Category Archives: Wyoming Stem Cells

If you or a loved one suffer from Cystic Fibrosis, therapies using adult stem cells may restore your quality of life to a previously unexpected level.

Read this informative news release on how stem cells were used to treat Cystic Fibrosis.

Because adult stem cell therapies are safe, simple, and non-invasive, they particularly help those who have exhausted the possibilities of other treatments. Angelo DiStefano had been told by his CF specialist at Vanderbilt that no more could be done for him and that stem cells would not help. DiStefano was near death in early 2011 when he arrived at our treatment center in the Dominican Republic. He was brought in to the Center on a gurney. When he returned a year later for his second treatment, he walked in to the center on his own -without oxygen!

Below is photo of a healthy Angelo at the Annual Cystic Fibrosis Foundation Gala in Fort Lauderdale in December 2011. The gala was the first time in his 12 year marriage that he could dance with his wife. He is pictured with former Govener Jeb Bush and his wife.

Intercellularis a world leader in the therapeutic use of adult stem cell therapy. Headquartered on the Gulf Coast of Florida in Bonita Springs, Intercellular is led by a team of medical specialists devoted to expanding the treatment possibilities for Adult Stem Cells.

Treatments using your own adult stem cells (which contain the genetic markers for Cystic Fibrosis) combined with the adult stem cells of a relative have been shown to restore some normal functions that had been written off as gone forever. This unique, two pronged attack on both the disease and its underlying cause has produced startlying results. Patients show renewed vigor with a stronger respiratory function. They may recover their independence from breathing devices and other kinds of medical apparatus. They may be freed from their dependence upon others. Hospitalizations have been shown to be reduced dramatically.

Intercellularis the only known provider, using stem cells to treat Cystic Fibrosis, so call or write us today for a free evaluation.

Note: If your oxygen usage is such that you cannot fly commercial airlines, an intermediate course of treatment may be required to reduce your dependency on oxygen before the complete treatment can be performed.

See original here:
Regenocyte, Adult Stem Cell Treatment for Cystic Fibrosis

Adult Stem Cell Therapy

Adult stem cells circulate throughout our bodies and act as natural healers. These cells have vast potential and limitless capabilities. For more than 40 years, adult stem cells have been used to treat cancer patients. Recent advancements in adult stem cell therapy have been astounding. Cells from an ill patient are being used as part of the treatment. There is no possibility of the body rejecting the new tissue formed, making stem cell treatment safe and effective in achieving positive medical outcomes. It is important to note that adult stem cell therapy is not controversial because it involves the use of a patients own tissues and NOT derived from embryos.

Clinical results from cardiac, pulmonary, neurological and vascular procedures have shown that the adult stem cell procedures are as safe as traditional procedures and are complimentary to current medical practice.

Visit our Facebook Page and read more about our real life patients and how adult stem cell therapy has changed their lives.

Adult stem cells are extracted from the patients bone marrow and fat (adipose). At Intercellular Sciences, the naturally occurring stem cells in the blood are cultivated into millions of Regenocyte Adult Stem Cells. The Regenocyte Stem Cells are produced in our international treatment center and are administered into the area of need for the patient. Once injected, they stimulate tissue re-growth and greater blood flow to the affected areas. The goal of the treatment is to replace damaged cells and to promote the growth of new blood vessels and tissues in order to help the target organ function at a greater capacity. There is no risk of rejection since the Adult Stem Cells received are directly from the patient.

Regenocyte Adult Stem Cell Therapy is safe, highly effective and presents minimal risk.

Cardiac:

Pulmonary:

Vascular:

Neurologic:

See the article here:
Adult Stem Cell Therapy is safe, effective, with minimal risk.

A handful of people with type 1 diabetes have been able to survive without insulin shots for more than two-and-a-half years, on average, after having their own blood stem cells removed and reimplanted through intravenous injection, U.S. and Brazilian researchers reported Tuesday.

Patients had their own blood stem cells removed and reimplanted through intravenous injection.

Overall, the technique has been tried in 23 people, mostly boys and young men, who were treated within six weeks of a new diagnosis of type 1 diabetes. People who have type 1 diabetes, an autoimmune disease that destroys the insulin-producing cells in the pancreas, typically need insulin shots to survive. (People with type 1 make up only about 10 percent of all diabetics; most people have type 2, which can be controlled with diet, exercise, oral drugs, or insulin shots.)

