1. What is Transhumanism?  
    Transhumanism is a loosely defined movement that has developed    gradually over the past two decades. It promotes an    interdisciplinary approach to understanding and evaluating the    opportunities for enhancing the human condition and the human    organism opened up by the advancement of technology. Attention    is given to both present technologies, like genetic engineering    and information technology, and anticipated future ones, such    as molecular nanotechnology and artificial    intelligence.1  
    The enhancement options being discussed include radical    extension of human health-span, eradication of disease,    elimination of unnecessary suffering, and augmentation of human    intellectual, physical, and emotional capacities.2    Other transhumanist themes include space colonization and the    possibility of creating superintelligent machines, along with    other potential developments that could profoundly alter the    human condition. The ambit is not limited to gadgets and    medicine, but encompasses also economic, social, institutional    designs, cultural development, and psychological skills and    techniques.  
    Transhumanists view human nature as a work-in-progress, a    half-baked beginning that we can learn to remold in desirable    ways. Current humanity need not be the endpoint of evolution.    Transhumanists hope that by responsible use of science,    technology, and other rational means we shall eventually manage    to become post-human, beings with vastly greater capacities    than present human beings have.  
    Some transhumanists take active steps to increase the    probability that they personally will survive long enough to    become post-human, for example by choosing a healthy lifestyle    or by making provisions for having themselves cryonically    suspended in case of de-animation.3 In contrast to    many other ethical outlooks, which in practice often reflect a    reactionary attitude to new technologies, the transhumanist    view is guided by an evolving vision to take a more active    approach to technology policy. This vision, in broad strokes,    is to create the opportunity to live much longer and healthier    lives, to enhance our memory and other intellectual faculties,    to refine our emotional experiences and increase our subjective    sense of well-being, and generally to achieve a greater degree    of control over our own lives. This affirmation of human    potential is offered as an alternative to customary injunctions    against playing God, messing with nature, tampering with our    human essence, or displaying punishable hubris.  
    Transhumanism does not entail technological optimism. While    future technological capabilities carry immense potential for    beneficial deployments, they also could be misused to cause    enormous harm, ranging all the way to the extreme possibility    of intelligent life becoming extinct. Other potential negative    outcomes include widening social inequalities or a gradual    erosion of the hard-to-quantify assets that we care deeply    about but tend to neglect in our daily struggle for material    gain, such as meaningful human relationships and ecological    diversity. Such risks must be taken very seriously, as    thoughtful transhumanists fully acknowledge.4  
    Transhumanism has roots in secular humanist thinking, yet is    more radical in that it promotes not only traditional means of    improving human nature, such as education and cultural    refinement, but also direct application of medicine and    technology to overcome some of our basic biological limits.  
    2. A Core Transhumanist Value: Exploring the Post-human    Realm  
    The range of thoughts, feelings, experiences, and activities    that are accessible to human organisms presumably constitute    only a tiny part of what is possible. There is no reason to    think that the human mode of being is any more free of    limitations imposed by our biological nature than are the modes    of being of other animals. Just as chimpanzees lack the    brainpower to understand what it is like to be human, so too do    we lack the practical ability to form a realistic intuitive    understanding of what it would be like to be post-human.  
    This point is distinct from any principled claims about    impossibility. We need not assert that post-humans would not be    Turing computable or that their concepts could not be expressed    by any finite sentences in human language. The impossibility    is more like the impossibility for us to visualize a    twenty-dimensional hypersphere or to read, with perfect    recollection and understanding, every book in the Library of    Congress. Our own current mode of being, therefore, spans but a    minute subspace of what is possible or permitted by the    physical constraints of the universe. It is not farfetched to    suppose that there are parts of this larger space that    represent extremely valuable ways of living, feeling, and    thinking.  
