play. The cause is usually osteoarthritis, which affects nearly one in every five dogs. The progressive, chronic degeneration of cartilage characteristic of this condition can occur in various joints and at almost any age, and the pain that results can be debilitating.

Geriatric pets most commonly develop it in the hip, stifle (knee) or elbow; however, it is also often seen in dogs with hip or elbow dysplasia as early as one to two years of age. Treatments range from supplements and antiinflammatory medications to surgical intervention and, increasingly, stem cell therapy.

Over the last decade, regenerative medicine, which has been around in the human sphere for nearly a quarter of a century, has become more common in veterinary medicine, and stem cell therapy is at the forefront. Stem cells are the bodys way of regenerating itself. Biological blank slates, they have the potential to specialize into one of many types of cellsskin, muscle, nerve, bone, tendon or ligamentand virtually any organ, and can be found in every organ in the body.

According to Dr. Samuel Franklin, assistant professor of small animal orthopedic surgery at the University of Georgia, a good candidate for the therapy has failed treatment with less invasive and less expensive treatment and has arthritis that does not benefit from surgery. Franklin also notes that while stem cell therapy helps modulate inflammation, stem cells do not regenerate cartilage.

In 2005, Dr. Brian Voynick of the American Animal Hospital in Randolph, N.J., was the first U.S. veterinarian to use stem cell therapy in dogs. He recommends it for young dogs with early signs of hip dysplasia and lameness because it is less invasive and more proactive than surgery.

In cases of hip dysplasia, we see [improvement in] greater than 90 percent of casesbetter mobility, less or no lameness, and increased quality of life. Sometimes, we see improvement on radiographs, says Voynick. These results are typical when the therapy is used in conjunction with platelet rich plasma (PRP), a concentrated mix of platelets and growth factors taken from the patients own blood. According to Voynick, PRP turbocharges the cells activation. Once injected, stem cells have an anti-inflammatory effect within the joint and contribute to the reformation and architectural organization of the tissues.

Voynick recalls a case of a dog with severe hip osteoarthritis treated with stem cell therapy and PRP. [Before treatment] she could not stand up from a lying position. Three days later, she was walking and wagging her tail.

Normally, however, the response is not quite so dramatic. Though improvement in lameness and pain is sometimes seen within the first week, it more commonly comes within a period of about 90 days. The exact duration of the injections effectiveness is not known, but it is thought that, at least initially, monthly injections are most beneficial. Patients are rechecked at 30, 60 and 90 days post-treatment, and injections may be repeated if lameness returns.

Stem cell therapy is also being used for osteoarthritis resulting from cranial cruciate ligament (CCL) injuries. This common injury of the canine knee is more often seen in large-breed dogs but can affect dogs of all sizes. CCL injuries may be treated medically with rest and medication, or they may require surgery.

With a full [CCL] tear, we want the stabilization of surgery, says Voynick, adding that stem cell therapy can be beneficial post-operatively during rehabilitation, especially if the injury is accompanied by muscle loss.

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Adipose-Derived Mesenchymal Stem Cells; Normal … – ATCC

Posted: October 19, 2015 at 5:46 pm

Tissue Lipoaspirate: derived from white adipose tissue Morphology Spindle-shaped, fibroblast-like Biosafety Level 1

[These primary cells are not known to harbor an agent recognized to cause disease in healthy adult humans. Handle as a potentially biohazardous material under at least Biosafety Level 1 containment. Cells derived from primate lymphoid tissue may fall under the regulations of 29 CFR 1910.1030 Bloodborne Pathogens.

ATCC recommends that appropriate safety procedures be used when handling all primary cells and cell lines, especially those derived from human or other primate material. Detailed discussions of laboratory safety procedures are provided in Laboratory Safety: Principles and Practice, 2nd ed. (ASM Press, Washington, DC) (Fleming et al., 1995) and Caputo, J.L. Biosafety procedures in cell culture. (1988) J. Tissue Culture Methods 11:223.

Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the following publication: Biosafety in Microbiological and Biomedical Laboratories, 5th ed. HHS Publication No. (CDC) 93-8395. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Washington DC: U.S. Government Printing Office; 2007. The entire text is available online athttp://www.cdc.gov/biosafety/publications/bmbl5/index.htm.]

