The promise of embryonic stem cell research has been thwarted by an inability to answer a simple question: How do you know a good stem cell from a bad one?
Yale researchers report in the Sept. 4 issue of the journal Cell Stem Cell that they have found a marker that predicts which batch of personalized stem cells will develop into a variety of tissue types and which will develop into unusable placental or tumor-like tissues.
Scientists have been unable to capitalize on revolutionary findings in 2006 that adult cells could be made young again with the simple introduction of four factors. Hopes were raised that doctors would soon have access to unlimited supplies of a patients own iPSCs induced pluripotent stem cells that could be used to repair many types of tissue damage. However, efforts to direct these cells to therapeutic goals have proved difficult. Many attempts to use cells clinically have failed because they form tumors instead of the desired tissue.
The team of Yale Stem Cell Center researchers led by senior author Andrew Xiao identified a variant histone a protein that helps package DNA which can predict the developmental path of iPSC cells in mice. An accompanying paper in the same journal by researchers at the Whitehead Institute at MIT and Hebrew University in Israel also identifies at different marker that also appears to predict stem cell fate.
The trend is to raise the standards and quality very high, so we can think about using these cells in clinic, Xiao said. With our assay, we have a reliable molecular marker that can tell what is a good cell and what is a bad one.
Lead author of the paper is Tao Wu of Yale.
Research is funded by Yale and Connecticut Stem Cell Foundation.
See the rest here:
YaleNews | How to tell good stem cells from the bad: Yale ...
- Home | Department of Animal Science - September 25th, 2022
- Blood, sweat, and many miles for cellular therapy - Martha's Vineyard Times - July 27th, 2022
- An Experimental Treatment Failed in Mice, and Researchers Did the Right Thing: They Published About It - UConn Today - UConn - June 22nd, 2022
- BrainStorm Strengthens Executive Team with Key Appointments in R&D and Legal USA - English - USA - English - PR Newswire - May 15th, 2022
- Is Stem Cell Research Illegal in The United States? - April 6th, 2022
- The Pfizer-BioNTech vaccine explained: Whats in it and how does it work - KELOLAND.com - October 16th, 2021
- COVID SCIENCE-Coronavirus may have reached U.S. last December; some cancer therapies may prolong infectiousness - Reuters - December 3rd, 2020
- Yale New Haven Health Docs: Interpreting the Uptick in Covid-19 Cases - Greenwich Free Press - October 31st, 2020
- Stem Cell Therapy Connecticut - Boston Stem Cell Center - October 24th, 2020
- Buzzing to Rebuild Broken Bone: Its Electric! - UConn Today - July 2nd, 2020
- Connecticut governor seeks 3rd party review of nursing homes - Thehour.com - June 13th, 2020
- The Growing Prison Pandemic Wasn't Inevitable, and It's Not Too Late to Fight It - brennancenter.org - April 9th, 2020
- Yiviva Announces Dosing of First Patient in Phase 2b Study of First-Line YIV-906 Plus Sorafenib Combination Therapy in the Treatment of Hepatocellular... - April 6th, 2020
- Stem cells that can grow new bone discovered by researchers - Drug Target Review - March 7th, 2020
- University of Connecticut Reverses Prader-Willi Syndrome in Lab by Restoring Silent Genes - Gilmore Health News - January 5th, 2020
- Comparing of Brainstorm Cell Therapeutics Inc. (BCLI) and Cara Therapeutics Inc. (NASDAQ:CARA) - The Broch Herald - December 15th, 2019
- Redding woman donates bone marrow, saves life of a father - FOX61 Hartford - November 19th, 2019
- Center for Regenerative Medicine and Skeletal Development ... - September 14th, 2019
- Connecticut Stem Cells | Stem Cell TV - September 10th, 2019
- Our Doctors - MD Stem Cells - April 6th, 2019
- Hartford, CT - Stem Cells Transplant Institute - January 24th, 2019
- Connecticut Pours Millions Into Embryonic Stem Cell ... - December 21st, 2018
- Stem Cell Transplants - Connecticut Children's Medical Center - November 14th, 2018
- Stem Cell Research Program - Grants - portal.ct.gov - September 24th, 2018
- Stem Cell Research Program - portal.ct.gov - June 23rd, 2018
- Regenerative Therapies | DAVID KLOTH, MD | Connecticut ... - June 23rd, 2018
- FDA Response - U.S. Stem Cell Clinic - October 14th, 2017
- Connecticut & New England Stem Cell Injection Therapy ... - September 24th, 2017
- EBAL schools to raise funds for San Ramon Valley alum Jake Javier - SFGate - August 6th, 2017
- Jeff Jacobs: Hall Of Fame Coach Holowaty Fights Illness And Gives Back - Hartford Courant - July 7th, 2017
- Biological Industries USA Signs Agreement with Mill Creek Life ... - Business Wire (press release) - March 12th, 2017
- Stormy Chamberlain - Faculty Directory UConn Health - November 27th, 2016
- Faculty Directory UConn Health - November 25th, 2016
- Cells Harvested From Human Urine Used to Make Stem Cells - September 18th, 2016
- Skeletal muscle stem cells - National Center for ... - August 22nd, 2016
- StemCONN - July 31st, 2016
- STEM CELL TECHNOLOGIST with Yale-New Haven Hospital | 31281935 - October 5th, 2015
- Stem cell research blooms at Yale and in Connecticut - October 5th, 2015
- Stem Cells jobs - Science Careers - October 1st, 2015
- Bridgeport Connecticut Stem Cell Research | Bridgeport CT ... - June 20th, 2015
- Stem Cells: Thematic Research Areas - June 4th, 2015
- 365 days: Nature's 10 - December 18th, 2014
- Stem cells - Dr Olivier Clinic - November 16th, 2014
- D.C.s best places to get beautiful: Nusta Spa and Bang Salon - October 16th, 2014
- Connecticut Stem Cell Therapy | Stem Cell Treatments - September 25th, 2014
- Walk To End Alzheimers - September 16th, 2014
- Connecticut (Stem Cell) - what-when-how - September 5th, 2014
- How to tell good stem cells from the bad: Yale researchers answer key question - September 5th, 2014
- Stem Cell Treatment for Spinal Cord Injury (SCI) with CT ... - August 23rd, 2014
- UConn-Wesleyan University Stem Cell Core UConn Health - August 23rd, 2014
- Connecticut Catholics respond to ALS ice bucket controversy - August 23rd, 2014
- Induced Pluripotent Stem Cell Services Induced ... - August 23rd, 2014
- Stem Cell Institute: Cell and Genome Sciences: UConn Health - August 22nd, 2014