    We can conceive of aesthetic and contemplative pleasures whose    blissfulness vastly exceeds what any human being has yet    experienced. We can imagine beings that reach a much greater    level of personal development and maturity than current human    beings do, because they have the opportunity to live for    hundreds or thousands of years with full bodily and psychic    vigor. We can conceive of beings that are much smarter than us,    that can read books in seconds, that are much more brilliant    philosophers than we are, that can create artworks, which, even    if we could understand them only on the most superficial level,    would strike us as wonderful masterpieces. We can imagine love    that is stronger, purer, and more secure than any human being    has yet harbored. Our everyday intuitions about values are    constrained by the narrowness of our experience and the    limitations of our powers of imagination. We should leave room    in our thinking for the possibility that as we develop greater    capacities, we shall come to discover values that will strike    us as being of a far higher order than those we can realize as    un-enhanced biological humans beings.  
    The conjecture that there are greater values than we can    currently fathom does not imply that values are not defined in    terms of our current dispositions. Take, for example, a    dispositional theory of value such as the one described by    David Lewis.5 According to Lewiss theory, something    is a value for you if and only if you would want to want it if    you were perfectly acquainted with it and you were thinking and    deliberating as clearly as possible about it. On this view,    there may be values that we do not currently want, and that we    do not even currently want to want, because we may not be    perfectly acquainted with them or because we are not ideal    deliberators. Some values pertaining to certain forms of    post-human existence may well be of this sort; they may be    values for us now, and they may be so in virtue of our current    dispositions, and yet we may not be able to fully appreciate    them with our current limited deliberative capacities and our    lack of the receptive faculties required for full acquaintance    with them. This point is important because it shows that the    transhumanist view that we ought to explore the realm of    post-human values does not entail that we should forego our    current values. The post-human values can be our current    values, albeit ones that we have not yet clearly comprehended.    Transhumanism does not require us to say that we should favor    post-human beings over human beings, but that the right way of    favoring human beings is by enabling us to realize our ideals    better and that some of our ideals may well be located outside    the space of modes of being that are accessible to us with our    current biological constitution.  
    We can overcome many of our biological limitations. It is    possible that there are some limitations that are impossible    for us to transcend, not only because of technological    difficulties but on metaphysical grounds. Depending on what our    views are about what constitutes personal identity, it could be    that certain modes of being, while possible, are not possible    for us, because any being of such a kind would be so different    from us that they could not be us. Concerns of this kind are    familiar from theological discussions of the afterlife. In    Christian theology, some souls will be allowed by God to go to    heaven after their time as corporal creatures is over. Before    being admitted to heaven, the souls would undergo a    purification process in which they would lose many of their    previous bodily attributes. Skeptics may doubt that the    resulting minds would be sufficiently similar to our current    minds for it to be possible for them to be the same person. A    similar predicament arises within transhumanism: if the mode of    being of a post-human being is radically different from that of    a human being, then we may doubt whether a post-human being    could be the same person as a human being, even if the    post-human being originated from a human being.  
    We can, however, envision many enhancements that would not make    it impossible for the post-transformation someone to be the    same person as the pre-transformation person. A person could    obtain considerable increased life expectancy, intelligence,    health, memory, and emotional sensitivity, without ceasing to    exist in the process. A persons intellectual life can be    transformed radically by getting an education. A persons life    expectancy can be extended substantially by being unexpectedly    cured from a lethal disease. Yet these developments are not    viewed as spelling the end of the original person. In    particular, it seems that modifications that add to a persons    capacities can be more substantial than modifications that    subtract, such as brain damage. If most of someone currently    is, including her most important memories, activities, and    feelings, is preserved, then adding extra capacities on top of    that would not easily cause the person to cease to exist.  