All tissues used for isolation are obtained under informed consent and conform to HIPAA standards to protect the privacy of the donors personal health information. It is best to use caution when handling any human cells. We recommend that all human cells be accorded the same level of biosafety consideration as cells known to carry HIV. With infectious virus assays or viral antigen assays, even a negative test result may leave open the possible existence of a latent viral genome.

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Adult stem cell differentiation, regenerative medicine, cell therapy, tissue engineering, creation of iPS cell lines

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California: The Leader in Stem Cell Research | California …

Posted: October 19, 2015 at 5:46 pm

En Espaol

With funding from CIRM, California has become a world-leader in stem cell research. Learn more about how CIRM changes the landscape of research in California and about laws in other states.

How will CIRM accelerate stem cell therapies? What are the economic implications of stem cell research? How does CIRM save the state money? What were the federal restrictions on human embryonic stem cell research under President Bush? How did federal regulations of human embryonic stem cell research change under President Obama? What is happening with stem cell research in other states?

As the largest source of funding for stem cell research outside the National Institutes of Health, CIRM supports innovative research programs focused on accelerating treatments to patients in need.

In addition, CIRM has also supported the construction of state-of-the-art facilities that were needed in order to build the infrastructure and perform research without the restrictions that came with federal funding under President George W. Bush.

CIRM Major Facilities Speed Stem Cell Science and Create Jobs [4:20]

CIRM has specifically targeted areas that will help push stem cell research toward the clinic. Our SEED grants pulled more scientists into stem cell research than ever before, and the Comprehensive awards supported leading stem cell scientists already in California. CIRM encouraged young faculty to commit their labs to stem cell science through two rounds of New Faculty awards. Finally, training grants and Bridges awards ensure a next generation of stem cell scientists and laboratory personnel to fill the needs of a growing stem cell research sector in California.

This NPR story discusses the value of stem cell funding in California:

Stem cell research has the potential to treat diseases that are currently burdened with high health care costsespecially chronic conditions such as heart disease, Alzheimers disease or diabetes, the costs of which threaten to cripple the healthcare system. Even if a stem cell-based therapy doesnt entirely cure a disease, reducing its impact would be an enormous economic benefit.

In addition to reduced health care costs, new therapies would allow those people to go back to work, or allow their caregivers to work again. This increased productivity funnels tax dollars right back into the state.

Stem cell research is expected to be a boon to the biotech industry, bringing new companies to the state and creating high-paying jobs. The new CIRM-funded facilities also provide construction jobs throughout the state.

CIRM funding creates jobs, saves health care costs and creates tax revenue. So far, CIRM's 12 major facilities construction projects are generating 13,000 job-years of employment, bringing in over $100 million in new tax revenue. In addition, CIRMs research grants create tens of thousands of additional job-years.

As of January 2015, CIRM has not cost the state's general fund any money. The bonds used to fund CIRM's activities were forward capitalized, so that the agency paid all its own interest costs for the first five years. Once the state begins paying interest, tax revenue generated by CIRM research grants should exceed interest costs for at least the next three to five years.

New therapies developed from CIRMfunding will be available to the state at a reduced cost, further lowering state spending on health care. Some new therapies will save money compared to current therapies. Over time, these savings should far exceed CIRMs costs to the general fund. Furthermore, intellectual property developed through CIRM funding will generate income to the state.

Individual states have passed legislation that either allow some forms of human embryonic stem cell research or specifically ban certain forms of research. A handful of states have passed laws to either fund stem cell research or at least encourage the research. Other states have laws that make the research extremely difficult and in some cases illegal.

Federal institutions could only fund research with human embryonic stem cell lines that had been created before Aug. 9, 2001when president Bush made his announcement regarding funding for stem cell research. At the time of the announcement there were only 22 lines available for federal funding, and many of those are showing signs of degradation from so many years of growing in a lab.

Because of these restrictions, the National Institutes of Health (NIH) mainly funded adult stem cell research. Federal funds could not be used to create new human embryonic stem cell lines, a strategy that is critical in order to fulfill the promise of new therapies based on embryonic stem cell research.

