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Stem cell researchers discover promising lead in quest for hair regrowth – PhillyVoice.com

Posted: August 18, 2017 at 10:45 am

The ever-elusive cure for thinning hair, a concern that plagues both men and women, may have taken a taken a tentative step forward with the results of a new research study that focuses specifically on the role of follicle stem cells.

In new findings published in Nature Cell Biology, UCLA researchers revealed the discovery of a new way to activate hair regrowth by focusing on the unique metabolism of "quiescent" hair follicle stem cells. Although long-lived, these stem cells are normally inactive until the start of a new hair cycle, when they quickly spur regrowth in the anagen phase.

The UCLA study authors explain how the metabolism of hair follicle stem cells the way they divide, produce energy and respond to their environment differs from other cells of the skin:

Converting pyruvate into lactate could be the key to promoting more active follicles.

Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly, said Heather Christofk, an associate professor of biological chemistry and molecular and medical pharmacology.

In one test on mice, the researchers found that when they genetically blocked lactate production, hair follicle stem cell activation was prevented. A second test, completed in collaboration with the Rutter Lab at the University of Utah, found that genetically increasing lactate production in mice accelerated hair follicle stem cell activation and increased the overall hair cycle.

Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells, said Lowry, a professor of molecular, cell and developmental biology. Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.

The research team identified two drugs, RCGD423 and UK5099, that each promoted lactate production when applied to the skin of mice. The first drug works by activating a cellular signaling pathway called JAK-stat, increasing lactate production and in turn the activation of hair follicle stem cells to stimulate hair growth. The second drug blocks pyruvate from entering the mitochondria, forcing the production of lactate in the hair follicle stem cells and accelerating hair growth in mice.

Both experimental drugs are covered by provisional patent applications filed by the UCLA Technology Development Group on behalf of UC Regents. They have been used in preclinical tests only and have not been tested in humans or approved by the Food & Drug Administration.

Through this study, we gained a lot of interesting insight into new ways to activate stem cells, said Aimee Flores, a predoctoral trainee in Lowrys lab and first author of the study. The idea of using drugs to stimulate hair growth through hair follicle stem cells is very promising given how many millions of people, both men and women, deal with hair loss. I think weve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general.

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UCLA scientists identify a new way to activate stem cells to make hair grow – UCLA Newsroom

Posted: August 18, 2017 at 10:45 am

UCLA researchers have discovered a new way to activate the stem cells in the hair follicle to make hair grow. The research, led by scientists Heather Christofk and William Lowry, may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss associated with such factors as hormonal imbalance, stress, aging or chemotherapy treatment.

The research was published in the journal Nature Cell Biology.

Hair follicle stem cells are long-lived cells in the hair follicle; they are present in the skin and produce hair throughout a persons lifetime. They are quiescent, meaning they are normally inactive, but they quickly activate during a new hair cycle, which is when new hair growth occurs. The quiescence of hair follicle stem cells is regulated by many factors. In certain cases they fail to activate, which is what causes hair loss.

In this study, Christofk and Lowry, of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, found that hair follicle stem cell metabolism is different from other cells of the skin. Cellular metabolism involves the breakdown of the nutrients needed for cells to divide, make energy and respond to their environment. The process of metabolism uses enzymes that alter these nutrients to produce metabolites. As hair follicle stem cells consume the nutrient glucose a form of sugar from the bloodstream, they process the glucose to eventually produce a metabolite called pyruvate. The cells then can either send pyruvate to their mitochondria the part of the cell that creates energy or can convert pyruvate into another metabolite called lactate.

Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly, said Christofk, an associate professor of biological chemistry and molecular and medical pharmacology.

The research team first blocked the production of lactate genetically in mice and showed that this prevented hair follicle stem cell activation. Conversely, in collaboration with the Rutter lab at University of Utah, they increased lactate production genetically in the mice and this accelerated hair follicle stem cell activation, increasing the hair cycle.

Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells, said Lowry, a professor of molecular, cell and developmental biology. Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.

The team identified two drugs that, when applied to the skin of mice, influenced hair follicle stem cells in distinct ways to promote lactate production. The first drug, called RCGD423, activates a cellular signaling pathway called JAK-Stat, which transmits information from outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth. The other drug, called UK5099, blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

Through this study, we gained a lot of interesting insight into new ways to activate stem cells, said Aimee Flores, a predoctoral trainee in Lowrys lab and first author of the study. The idea of using drugs to stimulate hair growth through hair follicle stem cells is very promising given how many millions of people, both men and women, deal with hair loss. I think weve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general; Im looking forward to the potential application of these new findings for hair loss and beyond.

The use of RCGD423 to promote hair growth is covered by a provisional patent application filed by the UCLA Technology Development Group on behalf of UC Regents. The use of UK5099 to promote hair growth is covered by a separate provisional patent filed by the UCLA Technology Development Group on behalf of UC Regents, with Lowry and Christofk as inventors.

The experimental drugs described above were used in preclinical tests only and have not been tested in humans or approved by the Food and Drug Administration as safe and effective for use in humans.

