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250598 Shares in Puma Biotechnology Inc (PBYI) Acquired by Norges Bank – The Cerbat Gem

Posted: April 27, 2017 at 10:46 am

250598 Shares in Puma Biotechnology Inc (PBYI) Acquired by Norges Bank
The Cerbat Gem
Puma Biotechnology logo Norges Bank acquired a new position in Puma Biotechnology Inc (NYSE:PBYI) during the fourth quarter, according to its most recent Form 13F filing with the SEC. The firm acquired 250,598 shares of the biopharmaceutical ...
-$2.08 EPS Expected for Puma Biotechnology Inc (PBYI) This QuarterSports Perspectives
Analyst Observation On 2 Stocks: Delta Technology (DELT), Puma Biotechnology (PBYI)Post Analyst

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250598 Shares in Puma Biotechnology Inc (PBYI) Acquired by Norges Bank - The Cerbat Gem

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3D Systems and United Therapeutics partner to 3D print organ scaffolds for human transplants – TCT Magazine

Posted: April 27, 2017 at 10:46 am

3D Systems has announced a bioprinting agreement with United Therapeutics which will see the two companies develop solid-organ scaffolds for human transplants with 3D printing.

Combining their respective expertise in 3D printing and regenerative medicine and organ manufacturing, the collaboration will remain for a number of years.

The agreement will pit 3D Systems personnel alongside professionals from a United Therapeutics subsidiary, Lung Biotechnology PBC. Since the collaboration will primarily focus on the development of 3D printing systems for solid-organ lung scaffolds, Lung Biotechnology PBC is seen as best placed to work with 3D Systems.

The printing system will target collagen, and other building block proteins, as scaffold raw materials. Lung Biotechnology PBC will cellularize the scaffolds with patient-specific biological material, including re-differentiated stem cells.

Our partnership with 3D Systems is a major step forward in creating an unlimited supply of tolerable transplanted organs, said Martine Rothblatt, Ph.D., Chairman and Chief Executive Officer of United Therapeutics. By cellularizing scaffolds created with 3D Systems printers with a patients own cells, there will no longer be a need for immunosuppression and a vastly greater number of patients can extend their enjoyment of life through organ transplantation.

3D Systems is a company with a wealth of experience in the medical sector. Its precision healthcare capabilities include simulation, virtual surgical planning, and the printing of medical and dental devices. Two of 3D Systems leading executives are not only confident in their companys own knowledge of the medical 3D printing sector, but also of United Therapeutics own expertise. Though conceding the challenge is not straight forward, the pair foresee new solutions being born from the partnership.

As a global leader in healthcare solutions, we are part of many developments and applications for 3D printing coming together including bioprinting, said Vyomesh Joshi, Chief Executive Officer, 3D Systems. We believe bioprinting is a powerful opportunity and we are uniquely positioned with the broadest portfolio of technologies to partner with companies of the calibre of United Therapeutics to provide healthcare solutions of the future.

Chuck Hull, Executive Vice President, Chief Technology Officer, 3D Systems, added: Combining the resources of United Therapeutics and 3D Systems transforms our capability to tackle this difficult challenge. This project will be based out of our new bioprinting lab in San Diego, CA, and will rely on expertise across many technical disciplines within 3D Systems as well as the domain knowledge of our technical partners at Lung Biotechnology PBC.

Meanwhile, the collaboration and joint development will add another technology alternative to United Therapeutics pursuit of an unlimited supply of organs for human transplantation.

Dr Rothblatt concludes: Our Lung Biotechnology public benefit corporation is taking personal regenerative medicine to its highest level yet with this practical, economic solution to a major health care program. Indeed, we expect one personalised organ transplant will avoid years of health care spending on palliative medical therapies.

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3D Systems and United Therapeutics partner to 3D print organ scaffolds for human transplants - TCT Magazine

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Lonza US cell therapy plant slapped with FDA warning letter – FiercePharma

Posted: April 27, 2017 at 10:44 am

Swiss CDMO leader Lonza has had its cell therapy facility in the U.S. slapped with a warning letter after halting some production there two months ago because of sterility problems with a product it was producing for a client.

The company acknowledged the FDA action in its first-quarter earnings report Tuesday, saying that the warning letter was issued Monday for its facility in Walkersville, Maryland. The FDA had concerns about issues including validation and aseptic process simulations, the drugmaker said.

Lonza takes this issue seriously, and has already started to address all issues raised by the FDA, the company said.

