Category Archives: Regenerative Medicine

Chicago, Sept. 13, 2022 (GLOBE NEWSWIRE) -- According to the new market research report "Cell Culture Media Market by Type(Serum-free (CHO, BHK, Vero Cell), Stem Cell, Chemically Defined, Classical, Specialty), Application(Biopharmaceutical (mAbs, Vaccine), Diagnostics, Tissue Engineering), End User(Pharma, Biotech) - Global Forecast to 2026", is projected to USD 10.3 billion by 2026 from USD 4.9 billion in 2021, at a CAGR of 16.0 % between 2021 and 2026.

Browse in-depth TOC on "Cell Culture Media Market"314 - Tables41 - Figures303 - Pages

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The growth of this market is majorly driven by the rising R&D spending in pharmaceutical companies, emerging cell culture technologies for cell-based vaccines, increasing demand for monoclonal antibodies, growth in stem cell research, the launch of new cell culture media by market players, and the growing focus on personalized medicine. On the other hand, expensive cell biology research products and ethical concerns regarding cell biology research are expected to hinder the growth of this market.

Based on type, the cell culture media market is segmented intoserum-free media, classical media & salts, stem cell culture media, specialty media, chemically defined media, and other cell culture media. In 2020, the serum-free media segment accounted for the largest share of the market. This can be attributed to the advantages of serum-free media over other types of media, including consistent performance, increased growth & productivity, better control over physiological responsiveness, and reduced risk of contamination by serum-borne adventitious agents in cell culture.

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Based on application, the cell culture media market is categorized into biopharmaceutical production, diagnostics, drug discovery & development, tissue engineering & regenerative medicine, and other applications. The biopharmaceutical production segment is further divided into monoclonal antibody production, vaccine production, and other therapeutic protein production. The tissue engineering & regenerative medicine segment is further divided into cell & gene therapy and other tissue engineering & regenerative medicine applications.The biopharmaceutical production segment is estimated to grow at the highest rate during the forecast period. The high growth of this segment is attributed to the commercial expansion of major pharmaceutical and biotechnology companies, the increasing demand for mAbs, and the growing regulatory approvals for the production of cell culture-based vaccines.

Based on end user, the cell culture media market is segmented into pharmaceutical & biotechnology companies, hospitals & diagnostic laboratories, research & academic institutes, and other end users (such as cell banks, CDMOs, and CROs). In 2020, the pharmaceutical & biotechnology companies segment accounted for the largest share of the market. This end-user segment is also estimated to grow at the highest growth rate during the forecast period.

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Geographical Growth Scenario:

The global cell culture media market has been segmented into North America, Europe, the Asia Pacific, Latin America, and the Middle East and Africa. The Asia Pacific market is estimated to register the highest CAGR during the forecast period. The growing geriatric population, favorable regulatory guidelines, government support for cell culture-based vaccine production, low manufacturing costs, and the growing focus of global market players on emerging Asian economies are the major factors contributing to the growth of the market in the Asia Pacific.

Key Players:

Key players in the cell culture media market include Thermo Fisher Scientific, Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), and Sartorius AG (Germany), Corning Incorporated (US).

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Cell Expansion Market by Product (Reagent, Media, Flow Cytometer, Centrifuge, Bioreactor), Cell Type (Human, Animal), Application (Regenerative Medicine & Stem Cell Research, Cancer & Cell-based Research), End-User, and Region - Global Forecast to 2025

Cell Culture Market by Product (Consumables (Media, Serum, Reagent, Vessels), Equipment (Bioreactor, Centrifuge, Incubator)), Application (Vaccines, mAbs, Diagnostics, Tissue Engineering), End User (Pharma, Biotech, Hospital) - Global Forecast to 2026

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Cell Culture Media Market worth $10.3 billion by 2026 - Exclusive Report by MarketsandMarkets - GlobeNewswire

SAN DIEGO & PHILADELPHIA--(BUSINESS WIRE)--Capstan Therapeutics, Inc., a biotechnology company dedicated to developing and delivering precise in vivo cell engineering to patients, launched today with $165 million in financing to build on the foundational insights of world-renowned leaders in mRNA and cell therapy, combining the power of cell therapy with the precision of genetic medicines to help bring safer, first-in-class medicines to more patients in multiple indications.

Capstans foundational precision in vivo engineering technology builds on research conducted in the laboratories of world-renowned mRNA and cell therapy scientists at the University of Pennsylvania.

Capstans funding includes a recently closed $102 million Series A financing led by Pfizer Ventures and joined by Leaps by Bayer, Eli Lilly and Company, Bristol Myers Squibb, Polaris Partners, Alexandria Venture Investments, and all existing investors, which follows a $63 million seed financing led by Novartis Venture Fund and OrbiMed and joined by RA Capital, and Vida Ventures in November 2021.

