Etched in DNA: Decoding the secrets of the past – Christian Science Monitor

Posted: January 5, 2020 at 4:03 am

The study of ancient DNA has enriched our evolving tale of early human history. In the field, its resolved long-standing debates, raised new questions, and added nuance to our perpetual quest to answer what it means to be human.

A decade ago, a team of scientists announced that they had pieced together the full genome of a 38,000-year-old Neanderthal. Their findings ushered in a new decade of discovery and understanding. The sequence was not only a marvel of new technology; it shed light on a debate about how these archaic humans may have interacted with our direct ancestors.

The two had interbred. The idea had circulated in some circles, but had long been considered the musings of a lunatic fringe by many in the field. But now, there it was, etched in the DNA.Paleogeneticists are also digging into ancient genomes looking for biological answers to those questions.

But piecing together a fuller story will take a multidisciplinary approach.Im done with who questions, says archaeology professor John Shea. Ancient DNA is freeing archaeologists up to start looking at the really interesting questions. And the most interesting question is how.

Human origins research. The phrase probably evokes an image of dusty scientists hunched over in the sun, combing the ground for scraps left behind by people of millennia past. The field has long been the realm of stones and bones, with test tube-filled laboratories playing second fiddle.

But thats changing. Paleoanthropology has found a second home in the lab, as geneticists have joined the field, extracting DNA from fossils in search of new insights into early human history.

Its white coat science, says John Shea, a professor of archaeology at Stony Brook University. Its not bluejeans and khaki shirt science.

Over the past decade, the study of ancient DNA has enriched our evolving tale of early human history. In the field, its resolved long-standing debates, raised new questions, and added nuance to our perpetual quest to answer what it means to be human.

I cant tell you how many times Ive had to rewrite lectures because of new paleogenetics revelations, says Jennifer Raff, an anthropological geneticist at the University of Kansas. I cant wait to see what the next decade brings.

Ancient DNA, or aDNA, was just beginning to catch on when Dr. Raff finished her dual Ph.D. in anthropology and genetics in 2008. Fragments of ancient genomes were being sequenced, analyzed, and discussed. But Dr. Raff was unsure if science could ever recover full genomes from long back in time.

But then it happened. The following year, a team of scientists announced that they had pieced together the full genome of a 38,000-year-old Neanderthal. They published their findings in May 2010 in the journal Science, ushering in a new decade of discovery and understanding.

The sequence was not only a marvel of this new technology; it shed light on a long-standing debate about how these archaic humans may have interacted with our direct ancestors.

The two had interbred. The idea had circulated in some circles, but had long been considered the musings of a lunatic fringe by many in the field. But now, there it was, etched in the DNA.

For decades, scientists categorized hominins based on the differences in the shape of their bones. But DNA has brought a faster way to get more definitive answers about the identities of ancient peoples.

Im done with who questions, Dr. Shea says. Ancient DNA is freeing archaeologists up to start looking at the really interesting questions. And the most interesting question is how. How did a group of ancient people move across a forbidding landscape? How did they survive through frigid winters?

Those questions can help to animate our view of the past, and deepen our understanding of where we come from. Paleogeneticists are digging into ancient genomes looking for biological answers to those questions, too, but piecing together a fuller story will take a multidisciplinary approach, says Dr. Raff.

Theres a whole field of anthropology that talks about what makes us human, and thats not just our biology, she says. Its also culture and technology and behavior and ecology. Theres just so much that goes into understanding the past.

The revelation that Neanderthals interbred with early Homo sapiens has raised some fundamental questions about what it means to be human.

Traditionally, the line between species is defined by whether they can interbreed and produce viable offspring that can, in turn, produce viable offspring. But, due to similarities in the bones and now the genetic evidence, some anthropologists have labeled Neanderthals as Homo sapiens neanderthalensis and anatomically modern humans as Homo sapiens sapiens.

One such researcher is Fred Smith, professor emeritus of anthropology and biology at Illinois State University. He argues it from a morphological point of view, too.

You would never mistake a Neanderthal for anything but a human, Dr. Smith says. It might not be a human that youd like to go on a blind date with, but if you saw one, you wouldnt think of it as not being human.

By that logic, many researchers refer to other members of the genus Homo as human, too. But some say it might be our understanding of speciation that needs revising, not the distinctions among species in the genus.

The pattern of evolutionary thinking is that you have a point in time where two lineages diverge, after which they do not cross again, says Rick Potts, director of the Smithsonian National Museum of Natural Historys Human Origins Program.

But that branching model of evolution and speciation is proving to be too simplistic across biology, with hybridizing appearing among present-day creatures, too. Evolution and the formation of species are a process, not an event, he says.

Regardless of whether we can call Neanderthals one of us, the revelation of prehistoric trysts between the two peoples has changed our perception of those other humans.

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Before ancient DNA came on the scene, Neanderthal was often lobbed as an insult and sometimes still is. When archaeologists suggested that they had found Neanderthal art and musical instruments, they were dismissed quickly, as the logic went that only Homo sapiens could have the cognitive abilities for that level of creativity. But with the revelation that we are similar enough to them that we could interbreed, that kind of research has been entertained and discussed more frequently.

I think it gives a very important correction on those who would see the Neanderthal simply as incapable of thought, incapable of being clever, Dr. Potts says. And it also, I think, gives a bit of humility to ourselves for those who are willing to look at it.

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Etched in DNA: Decoding the secrets of the past - Christian Science Monitor

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