Lonza first learned about the issue in December after product end-user notified the FDA of the issue, Lonza spokeswoman Constance Ward said in an email Tuesday. Lonza opened an investigation after confirming the sterility issue. She said the plant halted production of the product in the affected manufacturing area in early February, while also quarantining the inventory it had on hand.

"After inspecting both the customer of the product and the Walkerville operations, the FDA issued Lonza a warning letter that identified issues involving validation, aseptic process simulations, corrective and preventive actions, and environmental monitoring, Ward explained.

She said the company expects to have the problems resolved and FFM media manufacturing back online by mid-2017. The company had already begun a $7.6 million manufacturing upgrade at the facility, which Ward said is slated to be finished in 2018.

While the drugmaker said it expects the latest FDA action to have minimal impact on revenues of its Pharma & Biotech segment, it reported sales in the segment were softer in the first quarter because of the action. Without providing specific numbers, the contract manufacturer Tuesday reported that growth in that segment was driven by demand in mammalian manufacturing, as well as in clinical development and licensing.

This is not the first time that Lonza has faced FDA concerns about its biologics operations in the U.S. An API plant it had in Hopkinton, Massachusetts, was cited in 2011 over a plethora of problems, creating supply problems for a drug it manufactured there at the time for French drugmaker Ipsen. After struggling to get issues resolved, Lonza simply closed the plant and concentrated its biologics work at its extensive site in Visp, Switzerland.

Lonza is preparing to expand its Visp biologics capability further. It will break ground in the second half of the year on a new large-scale biologics production facility that it is building in partnership with Frances Sanofi. The companies announced in February that they would share the cost, and capacity, of a 270 million ($286.3 million) plant at Lonzas site in Visp.

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HemaCare Will Attend International Society of Cell Therapy in … – Business Wire (press release)

Posted: April 27, 2017 at 10:44 am

LOS ANGELES--(BUSINESS WIRE)--HemaCare Corporation (OTCBB: HEMA), a leader in cell and tissue collection, processing and cell therapy solutions, will be exhibiting at the annual meeting of the International Society of Cell Therapy (ISCT) in London, UK, May 3-6, 2017. This year marks the 25th anniversary of the ISCT, a global society that unites clinicians, researchers, regulators, technologists and industry partners with a shared vision to translate cellular therapy into clinical practice. HemaCare will meet with its customers and European distributors at the conference and showcase its growing portfolio for cell therapy developers around the world.

Attending this meeting enables us to capture the latest developments in cell therapy and better serve our customer needs, said Pete van der Wal, Chief Executive Officer for HemaCare.The field of cell therapy is rapidly evolving. Our products and services are embedded in some of the most critical phases of translational research, enabling scientists to work with high quality human cells from our well-characterized donor pool.

The conference is being held at ExCel London Conference Center. Look for us there, or view our products and services at http://www.hemacare.com.

About HemaCare

HemaCare specializes in the customization of human-derived biological products and services for customers research and cell therapy protocols. HemaCares network of FDA-registered, GMP/GTP-compliant collection centers ensures donor material is available for fresh shipment to customers, as well as for internal use within HemaCares isolation laboratory. In this laboratory, human biological material such as peripheral blood, bone marrow, and cord blood from donor and patient subjects is isolated into various primary cell types for distribution to customers in fresh and frozen formats. HemaCare's extensive registry of well-characterized repeat donors provides consistent primary human cells and biological products for advanced biomedical research and cellular therapy process development.

For 39 years, HemaCare has provided human-derived primary blood cells and tissues for biomedical research, supported cell therapy clinical trials and commercialization with apheresis collections, and provided a wide range of consulting services. HemaCare directly supports benchtop immunology and oncology research, compound screening for drug discovery, and assay development and qualification, as well as enables customers to advance both autologous and allogeneic cellular therapies. For more information, please visit http://www.hemacare.com.

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Overcoming diabetes through churches in Columbia’s African-American community – Columbia Missourian

Posted: April 27, 2017 at 10:43 am

COLUMBIA Verna Laboy's paternal grandmother lost both legs to diabetes complications. Very recently, one of her cousins lost a leg also to diabetes. Yet another cousin is on dialysis, a complication of the same disease.

"This is personal for me," she says.

She doesn't pretend to be an expert that's not where the passion comes from. She, herself, was "on the fast track" to diabetes and has found it hard to stick with an exercise or diet.

All of that has made Laboy a passionate force behind Live Well By Faith, a wellness program launched one year ago through the Columbia/Boone County Health and Human Services Department for black churches in Boone County.