Advancing Breakthrough Therapies through Precision in vivo Engineering

The company plans to use the funds to further its mission of advancing the clinical promise of cell-based therapies by enabling precise in vivo engineering of cells with payloads necessary to benefit patients across multiple disease categories. Capstans modular platform leverages the biological and technological expertise of its founding scientists and includes proprietary targeted lipid nanoparticles (tLNP) technology, a suite of targeting moieties to mediate cell type-specific uptake, and disease-specific mRNA payloads aimed at directly engineering, or ablating pathogenic cells through in vivo generated CAR T cells.

Capstan is prioritizing programs based on the potential to transform clinical standards of care. The companys initial efforts will focus on developing first-in-class in vivo CAR therapies, with the goal to deliver treatments in an outpatient setting, for patients who have diseases for which there are no effective treatments. Capstan also plans to leverage its precision delivery and engineering technology to advance new therapies for certain monogenic blood disorders.

Visionary Team of Accomplished Executives Poised to Deliver a Transformational Approach

Capstan is also pleased to announce that Laura Shawver, Ph.D., has joined the company as President and Chief Executive Officer. Dr. Shawver brings more than 20 years of experience in executive leadership positions in oncology and other serious diseases to this role, most recently serving as CEO of Silverback Therapeutics and President and CEO of Synthorx.

Our ambition at Capstan is to invent new clinical paradigms through targeted in vivo reprogramming of cells, said Dr. Shawver. Our founding scientific and operational team is purpose-built to advance programs to the clinic that unite decades of combined experience in groundbreaking CAR therapies with the latest advances in mRNA delivery technology. We are also fortunate to have a distinguished investor syndicate that understands the cell therapy landscape and recognizes the potential of this innovative approach. I am thrilled to lead this team as we work toward making this vision a reality for patients.

Laura is an exceptional leader with a well-established track record in drug development and passion for addressing unmet needs in oncology and other serious diseases, said Michael Baran, Ph.D., Partner, Pfizer Ventures. We are delighted to have someone of Lauras caliber captain this exciting next chapter for Capstan to help unlock the potential of this transformative approach for patients.

Dr. Shawver joins an accomplished leadership team of industry veterans who have been at the forefront of cell and gene therapy, including Adrian Bot, M.D., Ph.D., Chief Scientific Officer, formerly Global Head and Vice President of Translational Medicine at Kite, a Gilead Company and previously Chief Scientific Officer at Kite Pharma; and Priya Karmali, Ph.D., Chief Technology Officer, who has over two decades of experience in the field of lipid nanoparticle mediated nucleic acid delivery technologies.

Building on Pioneering Work of World-Renowned Scientific Founders

Capstan builds on a deep history of collaborative research in mRNA-enabled and CAR-based medicines by our incredible group of scientific founders, said Christian Homsy, M.D., MBA, Capstans founding CEO. The company was established to deliver on the promise of cell-based medicines, and with Laura at the helm, is well-positioned to make rapid progress towards clinical evaluation.

The companys scientific founders include several of the experts from the University of Pennsylvania who authored two landmark studies establishing preclinical proof-of-concept for non-viral, in vivo CAR-T therapy that Capstan plans to develop and advance toward the clinic. A 2019 Nature publication demonstrated the preclinical use of ex vivo CAR-T cell therapy against FAP, a fibrosis-related target. A follow-on study published in Science earlier this year built on these earlier results and demonstrated the production of functional CAR-T cells in vivo in a mouse model following a single IV administration of an mRNA encoding an anti-FAP CAR packaged in CD5-targeted-LNPs. The scientific founders span diverse areas of research expertise:

Capstan is uniting several recent life science technological advances in a manner that can hopefully unlock the potential of these technologies to develop new medicines for patients across a wider range of diseases, said Drew Weissman, M.D., Ph.D., Co-Founder of Capstan, who serves as the Roberts Family Professor in Vaccine Research and Director of the Penn Institute for RNA Innovation in the Perelman School of Medicine at the University of Pennsylvania, and co-recipient of the 2021 Lasker-DeBakey Clinical Medical Research Award.

Research conducted at Penn demonstrates the tremendous promise of harnessing mRNA and targeted LNP delivery to train a patients body to make CAR-T cells in vivo, potentially creating new treatment options, said Jonathan Epstein, M.D., Chief Scientific Officer at Penns Perelman School of Medicine. We believe this approach has the potential to make an important impact not only in oncology, but also in fibrosis and many other diseases. My fellow scientific co-founders and I all look forward to actively partnering with Capstan in our collaborative effort to develop medicines that may benefit patients around the world.