After the transplant, 20 of the 23 patients became insulin-free for at least a few months or even years. Twelve of them stayed free of insulin for an average of 31 months and eight patients had periods ranging from six to 47 months in which they were free from insulin. Health.com: A surprising new lip benefit -- stem cells

One patient was free of daily insulin for more than four years before needing insulin shots, according to the report in the Journal of the American Medical Association. The stem cell transplants were performed at a single center in Brazil.

The new findings are "very encouraging," says Dr. Richard K. Burt, associate professor of medicine at Northwestern University's Feinberg School of Medicine, who presented the findings at a Washington press briefing. Still, he said, more study is needed before it's known whether the treatment truly alters the course of the disease. "I never use the word 'cure,'" says Burt, who is also chief of the Division of Immunotherapy and Autoimmune Diseases at Northwestern Memorial Hospital in Chicago, Illinois. "We just have to wait and see."

Two years ago, Burt and colleagues showed that 14 of 15 patients (who were also included in the new study) treated this way were able to go without insulin injections for one to 35 months, but it wasn't clear if this was due to closer medical follow-up and lifestyle changes. In the new study, the researchers measured a protein that suggested the patients did indeed have insulin-producing beta cells, which are typically destroyed by the autoimmune disease.

So far, stem cell transplantation is the only therapy shown to reverse type 1 diabetes in humans, the research team noted. Health.com: Eating to control cholesterol -- everyday diet strategies to lower LDL

However, Dr. Mohamed El-Shahawy, a transplant nephrologist and a member of the islet cell transplantation team at City of Hope in Duarte, California, cited a number of concerns around the study and risks to patients.

"This study basically subjects patients to an unproven high-risk procedure," he said. "Could it be a breakthrough? I don't see it."

Read the original here:
Stem cell transplant 'very encouraging' for type 1 ...

Looking for help with Acne Keloidalis Nuchae in Lander? Listed below are doctors and medical centers in and near Lander Wyoming.

If you are not looking for help with Acne Keloidalis Nuchae, check out the popular Acne Keloidalis Nuchae info on the right navigation area of the page. On the Acne Keloidalis Nuchae pages we include website links so you can check out Acne Keloidalis Nuchae online.

Are you searching for information about Acne Keloidalis Nuchae? Have you or someone you know been diagnosed with Acne Keloidalis Nuchae? Have you considered Stem Cell treatments for Acne Keloidalis Nuchae? Welcome to the stem cell center service for the state of KY! Many diseases and illnesses don't have to be as treacherous as once thought. There are potential cures and treatments available that are quite effective and very hopeful for Acne Keloidalis Nuchae If you are ready to consider adult stem cell treatment and adult stem cell therapy as an alternative for your medical disorder Acne Keloidalis Nuchae, then you are at the right place. Here at alternativetreatmentsfor.com we specialize in providing effective stem cells for Acne Keloidalis Nuchae in or near Lander, KY 82520. For immediate, free, and confidential assistance, download or .pdf file and call our helpline NOW!

Are you searching for a stem cell? Have you or someone you know been diagnosed with Acne Keloidalis Nuchae ? Welcome to the stem cell center service for the state of Wyoming! Many diseases and illnesses are more treatable than most people once thought. There are many potential cures - stem cells and treatments available that have proven to be quite effective and very hopeful for Acne Keloidalis Nuchae

If you are open to the idea of adult stem cell treatment and adult stem cell therapy as an alternative method of treatment for your medical disorder Acne Keloidalis Nuchae, then you have found the right place. Here at naturalcurefor.com we specialize in helping people heal by providing effective and stem cells for Acne Keloidalis Nuchae in or near Lander, Wyoming 82520. For immediate, free, and confidential assistance, download our .pdf file and call our helpline NOW!

We have successfully helped many people in Wyoming. We can help you attain real, effective, stem cells and alternative treatments for Acne Keloidalis Nuchae. Health improvements after our natural method of treatments have been used have shown terrific results in a very high percentage of cases. Every human being deserves to have good health and that is our desire to sincerely provide a network of resources available to help you or your loved one achieve better health. Don't let another day or week go by. Don't think that the pain or the Acne Keloidalis Nuchae you or a loved one have endured cannot be ended or put on a better more natural healing path to good health. Don't give up hope. We can help you recover, but you have to take the first step by contacting us now!