Data from a county-wide survey in 2013 showed that of the 9,300 people living with diabetes in Boone County, black people were four times more likely to die from complications related to the disease than their white counterparts. Nationally, black women are just under two times more likely than white women to die from diabetes complications, while black men are about one and a half times more likely than white men to die from diabetes complications, according to the Centers for Disease Control and Prevention.

Type 2 diabetes the more common form of the chronic disease occurs when the level of blood glucose (sugar) in a person's body is higher than normal because insulin ceases to be produced properly, according to theAmerican Diabetes Association. As a result, the body's cells are starved for energy and the eyes, kidneys, nerves and heart can be effected. Factors associated with diabetes include obesity, a family history of the disease and race and ethnicity.

Verna Laboy saves leftover food April 2 after the Live Well By Faith cooking class. Laboy runs the Live Well By Faith wellness program through St. Luke United Methodist Church in Columbia, which aims to address health disparities in minority communities through church programs.

Laboy, a self-proclaimed "health evangelist" and community activist, has been working with black churchgoers since April 2016 to educate people about the consequences of unhealthy lifestyles, to encourage healthy eating and to provide programsfor long-term success in health management.

"Food is important to this culture, and it's cooked the wrong way. It's a lethal digestion," Laboy said. "It's an addiction that needs to be addressed, a very unhealthy addiction. We need to increase our health literacy."

Laboy uses the word "bulldozer" to describe how she's paving the way towards bringing down the rates of diabetes and heart disease among blacks in Boone County.

"I don't have a health background. I'm not a personal trainer. I'm not a nutritionist," she said.

Her own struggle to change her lifestyle has been a source of insight.

"But I've been on this journey for years, unable to stay consistent," she said.

She and other "health ministers" at the Live Well By Faith-accredited churches are "looking for people that are dealing with the challenges themselves to adopt (healthy) behaviors and see the changes and take people on the journey with them," she said.

Laboy enthusiastically and passionately evangelizes on a healthy lifestyle.

"Verna's not doing the work," she said, slipping into third person, as she often does. "You have to do the work. This is your church. This is your congregation. This is your family. This is your life."

Diabetes can lead to high blood pressure, heart disease, amputations and death if not managed well, according to the American Diabetes Association.

Lifestyle factors and genetics are the primary influences of type 2 diabetes, according to a study published in 2012. Type 2 diabetes involves insulin resistance and declining insulin production and components of the disease include physical inactivity, sedentary lifestyle, cigarette smoking and a generous consumption of alcohol.

Maintaining a healthy diet for the prevention or treatment of diabetes combined with physical activity is associated with lowered risks of diabetes, according toa study published by the Journal of Education and Health Promotion. Eating smaller serving sizes and cutting calories improves insulin sensitivity, and regular physical activity helps with weight loss and may also decrease blood pressure.

Increasinghealth literacy entails learning about what types of foods are recommended for healthful living, what types of food to avoid and fitness.Focusing meal planning around nutrient dense foods such as vegetables, beans, whole grains, fruit, non-fat dairy, fish and lean meats is one way to decrease the risk of diabetes, according to theAmerican Diabetes Association.

But the church is an especially important institution for many black Americans.

From left, Frances Logan, Shae Brown and Mary B. Warren wash their hands during the Live Well By Faith cooking class April 2 in Columbia. Each attendee washed their hands for 20 seconds, which was a technique they reviewed at the start of the workshop.

Annabelle Simmons, a health minister at St. Luke United Methodist Church, joined the Live Well By Faith team . After she took a healthy lifestyle class through the program, she said her eyes were opened about health.

But she wasn't sure exactly which of the possible Life Well by Faith courses she would teach.

There it was: "Cooking Matters." She thought to herself, "I know how to cook," but had to become certified to teach it. That entailed learning about how to hold a knife properly, how to slice correctly, among other kitchen skills.

The healthy cooking and eating topics changed her habits: learning how to read food labels, how much food is in a serving, the calorie count, the protein count, etc. "And now, every time I go shopping, I'm looking at the labels, so I know it works," she said.

The class also teaches people how to cook healthy food on a budget, Laboy said: "They can see how cheap they can cook good food, healthy food."

In addition to what she learned in "Cooking Matters," Simmons also learned how to take a blood pressure reading, which she does on Sundays free if church members ask her to do so. The health ministers at St. Luke also signed off on a water policy, requiring that water be offered with every meal offered at a church event.

"People were going, 'But I want punch, I want coffee,'" Simmons said.

A "no fried foods" policy is also in place.

And yet, people still gather around the table.

"We get to fellowship with one another around food, preparing the food together," Simmons said.