About Capstan (www.capstantx.com)

Capstan Therapeutics is advancing precision in vivo cell engineering to develop therapeutics for a broad range of disease categories with unmet or underserved clinical need. The core technology comprises targeted Lipid Nanoparticles (tLNPs) to enable engineering or ablation of pathogenic cells in the body. The company is combining the power of cell therapy with the precision of genetic medicines to develop new treatment options for patients for oncology, fibrosis, inflammation-related diseases, and monogenic blood disorders. The Company is co-founded by pioneers in the field of CAR-based immunotherapy, nucleic acid drug delivery, tLNPs, and regenerative medicine, including experienced industry leaders, as well as academic faculty members from the University of Pennsylvania. Capstan has a bicoastal presence with operations in San Diego, CA and Philadelphia, PA. For more information, please visit http://www.capstantx.com and follow us on LinkedIn.

University of Pennsylvania Financial Disclosure: The laboratories of Drs. Epstein, Weissman, Pur, Albelda and June have received, or may receive in the future, sponsored research funding from Capstan. Penn, and Drs. Weissman, June, Levine, Epstein, Pur, Albelda, Parhiz and Aghajanian each own equity interests in Capstan. Penn and Drs. Weissman, June, Levine, Epstein, Pur, Albelda, Parhiz and Aghajanian have either received, or may receive in the future, license-related financial consideration related to the licensing of certain Penn intellectual property to Capstan. In their capacity as Penn faculty, Drs. Weissman, Albelda, June and Levine also have existing sponsored research and founding relationships with other commercial entities focused on the research and development of mRNA, LNP, cell therapy or immunotherapy technologies.

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Capstan Therapeutics Launches with $165 Million to Deliver on the Clinical Promise of Precise In Vivo Cell Engineering - Business Wire

During the projected period, the market is anticipated to grow as patient preferences shift from traditional medication distribution to the use of enhanced drug administration.

JERSEY CITY, N.J., Sept. 15, 2022 /PRNewswire/ -- Verified Market Research recently published a report, "Pharmaceutical Drug Delivery Market" By Route of Administration (Oral Drug Delivery, Injectable Drug Delivery), By Application (Infectious Diseases, Cancer), and By Geography.

According to an extensive study conducted by Verified Industry Research on the Pharmaceutical Drug Delivery Market, the market was valued at USD 1,403.2 Billion in 2021 and is projected to reach USD 2,583 Billion by 2030, growing at a CAGR of 6.6% from 2022 to 2030.

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Browse in-depth TOC on "Pharmaceutical Drug Delivery Market"

202 - Pages126 Tables37 Figures

Global Pharmaceutical Drug Delivery Market Overview

The processes, formulations, manufacturing procedures, storage arrangements, and technologies utilized to deliver a pharmaceutical substance to its designated therapeutic location are referred to as drug delivery. To increase efficacy and safety, as well as patient convenience and compliance, principles relating to drug production, mode of administration, site-specific targeting, metabolism, and toxicity are applied.

Drug delivery uses a variety of excipients, medicine carriers, and medical devices to modify the pharmacokinetics and specificity of a drug. There is a greater focus on extending a drug's duration of action and bioavailability in order to improve therapeutic outcomes.

Drug delivery is a concept that is closely related to dose form and mode of administration; in fact, the latter is occasionally included in the definition. Despite the fact that the phrases drug delivery and route of administration are sometimes used interchangeably, they are two different ideas. The term "route of administration" refers to the way a medication takes to enter the body, even if "drug delivery" also includes the engineering of delivery systems and may comprise various dosage forms and devices.

Chronic illness incidence is on the rise, the biologics industry is expanding, and new innovative products are being introduced. Ocular inserts, insulin jets, wearables, and other medical devices are being used more often as a result of innovative product debuts that have raised user satisfaction and productivity. The global pharmaceutical delivery market is anticipated to increase as a result of significant investments made by manufacturers in identifying patient requirements and developing products that address those needs.

The Global pharmaceutical drug delivery market has been segmented by Verified Market Research by route of administration, under which the oral drug delivery segment is expected to lead the market. The infectious diseases segment leads the market by application.

Key Developments

Key Players

The major players in the market are Johnson & Johnson, Novartis International AG, F. Hoffmann-La Roche AG, Pfizer Inc., Bayer AG, GlaxoSmithKline plc, Boehringer Ingelheim, Merck & Co., Inc., Sanofi, and AbbVie Inc.

Verified Market Research has segmented the Global Pharmaceutical Drug Delivery Market On the basis of Route of Administration, Application, and Geography.

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Pharmaceutical Drug Delivery Market is expected to generate a revenue of USD 2,583 Billion by 2030, Globally, at 6.6% CAGR: Verified Market Research -...

