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Why so many biotechnology start-ups, like Theranos, fail | Genetic … – Genetic Literacy Project

Posted: April 25, 2017 at 4:42 am

Two years after the $9 billion start-up unicorn Theranos crumbled, Silicon Valley still appears to be struggling to learn its lesson when it comes to health and medical start-ups. Improbable-sounding companies continue to turn up with tens of millions of dollars in funding, no published research to back them up, and nothing but criticism from scientists.

Venture-capital firms insist that the standard that needs to be met for investment is much higher for medical start-ups, which must prove that their technology works with data, not just a pitch. And yet somehow, when these start-ups finally surface to public consciousness, they dont appear to pass even the most basic smell test with literally any experienced researcher in the field.

There is a pervasive sense in Silicon Valley, bolstered by ten years of world-conquering success, that any sufficiently intelligent, sufficiently driven person can will what they want.

But the move fast and break things mantra that has helped Silicon Valley disrupt countless industries over the last two decades is more dangerous when applied to medical scienceThe things being broken by health start-ups are laws of science and ironclad guidelines for research. When a health start-up moves fast and breaks things, it can directly result in the death, dismemberment, and injury of real people.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Why Silicon Valley Keeps Getting Biotechnology Wrong

For more background on the Genetic Literacy Project, read GLP on Wikipedia

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Life Extension and Insilico Medicine Use AI to Develop Ageless Cell – WholeFoods Magazine

Posted: April 25, 2017 at 4:41 am

Fort Lauderdale, FL Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and inflammatory response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points a process that could have taken decades to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

Specifically, NAC upregulates signaling pathways that protect cells against oxidative stress, which promotes cellular senescence. It also reduces pathways that promote inflammation. Myricetin regulates a family of stress-responsive signaling molecules known to regulate aging in many tissues. It also promotes cell differentiation and self-repair. Gamma tocotrienol modulates the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation. And EGCG regulates the Wnt pathway that determines the fate of developing cells and also prevents sugar-induced damage to tissues, helping to suppress their pro-aging effects.

Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets, said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.

Scientists found these four nutrients have various complementary and reinforcing properties to influence key anti-aging pathways and combat aging factors by modulating specific biological pathways. By rejuvenating near-senescent cells and encouraging the bodys healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level, said Michael A. Smith, M.D., senior health scientist for Life Extension. Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine said, Together, these four natural compounds represent the beginning of the future anti-aging cocktails identified using artificial intelligence under expert human supervision.

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Scientists step closer to finding cause of multiple sclerosis – Medical News Today

Posted: April 25, 2017 at 4:41 am

As they find out more about the cell biology of multiple sclerosis, scientists are gradually unraveling the mysteries of the disease, although the exact causes are still unclear. Now, a new study continues this progress with a significant discovery about a new cellular mechanism. It suggests that high levels of the protein Rab32 disrupt key communications involving mitochondria. The disruption causes these "cellular batteries" to misbehave, leading to the toxic effects seen in the brain cells of people with multiple sclerosis.

The new study is the work of researchers from the University of Exeter in the United Kingdom and the University of Alberta in Canada. They report their findings in the Journal of Neuroinflammation.

Co-author Paul Eggleton, an immunologist and professor at the University of Exeter Medical School, says that multiple sclerosis can have a "devastating impact on people's lives," and yet, unfortunately, the present situation is that "all medicine can offer is treatment and therapy for the symptoms."

Multiple sclerosis (MS) is a disease in which the immune system mistakenly attacks tissue of the central nervous system - which comprises the brain, spinal cord, and optic nerve.

As the disease progresses, it destroys more and more of the fatty myelin sheath that insulates and protects the nerve fibers that send electrical messages in the central nervous system.

This destruction can lead to brain damage, vision impairment, pain, altered sensation, extreme fatigue, problems with movement, and other symptoms.

As research into the cause of MS progresses, scientists are becoming increasingly interested in the role of mitochondria - the tiny components inside cells that produce units of energy for powering the cell.