    Preservation of personal identity, especially if this notion is    given a narrow construal, is not everything. We can value other    things than ourselves, or we might regard it as satisfactory if    some parts or aspects of ourselves survive and flourish, even    if that entails giving up some parts of ourselves such that we    no longer count as being the same person. Which parts of    ourselves we might be willing to sacrifice may not become clear    until we are more fully acquainted with the full meaning of the    options. A careful, incremental exploration of the post-human    realm may be indispensable for acquiring such an understanding,    although we may also be able to learn from each others    experiences and from works of the imagination. Additionally, we    may favor future people being posthuman rather than human, if    the posthumans would lead lives more worthwhile than the    alternative humans would. Any reasons stemming from such    considerations would not depend on the assumption that we    ourselves could become posthuman beings.  
    Transhumanism promotes the quest to develop further so that we    can explore hitherto inaccessible realms of value.    Technological enhancement of human organisms is a means that we    ought to pursue to this end. There are limits to how much can    be achieved by low-tech means such as education, philosophical    contemplation, moral self-scrutiny and other such methods    proposed by classical philosophers with perfectionist leanings,    including Plato, Aristotle, and Nietzsche, or by means of    creating a fairer and better society, as envisioned by social    reformists such as Marx or Martin Luther King. This is not to    denigrate what we can do with the tools we have today. Yet    ultimately, transhumanists hope to go further.  
    3. The Morality of Human Germ-Line Genetic Engineering  
    Most potential human enhancement technologies have so far    received scant attention in the ethics literature. One    exception is genetic engineering, the morality of which has    been extensively debated in recent years. To illustrate how the    transhumanist approach can be applied to particular    technologies, we shall therefore now turn to consider the case    of human germ-line genetic enhancements.  
    Certain types of objection against germ-line modifications are    not accorded much weight by a transhumanist interlocutor. For    instance, objections that are based on the idea that there is    something inherently wrong or morally suspect in using science    to manipulate human nature are regarded by transhumanists as    wrongheaded. Moreover, transhumanists emphasize that particular    concerns about negative aspects of genetic enhancements, even    when such concerns are legitimate, must be judged against the    potentially enormous benefits that could come from genetic    technology successfully employed.6 For example, many    commentators worry about the psychological effects of the use    of germ-line engineering. The ability to select the genes of    our children and to create so-called designer babies will, it    is claimed, corrupt parents, who will come to view their    children as mere products.7 We will then begin to    evaluate our offspring according to standards of quality    control, and this will undermine the ethical ideal of    unconditional acceptance of children, no matter what their    abilities and traits. Are we really prepared to sacrifice on    the altar of consumerism even those deep values that are    embodied in traditional relationships between child and    parents? Is the quest for perfection worth this cultural and    moral cost? A transhumanist should not dismiss such concerns as    irrelevant. Transhumanists recognize that the depicted outcome    would be bad. We do not want parents to love and respect their    children less. We do not want social prejudice against people    with disabilities to get worse. The psychological and cultural    effects of commodifying human nature are potentially important.  
    But such dystopian scenarios are speculations. There is no firm    ground for believing that the alleged consequences would    actually happen. What relevant evidence we have, for instance    regarding the treatment of children who have been conceived    through the use of in vitro fertilization or embryo screening,    suggests that the pessimistic prognosis is alarmist. Parents    will in fact love and respect their children even when    artificial means and conscious choice play a part in    procreation.  
    We might speculate, instead, that germ-line enhancements will    lead to more love and parental dedication. Some mothers and    fathers might find it easier to love a child who, thanks to    enhancements, is bright, beautiful, healthy, and happy. The    practice of germ-line enhancement might lead to better    treatment of people with disabilities, because a general    demystification of the genetic contributions to human traits    could make it clearer that people with disabilities are not to    blame for their disabilities and a decreased incidence of some    disabilities could lead to more assistance being available for    the remaining affected people to enable them to live full,    unrestricted lives through various technological and social    supports. Speculating about possible psychological or cultural    effects of germ-line engineering can therefore cut both ways.    Good consequences no less than bad ones are possible. In the    absence of sound arguments for the view that the negative    consequences would predominate, such speculations provide no    reason against moving forward with the technology.  
