The Oregon Stem Cell Center conducts basic and applied research in the field of Stem Cell Biology with the long-term goal to harness the properties of stem cells for regenerative medicine and cell therapy.
Our mission
Cell and transplantation therapy have been part of mainstream medicine for decades, but cell therapy has made only limited advances in several years. Cell therapy is currently used in transfusion medicine, bone marrow transplantation, orthopedics and in dermatology. Although clinical trials have clearly documented the potential for novel cell therapies, cell supply has been severely limiting and is the main obstacle to more wide-spread success. Islet transplants have worked for type 1 diabetes, fetal cells were successful for severe Parkinson's disease and hepatocytes have been useful for the treatment of metabolic disease. Stem cell biology promises to solve the problem of limited cell availability by finding ways to isolate cells from living donors, cadavers or immortal stem cell sources.
Our cores
The Oregon Stem Cell Center has 3 cores:
Philip Streeter, Ph.D. is the director of these core laboratories. The main goal of the cores is to generate novel reagents for the isolation of stem cells and their differentiated offspring by generating monoclonal antibodies directed against cell surface antigens of living cells. To date, antibodies useful for cell sorting of living cells are only available for a very limited number of tissues, chiefly blood tissues. It therefore has not been possible to isolate and purify living liver stem cells, pancreas stem cells, cardiac stem cells etc.
The Oregon stem cell cores are poised to embark on a systematic effort to produce novel cell surface antibodies for all tissues of the mouse, rat, primates and humans. The cell sorting core uses a state-of-the-art Cytopeia high speed InFlux instrument and is capable of sorting large and fragile cells without loss of viability. Pamela Canaday is the FACS operator. The cell isolation core will provide cell isolations services including tissue procurement and protease digestion of these tissues.
Center description
The Oregon Stem Cell Center was created on January 1, 2004 and is directed by Markus Grompe, M.D. The center is housed on the top (7th) floor of the Biomedical Research Building.In 2009, the center administratively became part of the Pap Family Pediatric Research Institute.
The center has both primary and affiliate faculty members representing multiple departments and centers at OHSU. Research topics that are covered include pluripotent stem cells, hematopoietic stem cells, leukemia stem cells, hepatic and pancreatic progenitors, mesenchymal stem cells, neural stem cells, muscle stem cells and intestinal stem cells.
The OSCC has 3 cores, a monoclonal antibody production core, a cell sorting core and a cell isolation core. Philip Streeter, Ph.D. is the director of these core laboratories. The main goal of the cores is to generate novel reagents for the isolation of stem cells and their differentiated offspring by generating monoclonal antibodies directed against cell surface antigens of living cells. The cell sorting core uses a state-of-the-art Cytopeia high speed InFlux instrument and is capable of sorting large and fragile cells without loss of viability. The cell isolation core will provide cell isolations services including tissue procurement and protease digestion of these tissues.
Continue reading here:
About | OHSU
- Oregon baby undergoes fetal surgery for spina bifida | kgw.com - November 24th, 2022
- Neuronal ceroid lipofuscinosis - Wikipedia - November 16th, 2022
- Examining cooperation in nature: Q&A with author Kristin Ohlson - Mongabay.com - September 25th, 2022
- Aileron Therapeutics Announces Late-Breaking Oral Presentation of Non-Clinical Data Demonstrating ALRN-6924 Protected Human Hair Follicles and Their... - May 15th, 2022
- Stem cell timeline: The history of a medical sensation ... - January 5th, 2022
- Gene Therapy for Hearing Loss on the Horizon : The Hearing Journal - LWW Journals - January 5th, 2022
- How to live longer: Green tea may halt brain decline and prolong life - Toys Matrix - December 10th, 2021
- Harvard study links exposure to wildfire smoke and COVID-19 with implications for BC - The Globe and Mail - August 31st, 2021