Fast facts about MS

Learn more about MS

In earlier work, the team behind the new study was the first to provide an explanation for the role of defective mitochondria in MS through clinical and laboratory experiments.

In their new investigation, the researchers study a protein called Rab32, which is known to be involved in certain mitochondrial processes.

They found that levels of Rab32 are much higher in the brains of people with MS and hardly detectable in brains of people without the disease.

They also discovered that the presence of Rab32 coincides with disruption to a communication system that causes mitochondria to malfunction, causing toxic effects in the brain cells of people with MS.

The disruption is caused by a cell compartment called the endoplasmic reticulum (ER) being too close to the mitochondria.

The ER produces, processes, and transports many compounds that are used inside and outside the cell.

The researchers note that one of the functions of the ER is to store calcium, and if the distance between the ER and mitochondria is too short, it disrupts the communication between the mitochondria and the calcium supply.

Calcium uptake into mitochondria is already known to be critical to cell functioning.

Although they did not discover what causes Rab32 levels to increase, the team believes that the problem may lie in a defect in the base of the ER.

The study could help scientists to find ways to use Rab32 as a treatment target, as well as look for other proteins that may cause similar disruptions, note the authors.

"Our exciting new findings have uncovered a new avenue for researchers to explore. It is a critical step, and in time, we hope it might lead to effective new treatments for MS."

Prof. Paul Eggleton

Learn how a new immunotherapy reversed paralysis in mouse models of MS.

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Experimental Stem Cell Therapy Could Treat Damaged Knee Cartilage – BU News Service

Posted: April 25, 2017 at 4:41 am

Skiing in Aspen, Sean Fair mistimed a landing and felt a shooting pain in his right knee as he crumpled into the snow. He had to slide down the steep slope on his left ski. The doctor revealed that Fairs agony originated from a quarter-sized hole in the cartilage of his knee.

For an active person like Fair, traditional surgery options, like a total knee replacement, restrict motion and are less than ideal. Advances in experimental cartilage repair stem cell treatments, however, now offer new opportunities for young patients to preserve mobility, that defining value of youth.

Fair played football, among other sports, in high school. He played tennis in college and continued to play until he had his ski incident at the age of 31.

All of a sudden, not being able to do anything, I felt 80, he said. All my friends would play tennis together but I would have to sit back and watch.

Sean Fair was diagnosed with OCD, or osteochondritis dissecans. This condition typically develops in teenagers but doesnt usually present symptoms until adulthood when the joint experiences some form of trauma. OCD lesions involve holes, cracks, or loose articular cartilage in a joint.

Fair met with Dr. Andreas Gomoll, an orthopedic surgeon at the Brigham and Womens Hospital in Boston. They discussed knee replacement surgery, microfracture surgery and the possibility of using healthy cartilage from a cadaver donor.

Knee replacement surgery for patients as young as Fair often results with low satisfaction. People who receive the standard metal and plastic knee replacement are functionally limited and face unexpected physical challenges when it comes to activities more intense than a walk. Microfracture surgery would be better, but Fairs injury was too large for that to be practical. Fair and Gomoll decided to wait for a cadaver donor. While waiting, however, Fair joined a clinical trial to test a new approach that would fill the gap in his cartilage with stem cells.

Stem cells can be thought of as undecided cells. Theyre mostly present in embryos and neonates, but they are also found in adults as well. Given the correct environment, and depending on the type of stem cell, they can become more specific cells, like muscle cells or cartilage-forming cells. In Fairs case, Gomoll used donated umbilical cord stem cells from healthy babies delivered in the US. Umbilical cord stem cells are useful because they are able to morph into cartilage-forming cells, they dont require the destruction of an embryo and they have immunosuppressive properties that wouldnt cause Fairs body to reject them.

Anatomical representation of the human knee.