Dee Campbell-Carter, a lifestyle coach for the health ministry at Friendship Missionary Baptist Church, said the church will start a "Cooking Matters" class later this year. The health ministry at Friendship Baptist offers blood pressure checks every second and fourth Sunday before and after service lets out as well as "SweatSuit Sundays," when the congregation stops in the middle of service to do high- and low-impact exercises to gospel music.

"The thing we're doing is building a faith community that's cross-pollinating," Laboy said. This means that if a class is offered at one church, all the other churches are invited to send participants.

Dee Campbell-Carter, left, and Dorothy Slaughter tend to a garden plot April 17 at Friendship Baptist's community garden. Campbell-Carter is in charge of the garden, which came to fruition in January.

As the sun set last week, Campell-Carter strolled between garden plots behind Friendship Missionary Baptist filled with budding greens, tomatoes and peppers while bees hovered over dandelion-covered grass. Campbell-Carter and community member Dorothy Slaughter tilled the soil, pulling weeds and watering mustard and collard greens and kale.

The garden is called "Friendship Gardens," and the food harvested in the plots will be used in the "Cooking Matters" class when it begins.

Half-built garden beds lay ready for the next stage: being raised on stilts for planting. They will be waist high to accommodate children or those who are wheelchair bound, Cambell-Carter said.

The garden is a placewhere church memberscan grow healthy produce to take home and cook.

Cambell-Carter described Slaughter as the go-to gardener. She taught the community how to dig weeds out from their root with a simple tools like a plastic knife, and that coffee grounds are a good fertilizer and deterrent for some pests.

Calvin Miles, another member of Friendship Baptist Church, is the handy man on site. He put the finishing touches on the community garden sign his son painted that will stand over their "harvest trailer." He also built the raised flats for youth or those with disabilities.

Healthy food fits with his spiritual life, Miles said: "Body, mind and spirit. They all come together."

Calvin Miles paints Friendship Missionary Baptist's Friendship Garden sign on April 17. Miles' son painted the majority of the sign, while Miles added the finishing touches.

"When I see things like (Friendship Gardens) take offit's just everything," Laboy said.

But not every health ministry takes root as easily nor does every program.

Paula Williams chaired the board for the Boone County Minority Health Network until it disbanded last year. The network began in 2005 with the purpose of addressing health disparities. It ultimately died due to lack of funding.

"There was no full-time, dedicated staff to keep up with the grant writing," Williams said.

Live Well By Faith is on a two-year grant from the Boone County Commission, and Laboy is optimistic about getting it renewed. "I'm letting anyone out there that's doing this kind of work know that Verna is available to take this to the next level," she said.

There's one year left on the grant. Then, the Columbia/Boone County Department of Public Health and Human Services will re-apply. "We are just getting started," Laboy said.

She recognizes that it takes time to change a culture.

"We have to make different choices," she said. "We're living longer. Do you want to live in a nursing home? Do you want illness to take you out in such a way where someone who doesn't want to take care of you is forced to take care of you? It's a tough conversation to have, but someone has to put it out there."

Churches around Boone County are having that conversation. Laboy hopes "Cooking Matters" will be offered in 15 African-American churches in the upcoming year. Urban Empowerment Ministries has a Weight Watchers program with 22 members representing five different church communities.

Five other churches are interested in the upcoming "Eat Healthy, Be Active" program, Laboy said. She and six trained lifestyle coaches from those health ministries will be meeting to talk about bringing the curriculum to those five churches. The Columbia/Boone County Department of Public Health and Human Services has a "Shazzy Fitness" program that brings community members together to work out to gospel music.

"These are small ways we're chipping away at the health literacy and health consciousness of people," Laboy said.

Dorothy Slaughter removes weeds from her garden plot on the evening of April 17. The garden, a part of the Live Well By Faith program at Friendship Missionary Baptist Church, is open to community members to grow healthy produce to use in their meals.

"This is the hardest work I've ever done," Laboy said. "And it's taking care of myself. Why is that so hard to do? Because we're going against the grain; it's going against the culture," she said. "Great-grandma made the biscuits this way. Grandma made the greens this way. Mom makes the cobbler this way. So our tastes have adjusted, but it's killing us."

There are healthier ways of doing things, Simmons said. "You start developing a habit of being healthy rather than choosing the cake. It's been a long time since I've had cake, now. I want cake; I love cake! But it's an unhealthy choice."

Laboy shared similar sentiments. "You've got to be able to tell yourself no," she said.

"This is a lifestyle transformation change for me and I have to do it. If no one else does it, Verna has to show up for Verna."