The research was supported by a California Institute for Regenerative Medicine training grant, a New Idea Award from the Leukemia and Lymphoma Society, the National Cancer Institute (R25T CA098010), the National Institute of General Medical Sciences (R01-GM081686 and R01-GM0866465), the National Institutes of Health (RO1GM094232), an American Cancer Society Research Scholar Grant (RSG-16-111-01-MPC), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (5R01AR57409), a Rose Hills Foundation Research Award and the Gaba Fund. The Rose Hills award and the Gaba Fund are administered through the UCLA Broad Stem Cell Research Center.

Further research on the use of UK5099 is being funded by the UCLA Technology Development Group through funds from California State Assembly Bill 2664.

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Nanochip Could Heal Injuries or Regrow Organs with One Touch – NewsFactor Network

Posted: August 18, 2017 at 10:44 am

A novel device that reprograms skin cells could represent a breakthrough in repairing injured or aging tissue, researchers say. The new technique, called tissue nanotransfection, is based on a tiny device that sits on the surface of the skin of a living body. An intense, focused electric field is then applied across the device, allowing it to deliver genes to the skin cells beneath it -- turning them into different types of cells.

That, according to the researchers, offers an exciting development when it comes to repairing damaged tissue, offering the possibility of turning a patient's own tissue into a "bioreactor" to produce cells to either repair nearby tissues, or for use at another site.

"By using our novel nanochip technology, injured or compromised organs can be replaced," said Chandan Sen [pictured above], from the Ohio State University, who co-led the study. "We have shown that skin is a fertile land where we can grow the elements of any organ that is declining."

The ability for scientists to reprogram cells into other cell types is not new: the discovery scooped John Gurdon and Shinya Yamanaka the Nobel Prize in 2012 and is currently under research in myriad fields, including Parkinson's disease.

"You can change the fate of cells by incorporating into them some new genes," said Dr Axel Behren, an expert in stem cell research from the Francis Crick Institute in London, who was not involved in the Ohio research. "Basically you can take a skin cell and put some genes into them, and they become another cell, for example a neuron, or a vascular cell, or a stem cell."

But the new approach, says Sen, avoids an intermediary step where cells are turned into what are known as pluripotent stem cells, instead turning skin cells directly into functional cells of different types. "It is a single step process in the body," he said.

Furthermore, the new approach does not rely on applying an electric field across a large area of the cell, or the use of viruses to deliver the genes. "We are the first to be able to reprogram [cells] in the body without the use of any viral vector," said Sen.

The new research, published in the journal Nature Nanotechnology, describes how the team developed both the new technique and novel genes, allowing them to reprogramme skin cells on the surface of an animal in situ.

"They can put this little device on one piece of skin or onto the other piece of skin and the genes will go there, wherever they put [the device]," said Behrens.

The team reveal that they used the technique on mice with legs that had had their arteries cut, preventing blood flow through the limb. The device was then put on the skin of the mice, and an electric field applied to trigger changes in the cells' membrane, allowing the genes to enter the cells below. As a result, the team found that they were able to convert skin cells directly into vascular cells -with the effect extending deeper into the limb, in effect building a new network of blood vessels.

"Seven days later we saw new vessels and 14 days later we saw [blood flow] through the whole leg," said Sen.

The team were also able to use the device to convert skin cells on mice, into nerve cells which were then injected into the brains of mice who had experienced a stroke, helping them to recover.

"With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you're off," said Sen.

The new technology, said Behrens is an interesting step, not least since it "avoids all issues with rejection".

"This is a clever use of an existing technique that has potential applications -- but massive further refinement is needed," he said, pointing out that there are standard surgical techniques to deal with blockages of blood flow in limbs.

What's more, he said, the new technique is unlikely to be used on areas other than skin, since the need for an electric current and the device near to the tissue means using it on internal organs would require an invasive procedure.

"Massive development [would be] needed for this to be used for anything else than skin," he said.

But Sen and colleagues say they are hoping to develop the technique further, with plans to start clinical trials in humans next year.

2017 Guardian Web under contract with NewsEdge/Acquire Media. All rights reserved.

Image credit: The Ohio State University Wexner Medical Center.

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Amanda Grappone Osmer breaks down car sales stereotypes with focus on kindness, integrity – The Keene Sentinel

Posted: August 18, 2017 at 10:41 am

In 2014, during a speech in Manchester, Amanda Grappone Osmer made a startling admission.

I know why you hate me, she began, when it came her time to speak at TEDx Amoskeag Millyard. You all have memories of someone like me that takes you back to a time and place that you wish you didnt have to think about.

Your palms start to sweat. Your stomach is in a knot. Like me, your heart races. You just have an overall feeling of dread.

Mentally, you start to make a tally when you see me coming of all the ways you might get ripped off.

She describes further this experience with her at its center.

When you see me, you load up for bear. Because you know you need to, just to get through our conversation, she says.

You hate me because I am a car salesman. A fourth-generation car salesman.

And with a deep breath, she adds, I understand.

Osmers speech spoke to a stereotypical experience someone might have purchasing a car, an experience that she likened to being under the ether and one that her companys philosophy seeks to counter. Her personal mission and that of Grappone Automotive Group in Bow, for which she is CEO, moves well past the showroom to all aspects of the business, employee relationships and the manner in which she leads an engaged community life.