The procedure looked simple. Gomoll made a vertical incision in Fairs kneecap, cutting through the skin and the yellow fat to expose the white cartilage. Gomoll used stainless steel tools to clamp open the incision, while he used a metal ring spanner to scrape the edges of the cartilage pothole. (Picture using a spoon to carve a hole in a large eraser.) Next, the surgeon drilled seven coffee stirrer-sized holes into the bone at the bottom of the quarter-sized pothole. He injected the clear stem cell gel into each coffee stirrer-sized hole and then filled the quarter-sized hole up to its edges with the rest of the stem cell gel. Gomoll smoothed down the stem cell gel like icing on a cake. Then he sutured the wound closed.

Fair wasnt quick to start walking right after the procedure. His knee needed to heal and then he would have to follow a strict rehabilitation process of weekly physical therapy sessions.

Months after his surgery, the stem cells in Fairs knee developed into chondrocytes, cells that secrete a matrix of cartilage, and sealed the pothole in Fairs knee. As of now, Fair is thankful for his treatment. His right knee has healed, but hes still not at 100 percent.

My other knee unfortunately, because of all the issues the [right knee] had, also needs reconstruction, Fair said. Ive got to be careful when I carry my two-and-half-yearold down the steps. Functionally I can walk. I can chase him. I can outrun him, still. Other than that, its not a lot of peripheral movement I can do yet.

According to Gomoll, about 15 other Americans have received the same experimental treatment as Fair. Before this therapy can be offered at any hospital in the US, the clinical trial must obtain FDA approval after proving its efficacy with a larger, more randomized sample of patients. But Gomoll doesnt seem too worried. He says hundreds of patients in South Korea have already undergone the same procedure. Getting there will take some time and money; running comprehensive trials is expensive. Once the procedure is approved, Gomoll imagines thousands of cartilage damaged patients like Fair would potentially be treated with stem cells in the United States.

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Global Stem Cell Therapy Market – Analysis, Technologies and … – Yahoo Finance

Posted: April 25, 2017 at 4:41 am

DUBLIN, April 24, 2017 /PRNewswire/ --

Research and Markets has announced the addition of the "Global Stem Cell Therapy Market 2017-2021" report to their offering.

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The global stem cell therapy market to grow at a CAGR of 36.52% during the period 2017-2021.

The report, Global Stem Cell Therapy Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.

The latest trend gaining momentum in the market is evolution of new destinations in the development of stem cell therapies. Traditionally, the US and European countries are the key destinations for clinical trials for stem cell therapy products. However, the transformation of regulatory landscape in countries such as Japan and South Korea has made these regions as attractive destinations for the development of stem cell therapy products.

According to the report, one of the major drivers for this market is increase in federal funding in stem cell therapy. Research and clinical trials of stem cell therapy require huge investment, which many research institutes and small companies cannot afford. Therefore, many federal organizations provide funding to these institutes and small companies to help their innovative ideas in the development of stem cell therapies. Worldwide, many government organizations have noticed the importance of regenerative medicine, and thus they have allocated funds and grants in that area. For instance, in the US, the NIH and CIRM provide most of the funds.

Key vendors

Key Topics Covered:

Part 01: Executive summary

Part 02: Scope of the report

Part 03: Research Methodology

Part 04: Introduction

Part 05: Understanding of stem cell therapy

Part 06: Ethical issues and regulatory landscape

Part 07: Key clinical trials

Part 08: Market landscape

Part 09: Market segmentation by therapy

Part 10: Market segmentation by applications

Part 11: Geographical segmentation

Part 12: Market drivers

Part 13: Impact of drivers

Part 14: Market challenges

Part 15: Impact of drivers and challenges

Part 16: Market trends

Part 17: Vendor landscape

Part 18: Key vendor analysis

For more information about this report visit http://www.researchandmarkets.com/research/gdv8s6/global_stem_cell

Media Contact:

Laura Wood, Senior Manager press@researchandmarkets.com

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Global CAR T Cell Therapy Market & Clinical Trials Insight 2022: 99 … – Yahoo Finance

Posted: April 25, 2017 at 4:41 am

DUBLIN--(BUSINESS WIRE)--

Research and Markets has announced the addition of the "Global CAR T Cell Therapy Market & Clinical Trials Insight 2022" report to their offering.