Laboy shares her experiences on the Live Well By Faith Facebook page regularly, reminding those who are on the journey with her that they can succeed even if some days are hard. "Victory I make it to the gym this morning and boy was it a struggle. I wanted to quit!" she shared in a recent post.

"Setbacks are set-ups for a come back!" she wrote in an earlier post.

Campbell-Carter faced a setback as well. "I had to creatively regroup my workout plan when my (Activity and Recreation Center) membership expired last December," she said. Her insurance stopped reimbursing her for the membership, but she said she knew she wanted to stay active.

Campbell-Carter ultimately chose to start budgeting for weekend classes, and during the week she does yoga, gardening or goes on a "PRAYER walk," which is the term used in the Friendship Baptist health ministry to describe a neighborhood walk a group or individual can participate in. "It's great to feel increases in my muscle strength and tone. Also, I sleep so good at night," she said.

Laboy sees the proof at the gym, not just in herself but in others.

"When I'm at the gym working out and I see some of my diabetes self-management folks walking around on the track or working out on the equipment, my heart just smiles," she said.

But there's so much more to do."I can't just plant the seed and leave," Laboy said. "I have to keep coming back and watering it, and when I come, I'm coming with a tank of water and fertilizer."

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Smartphone-Controlled Cells Keep Diabetes In Check – IEEE … – IEEE Spectrum

Posted: April 27, 2017 at 10:43 am

Smartphones can already control homes and cars, anddiagnosediseases. Chinese and Swiss researchers now show that a smartphone can command engineered cells implanted in diabetic mice to produce insulin.

The researchers demonstrated a clever closed-loop system in which a digital glucometer transmits data on the rodents blood glucose levelsto a smartphone, which processes the data and then signals the implanted cells to deliver insulin.This is a step towards a new era of personalized, digitalized precision medicine, says Haifeng Ye of East China Normal University,who led the work reported in Science.

Cell-based therapies are a radical new medical treatment option being investigated by researchers. The idea is to turn cells into disease-fighting weapons by engineering them to produce therapeutic chemicals and proteins that they would churn out once implanted in the body. Living white blood cells, for instance, have been designed to fight cancer, HIV, and other diseases.Hundreds of cell therapies are undergoing clinical trials. But none can be controlled from outside the body.

Ye and his colleagues have come up with an innovative way to add smarts to cell-based therapy. They chose diabetes as the target disease.

They initially inserted light-sensitive bacterial proteins into mammalian cells. When exposed to far-red light (wavelength of about 730 nanometers), the protein activateda genetic pathway that causedthe cells to produce insulin.

After that success, they team made dime-sizedevices in which circular power-receiving coils surround a hydrogel that is embedded with the engineered cells and far-red LEDs. These devices were implanted under the skin of diabetic mice. When an external transmitting coil wirelessly switches on the LEDs via electromagnetic induction, their light triggers the cells to produce insulin in the animals.

The team made three things to remotely control the engineered cells: a custom-engineered Bluetooth-active glucometer,an Android-based smartphone app,and an intelligent control box that controls the power-transmitting coil.

When the researchers placemice blood samples on the glucometer, it sends measurements to the smartphone via Bluetooth. The phone app compares these levels to a pre-set threshold, then signals the control box to turn on the power-transmitter coil, which switches on the LEDs long enough for the cell implant to deliver the right amount of insulin.

The animals blood glucose typically went down to nondiabetic levels within two hours of irradiation. The system maintained the blood glucose concentration in mice for 15 days without any side effects. After that it could be replaced, Ye says, but a much longer performance or replacement frequency of the implant needs to be further investigated in humans.

One big limitation of the system is that it needs manual blood draws. Another is that the animals need to be close to the transmitting coil and be exposed to EM radiation to switch on the LEDs.

But a bit more engineering could yielda diabetesmonitoring-and-treatment system that isfully automatic and portable. A continuous glucose monitorcould send blood sugar measurements to the users phone. The phone would trigger a battery-powered LED wristband to shine light on the implanted insulin-producing cells.

IEEE Spectrums biomedical engineering blog, featuring the wearable sensors, big data analytics, and implanted devices that enable new ventures in personalized medicine.

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Smartphone-Controlled Cells Keep Diabetes In Check - IEEE ... - IEEE Spectrum

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Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027 … – Yahoo Finance

Posted: April 27, 2017 at 10:43 am

DUBLIN--(BUSINESS WIRE)--

Research and Markets has announced the addition of the "Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027" report to their offering.