DALLAS Sept. 09, 2022 Childrens Health,one of the largest and most prestigious pediatric health care providers in the country and the leading pediatric health care system in North Texas, today announced that Childrens Health will initiate and create an approximately 100-bed inpatient unit at the new State Psychiatric Hospital for children and adolescents. The adult hospital is being developed through a partnership between UTSouthwestern Medical Center and the Texas Health and Human Services Commission (HHSC). The pediatric unit is in addition to 200 adult beds at the new state hospital, which is currently in the planning stages of design and construction and expected to open in fall 2025 with the pediatric addition scheduled to open in early 2026.

This donation is a key part of our comprehensive strategy and ongoing commitment to expand access to pediatric and adolescent behavioral health services in North Texas, said Lindsey Tyra, Executive Vice President and Chief Strategy Officer at Childrens Health. We know that addressing this growing pediatric mental health crisis requires a concerted, coordinated response from resources and experts across our community. In collaboration with UTSouthwestern through our joint pediatric enterprise, we are building a sweeping and forward-looking approach to this escalating problem that will also be part of a larger statewide system.

According to the Childrens Health 2021 Beyond ABC Report, an estimated 133,375 North Texas children suffer from an emotional disturbance or addictive disorder, and in 2020 alone, there was a 24% increase in mental health-related Emergency Room visits for children ages 5 to 11. By supporting the expansion of inpatient pediatric psychiatric services at the new state hospital, more North Texas children and adolescents through age 17 with complex mental health needs will have access to behavioral health services when they need it most.

Hicham Ibrahim, M.D.

Our goal is to build a state-of-the-art facility that meets the needs of the communities we serve, says Dr. Hicham Ibrahim, Professor of Psychiatry and Associate Vice President and Chief Medical Officer, Ambulatory Services at UTSouthwestern. This donation gives us the opportunity to better address the mental health crisis affecting pediatric patients in our region and provide them with the specialized care they deserve.

This hospital will save lives, and with this donation, thatll include the lives of children as well, said Scott Schalchlin, Deputy Executive Commissioner for the HHSC Health and Specialty Care System. By expanding access to children and adolescents, were helping to address a truly critical need in our communities: taking care of the mental and physical health of our young people.

For updates on the hospitals progress and additional information on how Childrens Health is working with UTSouthwestern and the Texas Health and Human Services Commission, visit State Hospital Construction Projects.

About UTSouthwestern Medical Center

UTSouthwestern, one of the nations premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institutions faculty has received six Nobel Prizes, and includes 26 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,900 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UTSouthwestern physicians provide care in more than 80 specialtiesto more than 100,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits a year.

About Childrens Health

Childrens Healthis committed to making life better for children. As one of the largest and most prestigious pediatric health care providers in the country and the leading pediatric health care system in North Texas, Childrens Health cares for children through more than 750,000 patient visits annually. The Childrens Health system includes its flagship hospital, Childrens Medical Center Dallas, as well as Childrens Medical Center Plano, the Childrens Health Care Network, specialty centers, rehabilitation facilities and physician services. Childrens Medical Center Dallas continues to be the only North Texas hospital to be ranked in 10 out of 10 pediatric specialties byU.S. News & World Report. Through its academic affiliation with UTSouthwestern Medical Center, Childrens Health is a leader in life-changing treatments, innovative technology and ground-breaking research. This affiliation led to establishing the Childrens Medical Center Research Institute in 2011, committed to pursuing research in regenerative medicine, cancer biology and metabolism. For more information, follow Childrens Health onFacebook,Twitter,Instagram LinkedInYouTube, or visitChildrens.com.

About Texas Health and Human Services

The Texas Health and Human Services Commission owns or operates10 state hospitals, one residential treatment center and 13 state supported living centers across the state. State hospitals provide inpatient psychiatric services to adults, children and adolescents, and state supported living centers serve individuals with intellectual or developmental disabilities. HHSC is also working to serve the growing needs of Texans by modernizing or expanding state hospitals throughout Texas and building a new hospital in Dallas.

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Children's Health will fund pediatric unit at the Texas Health and Human Services Commission UT Southwestern Medical Center psychiatric hospital - UT...

NEWARK, Del, Sept. 14, 2022 (GLOBE NEWSWIRE) -- A recently published study by FMI expects the global demand for cell line development market to increase at a CAGR of 5% during the forecast period between 2022 and 2032, reaching a total of US$ 7.66 Billion in 2032, according to a report from Future Market Insights (FMI). From 2017 to 2021, sales witnessed significant growth, registering a CAGR of 6.1%.

The reasons for surge in the market include the increasing demand for regenerative medicine, shifting in focus towards advanced oncology research and rising demand for biologically derived pharmaceuticals. The advancements in culture technologies are expected to significantly impact the growth of the cell line development market through the forecast period. Moreover, the use of monoclonal antibodies as therapeutic agents to treat different types of diseased cells has invoked prospects of growth of the cell line development market.