The business mission: Dedication to building lifelong relationships with our team members, guests and community by serving with integrity, kindness and respect.

And ingrained among her personal objectives is being a little bit better than the day before.

Osmer, the keynote speaker for The Keene Sentinels Extraordinary Women Awards on Aug. 24, graduated from the University of New Hampshire with a degree in humanities. In her teens, she worked at her familys dealership, which was started by her great-grandparents in Concord in 1924 as a Gulf service station. It is now five dealerships. But, despite her early work at the dealership, Osmer didnt envision a future for herself in the cars.

In 2001, after school and marriage, she moved to the West Coast, to the North Bay region of San Francisco. Her marriage ended after a short time, leaving her uncertain what to do next. She applied for all sorts of jobs with no luck, she says. Needing something and knowing something about cars, she found herself selling for Lexus of Marin.

I had never sold anything in my life, she says from her second-floor office at Grappones Toyota franchise, not far from the end of Interstate 89. Her notion of sales, she says, was all wrong, and she learned, You have to be nice to people and honest, and you will earn their business.

Three years later, she was back at her family dealership, in charge of fixed operations service, paint and collision. She described this as the hardest job of my life.

It was difficult to find technicians who met company standards, and there were myriad other workforce challenges, not the least of which is that few women run collision and service centers.

I knew nothing about that world, she recalls. It was constant stress.

But it was in this role that she discovered new ways of doing things that would change her and the company she would come to run. She found a mentor in Jeffrey Liker, the author of The Toyota Way, a best-seller at more than 650,000 copies and translated into 27 languages.

Liker, with whom Osmer corresponds, is professor of industrial and operations engineering at the University of Michigan and has written extensively about how Toyotas manufacturing processes employed principles to reduce waste, boost efficiency and create collaborative workforces to solve problems. He has also profiled other companies using these strategies and measurements, first pioneered by W. Edwards Deming in post-World War II Japan.

I fell in love with lean manufacturing, says Osmer, referring to the umbrella term under which these principles exist.

She opens Likers book frequently; her copy is dog-eared, heavily highlighted and fingerprinted and never far from reach. There are, in the lean world, seven categories of waste transport, inventory, motion, waiting, overproduction, over-processing and defects.

Osmer considers it one of her lifes highlights being invited to speak at the headquarters of Dupont in Delaware at a gathering of collision center specialists a conference at which Liker was speaking, too.

Shes asked if Grappone is an efficient operation.

Its a goal, she says candidly, referring to a never-ending focus on continuous improvement.

From the service operation, Osmer was promoted to COO and director of sales. The sales process was going through a similar evolution, she says.

We had peeled away from the current (traditional) way of doing things, she says, referring to the industry standard of commission-based selling. We had to figure out what is our way I really started to notice that we didnt have anyone recognizing the human experience.

The company hired a director of corporate potential a key decision and embarked on strategic planning that led to an unusual, if not dramatically different approach to business. Its primary commitment, she says, is to Grappones 340 employees. They come first in the mission statement by design. Second, the company seeks lifelong relationships with customers and believes this is best achievable if the sales and service experience is not one of negotiation. This, she says, creates integrity and expectations of consistent treatment. Theres a set price for everything, including financing terms. Everyone pays the same, removing the ether to which she referred in her TEDx speech.

Her sales team does not operate on commissions.

It didnt make sense to race to the bottom on pricing, she says.

Having Toyota as a flagship franchise was helpful; expectations of franchises are reasonable, she says, allowing room for Grappones way.

Always trying to be less wasteful as a company, Osmer said an eighth measure of waste also became a Grappone focus the waste of human creativity. Maybe more than any of the other principles, Osmer emphasizes a workplace that allows innovation to occur. As she describes ways this has been manifested, Ron Malachi, the companys inventory pricing specialist, walks by her office.

He ducks in when asked and rattles off several recent problems a team of folks has solved, including storing extra car inventory at a nearby indoor sports facility.

They get some income, and we get a place (to keep the cars), he says.

Osmer is one of five children born to Robert and Beverly Grappone. Her younger brother, Greg, was her only sibling to be part of the business, eventually becoming the groups chief information officer.

Greg, who had health challenges early in his life, developed cutaneous T-cell lymphoma in his 30s. He found he needed a blood stem cell transplant when the disease turned aggressive.

Osmer was a match for the transplant. Treatment involved eradicating Gregs immune system and injecting new stem cells through a transfusion of Osmers blood. The cancer was killed, but a gruesome side effect graft versus host disease took hold. Osmer described the horrific condition that transpired as one that literally hardened his tissues.

Greg died in 2015, leaving behind a wife and a two-year-old daughter.

In his name, Osmer works on a project that would develop a six-mile abandoned rail line into a new bike and walking path that connects to the Northern Rail trail and would link Concord to Lebanon. It is but one page in her deep portfolio of community work.

She says this involvement in social causes is informed by her familys work.

We were always taught its not about us, she says. Dad just didnt get hung up on material things. I dont get upset when I dont have more things. Its better to express me through how much I help people.

She sees herself as dedicated to serving a lot of people, and it starts with the employees, as the mission suggests.

People need to feel safe; psychological safety, physical safety and having flexibility, she says, describing how the company culture is modeled.