Type 1 Diabetes Mellitus (T1DM) is a multisystem disease that progressively destroys the pancreas' ability to produce insulin. This leads to a chronic condition of defective metabolism of fat, carbohydrates and proteins due to the lack of insulin. It occurs mainly in childhood and adolescents, however a rising number of latent autoimmune diabetes of adulthood (LADA) cases have been reported mainly due to a better understanding and diagnosis of the disease.

This report provides the current prevalent population for Type 1 Diabetes Mellitus across 12 Major Markets (USA, Canada, France, Germany, Italy, Spain, UK, Brazil, Japan, India, China and Russia) split by gender and 5-year age cohort. Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and prognosis along with specific variations by geography and ethnicity.

Providing a value-added level of insight from the analysis team, several of the main symptoms and co-morbidities of Type 1 Diabetes Mellitus have been quantified and presented alongside the overall prevalence figures. These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.

Reasons to Buy:

- Able to quantify patient populations in global Type 1 Diabetes Mellitus market to target the development of future products, pricing strategies and launch plans.

- Gain further insight into the prevalence of the subdivided types of Type 1 Diabetes Mellitus and identify patient segments with high potential.

- Delivery of more accurate information for clinical trials in study sizing and realistic patient recruitment for various countries.

- Provide a level of understanding on the impact from specific co-morbid conditions on Type 1 Diabetes Mellitus prevalent population.

- Identify sub-populations within Type 1 Diabetes Mellitus which require treatment.

- Gain an understanding of the specific markets that have the largest number of Type 1 Diabetes Mellitus patients.

Key Topics Covered:

1. Introduction

2. Cause of the Disease

3. Risk Factors & Prevention

4. Diagnosis of the Disease

5. Variation by Geography/Ethnicity

6. Disease Prognosis & Clinical Course

7. Key Comorbid Conditions/Features associated with the disease

8. Methodology for quantification of patient numbers

9. Top-line Prevalence for Type 1 Diabetes Mellitus

10. Features of Type 1 Diabetes Mellitus Patients

10.1 Comorbidities and Sequelae in T1DM Patients

10.2 T1DM patients with Retinopathy

10.3 Prevalence of T1DM defining antibodies

11. Abbreviations used in the report

12. Patient-Based Offering

13. Online Pricing Data and Platforms

14. References

15. Appendix

For more information about this report visit http://www.researchandmarkets.com/research/j3bqpv/type_1_diabetes

View source version on businesswire.com: http://www.businesswire.com/news/home/20170427005670/en/

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Pac-Man meets biotechnology – Phys.Org

Posted: April 26, 2017 at 3:44 pm

April 26, 2017 The authors artwork, illustrating the article, was also featured on the cover of Lab on a Chip. Credit: Royal Society of Chemistry

Scientists in the U.S have a designed a computer game that could help with biomedical research.

Scientists increasingly use miniscule robots to solve a range of problems, from cancer treatment to water purification. And, as with a lot of technology, the race is on to make these devices ever smaller.

However there is a limit to how far you can go with a mechanical device moving parts such as motors can physically only get so small.

So scientists are looking to the natural world to help. Single cell organisms, such as bacteria and algae, could make the parts in the miniaturised robots move, without the need for an external power source.

Such organisms respond to changes in their environment such as light and food by moving, and if these movements can be harnessed, we can use them as motors.

In a new paper just published in Lab on a Chip, Ingmar Riedel-Kruse and fellow scientists from Stanford University in the U.S. have demonstrated the use of one such organism, in the form of a game.

It's based on Euglena gracilis, single cell algae that move in response to changes in strong light. In the game, the organisms are directed around a maze or "captured" in a space on the screen by the users turning lights on and off. The ability to control the movement of the algae demonstrates their potential application in mini, single cell organism-driven motors.

In this set-up, the algae's movements are programmable a promising first step towards creating a microcomputer built on biotechnology.

Explore further: Single cell organism firm joins top ranks of Japan bourse

More information: Amy T. Lam et al. Device and programming abstractions for spatiotemporal control of active micro-particle swarms, Lab Chip (2017). DOI: 10.1039/C7LC00131B

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Skepticism About Biotechnology Isn’t Anti-Science – Slate Magazine

Posted: April 26, 2017 at 3:44 pm

AquAdvantage salmon.

AquAdvantage

Keep Frankenfish off my Dish! a protesters sign read. Another, adorned with six red hearts, suggested that real people love real salmon. A couple of years ago, protests against the approval and sale of genetically modified salmon targeted the Food and Drug Administration and supermarket chains across the country, attempting to halt the approval and sale of the AquAdvantage salmonan Atlantic salmon modified with DNA from the Chinook salmon and the ocean pout. The borrowed genetic material lets the fish grow year-round and reach market size in half the time as its natural counterpart, but its also spurred passionate public debate.