In addition to not funding basic research, scientists could not use any equipment or lab space that had been paid for by federal funds to do work with non-federally approved human embryonic stem cell lines. This is why CIRM invested more than $271 million in grants that have funded the construction of new stem cell research facilities where work on all types of stem cells takes place.

On March 9, 2009, President Barack Obama lifted the restrictions on federal funding for human embryonic stem cell lines created after August 9, 2001. New regulations to guide this funding were finalized by the NIH in July 2009. The first stem cell lines to be reviewed and approved under the new guidelines were announced five months later.

This decision put an end to the restrictions on working with new cell lines with federal equipment. Institutions that had previously maintained dual laboratory space and equipment for working with federal and non-federal stem cell lines could immediately start using federal equipment in research with all cell lines.

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California Researchers Look Forward to Obama's Stem Cell Research Policies (4:22)

CIRM Statement: Obama's Policies will up the Value of California's Investment inStem Cells

This NIHpage contains information about the federal stem cell policy

Updated 1/15

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California: The Leader in Stem Cell Research | California ...

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The Official Blog of CIRM, California's Stem Cell Agency

Posted: October 19, 2015 at 5:46 pm

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Cloning – Wikipedia, the free encyclopedia

Posted: October 19, 2015 at 5:45 pm

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Erectile Dysfunction in Loveland, CO

Posted: October 19, 2015 at 5:44 pm

Mallory Family Wellness offers stem cell therapy for erectile dysfunction for the residents of Loveland, Fort Collins, and the surrounding Northern Colorado communities.

ED is a mans inability to consistently produce or maintain an erection during sexual activity. Most commonly it is caused by a physical issue. Some disease related issues which can cause erectile dysfunction include: heart disease, diabetes, prostate or kidney disease, neurological disorders or blood vessel disease. Other physical causes include: surgery, injury, hormone imbalance, enlarged prostate, tobacco, drugs, alcohol or stress. In most cases it is not simply mind over matter.

ED is something many men do not like to talk about. At Mallory Family Wellness, we make it our business to talk to our patients about health concerns of all types. Our number one goal is treating the whole person and not just the symptoms. ED is nothing to be embarrassed about and is a condition we take seriously at Mallory Family Wellness.

ED can be treated successfully using stem cell therapy. Stem cells are harvested from your own body fat. Once harvested, the stem cells are purified and then infused back into the body through an intravenous (into a vein) injection. For ED, injections are also performed directly into the penis. The infused stem cells are able to transform into endothelial cells causing a secretion of vasculotrophic and neurotrophic factors. Treating erectile dysfunction with stem cell therapy increases blood flow and pressure which means a firmer, more sustainable erection. To find out more about this safe and affordable therapy contact Mallory Family Wellness at 970-669-9245.

The cost of your stem cell therapy is dependent upon your individual condition, nature of the procedure needed, and responsiveness to the therapy. Dr. Mallorys staff will discuss stem cell injection therapy prices with you on an individual basis. With regards to the therapy, it is not covered by insurance, as its categorized with other transplant type therapies and is considered investigational. It is typically eligible for coverage out of a Healthcare Savings Account (HSA) or Healthcare Retirement Account (HRA).

Payment for the procedure may be made by cash, check or HSA/HRA credit cards*. Mallory Family Wellness also works with CareCredit to provide financing options for our patients. You can be pre-approved for CareCredit financing of your procedure within a few hours.

*Patients should verify this eligibility.

Dr. Mallory specializes in regenerative medicine; visit our other stem cell therapy pages including asthma, COPD, ischemic limb disorders, and ortho-arthritic joint injury.

At Mallory Family Wellness, you are our priority. With advanced training in Osteopathic Manipulative Medicine, we dont just treat the symptoms. We treat the whole person to address the root of the problem. And well work with you so you can prevent illness and remain healthy.

See for yourself why families from Loveland, Fort Collins, and the surrounding Northern Colorado communities, as well as Wyoming, North Dakota, South Dakota, Kansas, Nebraska, and Iowa, come to us. You can count on us to provide optimal care for your optimal health!

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Erectile Dysfunction in Loveland, CO

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Epigenetics: Current Research and Emerging Trends | Book

Posted: October 19, 2015 at 5:42 pm

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