Lander, Wyoming - Stem cell for Acne Keloidalis Nuchae - We Can Provide Some Tremendous Hope if You Are Willing to Consider Adult Stem Cell Therapy and Treatments as Your Path Back To Good Health

Treating Acne Keloidalis Nuchae in a traditional medical manner is sometimes a long and grueling process that can offer less hope than you deserve. Additionally, many traditional medical treatments are riddled with drugs and medications that can sometimes cause even more harm to other parts of the body. Further risks of medication mixups, allergies, destruction of the immune system and the constant level of additional medical treatments that may be required, can sometimes weigh heavily on a patient and their chances of regaining a healthful way of life. Recovery can become difficult or almost impossible in some cases.

We offer an alternative treatment or a more stem cell process that centers around the idea of using your own adult stem cells as the basis of this natural treatment. In some areas of the country, traditional medicine and medical practices may not have acknowledged the benefits that stem cell treatments can bring to the healing process. Stem cell treatments may not be a standard course of medical treatment quite yet, but that may be a result of other political and/or profit motives. But rest assured that is all changing and changing quite rapidly as more and more success and overwhelming evidence indicates that adult stem cell therapy is a very successful and viable treatment process for Acne Keloidalis Nuchae.

Stem cell treatment is extremely effective and very safe. It is also very natural, ethical and a very effective way in assisting the body to heal naturally and wholesomely. It embodies the very idea of "healing" rather than simply medicating a symptom. The main idea of how adult stem cell treatments work are as follows...

View post:
Stem Cell Therapy for Acne Keloidalis Nuchae in Lander Wyoming

Chester was what veterinarians would call a lame dog. He had OCD in both elbows diagnosed at 8 months. Unfortunately, this disease is progressive. Improvement is expected with a treatment of medical and surgical management, but NOT normality because varying degrees of arthritic change already exist and will progress.

Chester was treated with one or more anti-inflammatory drugs once a day, plus something to protect his tummy from the medicine, as well as having the arthroscopic surgery in both elbows before he was a year old. Months after the surgery he was slow to get up and would often cry if we left him alone in a room. We knew he was still in pain.

At about 2 years old he had the stem cell treatment and he was back to his pre-diagnoses self!

Because Labs can act like puppies for a long time, he is now a big 100 lb baby and is full of energy . With the stem cell treatment Chester can again happily run and swim. He gets a walk to the park and to chase his ball daily. In the winter he goes with me to the beach and loves to body surf, something we used to have to moderate so he wouldn't get too sore. Since Vet-Stem's treatment Chester has been off all drugs too! It's truly amazing.

Although Chester is 4 years old now, it's fun to see our "puppy" running around and acting like the goofy Lab that he is.

Our family is truly grateful for the Vet-Stem treatments, it's been a little miracle for our family and for Chester!

- Tabitha & Graham Unterberger & Chester

View post:
Australian Veterinary Stem Cells Pty Ltd

Wichita, KS (PRWEB) September 10, 2014

Ryan Benton, a 28 year-old Duchennes muscular dystrophy patient from Wichita, Kansas, received his first umbilical cord tissue-derived mesenchymal stem cell treatment yesterday following US FDA approval of his doctors application for a single patient, investigational new drug (IND) for compassionate use.

Duchenne muscular dystrophy (DMD) is a rapidly progressive form of muscular dystrophy that occurs primarily in boys. It is caused by an alteration (mutation) in a gene, called the DMD gene, which causes the muscles to stop producing the protein dystrophin. Individuals who have DMD experience progressive loss of muscle function and weakness, which begins in the lower limbs and leads to progressively worsening disability. Death usually occurs by age 25, typically from lung disorders. There is no known cure for DMD.

This trial, officially entitled Allogeneic transplantation of human umbilical cord mesenchymal stem cells (UC-MSC) for a single male patient with Duchenne Muscular Dystrophy (DMD) marks the first time the FDA has approved an investigational allogeneic stem cell treatment for Duchennes in the United States.

Ryan received his first intramuscular stem cell injections from allergy and immunology specialist, Van Strickland, M.D at Asthma and Allergy Specialists in Wichita, Kansas. He will receive 3 more treatments this week on consecutive days. Dr. Strickland will administer similar courses to Ryan every 6 months for a total of 3 years.