In November 2015, the FDA approved the AquAdvantage salmon as the first genetically engineered animal for human consumption. According to the hype, the AquAdvantage salmon could help with reducing global hunger, decreasing the carbon footprint of aquaculture (the cultivation of fish and other aquatic life), and shoring up dwindling wild fish stock. The regulatory process behind the approval of the AquAdvantage salmon took almost 20 years.

But the approval was quickly followed by a flurry of controversy and charges of insufficient consideration of key issues. A consortium of environmental groups lead by Earthjustice and the Center for Food Safety sued the FDA for approving the AquAdvantage salmon, in their words, without considering or fullydisclosing the environmental and other risks of this unprecedented decision. Two months after the approval, Congress also threw a wrench in the works by adding a rider to a spending bill that tasked the FDA with spending not less than $150,000 to develop labeling and implement a program of consumer disclosure for the fish before it could be made available for sale. As a result the fish is not yet anywhere near U.S. dinner plates, caught up in a seemingly endless process of contestation, with no clear end in sight.

To many in bioscience and biotechnology circles, this is a case of politics contaminating science. In an open letter to President Obama in 2014, a group of concerned international scientists and global technology company executives argue this point:

These scientists and others offer a picture of a Manichean world divided into those who are for scientific and technological progress and those who are against ita representation of the world that we have been seeing more and more of lately in reports of a war on science. But drawing this line is dangerous. The real problem here is the regulatory process itself, which forces dissent to take the narrow form of challenges to scientific data and methodology and ignores other questions about whats at stake.

The FDA approval process for the AquAdvantage salmon took longer and included more opportunities for public comment than most products the FDA reviews. This unique openness to public input was balanced by a careful parsing of what counts as scientifically and contextually relevant and what does not. The agency received 38,000 comments in response to its draft assessment alone, but it determined that just 90 were worth considering. The remaining comments were discounted as irrelevant because they did not directly address the details of the regulation process, or they raised issues beyond the mandate of the agency. These disregarded comments focused on a wide range of concerns, including patenting and ownership regimes of seed and crops; how deploying genetically modified corn and soy would affect the United States image around the world; continuing failures of existing market configurations to address inequality and food distribution; and the long history of multinational corporations central to the commercialization of biotechnologies, such as Monsanto, intentionally obscuring the negative impacts of their chemical products and byproducts while undermining human health.

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Being Skeptical About Biotechnology Doesnt Make You Anti-Science

So the FDA is not the forum for deliberation on the meaning of giving entry to this new form of life into our environment, grocery stores, and dining rooms. But what is? The FDA approval process is the only existing avenue for public consideration of technological innovation of this kind. Accordingly, the agencys narrow reading of what kinds of input are relevant represents a significant dismissal of a broad range of relevant concerns.

Some might read the vast public preoccupation with a broad set of social, political, and economic issues as the contamination of science with politics. But I would suggest that this is actually a case of the reverse problem: seemingly endless conflict around the AquAdvantage salmon reflects the limitation of using narrow scientific terms to address questions of broad social, political, and economic significance. As things stand, the only legitimate way to engage in debates about the entry of the AquAdvantage salmon and other genetically modified organisms into our environments, meals, intellectual property regimes, and beyond is to contest its approval at the level of regulatory science. When the system asks the public to limit objections to narrow technical concerns, it undermines regulatory legitimacy and stultifies democratic debateand perhaps most importantly, it contributes to the problematic discourse around science itself. When our modes of public deliberation strictly define what counts as a legitimate view on these issues, we end up portraying a good portion of the population as against science, when that in fact could not be further from the truth.

The vast majority of people in the world, not being scientists or angel investors, have no say over the technological trajectories that will shape our world and our lives. We are instructed to continue funding basic science and patiently wait and watch as the world is transformed around us. Scientists often dismiss resistance to the AquAdvantage salmon and other biotechnologies as borne of scientific ignorance. But its a lot easier to understand peoples reluctance if you realize that the debate is about much broader questions than science alone can answer.

To position science on one side of these debates is not only patently false but detrimental to public discourse.