    Ruminations over hypothetical side-effects may serve to make us    aware of things that could go wrong so that we can be on the    lookout for untoward developments. By being aware of the perils    in advance, we will be in a better position to take preventive    countermeasures. For instance, if we think that some people    would fail to realize that a human clone would be a unique    person deserving just as much respect and dignity as any other    human being, we could work harder to educate the public on the    inadequacy of genetic determinism. The theoretical    contributions of well-informed and reasonable critics of    germ-line enhancement could indirectly add to our justification    for proceeding with germ-line engineering. To the extent that    the critics have done their job, they can alert us to many of    the potential untoward consequences of germ-line engineering    and contribute to our ability to take precautions, thus    improving the odds that the balance of effects will be    positive. There may well be some negative consequences of human    germ-line engineering that we will not forestall, though of    course the mere existence of negative effects is not a decisive    reason not to proceed. Every major technology has some negative    consequences. Only after a fair comparison of the risks with    the likely positive consequences can any conclusion based on a    cost-benefit analysis be reached.  
    In the case of germ-line enhancements, the potential gains are    enormous. Only rarely, however, are the potential gains    discussed, perhaps because they are too obvious to be of much    theoretical interest. By contrast, uncovering subtle and    non-trivial ways in which manipulating our genome could    undermine deep values is philosophically a lot more    challenging. But if we think about it, we recognize that the    promise of genetic enhancements is anything but insignificant.    Being free from severe genetic diseases would be good, as would    having a mind that can learn more quickly, or having a more    robust immune system. Healthier, wittier, happier people may be    able to reach new levels culturally. To achieve a significant    enhancement of human capacities would be to embark on the    transhuman journey of exploration of some of the modes of being    that are not accessible to us as we are currently constituted,    possibly to discover and to instantiate important new values.    On an even more basic level, genetic engineering holds great    potential for alleviating unnecessary human suffering. Every    day that the introduction of effective human genetic    enhancement is delayed is a day of lost individual and cultural    potential, and a day of torment for many unfortunate sufferers    of diseases that could have been prevented. Seen in this light,    proponents of a ban or a moratorium on human genetic    modification must take on a heavy burden of proof in order to    have the balance of reason tilt in their favor. Transhumanists    conclude that the challenge has not been met.  
    4. Should Human Reproduction be Regulated?  
    One way of going forward with genetic engineering is to permit    everything, leaving all choices to parents. While this attitude    may be consistent with transhumanism, it is not the best    transhumanist approach. One thing that can be said for adopting    a libertarian stance in regard to human reproduction is the    sorry track record of socially planned attempts to improve the    human gene pool. The list of historical examples of state    intervention in this domain ranges from the genocidal horrors    of the Nazi regime, to the incomparably milder but still    disgraceful semi-coercive sterilization programs of mentally    impaired individuals favored by many well-meaning socialists in    the past century, to the controversial but perhaps    understandable program of the current Chinese government to    limit population growth. In each case, state policies    interfered with the reproductive choices of individuals. If    parents had been left to make the choices for themselves, the    worst transgressions of the eugenics movement would not have    occurred. Bearing this in mind, we ought to think twice before    giving our support to any proposal that would have the state    regulate what sort of children people are allowed to have and    the methods that may be used to conceive them.8  
    We currently permit governments to have a role in reproduction    and child-rearing and we may reason by extension that there    would likewise be a role in regulating the application of    genetic reproductive technology. State agencies and regulators    play a supportive and supervisory role, attempting to promote    the interests of the child. Courts intervene in cases of child    abuse or neglect. Some social policies are in place to support    children from disadvantaged backgrounds and to ameliorate some    of the worst inequities suffered by children from poor homes,    such as through the provision of free schooling. These measures    have analogues that apply to genetic enhancement technologies.    For example, we ought to outlaw genetic modifications that are    intended to damage the child or limit its opportunities in    life, or that are judged to be too risky. If there are basic    enhancements that would be beneficial for a child but that some    parents cannot afford, then we should consider subsidizing    those enhancements, just as we do with basic education. There    are grounds for thinking that the libertarian approach is less    appropriate in the realm of reproduction than it is in other    areas. In reproduction, the most important interests at stake    are those of the child-to-be, who cannot give his or her    advance consent or freely enter into any form of contract. As    it is, we currently approve of many measures that limit    parental freedoms. We have laws against child abuse and child    neglect. We have obligatory schooling. In some cases, we can    force needed medical treatment on a child, even against the    wishes of its parents.  