Stable cell lines are used in various applications, such as drug screening, gene functional studies and biologics production. Increasing demand for monoclonal antibodies and other biological products will continue pushing sales in the cell line development market.

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Key Takeaways from the Market Study

Compared to the existing mammalian expression systems, human cell lines possess the ability to produce proteins analogous to naturally synthesized proteins in the human body. This property is advantageous for the advancement in protein therapeutics, and acts as a driver for the growth of the biopharmaceutical industry. says an analyst at FMI.

Market Competition

Key players in the cell line development market are Thermo Fischer Scientific, Inc., GE Healthcare, Merck KGaA, Lonza (Sartorius Stedim Biotech S.A.), Danaher, Corning Incorporated. WuXi Biologics, Selexis SA and American Type Culture Collection (ATCC).

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More Insights Available

FMI, in its new offering, presents an unbiased analysis of the global cell line development market, presenting historical analysis from 2017 to 2021 and forecast statistics for the period of 2022-2032.

The study reveals essential insights on the basis of product type (Reagent and Media, Equipment and Accessories and consumables), source type (Mammalian cell line and Non-mammalian cell line), cell lines (Recombinant, Hybridomas, Continuous and Primary cell lines) & region.

About the Healthcare Domain at Future Market Insights

The healthcare domain team at Future Market Insights offers expert analysis, time-efficient research, and strategic recommendations with an objective to provide authentic insights and accurate results to help clients worldwide. With a repertoire of over 100+ reports and 1 million+ data points, the team has been analyzing the industry lucidly in 50+ countries for over a decade. The team provides a brief analysis of key trends including competitive landscape, profit margin, and research development efforts.

Table of Content

1. Executive Summary

1.1. Market Overview

1.2. Market Analysis

1.3. FMI Analysis and Recommendations

1.4. Wheel of Fortune

2. Market Introduction

2.1. Market Taxonomy

2.2. Market Definition

3. Global Cell Line Development Market Opportunity Analysis

3.1. Macro-Economic Factors

3.2. Opportunity Analysis

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Cell Line Development Market Projected to Experience a CAGR of 5% from 2022 to 2032, value worth US$ 7.66 Billion | Future Market Insights, Inc. -...

image:From left to right, Alba Elas-Tersa, Eduardo Soriano, Yasmina Manso and Marta Pascual, from the Department of Cell Biology, Physiology and Immunology of the Faculty of Biology and the Institute of Neurosciences (UBNeuro) of the UB, and the CIBERNED. view more

Credit: UNIVERSITY OF BARCELONA

The correct development of the brain cortex is an essential process for the acquisition of correct cognitive skills. Reelin, a key extracellular protein in neuronal migration and synaptic plasticity, is determinant in this process. For this reason, the dysfunction genetic or at an expression level of this protein is involved in neurodevelopmental pathologies such as lissencephalies, epilepsy or some psychiatric disorders, particularly autism, schizophrenia and bipolar disorder or neurodegenerative diseases.

Now, an article published in the journal Proceedings of the National Academy of Sciences (PNAS) reveals the decisive role of reelin expressed by the Cajal-Retzius pioneer neurons (CR) or cortical GABAergic neurons in the process of corticogenesis and neuronal migration. The study was led by Professor Eduardo Soriano, from the Department of Cell Biology, Physiology and Immunology of the Faculty of Biology and the Institute of Neurosciences (UBNeuro) of the University of Barcelona, and the Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), and its first authors are the researchers Alba Vlchez and Yasmina Manso (UB-UBNeuro-CIBERNED).

The study is based on the analysis of genetically modified mice to inactivate the reelin gene in pioneer CR neurons and cortical GABAergic interneurons. While CR cells play an essential role at early stages, the study stresses the fundamental role of the GABAergic interneuron-derived reelin in late neuronal migration, states Professor Eduardo Soriano.

A new model for reelin protein action

The team also described the existence of transient migratory deficits in some neuronal populations, a process that indicates that reelin expressed by any other of the neuronal populations is sufficient to reverse and compensate for some effects in cortical lamination in the brain. Based on this study, the authors present a new model of action for reelin, in the development of the cerebral cortex based on the cooperation and the spatial, cellular and sequential specific expression of this key protein.

Several neuropsychiatric disorders are linked to alterations in neuronal migration and reelin deficits in interneurons. Thus, this study can provide a better understanding of the mechanisms associated with human brain disorders related to reelin deficits associated with migration alteration, concludes the research team.

