Jakub Tolar, M.D., Ph.D. – MED – Stem Cell Institute …

Institute Director

tolar003@umn.edu

Education

Dr. Tolar is an Associate Professor of Pediatrics at the University of Minnesota in the Division of Blood and Marrow Transplantation, and an attending physician at the University of Minnesota Amplatz Childrens Hospital Fairview. Dr. Tolar is trained both in basic science and in medicine. He received his M.D. from Charles University in Prague, Czech Republic, and his Ph.D. in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota. He completed a residency in Pediatrics and a fellowship in hematology/oncology and bone marrow transplantation at the University of Minnesota. He is board certified in Pediatric Hematology/Oncology. Dr. Tolar has been the Director of Stem Cell/Gene Therapies in the Division of Blood and Marrow Transplantation since 2011.

Dr. Tolar's research focuses on stem cell therapy for patients with lethal diseasescancer, inborn errors of metabolism, and devastating genetic disorders.

Research Interests

In the laboratory, he is currently working on inducing pluripotency in a variety of cell types and creating human disease models in a dish at the cellular level. He is also investigating gene editing using sequence-specific nucleases. Dr. Tolars primary motivation is improving patient care and the clinical translation of tissue stem cell and regenerative biology. He has several clinical trials that focus on the efficacy and safety of new treatments for diseases like epidermolysis bullosa and dyskeratosis congenita. He also leads the International Fanconi Anemia Gene Therapy Working Group.

Selected Recent Publications

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. Wagner JE, Ishida-Yamamoto A, McGrath JA, Hordinsky M, Keene DR, Woodley DT, Chen M, Osborn MJ, Lund T, Dolan M, Blazar BR, Tolar J. N Engl J Med. 2010;363(7):629-39.

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Jakub Tolar, M.D., Ph.D. - MED - Stem Cell Institute ...