List of Gene Therapy Clinical Trials – Rising Tide Biology

Medicine is becoming more personalized. Cell therapies, such as CAR-T, are perhaps the most dramatic example of personalized medicine. Blood is drawn from a lymphoma patient, their immune cells are separated out and shipped off to a central manufacturer site. A pharmaceutical company genetically modifies each batch of immune cells. These genetically engineered immune cells are then shipped back to the patient and infused back into their body. Thousands of patients have now been treated with these CAR-T cell therapies.

Could this CAR-T process be more efficient if we decentralized the manufacturing process?

What if regional hospitals and academic centers genetically engineered the patients immune cells on site, without shipping to a central manufacturer? This could shave many weeks off the processing time. For 3rd line cancer patients, time is critical. Many 3rd line lymphoma patients pass away while waiting for their cells to return from a centralized manufacturer. Each week eliminated in cell manufacturing time would save lives.

This 2020 article in Cancer Therapy and Prevention analyzes the potential costs savings of decentralized cell therapy.

Ill be exploring various applications of decentralization in cell and genetic medicine in future articles. If this concept is interesting to you, then please reach out and share your thoughts.

~Kevin

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List of Gene Therapy Clinical Trials - Rising Tide Biology