In such an environment, creativity is unleashed, efficiencies are found and people are retained. That environment includes an immaculate, welcoming Toyota dealership building that features a grand piano on its second floor a gift to Osmer from her grandfather.

So, its not a surprise that her team of six directors has more than 140 years of collective service to Grappone.

Away from the dealership, Osmers list of community-service positions is extensive and includes: board member, New Hampshire Public Broadcasting System; corporator, Canterbury Shaker Village; board member, The Endowment for Health; member, Partners for Community Wellness; member, New Hampshire Lemon Law Board; advisory member, Spark New Hampshire; advisory member, Stay Work Play New Hampshire; and advisory member, New Hampshire Charitable Foundations New Hampshire Tomorrow Initiative.

Recently, she became involved in President Donald Birx move to reorganize Plymouth State University into seven educational clusters, beginning this fall. They are: arts and technology; education, democracy and social change; exploration and discovery; health and human enrichment; innovation and entrepreneurship; justice and security; and tourism, environment and sustainable development.

I try to go where I can be most useful, she says, adding she prefers, in many cases, serving one term on a board rather than more to allow broader service.

Osmer lives with her husband, Tom, and three children (two girls and a boy) in a log home in Canterbury. The community, known for its Shaker history, suits her in many ways, from the caring she can expect from the Canterbury Library staff if she drops her son off some afternoon, to the wooded setting that allows her to indulge in trail running, to the neighborly warmth of the Canterbury Fair, recently held.

And, its just the right setting to play her banjo, her instrument of choice.

Osmers is a life being well lived and one seemingly grounded in the words she used to finish her TEDx speech.

So, this is not just about car sales. Its not just about a fourth-generation family business in Bow Junction, New Hampshire, she says. Ask yourselves. Do integrity, kindness and respect form the foundation of all of your relationships, with the people you love the most, with the people you work with, with the people you meet every day? Do they?

If they dont, dont worry about it, she says. Just know that you are under the ether with all of the rest of us. And its time to wake up.

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China, not Trump or Kim, calls shots – The Garden City Telegram

Posted: August 18, 2017 at 10:40 am

By DAVIS MERRITTCourtesy of the Wichita Eagle

Considering all the recent public bombast, one might think that Kim Jung Un and Donald Trump control the future of the Korean peninsula. They dont. China does.

Kim and Trump choose not to distinguish between rhetorical and actual threats, so seem compelled to demonstrate their manhood by over-reacting to either one. Thats how fights start, whether in kindergarten sandboxes, after senior proms or on the world stage with apocalyptic weapons. Fortunately, theres an involved adult around in this case China to keep the lid on.

If Trump were an enlightened, experienced leader rather than a spoiled, insulated autocrat, he would know that true strength is most effectively employed quietly and its exercise neednt be preceded by public bluster.

It has been inevitable for years with China as reluctant enabler that North Korea would develop nuclear missiles capable of hitting the U.S. Thats in Chinas best interest, but its also in Chinas best interest that they never be used.

Both China and North Korea know that any attack on American territories or facilities would result in the instantaneous destruction of North Koreas cities, military and the Kim regime. Thats the last thing China wants because the inevitable result of the collapse of Kim whether by fire and fury or strongly enforced economic sanctions would be millions of refugees flooding across the 880-mile Chinese-Korean border, eventually followed by reunification of Korea that would plant Korean and American forces along that border.

Which would also upset Trumps buddy Vladimir in Moscow, since Russia and Korea share 11 miles of border tucked into the northeast corner of the peninsula.

Given those realities, it is useless as well as a sign of weakness that Trump, every time Kim fires off another missile or his mouth, responds with threats of fire and fury, and America being locked and loaded.

Its possible, and scary, that both pathologically narcissistic men are talking primarily for home consumption and that either could talk himself into a testosterone-infused corner from which the only escape he could see would be to lash out militarily.

Kim and his familial predecessors long have used the threat of American aggression to justify the vast expense of the missile buildup that helps impoverish his miserable nation. Every public outburst from Trump strengthens Kims domestic propaganda hand, so Kim immediately responds (watch out Guam), and Trump doubles down.

Whether Trumps bombast helps him with more than his impenetrable, if shrinking, political base is uncertain. But if hostilities erupt, Americans will clearly know who to blame since 70 years of presidents have lived in a nuclear environment while maintaining Americas position in a changing world.

China and Russia recognize the danger of the Trump-Kim mouth-off, but they have limited options. They understand Mutually Assured Destruction and have avoided playing the N-card or overtly threatening to do so. They know there would be no winners, only survivors. They know that employing North Korea as a proxy combatant against the U.S. would also have the same net negative results, so North Korea will be allowed to join the club.

MAD is neither a comfortable status nor inexpensive, but its where the world is stuck and it has worked thus far. Trump, the prideful Great Disrupter, needs to figure that out, or, if he cannot, heed his advisors who have.

Davis Merritt, Wichita jounralist and author, can be reached at dmerritt9@cox.net

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Inside an appointment at Seattle Children’s Gender Clinic – KING5.com

Posted: August 18, 2017 at 10:40 am

Elisa Hahn, KING 6:37 PM. PDT August 14, 2017

Dr. David Breland checks Michael Hefferan during a checkup at Seattle Childrens Gender Clinic. (Photo: KING)

Seattle Children's hospital opened one of the first clinics for transgender kids in the state nearly a year ago, and now hundreds of patients from multiple states are seeking its services.