This is not the first time Ryan has undergone umbilical cord mesenchymal stem cell therapy. Since 2009, Ryan has been traveling to the Stem Cell Institute in Panama for similar treatments. Encouraging results from these treatments prompted Dr. Strickland to seek out a way to treat Ryan in the United States.

The stem cell technology being utilized in this trial was developed by renowned stem cell scientist Neil H. Riordan, PhD. Dr. Riordan is the founder and president of the Stem Cell Institute in Panama City, Panama and Medistem Panama. Medistem Panama is providing cell harvesting and banking services for their US-based cGMP laboratory partner.

Funding for this trial is being provided by the Aidan Foundation, a non-profit organization founded by Dr. Riordan in 2004 to provide financial assistance for alternative therapies to people like Ryan.

About Van Strickland, MD

Dr. Strickland came to Wichita in 1979 from his fellowship at the National Jewish Hospital in Denver. Since then he has spent one year in Wyoming, one year in Dallas, Texas and one year in Lees Summit Missouri before returning to full-time practice in Wichita, Kansas.

See the article here:
After FDA Approval, Duchennes Muscular Dystrophy Patient Receives First Umbilical Cord Stem Cell Treatment in the ...

Looking for help with Chondromalacia Patella in Alta? Listed below are doctors and medical centers in and near Alta Wyoming.

If you are not looking for help with Chondromalacia Patella, check out the popular Chondromalacia Patella info on the right navigation area of the page. On the Chondromalacia Patella pages we include website links so you can check out Chondromalacia Patella online.

Are you searching for information about Chondromalacia Patella? Have you or someone you know been diagnosed with Chondromalacia Patella? Have you considered Stem Cell treatments for Chondromalacia Patella? Welcome to the stem cell center service for the state of KY! Many diseases and illnesses don't have to be as treacherous as once thought. There are potential cures and treatments available that are quite effective and very hopeful for Chondromalacia Patella If you are ready to consider adult stem cell treatment and adult stem cell therapy as an alternative for your medical disorder Chondromalacia Patella, then you are at the right place. Here at alternativetreatmentsfor.com we specialize in providing effective stem cells for Chondromalacia Patella in or near Alta, KY 51002. For immediate, free, and confidential assistance, download or .pdf file and call our helpline NOW!

Are you searching for a stem cell? Have you or someone you know been diagnosed with Chondromalacia Patella ? Welcome to the stem cell center service for the state of Wyoming! Many diseases and illnesses are more treatable than most people once thought. There are many potential cures - stem cells and treatments available that have proven to be quite effective and very hopeful for Chondromalacia Patella

If you are open to the idea of adult stem cell treatment and adult stem cell therapy as an alternative method of treatment for your medical disorder Chondromalacia Patella, then you have found the right place. Here at naturalcurefor.com we specialize in helping people heal by providing effective and stem cells for Chondromalacia Patella in or near Alta, Wyoming 51002. For immediate, free, and confidential assistance, download our .pdf file and call our helpline NOW!

We have successfully helped many people in Wyoming. We can help you attain real, effective, stem cells and alternative treatments for Chondromalacia Patella. Health improvements after our natural method of treatments have been used have shown terrific results in a very high percentage of cases. Every human being deserves to have good health and that is our desire to sincerely provide a network of resources available to help you or your loved one achieve better health. Don't let another day or week go by. Don't think that the pain or the Chondromalacia Patella you or a loved one have endured cannot be ended or put on a better more natural healing path to good health. Don't give up hope. We can help you recover, but you have to take the first step by contacting us now!

Alta, Wyoming - Stem cell for Chondromalacia Patella - We Can Provide Some Tremendous Hope if You Are Willing to Consider Adult Stem Cell Therapy and Treatments as Your Path Back To Good Health

Treating Chondromalacia Patella in a traditional medical manner is sometimes a long and grueling process that can offer less hope than you deserve. Additionally, many traditional medical treatments are riddled with drugs and medications that can sometimes cause even more harm to other parts of the body. Further risks of medication mixups, allergies, destruction of the immune system and the constant level of additional medical treatments that may be required, can sometimes weigh heavily on a patient and their chances of regaining a healthful way of life. Recovery can become difficult or almost impossible in some cases.