Among the coauthors of the study are Marta Pascual and Alba Elas-Tersa (UB-UBNeuro-CIBERNED); Vctor Borrell and Adrin Crdenas, from the Institute of Neurosciences (CSIC-Miguel Hernndez University); Manuel lvarez-Dolado and Magdalena Martnez-Losa, from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), and Angus C. Nairn, from Yale University (United States).

Proceedings of the National Academy of Sciences

Experimental study

Animals

Specific contribution of Reelin expressed by CajalRetzius cells or GABAergic interneurons to cortical lamination

6-Sep-2022

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Originally posted here:
UB researchers identify new model of cerebral cortex development linked to reelin protein expression - EurekAlert

Dr. Julie Russak, Board-Certified Dermatologist

NEW YORK (PRWEB) September 12, 2022

Julie E. Russak, M.D., FAAD., is a Board Certified Dermatologist, Founder of Russak Dermatology Clinic in Manhattan and specializes in general and cosmetic dermatology, regenerative aesthetic medicine, skin cancer and dermatologic surgery. Dr. Russak has received numerous honors and recognition of her clinical excellence, including being selected as a New York Super Doctor by New York Times Magazine.

An Integrative Approach to Aesthetic Medicine and Metabolic Aging on the Cellular LevelThe new physician and nutritionist-led program utilizes a 360 approach to aesthetics and longevity, designed to empower patients with the clinical data, tools and treatments to reverse the signs of aging and feel their best. The program was designed for patients who want to receive a custom plan on how to approach anti-aging and wellness together.- Dr. Julie Russak

In-house Board Certified Holistic Nutritionist & Celebrity Health Coach, Jennifer Hanway, alongside Dr. Russak, leads all patients through their highly-personalized testing analysis and develops customized nutrition, supplement, lifestyle and aesthetic treatment plans. Jennifers deep knowledge of hormonal imbalances, gut health and body composition informs her holistic approach.

Aging well is the mission of the program, and that requires more than skin deep procedures. We have the ability to reprogram gene expression to increase our healthspan, while resetting our cells to a more youthful state. Benefits of the program include slowing premature aging internally and externally, healthy skin and hair, hormone and metabolism optimization, weight loss, increased lean muscle mass, increased energy levels and mental clarity. - Jennifer Hanway.

Russak Dermatology Clinic works with leading integrative laboratories, specializing in epigenetic and functional testing including biological age, food intolerance, gut health, micronutrient and hormone panels. Hormones tell your tissues and organs what to do. A slight imbalance can cause fatigue, anxiety, acne, hair loss, weight change and more. Hormone health is a critical pillar of the program. -Jennifer Hanway.

A Regenerative ResetDr. Russaks Regenerative Aesthetics menu was designed to go hand-in-hand with the program. It includes therapies such as exosomes, stem cell facelift technology, platelet rich plasma (PRP), IV drips and bio-stimulatory injectables. The clinic carries clinical-grade skincare and nutraceuticals that boost the body's natural regenerative responses and have secured brand partnerships available to their patients, including health-expert designed, organic meal delivery service, Daily Dose and integrative supplement brand, Nutrafol.

Russak Dermatology Clinic ExpansionThe newly expanded aesthetic center will house the Anti-Aging Wellness Program and regenerative aesthetics offerings. The mission of the newly expanded space is to guide patients on how to harness the regenerative power of their own body. Think of your skins health, but elevated and enhanced through integrative and cutting-edge aesthetic treatments that address your bodys total wellness, inside and out.

About Dr. Julie RussakJulie E. Russak, M.D., FAAD., is a Board Certified Dermatologist and Founder of Russak Dermatology Clinic. Dr. Russak serves as Faculty at Mount Sinai Hospital, where she teaches dermatology residents and medical students. Dr. Russak has distinguished herself in the medical community through her clinical research, scientific presentations, publications and aesthetic approach. She attends anti-aging, aesthetic and regenerative medical conferences around the world to incorporate advancements in these fields into her practice. Some notable conferences include the Aesthetic & Anti-Aging Medicine World Congress and the Annual Mount Sinai Winter Symposium Advances in Medical and Surgical Dermatology".

Dr. Russak is frequently sought out by beauty editors and industry outlets as an expert contributor, including Good Morning America, NewBeauty, Cosmopolitan, Forbes, and Marie Claire. Dr. Russak serves as a consulting Dermatologist and formulator to clean skincare brand, Covey.

For all marketing and media inquiries, please contact Gabrielle@RussakDermatology.com. Learn more at http://www.russakplus.com and IG: @russakderm

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NYC Dermatologist, Dr. Julie Russak, launches first Anti-Aging Wellness Program of its kind in the U.S. - PR Web

Andre Terzic, M.D., Ph.D.