For many kids like Michael Hefferan, the Gender Clinic has opened the door to a new life.

"It was about ninth grade that I came out to everyone at school with my family," Hefferan said.

The 17-year-old remembers hearing about a doctor at Children's who treats trans teenagers and demanded to see him.

"I was pretty much like, 'We need to schedule this as soon as we can. I don't care if it's on my birthday. We need to go in and we need to meet him,'" he said laughing.

Now more than 10 appointments in, Hefferan is here on a Tuesday for a routine checkup.

A nurse takes his vitals, checks his height, weight, and his blood pressure. As part of his transition, the Bothell High School student has been on hormone replacement therapy.

"My voice has gotten a lot deeper," Hefferan said. "I've grown some facial hair. I guess I feel more masculine in my body. I don't know how or why, but I do."

He keeps his medication in a plastic box. A syringe, a notebook where he keeps track of all his injections, his small bottles of testosterone, and band-aids. He administers the shots to himself once every two weeks.

"I just do it right in my stomach, an inch away from the belly button," he said.

Michael Hefferan discusses his physical and emotional health with Dr. David Breland at Seattle Childrens Gender Clinic. (Photo: KING)

This doctor's visit will help determine how the hormone therapy is working.

The appointment is mostly an open dialogue between doctor and patient. Dr. DavidBreland, who heads up the Gender Clinic at Seattle Children's, asks Hefferan how he's feeling, checking in on Hefferan's physical and emotional health.

"Are you dating anyone?" Breland asked.

"No," the teen answered.

The doctor also checks on the impact of the testosterone. Hefferan said he's been noticing facial hair. Breland notes his patient doesn't seem to have any acne.

Hefferan's mom has witnessed dramatic changes in his mood.

"He is so much happier," said Rayna Hefferan. "He's not as mad or as angry at times as he used to be."

Happiness is the goal, according to the clinic's director, and to have the outcome of the particular hormone.

"For testosterone, a lot of my patients want a deeper voice, they want some hair, they want more muscle mass, etc.," said Breland. "And a lot of my patients want to be as 'stealth' as possible. They want to be in the community and perceived as that gender."

"My chest is one of the things that make me most uncomfortable with my body," said Hefferan.

He now binds his chest, a technique used to minimize the appearance of a person's breasts.

"Top surgery is something I've always really wanted from the beginning," said Hefferan. "Just because I bind every day and it's not always the most comfortable."

Seattle Children's does not offer surgeries but provides referrals. For Hefferan, the procedure is on the horizon.

For now,Breland tells him to stay on the same dosage of testosterone, as they wait for his blood test results.

Hefferan is thankful to have a clinic who treats his true self.

"It's really important for the younger kids who come here to have that affirmation that you're okay," he said. "That there is nothing wrong with you for not feeling comfortable with the gender you were assigned when you were born."

Each patient goes through a mental health readiness assessment before starting treatment.

The Gender Clinic now has 250 active patients and hundreds more inquiring about treatment.

2017 KING-TV

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When P-I-G-S fly: Cam, Kalil, and the art of Panthers indoor silliness … – Durham Herald Sun (blog)

Posted: August 18, 2017 at 10:40 am

Would you like to be known as king of the pigs?

For the Carolina Panthers, this is a true honor. The pig in question is P-I-G, a shortened form of the backyard basketball game of H-O-R-S-E. The tournament in question is a 32-player bracket carefully written out on a piece of cardboard and played indoors with a toy basketball, a miniature hoop and an abundance of testosterone.

P-I-G commissioner Ryan Kalil also the Panthers five-time Pro Bowl center rules the league, seeds the bracket from 1-32 and has the final say on all of the many controversies.

The biggest story in the run-up to this years still-in-progress tournament has concerned the absence of quarterback Cam Newton, a previous P-I-G champion and noted pot-stirrer who took exception to some of Kalils many rules and decided not to enter.

He wanted me to beg him to get in, a chortling Kalil said of Newton, and I wouldnt do it.

I asked linebacker Thomas Davis P-I-G champion in 2015, a finalist in 2016 and the No. 1 seed in the 2017 bracket about Newtons reputation for rule-bending in the tournament.

Yeah, hes a big cheater, Davis said, laughing. Thats why were happy hes not in it.

Added Kalil of Newton: Thats one of the reasons I took it public this year, to show him that the league goes on without him.

Kalil has this year decided for the first time pulled back the curtain on the P-I-G tournament, which has been a diversion in the Panthers locker room for about a decade now.

The games originator and commissioner was former Panthers offensive tackle Jordan Gross, and Gross still serves as an unpaid consultant to Kalil on all rules disputes.

Most of the rules are in place to protect everybody and make it fair, Kalil said. I get being (NFL commissioner) Roger Goodell. ... You cant please everybody. You do what you think is best and somebody is not going to be happy.

If you think a game like this would not need many rules, you would be dead wrong. Kalil gave me only a sampling, and he kept thinking of others as we talked.