The report highlights the ongoing clinical and non-clinical advancement in the field of Car T Cell Therapy. As per report findings, the promise of CAR modified T cell therapy derives from its combined immunologic benefits and include the specificity of a targeted antibody, the ability to expand the T cell population and the potential for long term persistence to facilitate the ongoing tumor surveillance. The success in early phase trials, assess the feasibility of evaluating the treatment modality across the multiple centers and in larger patients. Currently, there are 99 CAR T Cell based therapies in clinical pipeline and most of them belong to Phase-I and Phase-I/II clinical trials.

In recent years, researchers have identified the chimeric antigen receptor as a potential target for molecular genetics to insert a new epitopes on the receptor region which allows a degree of control of the immune system. CAR T cell therapy satisfy the need to explore new and efficacious adoptive T cell therapy. The gene transfer technology could efficiently introduce the genes encoding CARs into the immune effector cells. The transferring of engineered T cells provides the specific antigen binding in a non-major histocompatibility complex.

The promise of CAR modified T cell therapy derives from its combined immunologic benefits and include the specificity of a targeted antibody, the ability to expand the T cell population and the potential for long term persistence to facilitate the ongoing tumor surveillance. The success in early phase trials, assess the feasibility of evaluating the treatment modality across the multiple centers and in larger patients.

Companies Mentioned

Key Topics Covered:

1. Chimeric Antigen Receptor (CAR) T Cell Therapy - Next Era in Immuno Oncology

2. Evolution of Chimeric Antigen Receptor (CAR) T-Cell Design

3. Principle of Chimeric Antigen Receptor Design

4. CAR T Cell Therapies Delivery Pipeline & Mechanism of Action

5. Approaches to Improve the CAR T Cell Therapy

6. Global CAR T Cell Therapy Clinical Trials for Cancer Treatment

7. Global CAR T Cell Therapies Clinical Pipeline by Company, Indication & Phase

8. Global Market Scenario of CAR T Cell Therapy

9. Global Market Size of CAR T Cell Therapy

10. Global CAR T Cell Therapy Market Dynamics

11. Global CAR T Cell Therapy Market Future Prospects

12. Competitive Landscap

For more information about this report visit http://www.researchandmarkets.com/research/3h29l7/global_car_t_cell

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HemaCare Will Attend International Society of Cell Therapy in London – Yahoo Finance

Posted: April 25, 2017 at 4:41 am

LOS ANGELES--(BUSINESS WIRE)--

HemaCare Corporation (HEMA), a leader in cell and tissue collection, processing and cell therapy solutions, will be exhibiting at the annual meeting of the International Society of Cell Therapy (ISCT) in London, UK, May 3-6, 2017. This year marks the 25th anniversary of the ISCT, a global society that unites clinicians, researchers, regulators, technologists and industry partners with a shared vision to translate cellular therapy into clinical practice. HemaCare will meet with its customers and European distributors at the conference and showcase its growing portfolio for cell therapy developers around the world.

Attending this meeting enables us to capture the latest developments in cell therapy and better serve our customer needs, said Pete van der Wal, Chief Executive Officer for HemaCare.The field of cell therapy is rapidly evolving. Our products and services are embedded in some of the most critical phases of translational research, enabling scientists to work with high quality human cells from our well-characterized donor pool.

The conference is being held at ExCel London Conference Center. Look for us there, or view our products and services at http://www.hemacare.com.

About HemaCare

HemaCare specializes in the customization of human-derived biological products and services for customers research and cell therapy protocols. HemaCares network of FDA-registered, GMP/GTP-compliant collection centers ensures donor material is available for fresh shipment to customers, as well as for internal use within HemaCares isolation laboratory. In this laboratory, human biological material such as peripheral blood, bone marrow, and cord blood from donor and patient subjects is isolated into various primary cell types for distribution to customers in fresh and frozen formats. HemaCare's extensive registry of well-characterized repeat donors provides consistent primary human cells and biological products for advanced biomedical research and cellular therapy process development.