Center for Regenerative Biotherapeutics, Mayo Clinic

Andre Terzic, M.D., Ph.D.: Regenerative medicine is an exciting component of modern health care. It harnesses breakthroughs in technologies to address major unmet needs of the population, both nationally but also globally. With the successes of traditional medicine, we'll live longer. And aging has been viewed as a major triumph of humanity. At the same time, unfortunately, with aging, we are facing with a growing pandemic of so-called chronic diseases diseases that live with us throughout our lifespan, heart disease, cancer, diabetes and so on.

So regenerative medicine comes with this new ability to understand how our body can heal and to harness its innate ability, that self-ability to heal, to actually provide new solutions to these patients in need. So the Center for Regenerative Biotherapeutics at Mayo Clinic has been built to address the unmet needs of patients. It builds on our new knowledge, bringing new ways to promote the self-repair ability of our body.

There have been magic moments during these few decades that we have built the regenerative medicine field. One such moment was when we saw, for the first time, how out of a stem cell, we can create new beating heart tissue. It was a revolution for us.

We would like to bring now this knowledge that may have started in one field to build it across fields as the new science allows, essentially, for learning between fields. We need true, radical innovation to move the current knowledge into new solutions. That is where regenerative medicine has a unique role. It changes the way we treat patients.

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About Regenerative Medicine - Center for Regenerative Biotherapeutics ...

Dublin, Sept. 06, 2022 (GLOBE NEWSWIRE) -- The "The Global Exosome Market - Market Size, Forecast, Trials, and Trends, 2022" report has been added to ResearchAndMarkets.com's offering.

Exosome technologies have been developing rapidly in recent years and substantial growth is expected for the market as they get integrated into the fields of liquid biopsy, precision medicine, and regenerative medicine. In particular, cancer-derived exosomes influence the invasive potential of cells by regulating angiogenesis, metastasis, and immunity, making them an extremely useful source of biomarkers for use in cancer detection, diagnosis, and therapeutic selection.

The cargo contained within exosomes can offer prognostic information for a range of diseases - including cardiovascular, renal, neurodegenerative, and metabolic diseases - as well as cancer. Researchers investigating exosome biomarkers have discovered, identified, and reported the presence of hundreds of biomolecules within the lumen of exosomes. This discovery has compelled a rapid rise in exosome-related cancer biomarker research, including the use of exosomes for the detection, monitoring, and treatment of a diverse range of oncologic conditions.

Importantly, exosomes are present within a diverse range of biofluids, including serum, plasma, urine, seminal fluid, CSF, saliva, tears, and breast milk. For this reason, exosome-based diagnostics are minimally invasive, offering ease of use and speed of detection. Exosomes can also act as prognostic indicators and predictors of a patient's response to a specific course of treatment.

Exosomes are also being explored for their use as cell-free therapeutics. For example, if a patient has a disease caused by a missing or defective protein or microRNA, the patient's exosomes can be isolated, modified with the appropriate siRNA or protein, and injected back into the patient for treatment. Numerous approaches are being researched for creating drug-loaded exosomes and exosomes themselves can exert powerful effects. For example, mesenchymal stem cell (MSC) derived exosomes have the capacity to suppress inflammation, prevent scar tissue formation, and mediate a healthy immune response.

The Era of Exosomes

For these reasons, exosomes have gone from being overlooked to rapidly gaining momentum as a novel strategy for accessing the therapeutic effects of cells without the risks and difficulties of administering cells to patients. Although exosomes were discovered more than 30 years ago, it was not until recently that the scientific community began to credit exosomes for a range of promising traits.

To date, three pharma companies (Takeda, Jazz Pharmaceuticals, and Roche Pharmaceutical Company) have signed partnership deals with exosome companies offering payment terms structured to deliver at or around $1 billion dollars. Within the past 5 years, there have been at least 7 partnership deals within the exosome industry, 8 large venture capital events, and 2 landmark acquisitions.

Today the exosome industry is witnessing:

Key Topics Covered:

1. REPORT OVERVIEW

2. EXOSOMES: AN OVERVIEW

3. EXOSOME ENGINEERING: THE NEW PLATFORM

4. MSC-DERIVED EXOSOMES IN REGENERATIVE MEDICINE

5. EXOSOME RESEARCH

6. COMMERCIALLY AVAILABLE EXOSOME RESEARCH TOOLS

7. SCIENTIFIC PUBLICATIONS IN EXOSOMES

8. EXOSOME PATENT LANDSCAPE

9. EXOSOMES: CLINICAL TRIAL LANDSCAPE

10. CURRENT STATUS OF EXOSOME MANUFACTURING

11. EXOSOME ISOLATION APPROACHES

12. DIAGNOSTIC APPLICATIONS OF EXOSOMES

13. THERAPEUTC APPLICATIONS OF EXOSOMES

14. APPLICATION OF EXOSOMES IN VACCINE DEVELOPMENT

15. CURRENT STATUS OF EXOSOME INDUSTRY

16. EXOSOME MARKET ANALYSIS

17. PROFILES OF EXOSOME MARKET COMPETITORSCompanies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/ekxak2

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Global Exosome Market Report 2022: Integration into Fields of Liquid Biopsy, Precision Medicine, and Regenerative Medicine Driving Growth -...