No dunks, Kalil said. And no jumping. In the past, we had guys who were more athletic than others doing some really crazy stuff. They felt like I changed the rules to make it more fair for the offensive and defensive linemen. But in fact I didnt want to have to explain to Coach why a guy rolled an ankle or something, so I banned it all. Its called too athletic. (Newton did not agree with this rule). So any shots called too athletic are completely banned.

Carolina Panthers center Ryan Kalil (67) said that contrary to what some teammates think the too athletic rule banning certain shots in his P-I-G tournament was not put in place simply to benefit the other offensive linemen who play alongside Kalil.

Jeff Siner jsiner@charlotteobserver.com

The point in P-I-G, of course, is not to get any letters and to make your opponent spell out the word first by missing three shots that you made. The player who gets to shoot first used to be determined by a 2-out-of-3 rock-paper-scissors contest. But in the interest of speeding up the game, the higher seed now always gets that right.

Kalil also reserves the commissioners power to hand out additional penalty letters to anyone showing poor sportsmanship or delaying the game.

If you miss a shot and out of anger you spike the ball or you toss it on the ground where somebody else has to go pick it up? Kalil said. Thats an automatic letter for you. Also, say you do a shot and then I have to match your shot and I miss. And then I catch the ball and do another practice shot? Automatic letter. Theres no extra practicing.

Any player who goes on injured reserve is also knocked out of the tournament, Kalil said. This may seem heartless, but Kalil said it is only because that players schedule no longer gives him the same break time as the others.

Thus, safety Dean Marlowe won his first-round matchup but then was disqualified for the rest of the 2017 tournament because he was recently placed on IR with his hamstring injury.

Carolina Panthers linebacker Luke Kuechly (left) found his way back into the P-I-G tournament run by center Ryan Kalil (67) when his toy horse won the Spartanburg Derby. Kuechly celebrated as if he had just made a game-winning interception.

Davie Hinshaw dhinshaw@charlotteobserver.com

How to replace him? Kalil decided to use a kids horse-racing game during training camp, where six players would pick a horse and the winner got back in. Linebacker Luke Kuechly won what was christened the Spartanburg Derby, which Kalil also put on social media. Kuechly celebrated his return to the tournament like he had just taken back an interception for a touchdown.

Newton was also a big part of the video Kalil posted for the Spartanburg Derby, and he has been hanging around the game occasionally without playing it. The quarterback teasingly posted on Instagram that Kalil should give the people what they want. This years tourney has NO entertainment or PHENOMS. ... The tourney needs a different marketing strategy.

Newton also told the teams website that his absence has struck a deep blow to every games attendance. Ive been the cash cow for that association for too long, he said.

It is true, Kalil admitted, that Newton as a competitor in any P-I-G game brings more players in to watch. The audience is encouraged to verbally abuse the players competing, but cannot touch them.

Cam doesnt have a lot of trick shots, Kalil said. But, as you can imagine, Cam has a lot of theatrics. So he has one shot where he leans against the wall and does the Saturday Night Live What is Love thing and he says Yeah, yeah, yeah about eight times. Then he does an easy shot. But what happens is you are so distracted by the Yeah, yeah that by the time you get to the easy shot youre so flustered and distracted that you end up missing."

There are controversies inside this years tournament as well. Quarterback Derek Anderson has a signature shot he calls The Dolphin, in which he bounces the ball off his forehead and into the hoop. At 6-foot-6, this shot is a lot easier to make for Anderson than it is for 5-9 cornerback Captain Munnerlyn, who complained it should be illegal.

We ruled in favor of D.A., Kalil said of Anderson. We felt like he was using his body type as an advantage. Captain has to figure out a shot that only a short guy could do.

Kalil is a playing commissioner but always loses quickly. I like to play, he said, but I dont like to win because it becomes very controversial if I go deep. I dont honestly throw any games, but I dont get upset if Im out early.

Last years tournament was won by the now-departed offensive tackle Mike Remmers who was much better at playing P-I-G than he was at blocking Von Miller in the Super Bowl so there will be a new champion this year. The tournament is headed toward the quarterfinals with a change of venue, and Kalil plans to get some games in during the Panthers five-day stay in Nashville this week.

Defensive end Julius Peppers has already been eliminated this year by offensive guard Trai Turner despite the fact Peppers once played in college basketballs Final Four.

Bracket Update!

A post shared by Ryan Kalil (@ryankalil67) on Aug 16, 2017 at 5:42am PDT

Defensive end Charles Johnson is still alive he eliminated a former champion in long snapper J.J. Jansen but believes he has been placed in the toughest part of the bracket.

I took out Duke! Johnson said, speaking of Jansen.

The problem is that North Carolina is still in your bracket, countered Kalil, speaking of Davis.

As for Davis, he exudes confidence and is Kalils pick to win his second championship this season.

Im pretty versatile, said Davis, who in slightly more important news signed a one-year contract extension with the Panthers Tuesday to play actual football. I can make them all.

The linebacker hasnt won the 2017 tournament yet, though. The tournament continues, with the winner taking home the piece of autographed cardboard the bracket has been written on and bragging rights as king of the pigs until next year.