    There is a difference between these social interventions with    regard to children and interventions aimed at genetic    enhancements. While there is a consensus that nobody should be    subjected to child abuse and that all children should have at    least a basic education and should receive necessary medical    care, it is unlikely that we will reach an agreement on    proposals for genetic enhancements any time soon. Many parents    will resist such proposals on principled grounds, including    deep-seated religious or moral convictions. The best policy for    the foreseeable future may therefore be to not legally require    any genetic enhancements, except perhaps in extreme cases for    which there is no alternative treatment. Even in such cases, it    is dubious that the social climate in many countries is ready    for mandatory genetic interventions.  
    The scope for ethics and public policy, however, extend far    beyond the passing of laws requiring or banning specific    interventions. Even if a given enhancement option is neither    outlawed nor legally required, we may still seek to discourage    or encourage its use in a variety of ways. Through subsidies    and taxes, research-funding policies, genetic counseling    practices and guidelines, laws regulating genetic information    and genetic discrimination, provision of health care services,    regulation of the insurance industry, patent law, education,    and through the allocation of social approbation and    disapproval, we may influence the direction in which particular    technologies are applied. We may appropriately ask, with regard    to genetic enhancement technologies, which types of    applications we ought to promote or discourage.  
    5. Which Modifications Should Be Promoted and which    Discouraged?  
    An externality, as understood by economists, is a cost or a    benefit of an action that is not carried by a decision-maker.    An example of a negative externality might be found in a firm    that lowers its production costs by polluting the environment.    The firm enjoys most of the benefits while escaping the costs,    such as environmental degradation, which may instead paid by    people living nearby. Externalities can also be positive, as    when people put time and effort into creating a beautiful    garden outside their house. The effects are enjoyed not    exclusively by the gardeners but spill over to passersby. As a    rule of thumb, sound social policy and social norms would have    us internalize many externalities so that the incentives of    producers more closely match the social value of production. We    may levy a pollution tax on the polluting firm, for instance,    and give our praise to the home gardeners who beautify the    neighborhood.  
    Genetic enhancements aimed at the obtainment of goods that are    desirable only in so far as they provide a competitive    advantage tend to have negative externalities. An example of    such a positional good, as economists call them, is stature.    There is evidence that being tall is statistically    advantageous, at least for men in Western societies. Taller men    earn more money, wield greater social influence, and are viewed    as more sexually attractive. Parents wanting to give their    child the best possible start in life may rationally choose a    genetic enhancement that adds an inch or two to the expected    length of their offspring. Yet for society as a whole, there    seems to be no advantage whatsoever in people being taller. If    everybody grew two inches, nobody would be better off than they    were before. Money spent on a positional good like length has    little or no net effect on social welfare and is therefore,    from societys point of view, wasted.  
    Health is a very different type of good. It has intrinsic    benefits. If we become healthier, we are personally better off    and others are not any worse off. There may even be a positive    externality of enhancing ours own health. If we are less likely    to contract a contagious disease, others benefit by being less    likely to get infected by us. Being healthier, you may also    contribute more to society and consume less of publicly funded    healthcare.  