- YOUR HEALTH: Finding cures by tracking cells - WQAD.com - July 21st, 2021
- 2017 Amtrak tragedy becomes call-to-action for Blood Donor Day this Sat., Dec. 18 - ilovekent.net - December 18th, 2020
- Blood donors needed to keep blood supply stocked for local patients - The B-Town (Burien) Blog - The B-Town Blog - October 16th, 2020
- Stem Cell & Regenerative Therapies | Oregon Regenerative ... - July 4th, 2020
- STEM CELL THERAPY IN PORTLAND, OREGON - Cornell Pain Clinic - July 4th, 2020
- Oregon Medical Centers Regenerative Medicine ... - July 4th, 2020
- Hospitals to Resume Elective Surgeries, Triggering a Surge in Blood Needs - southsoundtalk.com - May 17th, 2020
- 15 Good News Stories To Tackle The COVID-19 Sadness - IFLScience - March 22nd, 2020
- 2020 Emerging Scholars: Dr. Cathy Wong - Diverse: Issues in Higher Education - February 6th, 2020
- Five recent drug target discoveries for pancreatic cancer - Drug Target Review - December 13th, 2019
- Personalized Stem Cells, Inc. Announces First Patients Treated in FDA Approved Clinical Trial for Treatment of Osteoarthritis with Stem Cells - PR Web - November 18th, 2019
- Stem Cell Therapy Salem OR - oregonmedicalcenters.com - September 7th, 2019
- Saccharomyces cerevisiae - Wikipedia - May 13th, 2019
- PRP and Stem Cell Joint Regeneration | Portland Oregon - April 5th, 2019
- Adult Stem Cell Orthopedics - Oregon Regenerative Medicine - April 5th, 2019
- What are stem cells? Oregon Light Therapy - April 5th, 2019
- Inhibitory postsynaptic potential - Wikipedia - April 3rd, 2019
- Stem rust - Wikipedia - March 11th, 2019
- How A "Full Body Stem Cell Makeover" Works - Ben ... - March 9th, 2019
- Stem Cells | Medford | Ashland | Southern Oregon - December 23rd, 2018
- Stem Cell Therapy Portland Oregon | Stem Cell Therapy - September 2nd, 2018
- Portland, Oregon Stem Cell Transplants, West Haven Sylvan ... - August 18th, 2018
- Oregon Stem Cell Center Result of OHSU Research Strides ... - July 26th, 2018
- Stem Cells to Relieve Low Back Pain? WebMD - October 14th, 2017
- Gene editing used to repair diseased genes in embryos - NHSUK - NHS Choices - August 25th, 2017
- Stem Cells, Fetal Tissue Research & Cloning - Oregon Right ... - August 25th, 2017
- New Biomedical Engineering Grants Aim at Heart Failure and Resistant High Blood Pressure - Newswise (press release) - August 25th, 2017
- Altering human heredity? Researchers repair disease-causing gene - TRT World - August 17th, 2017
- The Public Needs to Weigh In on the Ethics of Genetically Engineering Humans - Slate Magazine - August 17th, 2017
- First embryo gene-repair holds promise for inherited disease - HollandSentinel.com - August 14th, 2017
- Early gene-editing holds promise for preventing inherited diseases - The Jerusalem Post - August 6th, 2017
- Embryo Gene-Editing Experiment Reignites Ethical Debate - Scientific American - August 6th, 2017
- Meet the Oregon researcher whose embryo work is shaking the medical world - Portland Business Journal - August 6th, 2017
- Editing human embryos with CRISPR is moving ahead now's the ... - Phys.Org - August 6th, 2017
- Scientists genetically modify human embryos for first time, reports say - Medical Xpress - August 6th, 2017
- First safe repair of disease-causing gene in human embryos - Virginian-Pilot - August 6th, 2017
- The Center for Traditional Medicine in Lake Oswego, Oregon - November 23rd, 2016
- News: VetStem Cell Therapy - November 23rd, 2016
- Oregon Stem Cell Center to focus on adult stem cells as ... - November 20th, 2016
- Oregon Regenerative Medicine - Advanced Joint and Injury ... - August 7th, 2016
- OHSU research team successfully converts human skin cells ... - October 19th, 2015
- Stem cells definition of Stem cells in the Free Online ... - February 17th, 2015
- Oregon Scientists Frustrated At Change In British Human Embryo Policy - February 3rd, 2015
- Obesity, high-fat diets during pregnancy could harm fetus - December 30th, 2014
- Arachnoiditis Stem Cell Treatment | eHow - November 23rd, 2014
- Oregon | Pet Stem Cell Therapy - October 23rd, 2014
- How to Volunteer for Clinical Stem Cell Research | eHow - October 3rd, 2014
- oregon Stem Cell Clinic - August 22nd, 2014
- Oregon Stem Cell Treatment | Stem Cell Treatments - August 22nd, 2014