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When P-I-G-S fly: Cam, Kalil, and the art of Panthers indoor silliness ... - Durham Herald Sun (blog)

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TAT holds global medical tourism event: "Amazing Thailand Health and Wellness Tourism Showcase 2017," focusing … – Markets Insider

Posted: August 17, 2017 at 3:49 am

BANGKOK, Aug. 17, 2017 /PRNewswire/ -- Mr. NoppadonPakprot, Deputy Governorfor Tourism Products and Business,Tourism Authority of Thailand (TAT) presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, which unveiled the latest "Functional & Regenerative Medicine" innovation in Thailand.

Mr. NoppadonPakprot, Deputy Governorfor Tourism Products and Business at TAT said, "Thailand has long been recognized as a world destination for medical tourism. According to a report by VISA and Oxford Economics, Thailand has once more been confirmed as one of Asia's top medical tourism destinations. Thailand now has 58 JCI-accredited hospitals, more than any other Southeast Asian country."

The Amazing Thailand Health and Wellness Tourism Showcase 2017, under the concept "Thailand: a Paradise for Longevity", showcased Thailand as a destination for longevity products and services.

Thailand has adopted the latest innovative medicine of the century: "Functional & Regenerative Medicine," the most popular health trend in the world. In fact, Thailand is the first and only country in Asia that has specialized Functional & Regenerative Medicine hospitals, namely Better Being Hospital and MALI hospital

Moreover, Thailand has become an anti-aging center in Asia with the largest number of American Academy of Anti-Aging Medicine-certified medical professionals in Asia with 500 doctors.

"Recently, the government implemented new medical tourism policies extending the visitor stay period to 90 days for members of CLMV countries andTaiwan in order to accommodate medical tourists traveling to Thailand. In addition, the long-stay visa has also been extended to 10 years for 14 countries as follow: Japan, Australia, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Sweden, Switzerland, UK, Canada and the U.S. These two recent policies should further enhance the positioning of Thailand to be a world-class medical tourism hub recognized the world over."

Mr. Noppadonnoted: "This is the 4th such event that TAT has organized, and this year we proudly present the top 44 Health and Wellness providers in Thailand. This event will display the potential of Thailand along with its plethora of health and wellness products to international awareness. It will also provide a marketing platform for Thai health and wellness providers to discuss prospective business deals with medical tourism facilitators and travel agencies from across the globe."

The one-day event highlighted why Thailand is a "Paradise for Longevity", along with holding an informative presentation on the concept of "Functional & Regenerative Medicine. In the afternoon, buyers had the chance to discuss business deals with the top 44 health and wellness providers in Thailand, including: General Hospital, Plastic Surgery Hospital, Regenerative Functional Medicine Hospital, Anti-Aging Clinic, Cosmetic & Aesthetic Clinic, Dental Clinic, Cell Therapy Clinic, and Lab Check Up, all of whom were ready to discuss prospective business deals with international buyers.

Mr. NoppadonPakprot concluded as follows: "We hope that this event will further strengthen the awareness of Thailand as the premier destination for health and wellness tourism, and that the trade event would help generate more than 500 million Baht to the Thai economy."

Ms. Jittima Udayachalerm, Director, Royal Orchid Plus Business Unit said, "Royal Orchid Plus is delighted to be part of this global medical tourism event at this time. We've created exciting marketing activities to support this project. "We've organized a special event, inviting Royal Orchid Plus Platinum and Gold members to come and get health check-ups for free, and also given them the chance to meet and buy special packages from the hospitals and clinics at the event. Additionally, we will promote an exclusive health and wellness deal to Royal Orchid Plus members through our online channels, including email, social media, and our website."

SOURCE Amazing Thailand Health and Wellness Tourism Showcase 2017

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TAT holds global medical tourism event: "Amazing Thailand Health and Wellness Tourism Showcase 2017," focusing ... - Markets Insider

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Biobanking Market by Product and Service(Equipment, Consumables, Services, Software), Sample Type (Blood … – Markets Insider

Posted: August 17, 2017 at 3:49 am

NEW YORK, Aug. 16, 2017 /PRNewswire/ -- Factors driving the growth of this market include the increasing number of genomics research activities for studying diseases; advances in biobanking and the growing trend of conserving cord blood stem cells of newborns; government & private funding to support regenerative medicine research, and the growing need for cost-effective drug discovery and development. On the other hand, the growth of this market is hindered to some extent due to the high cost of automation and issues related to biospecimen sample procurement.

Read the full report: http://www.reportlinker.com/p05064741/Biobanking-Market-by-Product-and-Service-Equipment-Consumables-Services-Software-Sample-Type-Blood-Products-Human-Tissues-Cell-Lines-Nucleic-Acids-Application-Regenerative-Medicine-Life-Science-Clinical-Research-Global-Forecast-to.html

"Automated storage is expected to register the highest CAGR during the forecast period" The biobanking market is classified by storage type into manual and automated storage. The automated storage type segment is expected to grow at a higher rate during the forecast period. This is attributed to launch of new and advanced automated storage equipment and increasing demand for the quality storage of samples.