    If we were living in a simple world where people were perfectly    rational self-interested economic agents and where social    policies had no costs or unintended effects, then the basic    policy prescription regarding genetic enhancements would be    relatively straightforward. We should internalize the    externalities of genetic enhancements by taxing enhancements    that have negative externalities and subsidizing enhancements    that have positive externalities. Unfortunately, crafting    policies that work well in practice is considerably more    difficult. Even determining the net size of the externalities    of a particular genetic enhancement can be difficult. There is    clearly an intrinsic value to enhancing memory or intelligence    in as much as most of us would like to be a bit smarter, even    if that did not have the slightest effect on our standing in    relation to others. But there would also be important    externalities, both positive and negative. On the negative    side, others would suffer some disadvantage from our increased    brainpower in that their own competitive situation would be    worsened. Being more intelligent, we would be more likely to    attain high-status positions in society, positions that would    otherwise have been enjoyed by a competitor. On the positive    side, others might benefit from enjoying witty conversations    with us and from our increased taxes.  
    If in the case of intelligence enhancement the positive    externalities outweigh the negative ones, then a prima    facie case exists not only for permitting genetic    enhancements aimed at increasing intellectual ability, but for    encouraging and subsidizing them too. Whether such policies    remain a good idea when all practicalities of implementation    and political realities are taken into account is another    matter. But at least we can conclude that an enhancement that    has both significant intrinsic benefits for an enhanced    individual and net positive externalities for the rest of    society should be encouraged. By contrast, enhancements that    confer only positional advantages, such as augmentation of    stature or physical attractiveness, should not be socially    encouraged, and we might even attempt to make a case for social    policies aimed at reducing expenditure on such goods, for    instance through a progressive tax on consumption.9  
    6. The Issue of Equality  
    One important kind of externality in germ-line enhancements is    their effects on social equality. This has been a focus for    many opponents of germ-line genetic engineering who worry that    it will widen the gap between haves and have-nots. Today,    children from wealthy homes enjoy many environmental    privileges, including access to better schools and social    networks. Arguably, this constitutes an inequity against    children from poor homes. We can imagine scenarios where such    inequities grow much larger thanks to genetic interventions    that only the rich can afford, adding genetic advantages to the    environmental advantages already benefiting privileged    children. We could even speculate about the members of the    privileged stratum of society eventually enhancing themselves    and their offspring to a point where the human species, for    many practical purposes, splits into two or more species that    have little in common except a shared evolutionary    history.10 The genetically privileged might become    ageless, healthy, super-geniuses of flawless physical beauty,    who are graced with a sparkling wit and a disarmingly    self-deprecating sense of humor, radiating warmth, empathetic    charm, and relaxed confidence. The non-privileged would remain    as people are today but perhaps deprived of some their    self-respect and suffering occasional bouts of envy. The    mobility between the lower and the upper classes might    disappear, and a child born to poor parents, lacking genetic    enhancements, might find it impossible to successfully compete    against the super-children of the rich. Even if no    discrimination or exploitation of the lower class occurred,    there is still something disturbing about the prospect of a    society with such extreme inequalities.  
    While we have vast inequalities today and regard many of these    as unfair, we also accept a wide range of inequalities because    we think that they are deserved, have social benefits, or are    unavoidable concomitants to free individuals making their own    and sometimes foolish choices about how to live their lives.    Some of these justifications can also be used to exonerate some    inequalities that could result from germ-line engineering.    Moreover, the increase in unjust inequalities due to technology    is not a sufficient reason for discouraging the development and    use of the technology. We must also consider its benefits,    which include not only positive externalities but also    intrinsic values that reside in such goods as the enjoyment of    health, a soaring mind, and emotional well-being.  
    We can also try to counteract some of the inequality-increasing    tendencies of enhancement technology with social policies. One    way of doing so would be by widening access to the technology    by subsidizing it or providing it for free to children of poor    parents. In cases where the enhancement has considerable    positive externalities, such a policy may actually benefit    everybody, not just the recipients of the subsidy. In other    cases, we could support the policy on the basis of social    justice and solidarity.  