We offer an alternative treatment or a more stem cell process that centers around the idea of using your own adult stem cells as the basis of this natural treatment. In some areas of the country, traditional medicine and medical practices may not have acknowledged the benefits that stem cell treatments can bring to the healing process. Stem cell treatments may not be a standard course of medical treatment quite yet, but that may be a result of other political and/or profit motives. But rest assured that is all changing and changing quite rapidly as more and more success and overwhelming evidence indicates that adult stem cell therapy is a very successful and viable treatment process for Chondromalacia Patella.

Stem cell treatment is extremely effective and very safe. It is also very natural, ethical and a very effective way in assisting the body to heal naturally and wholesomely. It embodies the very idea of "healing" rather than simply medicating a symptom. The main idea of how adult stem cell treatments work are as follows...

View original post here:
Stem Cell Therapy for Chondromalacia Patella in Alta Wyoming

References 1.. Discher, DE. Mooney, DJ. Zandstra, PW. Growth factors, matrices, and forces combine and control stem cells. Science (2009). 26324(5935), 16731677. Article Abstract 2.. Sato, N. Meijer, L. Skaltsounis, L. et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2004). 10(1), 5563. Article Abstract 3.. Schuldiner, M. Yanuka, O. Itskovitz-Eldor, J. et al. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 10 (2000). 97(21), 1130711312. Article Abstract 4.. Xu, C. Rosler, E. Jiang, J. et al. Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium. Stem Cells (2005). 23(3), 315323. Article Abstract 5.. Herszfeld, D. Wolvetang, E. Langton-Bunker, E. et al. CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat Biotechnol (2006). 24(3), 351357. Article Abstract 6.. Laflamme, MA. Chen, KY. Naumova, AV. et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol (2007). 25(9), 10151024. Article Abstract 7.. Lombardo, A. Genovese, P. Beausejour, CM. et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol (2007). 25(11), 12981306. Article Abstract 8.. Lebkowski, JS. Gold, J. Xu, C. et al. Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J (2001). 7(Suppl 2), S83S93. Abstract 9.. Zou, J. Maeder, ML. Mali, P. et al. Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009). 25(1), 97110. Article Abstract 10.. Gropp, M. Itsykson, P. Singer, O. et al. Stable genetic modification of human embryonic stem cells by lentiviral vectors. Mol Ther (2003). 7(2), 281287. Article Abstract 11.. Kooreman, NG. Wu, JC. Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging. J R Soc Interface (2010). 7(Suppl 6), S753S763. Article Abstract

12.. Cao, F. Drukker, M. Lin, S. Molecular imaging of embryonic stem cell misbehavior and suicide gene ablationCloning Stem Cells 2007 Spring; 91107117 [doi: 10.1089/clo.2006.0E16] [pmid: 17386018]

25.. Geron Corporation. . 2010Geron's IND for Spinal Cord Injury Placed on Hold [Press release] Retrieved from http://ir.geron.com/phoenix.zhtml?c=67323&p=irol-newsArticle&ID=1636249&highlight=

26.. Johnson, S. 2010FDA approves Geron's groundbreaking study of embryonic cellsSan Jose Mercury News. Retrieved from http://www.geneticsandsociety.org/article.php?id=5305

43.. Fischer, AH. Jacobson, KA. Rose, J. Paraffin embedding tissue samples for sectioningCSH Protoc 2008 1:pdb.prot4989. [doi: 10.1101/pdb.prot4989] [pmid: 21356832]

44.. Fischer, AH. Jacobson, KA. Rose, J. Cutting sections of paraffin-embedded tissuesCSH Protoc 2008 1:pdb.prot4987. [doi: 10.1101/pdb.prot4987] [pmid: 21356830]

Here is the original post:

Teratoma formation: A tool for monitoring pluripotency in ...

Stem cell research in relation to anti aging medicine is truly revolutionary. Scientists are saying they know more than enough to get started on the development of working anti-aging medicine - therapies that my slow down or reverse the root causes of age-related degeneration. The science behind it is combining biology, chemistry, and genetics.with ethical and moral constraints that may come into question- this will all lead to a very interesting brand of medicine. Although anti aging medicine has been known to some as a viable sub specialty, it is important to note that until recently stem cell research has been viewed in a skewed manner.