As the first genetically engineered animal developed for human consumption, the AquAdvantage salmon can be understood as an early form or precursor to products of more advanced practices of synthetic biology. Even as the power and precision of these techniques increases and the particular technical challenges associated with the salmon are left behind, the core issues and deep public resistance around the AquAdvantage salmon will likely persist and haunt continued efforts to reshape environments, economies, and human life through the biological sciences. Synthetic biology is billed as having the potential to transform the world in a way that will disrupt prevailing economic and geopolitical paradigms and reshape the very fabric of life. The one thing both sides of the fishy debate seem to agree on is that the AquAdvantage salmon is a pioneer technology, and what happens to this fish could set the stage for the role that biotechnology will play in our food system in the century to come. As one commentator opined for the New York Times:

This framing suggests that biotechnological innovation is a necessary and unmitigated good. But for many, the prospect of a world radically altered by biotechnology conjures past experiences in which scientific progress didnt go as plannedlike the devastation and political instability ushered in by nuclear weapons. Similarly, to some, a dam looks like progress, development, and economic prosperity. But to others, it looks like the violent end of a way of life, heralded by the destruction of ecosystems and entire species.

The debates over the AquAdvantage salmon arent narrow and technicaltheyre multifaceted, laden with questions of political, economic, and social values. They are about what kind of world we want to live in and what types of transformations are beneficial, desirable, and helpfuland for whom. To position science on one side of these debates is not only patently false but detrimental to public discourse and productive political deliberation.

Nonetheless, resistance to biotechnologies is often framed as a problem of the uneducated masses meddling in areas where they dont belong. The open letter to Obama by the concerned scientists and technologists, for example, claims:

Characterizing legitimate concerns about what kinds of technologies enter and help shape our world as anti-science is more likely to alienate than inspire everyday Americans to identify with this vision of what science can do, and to believe in it.

The long journey of the AquAdvantage salmon may turn out to have been a waste of time, energy, and resources on all sides, but perhaps we can make it productive in one way. Understanding the limitations of the process can help us think critically about how decision-making about synthetic biology going forward might be more open to a broader set of concerns and voices much earlier in the innovation process. The way forward is not drawing battle lines between those who are for or against science and closing down regulatory processes to all but the narrowest risk-based considerations. Rather, we should be forming and expanding spaces for a wide range of participants in creatively considering how to solve societys biggest challenges. We need new ways of thinking and talking about technological promise and possibility in the world that we live in.

This article is part of the synthetic biology installment of Futurography, a series in which Future Tense introduces readers to the technologies that will define tomorrow. Each month, well choose a new technology and break it down. Future Tense is a collaboration among Arizona State University, New America, and Slate.

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SSCI Receives a 2017 Biotechnology Award for Global Research … – Yahoo Finance

Posted: April 26, 2017 at 3:44 pm

WEST LAFAYETTE, Ind., April 26, 2017 /PRNewswire/ --SSCI, a division of Albany Molecular Research Inc. (AMRI), has been recognized by Global Health & Pharma (GHP) magazine as the winner of the 2017 Biotechnology Award for Best Global Research & Manufacturing Company in the United States.

"I am truly honored to accept this award on behalf of our dedicated team that is deeply committed to the mission of helping our clients achieve their product development goals and generate valuable intellectual property day in and day out," said David A. Engers, Ph.D., general manager at SSCI. "We are grateful to GHP for recognizing our commitment to client service and data integrity in order to provide unmatched value to the industries we have served for more than a quarter century."

GHP magazine recognizes that the biotechnology industry is increasingly viewed as being the frontline of medical science, and as this movement continues to gain momentum the publication is committed to following the most game-changing advances and revolutionary developments that will form the healthcare world for years to come.

Nathan Angell, GHP awards coordinator, expressed pride in every one of the award winners, "This award recognizes the hard work and dedication of the firms, such as SSCI, and the individuals behind them, that are driving innovation in this vital market. It has been my honor to recognize these dedicated professionals and I would like to wish them the very best of fortunes for the future."

About SSCIAMRI SSCI, LLC (SSCI), a division of AMRI, provides industry leading contract solid-state and analytical testing services and exists to help companies in the pharmaceutical, food, agrochemical, and other chemical industries develop better products and get them to market more quickly. SSCI provides comprehensive cGMP research and analytical services in the characterization and chemistry of solid materials, with particular expertise in small and large molecules being investigated for pharmaceutical use.To learn more about SSCI's solid-state and analytical chemistry services and capabilities,please contact 1-800-375-2179 | http://www.ssci-inc.com.

About GHP MagazineGlobal Health and Pharma (GHP) magazine is a global, information-sharing platform and a multi-disciplinary members community. The publication was established to enhance communication networks and collaboration across all themes and disciplines within three main categories; Human, Animal and Environmental Health.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/ssci-receives-a-2017-biotechnology-award-for-global-research-and-manufacturing-300445541.html

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