    Even if all genetic enhancements were made available to    everybody for free, however, this might still not completely    allay the concern about inequity. Some parents might choose not    to give their children any enhancements. The children would    then have diminished opportunities through no fault of their    own. It would be peculiar, however, to argue that governments    should respond to this problem by limiting the reproductive    freedom of the parents who wish to use genetic enhancements. If    we are willing to limit reproductive freedom through    legislation for the sake of reducing inequities, then we might    as well make some enhancements obligatory for all children. By    requiring genetic enhancements for everybody to the same    degree, we would not only prevent an increase in inequalities    but also reap the intrinsic benefits and the positive    externalities that would come from the universal application of    enhancement technology. If reproductive freedom is regarded as    too precious to be curtailed, then neither requiring nor    banning the use of reproductive enhancement technology is an    available option. In that case, we would either have to    tolerate inequities as a price worth paying for reproductive    freedom or seek to remedy the inequities in ways that do not    infringe on reproductive freedom.  
    All of this is based on the hypothesis that germ-line    engineering would in fact increase inequalities if left    unregulated and no countermeasures were taken. That hypothesis    might be false. In particular, it might turn out to be    technologically easier to cure gross genetic defects than to    enhance an already healthy genetic constitution. We currently    know much more about many specific inheritable diseases, some    of which are due to single gene defects, than we do about the    genetic basis of talents and desirable qualities such as    intelligence and longevity, which in all likelihood are encoded    in complex constellations of multiple genes. If this turns out    to be the case, then the trajectory of human genetic    enhancement may be one in which the first thing to happen is    that the lot of the genetically worst-off is radically    improved, through the elimination of diseases such as Tay    Sachs, Lesch-Nyhan, Downs Syndrome, and early-onset Alzheimers    disease. This would have a major leveling effect on    inequalities, not primarily in the monetary sense, but with    respect to the even more fundamental parameters of basic    opportunities and quality of life.  
    7. Are Germ-Line Interventions Wrong Because They Are    Irreversible?  
    Another frequently heard objection against germ-line genetic    engineering is that it would be uniquely hazardous because the    changes it would bring are irreversible and would affect all    generations to come. It would be highly irresponsible and    arrogant of us to presume we have the wisdom to make decisions    about what should be the genetic constitutions of people living    many generations hence. Human fallibility, on this objection,    gives us good reason not to embark on germ-line interventions.    For our present purposes, we can set aside the issue of the    safety of the procedure, understood narrowly, and stipulate    that the risk of medical side-effects has been reduced to an    acceptable level. The objection under consideration concerns    the irreversibility of germ-line interventions and the lack of    predictability of its long-term consequences; it forces us to    ask if we possess the requisite wisdom for making genetic    choices on behalf of future generations.  
    Human fallibility is not a conclusive ground for resisting    germ-line genetic enhancements. The claim that such    interventions would be irreversible is incorrect. Germ-line    interventions can be reversed by other germ-line interventions.    Moreover, considering that technological progress in genetics    is unlikely to grind to an abrupt halt any time soon, we can    count on future generations being able to reverse our current    germ-line interventions even more easily than we can currently    implement them. With advanced genetic technology, it might even    be possible to reverse many germ-line modifications with    somatic gene therapy, or with medical    nanotechnology.11 Technologically, germ-line changes    are perfectly reversible by future generations.  
    It is possible that future generations might choose to retain    the modifications that we make. If that turns out to be the    case, then the modifications, while not irreversible, would    nevertheless not actually be reversed. This might be a good    thing. The possibility of permanent consequences is not an    objection against germ-line interventions any more than it is    against social reforms. The abolition of slavery and the    introduction of general suffrage might never be reversed;    indeed, we hope they will not be. Yet this is no reason for    people to have resisted the reforms. Likewise, the potential    for everlasting consequences, including ones we cannot    currently reliably forecast, in itself constitutes no reason to    oppose genetic intervention. If immunity against horrible    diseases and enhancements that expand the opportunities for    human growth are passed on to subsequent generations in    perpetuo, it would be a cause for celebration, not regret.  