Progress in any one area of the science may lead to therapies for a specific class of age-related illnesses. It is reasonable to expect that over time, researchers will be able to fill in the gaps of stem cell research and where it can be appropriately utilized. Already Alzheimers patients are being promised immune therapies that may address suspected causes of neurodegradation. In age related illnesses, it is thought that the damaged mitochondrial DNA is responsible for the progression of the disease process. In the case of cancer therapy it is believed that manipulation of the telomeres may prevent or treat cancer in the body.

When discussing stem cell research in relation to life extension, it can mean many things. It may be a slow process, and one cannot expect to prevent all diseases at once. Anti aging medicine may be cost effective way of addressing the root cause of the disease, not just treating the disease itself.

There are seven proposed categories of biologic processes that can lead to this type of degenerative aging and age related diseases. Scientists have been able to work with potential therapies in the last two decades that have helped in understanding how stem cells will be able to prevent possible disease in the future. It is thought that tissue loses cells with the advancement of age, such as those in the heart and areas of the brain. Stem cell research and regenerative medicine have been providing very promising answers to degeneration through cell loss.

Elimination of telomere-related mechanisms that may cause cancer- by selectively modifying telomere elongation through tissue typing, this may be the answer to the prevention of cancer. Development of therapies to fix mitochondrial DNA may eliminate the functions that are party to the degenerative aging process. Proteins that are outside the cells, many that are vital to artery walls and skin elasticity, are developed early in life and are never recycled or recycled very slowly. These life long proteins are susceptible to chemical reactions that degrade effectiveness, and researchers can locate suitable enzymes or compounds to break down problem cross-links that they body may not be able to handle.

There are certain cases of cell accumulation, in areas where they are unwanted, specifically in the joints of the body, this is akin to arthritis, and other age related diseases. Stem cell therapy can aid in tailoring the body and the immune system to destroy cells as they become problematic, preventing any related problems.

It is understood that as we age, junk material known as amyloid accumulates outside our cells. Vaccines are currently under development for Alzheimer's, a condition featuring prominent amyloid plaques, and similar efforts could be applied to other classes of extra cellular junk material. There are numerous other diseases that can be treated in the same manner with the same methods when research has developed the appropriate therapies. When junk material builds up within the non-dividing long-life span of cells, thus impairing functions and causing damage, it is hard to ignore the repercussions they may have on the future. The biochemistry of this junk is fairly well understood; with the problem lying in the development of a therapy to break down the unwanted material.

With the development of anti aging medicine and the progression of research in the area of stem cells- it is easy to understand how this can truly revolutionize the future. Although there is much to learn about the topic, you may want to discuss with your doctor about how this may impact your future and your life.

Find out more :

Go here to read the rest:

Stem Cell Regrowth - Anti Aging

Primary Outcome Measures: Evidence of engraftment of donor hematopoietic cells following administration of low doses of busulfan and fludarabine [TimeFrame:Throughout study] [Designatedassafetyissue:No] Secondary Outcome Measures: Solid organ toxicity related to the conditioning regimen [TimeFrame:Throughout study] [Designatedassafetyissue:No] Incidence of grade II, III, or IV acute graft versus host disease (GVHD) [TimeFrame:Throughout study] [Designatedassafetyissue:Yes] Level of disease response [TimeFrame:Throughout study] [Designatedassafetyissue:No]

Hemoglobinopathies, such as sickle cell disease and thalassemia major, are genetic diseases associated with significant morbidity and premature death. Allogeneic bone marrow transplantation (BMT) is the only potential cure for severe hemoglobinopathies. Typical regimens have used high doses of chemotherapy or chemo-radiotherapy to ablate recipient hematopoiesis and to prevent graft rejection. The widespread use of this treatment has been limited by toxicity, risk of end-organ damage, and donor availability. This study will use a nonmyeloablative regimen of fludarabine and busulfan to attempt to generate consistent engraftment with donor hematopoietic stem cells in patients with severe hemoglobinopathy.

G-CSF mobilization of the donor's peripheral blood white blood cells will precede donor apheresis. A nonmyeloablative conditioning regimen of fludarabine and busulfan will be administered to patients prior to allogeneic peripheral blood stem cell infusions. FK506 and prednisone will be administered for graft versus host disease (GVHD) prophylaxis. Patients will be evaluated for engraftment, donor: host hematopoietic chimerism, toxicity, and hemoglobinopathy.

Excerpt from:

Stem Cell Transplantation After Reduced-Dose Chemotherapy ...