For 39 years, HemaCare has provided human-derived primary blood cells and tissues for biomedical research, supported cell therapy clinical trials and commercialization with apheresis collections, and provided a wide range of consulting services. HemaCare directly supports benchtop immunology and oncology research, compound screening for drug discovery, and assay development and qualification, as well as enables customers to advance both autologous and allogeneic cellular therapies. For more information, please visit http://www.hemacare.com.

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Scientists in Texas closer to diabetes cure with unconventional treatment – icFlorida

Posted: April 25, 2017 at 4:40 am

by: Marty Toohey, American-Statesman Staff Updated: Apr 24, 2017 - 9:52 PM

SAN ANTONIO, Tx. - Years of testing remain, but UT Health San Antonio researchers say theyve cured Type 1 diabetes in mice.

In peer-reviewed paper, they say a gene transfer can wake up cells in the pancreas to produce insulin.

>> Read more trending news

Health researchers at the University of Texas think they have found a way to trick the body into curing Type 1 diabetes.

The immune system of a person with diabetes kills off useful beta cells, but the UT researchers say they have found a way to make other cells in the pancreas perform the necessary work. Their approach, announced earlier this month in the academic journalCurrent Pharmaceutical Biotechnology, not only would have implications for Type 1, formerly called juvenile diabetes, but also could help treat the far more common Type 2 variety, also known as adult-onset diabetes.

The researchers have cured mice, which are genetically similar to people but different enough that new rounds of animal testing and millions of dollars more are needed before human trials can begin. The researchers approach is sure to garner skeptics, at least in part because it is a significant departure from the many other attempts at curing diabetes, which typically involve transplanting new cells and/or suppressing the immune systems attempts to kill off useful ones.

By contrast, were taking a cell that is already present in the body its there, and its happy and programming it to secrete insulin, without changing it otherwise, said Ralph DeFronzo, chief of the diabetes research at the UT Health Science Center at San Antonio.

Diabetes is a disease characterized by a persons inability to process carbohydrates, a condition that if untreated can lead to often-catastrophic health consequences: lethargy, diminished eyesight, heart attacks, strokes, blindness and a loss of circulation in the feet that could lead to amputation. The Centers for Disease Control and Preventionestimate that in 2014, about 29 million Americans almost 1 in 10 had diabetes.

The core problem is insulin. Most people naturally secrete that substance when they eat something with carbohydrates, such as bread, potatoes and candy bars. Insulin acts like a concierge that escorts the sugar from the bloodstream into the cells, providing the cells with the energy to function. In most people, the body is continually monitoring blood sugar and producing insulin as needed.

In Type 2 diabetes which makes up 9 out of 10 diabetes cases and is generally associated with older people and weight gain the cells reject the insulin, causing sugar to build up in the bloodstream even as cells are starved for energy. Type 2 is often treated with pills that tell the cells to let in the insulin. But in Type 2 diabetes, the body also often gradually loses the ability to produce insulin, requiring insulin injections.

In Type 1 the type the researchers studied the body has simply stopped producing insulin. This type often manifests in children, though it can sometimes develop in adults as well.

The reason the body stops producing insulin is that it kills off the pancreas beta cells, which produce insulin. People with Type 1 diabetes must get their insulin from injections or ingestion, a cumbersome and often imprecise task. Too little insulin and blood sugar levels stay high for extended periods, potentially damaging the body; too much and blood sugar levels crash, possibly causing a person with diabetes to faint or experience an even worse problems, such as a stroke.

DeFronzos partner, Bruno Doiron, decided to see whether the body could reliably produce insulin without transplanting new cells. He used a gene transfer technique on mice, delivered via a virus, that activated insulin production in cells already in the pancreas for instance, those that produced certain enzymes.