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With the promise of regenerative medicine comes the risk of widening health care disparities. Sometimes the newest discoveries, such as regenerative interventions, are out of reach for people in diverse ethnic or socioeconomic groups or they may not understand or trust new options for healing.

Mayo Clinicis trying to overcome those barriers by launching community outreach and a bioethics study aimed at improving access to regenerative medicine among underserved groups.

Regenerative medicine sometimes could look like a science fiction movie. It is important to learn from the community about how things could be better explained to them or how we can erase any doubts that they have about what we do, says Jorge Mallea, M.D., a pulmonologist at Mayo Clinic in Florida. Listening to their concerns, and explaining what we know, the things still we dont have solutions for, and what we are trying to accomplish could improve understanding and engagement.

Regenerative medicine is an emerging field of practice that is shifting the focus of health care from fighting disease to rebuilding health, with an emphasis on repairing, replacing or restoring diseased cells and tissues. Mayo ClinicsCenter for Regenerative Medicineis at the vanguard of this movement, supporting the concept of regeneration for all. Dr. Mallea chairs the centers Equity, Inclusion and Diversity Advisory Committee.

More diverse clinical trials

To ensure that regenerative therapies go beyond selected or priority groups, Mayo Clinic is expanding the recruitment for clinical trials to include more diversity in race, age and socioeconomic status. For example, a dermatology study in Rochester is exploring how certain regenerative interventions might affect ethnic groups with different skin tones.

We want to learn more about diverse groups to ensure the therapies we apply would work for people of different genders, races and genetics, says Dr. Mallea. Its important to have representation from diverse groups. We could learn in our clinical trials that certain groups need different doses or distinct ways of applying the interventions.

In other research,Zubin Master, Ph.D., a bioethicist in Mayo ClinicsBiomedical Ethics Research Program, is leading a bioethics study that seeks to understand possible economic, social and ethnic barriers toplatelet-rich plasma platelets spun from a persons own blood and containing growth factors as an orthobiologic treatment for kneeosteoarthritis. Platelet-rich plasma is a new regenerative intervention that shows healing potential. However, the Food and Drug Administration has not yet approved it. Therefore, patients must pay out of pocket for it.

Mohamed Addani, aMayo Clinic Graduate School of Biomedical Sciencesstudent within Dr. Masters team, will interview patients across Mayo Clinic who choose platelet-rich plasma as an intervention for knee osteoarthritis and those who opt instead for standard care. The team will compare those responses to a more demographically diverse group of patients whove made similar care choices at Detroit Medical Center. Researchers will examine race, ethnicity, socioeconomic and demographic variables, beliefs, attitudes, and understanding of regenerative medicine.

This study will provide the first scientifically based data on whether health disparities exist among patients seeking next-generation regenerative interventions such as platelet-rich plasma, says Dr. Master. The results will give us the unique opportunity to identify factors that are creating barriers to regenerative care and proactively address ways to overcome them.

The project seeks to improve access and make regenerative medicine more equitable among diverse and underserved groups.

Showcasing the cool stuff

Attracting a more diverse pool of regenerative medicine scientists and practitioners is another strategy to boost inclusivity. Mayo Clinic is taking regenerative medicine on the road to high schools and colleges near its destination locations in Arizona, Florida and Minnesota, showcasing what Dr. Mallea describes as the cool stuff in research and development. The hope is that it might inspire students, particularly those from underrepresented and disadvantaged communities, to consider a career in regenerative medicine.

We are sharing examples of our research, such as bioprinting of organs and developing new medicines from living organisms like cells to fight different diseases and cancers, says Dr. Mallea. We hope to plant a seed in their minds that regenerative medicine holds promise not only as a future therapy, but also a future career.

In addition, Mayo is using the Community Scientist Program to open its doors to scientists from the community who want to learn more. This program pairs community scientists with regenerative medicine researchers. Mayo hopes these strategies will improve the interaction and understanding needed to ensure access to new regenerative therapies as they are introduced in the practice.

Envision yourself working for a global leader in an industry fueled by innovation and growth. Mayo Clinic has opportunities for you. Join us at Floridas No. 1 hospital by visiting https://jobs.mayoclinic.org/. For more information on health care topics please visit Mayo Clinic Jacksonville at mayoclinic.org.

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