"Regenerative medicine to dominate the market during the forecast period"The biobanking market is segmented based on applications regenerative medicine, life science research, and clinical research. In 2017, the regenerative medicine segment is expected to command the largest share and is also estimated to grow at the fastest rate as compared to other segments. This can be attributed to increasing research activities in the field of regenerative medicine and rising demand for well-annotated and quality biosamples for research.

"Asia-Pacific is estimated to grow at the highest CAGR during the forecast period" Geographically, the biobanking market is dominated by North America, followed by Europe. The Asia-Pacific region is estimated to grow at the fastest rate which can be attributed to the large population in China and India, increasing research in regenerative medicine, and improving life sciences research infrastructure in the region.

The primary interviews conducted for this report can be categorized as follows:

The key players in the biobanking market include Thermo Fisher Scientific Inc. (U.S.), Tecan Group Ltd. (Switzerland), Qiagen N.V. (Germany), Hamilton Company (U.S.), Brooks Automation (U.S.), TTP Labtech Ltd (U.K.), VWR Corporation (U.S.), Promega Corporation (U.S.), Worthington Industries [(Taylor Wharton, U.S.)], Chart Industries (U.S.), Becton, Dickinson and Company (U.S.), Merck KGaA (Germany), Micronic (Netherlands), LVL Technologies GmbH & Co. KG (Germany), Panasonic Healthcare Holdings Co. Ltd (Japan), Greiner Bio One [Greiner Holding AG, Austria)], Biokryo GmbH (Germany), Biobank AS (Norway), Biorep Technologies Inc. (U.S.), Cell & Co Bioservices (France), RUCDR infinite biologics (U.S.), Modul-Bio (France), CSols Ltd (U.K.), Ziath (U.K.), and LabVantage Solutions Inc. (U.S.).

Study Coverage:The report analyses the biobanking market by product and service, sample type, storage type, application and regions. Apart from comprehensive geographic & product analysis and market sizing, the report also provides a competitive landscape that covers the growth strategies adopted by industry players over the last three years. In addition, the company profiles comprise the product portfolios, developments, and strategies adopted by prominent market players to maintain and increase their shares in the market.

Market research data, current market size, and forecast of the future trends will help key market players and new entrants to make the necessary decisions regarding product offerings, geographic focus, change in strategic approach, and levels of output in order to remain successful in the type, products, applications, end users, and regions.

Key benefits of buying the Report:This report will enable both established firms as well as new entrants/smaller firms to gauge the pulse of the market, which in turn will help these firms garner greater market shares. Firms purchasing the report can use any one or a combination of the below-mentioned five strategies for strengthening their market shares.

The report provides insights on the following pointers:

Read the full report: http://www.reportlinker.com/p05064741/Biobanking-Market-by-Product-and-Service-Equipment-Consumables-Services-Software-Sample-Type-Blood-Products-Human-Tissues-Cell-Lines-Nucleic-Acids-Application-Regenerative-Medicine-Life-Science-Clinical-Research-Global-Forecast-to.html

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View original content:http://www.prnewswire.com/news-releases/biobanking-market-by-product-and-serviceequipment-consumables-services-software-sample-type-blood-products-human-tissues-cell-lines-nucleic-acids-application-regenerative-medicine-life-science-clinical-research---g-300505662.html

SOURCE Reportlinker

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Biobanking Market by Product and Service(Equipment, Consumables, Services, Software), Sample Type (Blood ... - Markets Insider

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Advanced maternal age: ethical and medical considerations for assisted reproductive technology – Dove Medical Press

Posted: August 17, 2017 at 3:49 am

Brittany J Harrison,1 Tara N Hilton,1 Raphal N Rivire,1 Zachary M Ferraro,13Raywat Deonandan,4 Mark C Walker13,5

1Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; 2Division of Maternal-Fetal Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada; 3Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada; 4University of Ottawa Interdisciplinary School of Health Sciences, Ottawa, ON, Canada; 5Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, Ottawa, ON, Canada

Objectives: This review explores the ethical and medical challenges faced by women of advanced maternal age who decide to have children. Assisted reproductive technologies (ARTs) make post-menopausal pregnancy physiologically plausible, however, one must consider the associated physical, psychological, and sociological factors involved.Methods: A quasi-systematic review was conducted in PubMed and Ovid using the key terms post-menopause, pregnancy + MeSH terms [donations, hormone replacement therapy, assisted reproductive technologies, embryo donation, donor artificial insemination, cryopreservation]. Overall, 28 papers encompassing two major themes (ethical and medical) were included in the review.Conclusion: There are significant ethical considerations and medical (maternal and fetal) complications related to pregnancy in peri- and post-menopausal women. When examining the ethical and sociological perspective, the literature portrays an overall positive attitude toward pregnancy in advanced maternal age. With respect to the medical complications, the general consensus in the evaluated studies suggests that there is greater risk of complication for spontaneous pregnancy when the mother is older (eg, >35 years old). This risk can be mitigated by careful medical screening of the mother and the use of ARTs in healthy women. In these instances, a woman of advanced maternal age who is otherwise healthy can carry a pregnancy with a similar risk profile to that of her younger counterparts when using donated oocytes.

Keywords: maternal age, medical, ethical, assisted reproduction, menopause

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Advanced maternal age: ethical and medical considerations for assisted reproductive technology - Dove Medical Press

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