Were not fundamentally changing the cell, DeFronzo said. Were just giving it one additional task.

The mice immune systems did not attack the new insulin-producing cells. Most important, according to the findings: The cells produced the right amount of insulin: not so much that they sent a mouse into a blood sugar free fall, not so little that blood sugar levels stayed high. The mice have shown no sign of diabetes for more than a year, according to the findings.

Quite a bit of work remains before testing will start on people. If they can raise enough money they estimate $5 million to $10 million they can proceed to testing on larger animals, such as pigs, dogs or primates, a next step that would be planned in conjunction with the U.S. Food and Drug Administration.

They hope to start human trials in three years.

DeFronzo and Doiron said they expect skepticism but said much of it will be driven by how unconventional their work is. Doiron added that, although the technique is unconventional in the context of diabetes, using a virus to deliver a gene transfer is an established technique, having been approved dozens of times by the FDA to treat diseases.

We can use the cells the body has naturally, Doiron said. This will simply wake up the cells to produce insulin.

Type 1 and Type 2 diabetes

The work of Bruno Doiron and Ralph DeFronzo focuses on Type 1 diabetes, not Type 2.

Both diseases involve a problem with insulin, the substance that healthy bodies produce to take sugar from the bloodstream into the cells and power the body.

Type 2 is far more common. The main issue is that the cells reject insulin, causing sugar to build up in the bloodstream. The common treatment is a pill that makes the cells accept the insulin (and sugar it carries into the cell). But over time, people with Type 2 diabetes often lose the ability to produce insulin.

With Type 1 diabetes, people simply stop producing insulin. Their bodies kill off the cells in the pancreas that produce it.

Those with Type 1 diabetes must inject or ingest insulin. People with Type 2 often grow increasingly dependent on insulin injections, though Type 2 can sometimes be cured or controlled through diet and exercise.

2017 Cox Media Group.

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Diabetes program combines clinical, group and caregiver approach … – Traverse City Record Eagle

Posted: April 25, 2017 at 4:40 am

TRAVERSE CITY His father had it. His maternal grandfather had it. So Ross Sussman assumed his Type 2 diabetes day of reckoning would come.

"It was just a question of when," said Sussman, 83.

But prepping for the diagnosis does not make living with it any easier, Sussman said, after "when" became official 20 years ago.

"Like many people, I enjoy sweets. I had to cut way back, and I lost weight in maybe the first couple years, but then it kind of stopped," Sussman said.

It took a toll on his wife, Evy, too. She tried not to police her husband's eating habits, but cherished social routines like post-movie-or-concert dining changed unpleasantly, she said.

"Socially, it just felt funny when you're ordering a salad when everybody else ordered strawberry pie," said Evy, 75.

But Ross' diabetes class last summer empowered them both, they said, as it combined clinical, group and follow-up approaches to positive behavior.

"It really encouraged me in the way that nobody else can make me do what I'm supposed to screw up my mind or unscrew it to do," Ross said. "It's different from making promises to myself, where I'd probably keep half of them."

The couple lives part time in Minneapolis, Minnesota, and part time in Northport, where the Area Agency on Aging of Northwest Michigan offered a pilot version of LIFE with Diabetes last summer.

The agency will offer the program to Grand Traverse area diabetics over 50 this spring.

The program kicks off with a consultation with a nurse diabetes educator and registered dietitian, and spouses and caretakers are encouraged to attend.

"I liked being included, " Evy said. "As many conditions are, it's a family issue."

The program continues with six weekly group sessions, then wraps up with a three-month post-program follow-up session.

It's geared to promote self management and encouragement for those who need it, said Darcia Brewer, AAANM's registered dietitian and program manager.

"Once you're diagnosed, you get the initial education session. But life changes, conditions change and we face so much more than diabetes," Brewer said. "No one ever can be perfect 100 percent of the time. Even people who know all the information get busy with life, and lax with what we're doing at different stages of the process."