    There are some kinds of changes that we need be particularly    careful about. They include modifications of the drives and    motivations of our descendants. For example, there are obvious    reasons why we might think it worthwhile to seek to reduce our    childrens propensity to violence and aggression. We would have    to take care, however, that we do not do this in a way that    would make future people overly submissive or complacent. We    can conceive of a dystopian scenario along the lines of    Brave New World, in which people are leading shallow    lives but have been manipulated to be perfectly content with    their sub-optimal existence. If the people transferred their    shallow values to their children, humanity could get    permanently stuck in a not-very-good state, having foolishly    changed itself to lack any desire to strive for something    better. This outcome would be dystopian because a permanent cap    on human development would destroy the transhumanist hope of    exploring the post-human realm. Transhumanists therefore place    an emphasis on modifications which, in addition to promoting    human well-being, also open more possibilities than they close    and which increase our ability to make subsequent choices    wisely. Longer active lifespans, better memory, and greater    intellectual capacities are plausible candidates for    enhancements that would improve our ability to figure out what    we ought to do next. They would be a good place to    start.12  
    Notes  
    1. See Eric K. Drexler,    Nanosystems: Molecular Machinery, Manufacturing, and    Computation (New York: John Wiley & Sons, Inc., 1992);    Ray Kurzweil, The Age of Spiritual Machines: When Computers    Exceed Human Intelligence (New York: Viking, 1999); Hans    Moravec, Robot: Mere Machine to Transcendent Mind. (New    York: Oxford University Press, 1999).  
    2. See Robert A. Freitas    Jr., Nanomedicine, Volume 1: Basic Capabilities    (Georgetown, Tex.: Landes Bioscience, 1999).  
    3. See Robert Ettinger,    The Prospect of Immortality (New York: Doubleday, 1964);    James Hughes, The Future of Death: Cryonics and the Telos of    Liberal Individualism, Journal of Evolution and    Technology 6 (2001).  
    4. See Eric K. Drexler,    Engines of Creation: The Coming Era of Nanotechnology    (London: Fourth Estate, 1985).  
    5. See David Lewis,    Dispositional Theories of Value, Proceedings of the    Aristotelian Society Supp. 63 (1989).  
    6. See Erik Parens, ed.,    Enhancing Human Traits: Ethical and Social Implications.    (Washington, D. C: Georgetown University Press, 1998).  
    7. See Leon Kass, Life,    Liberty, and Defense of Dignity: The Challenge for    Bioethics (San Francisco: Encounter Books, 2002).  
    8. See Jonathan Glover,    What Sort of People Should There Be? (New York: Penguin,    1984); Gregory Stock, Redesigning Humans: Our Inevitable    Genetic Future (New York, Houghton Mifflin, 2002); and    Allen Buchanan et al., From Chance to Choice: Genetics &    Justice (Cambridge, England: Cambridge University Press,    2002).  
    9. See Robert H. Frank,    Luxury Fever: Why Money Fails to Satisfy in an Era of    Excess (New York: Free Press, 1999).  
    10. Cf. Lee M. Silver, Remaking Eden: How    Genetic Engineering and Cloning will Transform the American    Family (New York: Avon Books, 1997); and Nancy Kress,    Beggars in Spain (Avon Books, 1993).  
    11. See Freitas, op. cit.  
    12. For their helpful comments I am grateful    to Heather Bradshaw, Robert A. Freitas Jr., James Hughes,    Gerald Lang, Matthew Liao, Thomas Magnell, David Rodin, Jeffrey    Soreff, Mike Treder, Mark Walker, Michael Weingarten, and an    anonymous referee of the Journal of Value Inquiry.  
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Human Genetic Enhancements: A Transhumanist Perspective