Head, National Institutes of Health Stem Cell Technology …

Department of Health and Human Services

National Institutes of Health

Head, National Institutes of Health Stem Cell Technology Facility

The NIH invites applications from outstanding candidates to establish and direct a Stem Cell Technology Facility (SCTF) located within the intramural program of the National Center for Advancing Translational Sciences. The new Facility is part of a new phase of the NIH Center for Regenerative Medicine, an NIH Common Fund program (http://commonfund.nih.gov/stemcells/index ). The successful candidate will hold a doctoral degree in a relevant field and be a recognized expert and accomplished leader in the field of stem cell biology. S/he must have a strong track record in generating and working with induced pluripotent stem cells (iPSCs), embryonic stem cells, and/or adult stem cells, investigating their biology, differentiation to distinct cell types, screening using small molecules or other modalities, and potential iPSC therapeutic applications.

The Head will direct the scientific operation of the new Facility, comprised of 6 biological scientists with further informatics, automation, compound management, and project management support. The mission of the Facility is to address the top methodological or technical hurdles that currently impede therapeutic use of induced pluripotent stem cells and to rapidly deliver the resulting protocols, standards, data, and tool molecules to the public. The Head will be expected to create a world-class collaborative research group that will catalyze new approaches and uses of iPSCs and differentiated cells derived from them, transforming anecdotal reports into replicable, robust protocols, and creating tools and data that facilitate stem cell research and regenerative medicine. High-priority technology research areas for the Facility include, but are not limited to, derivation of a detailed set of QC standards to assess the differentiation state at specific stages leading to mature differentiated cell types of desired lineages, development of methods to assess heterogeneity of cultures and the functional role of this heterogeneity during directed differentiation, development of methods to produce mature differentiated cells with high efficiency, with the likely requirement for development of 3-dimensional culture conditions, and further advancement of modern gene-editing technologies in the context of iPSCs. The Facility will collaborate with researchers to validate the methods developed within for suitability in regenerative medicine applications. The ideal candidate will be highly innovative, interactive, and collaborative, and will serve as a spokesperson for the Facility at national and international forums.

Salary will be commensurate with experience. A full package of benefits, including retirement, health, life, long-term care insurance, and a Thrift Savings Plan, is available.

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Head, National Institutes of Health Stem Cell Technology ...