Munson Healthcare's Community Dashboard shows almost a quarter of the 5-county area's Medicare population (over 65) has diabetes a trend that shows no signs of slowing, Brewer said.

"Statistically, with increases in obesity and the number of diabetics who go undiagnosed, it's unfortunate, but that will continue to grow," Brewer said.

They hope to offer the program in low-income housing and apply to Medicare for future funding, she said. The agency currently is offering initial consultations May 8-10 with group sessions May 23 to June 27 from 10 a.m. to 12:30 p.m. at the Area Agency on Aging of Northwest Michigan, at no cost.

Ross compared living with Type 2 to living on a stagecoach.

"It's moving, and some people are driving, some are running behind it, and others are just being pulled along," Ross said.

For more information or to register please call 1-800-442-1713 by April 28.

Session dates/times: Individual consultations will be offered May 8-10. Group sessions on Tuesdays, May 23 to June 27 from 10 a.m. to 12:30 p.m., at the Area Agency on Aging of Northwest Michigan, 1609 Park Drive.

Requirements: 50 or older who have Type 2 diabetes (and family caregivers) living in the greater Grand Traverse region. Registration is required by April 28.

Cost: No cost to attend but need a primary care physician referral.

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Diabetes may cause more deaths than previously thought – The Messenger (subscription)

Posted: April 25, 2017 at 4:40 am

Four times as many deaths may be caused by diabetes, according to a recent study by Boston University School of Public Health published in the online journal PLOS One.

The study argued that diabetes caused 12 percent of deaths in the U.S. Currently, death certificates indicate that 3.3 percent of deaths in the U.S. are caused by diabetes. If the studys findings prove to be accurate, diabetes would become the third-leading cause of death in the United States, up from the seventh.

According to the Kentucky Behavioral Risk Factor Surveillance Survey, diagnosed diabetes among adults nearly doubled in Kentucky from 6.5 percent to 12.5 percent from 2000 to 2014. Now, one in eight Kentucky adults, or 424,670 people in Kentucky are estimated to have diagnosed diabetes.

In 2015, the rate of diabetes increased again to 13.4 percent. Nationally, nearly 10 percent of people have diabetes.

The Centers for Disease Control estimates 138,000 Kentuckians are living with undiagnosed diabetes.

The Pennyrile region of Kentucky has a comparatively average rate of diabetes, at 12.1 percent. Regions along the eastern part of Kentucky have rates as high as 17.8 percent.

It was surprising to me that they would put it at 3 percent, said Christian County Health Department Nurse Jennifer Boone. Diabetes is just so hard on the entire body. It effects the entire body. All the organ systems, everything.

Diabetes is a group of diseases in which high levels of blood sugar are found in the body for extended periods of time.

Type 1 Diabetes comes from the pancreas failing to produce enough insulin. Type 2 Diabetes is usually caused by obesity and inactivity, when the body does not respond to insulin properly. Type 2 Diabetes usually occurs in later stages in life and is considered a result of lifestyle choices.

Its a lifelong thing. A lot of people think that if they eat healthy, if they exercise, if they are able to come off their medication then they dont have diabetes, Boone said. Its not like its ever really cured. Its just managed well.

Diabetes can cause kidney failure. It can also cause blindness, as the blood vessels in the eye can become damaged by the high amount of blood sugar caused by diabetes.

Gums can also become infected and inflamed by diabetes.

Any open wounds take longer to heal with diabetes, leading to many festering sores for those who suffer from the disease.

Kentucky has the 12th highest mortality rate in America. Exercise and a good diet are considered to be good forms of diabetes prevention.

People with higher than average blood sugar levels are considered to have prediabetes. Those with that condition can prevent diabetes with exercise and a good diet.

The Christian County Health Department advocated for the expansion of the Hopkinsville Greenway System during the debate over H-CC WINS, because the organization believed that the system would promote walking in the community, which would lead to better health.

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